NO20004798L - Barbitursyrederivat og forebyggende og terapeutisk middel for ben og brusk inneholdende det samme - Google Patents

Barbitursyrederivat og forebyggende og terapeutisk middel for ben og brusk inneholdende det samme

Info

Publication number
NO20004798L
NO20004798L NO20004798A NO20004798A NO20004798L NO 20004798 L NO20004798 L NO 20004798L NO 20004798 A NO20004798 A NO 20004798A NO 20004798 A NO20004798 A NO 20004798A NO 20004798 L NO20004798 L NO 20004798L
Authority
NO
Norway
Prior art keywords
substituted
acid derivative
barbituric acid
bone
group
Prior art date
Application number
NO20004798A
Other languages
English (en)
Other versions
NO20004798D0 (no
Inventor
Kunikazu Sakai
Yusuke Satoh
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO20004798D0 publication Critical patent/NO20004798D0/no
Publication of NO20004798L publication Critical patent/NO20004798L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Barbitursyrederivat ifølge formel (I), der R og R1 uavhengig betegner et hydrogenatom, substituert eller usubstituert alkylgruppe eller GI - Ci5 - alkenylgruppe, en substituert eller usubstituert arylmetylgruppe, og substituert eller usubstituert arylgruppe, og R2 betegner en substituert eller usubstituert alkylgruppe eller Ci - C,5 alkenylgruppe, en substituert eller usubstituert arylmetylgruppe, og substituert eller usubstituert arylgruppe. Barbitursyrederivatet ifølge oppfinnelsen har en sterk inhiberende aktivitet på benresorpsjon og er et nyttig j.UiCuy ggcriuc Og terapeutisk iiiiddel for behandling av sykdommer som påvirker ben og brusk.
NO20004798A 1998-03-27 2000-09-26 Barbitursyrederivat og forebyggende og terapeutisk middel for ben og brusk inneholdende det samme NO20004798L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10100355A JPH11279157A (ja) 1998-03-27 1998-03-27 バルビツール酸誘導体およびそれらからなる骨・軟骨疾患予防・治療薬
PCT/IB1999/000961 WO1999050252A2 (en) 1998-03-27 1999-03-23 Barbituric acid derivative and preventive and therapeutic agent for bone and cartilage containing the same

Publications (2)

Publication Number Publication Date
NO20004798D0 NO20004798D0 (no) 2000-09-26
NO20004798L true NO20004798L (no) 2000-11-20

Family

ID=14271794

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004798A NO20004798L (no) 1998-03-27 2000-09-26 Barbitursyrederivat og forebyggende og terapeutisk middel for ben og brusk inneholdende det samme

Country Status (20)

Country Link
US (1) US6498164B1 (no)
EP (1) EP1064269A1 (no)
JP (1) JPH11279157A (no)
KR (1) KR20010042182A (no)
CN (1) CN1295565A (no)
AU (1) AU759249B2 (no)
BR (1) BR9909139A (no)
CA (1) CA2324584A1 (no)
CZ (1) CZ20003460A3 (no)
EA (1) EA200000992A1 (no)
HU (1) HUP0101505A3 (no)
IL (1) IL138433A0 (no)
NO (1) NO20004798L (no)
NZ (1) NZ506616A (no)
PL (1) PL343433A1 (no)
SK (1) SK14032000A3 (no)
TR (1) TR200002785T2 (no)
WO (1) WO1999050252A2 (no)
YU (1) YU57800A (no)
ZA (1) ZA200004473B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1722796A4 (en) * 2004-02-26 2008-01-23 Inotek Pharmaceuticals Corp TETRACYCLIC LACTAM DERIVATIVES AND USES THEREOF
CN102070623B (zh) * 2010-12-20 2012-07-25 新乡医学院 一种巴比妥酸衍生物及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2921072A (en) * 1956-10-18 1960-01-12 Jr Edgar A Ferguson Nicotinic acid substituents of barbituric acid
GB1339748A (en) * 1970-07-02 1973-12-05 Ici Ltd Pyrimidine derivatives
JPS5829281B2 (ja) * 1974-06-04 1983-06-22 日本曹達株式会社 バルビツ−ル酸系除草剤
US4695673A (en) * 1985-11-20 1987-09-22 Stauffer Chemical Company Process for the production of acylated 1,3-dicarbonyl compounds
US4797147A (en) * 1986-06-09 1989-01-10 Stauffer Chemical Company Herbicidal method and composition utilizing certain 5-(2-substituted benzoyl)-barbituric acids
US4938796A (en) * 1987-07-06 1990-07-03 Ici Americas Inc. Herbicidal compositions of acylated 1,3-dicarbonyl herbicides and antidotes therefor
JP2588780B2 (ja) * 1989-09-26 1997-03-12 富士写真フイルム株式会社 電子写真感光体
US5102760A (en) * 1989-09-18 1992-04-07 Fuji Photo Film Co., Ltd. Electrophotographic photoreceptor and electrophotographic printing plate precursor comprising phthalocyanine pigment and thiobarbituric acid derivative
JP2588779B2 (ja) * 1989-09-18 1997-03-12 富士写真フイルム株式会社 電子写真式製版用印刷原版
JPH03179361A (ja) * 1989-12-07 1991-08-05 Fuji Photo Film Co Ltd 光導電性組成物およびそれを用いた電子写真感光材料
US5141943A (en) * 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
NL9001075A (no) * 1990-05-04 1991-12-02 Duphar Int Res
DE59208375D1 (de) * 1991-06-05 1997-05-28 Ciba Geigy Ag Benzo-1,2,3-thiadiazol-Derivate
EP0809634A4 (en) * 1995-02-13 1998-05-20 Kirpal S Gulliya NEW USES FOR BARBITURIC ACID ANALOGS
JPH10316608A (ja) * 1997-05-14 1998-12-02 Hoechst Yakuhin Kogyo Kk ポリヒドロキシフェノール誘導体およびそれらからなる骨・軟骨疾患予防・治療剤

Also Published As

Publication number Publication date
YU57800A (sh) 2002-10-18
HUP0101505A2 (hu) 2002-03-28
IL138433A0 (en) 2001-10-31
PL343433A1 (en) 2001-08-13
JPH11279157A (ja) 1999-10-12
WO1999050252A2 (en) 1999-10-07
US6498164B1 (en) 2002-12-24
SK14032000A3 (sk) 2001-03-12
ZA200004473B (en) 2001-05-30
CZ20003460A3 (cs) 2001-08-15
EP1064269A1 (en) 2001-01-03
NO20004798D0 (no) 2000-09-26
KR20010042182A (ko) 2001-05-25
WO1999050252A3 (en) 2000-01-13
AU3726099A (en) 1999-10-18
CN1295565A (zh) 2001-05-16
BR9909139A (pt) 2000-12-05
CA2324584A1 (en) 1999-10-07
AU759249B2 (en) 2003-04-10
HUP0101505A3 (en) 2002-06-28
TR200002785T2 (tr) 2001-02-21
NZ506616A (en) 2003-04-29
EA200000992A1 (ru) 2001-06-25

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