|
ES2307482T3
(es)
|
1999-02-10 |
2008-12-01 |
Pfizer Products Inc. |
Dispersiones farmaceuticas solidas.
|
|
US6440959B1
(en)
*
|
1999-04-21 |
2002-08-27 |
Hoffman-La Roche Inc. |
Pyrazolobenzodiazepines
|
|
AR033651A1
(es)
*
|
1999-10-01 |
2004-01-07 |
Hoffmann La Roche |
Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento
|
|
US6313143B1
(en)
*
|
1999-12-16 |
2001-11-06 |
Hoffmann-La Roche Inc. |
Substituted pyrroles
|
|
MXPA02011427A
(es)
*
|
2000-05-16 |
2004-09-10 |
Johnson & Johnson |
Procedimiento para revestir dispositivos medicos utilizando dioxido de carbono supercritico.
|
|
US6469179B1
(en)
|
2000-10-03 |
2002-10-22 |
Hoffmann-La Roche Inc. |
Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
|
|
US6482847B2
(en)
|
2000-10-03 |
2002-11-19 |
Hoffmann-La Roche Inc. |
Amorphous form of cell cycle inhibitor having improved solubility and bioavailability
|
|
US20050048126A1
(en)
|
2000-12-22 |
2005-03-03 |
Barrett Rabinow |
Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
|
|
US9700866B2
(en)
|
2000-12-22 |
2017-07-11 |
Baxter International Inc. |
Surfactant systems for delivery of organic compounds
|
|
US6884436B2
(en)
|
2000-12-22 |
2005-04-26 |
Baxter International Inc. |
Method for preparing submicron particle suspensions
|
|
US6977085B2
(en)
|
2000-12-22 |
2005-12-20 |
Baxter International Inc. |
Method for preparing submicron suspensions with polymorph control
|
|
US6951656B2
(en)
|
2000-12-22 |
2005-10-04 |
Baxter International Inc. |
Microprecipitation method for preparing submicron suspensions
|
|
US8067032B2
(en)
|
2000-12-22 |
2011-11-29 |
Baxter International Inc. |
Method for preparing submicron particles of antineoplastic agents
|
|
US7193084B2
(en)
|
2000-12-22 |
2007-03-20 |
Baxter International Inc. |
Polymorphic form of itraconazole
|
|
US6869617B2
(en)
|
2000-12-22 |
2005-03-22 |
Baxter International Inc. |
Microprecipitation method for preparing submicron suspensions
|
|
US6548531B2
(en)
|
2001-02-09 |
2003-04-15 |
Hoffmann-La Roche Inc. |
Method for cancer therapy
|
|
US6716845B2
(en)
*
|
2001-03-30 |
2004-04-06 |
Hoffmann-La Roche Inc. |
Barbituric acid derivatives
|
|
WO2003013478A2
(en)
*
|
2001-05-30 |
2003-02-20 |
Csir |
Method of encapsulating an active substance
|
|
US20030044514A1
(en)
*
|
2001-06-13 |
2003-03-06 |
Richard Robert E. |
Using supercritical fluids to infuse therapeutic on a medical device
|
|
WO2002102373A1
(en)
*
|
2001-06-15 |
2002-12-27 |
F. Hoffmann-La Roche Ag |
Method for administration of cancer therapeutic
|
|
BR0210518A
(pt)
|
2001-06-22 |
2004-06-22 |
Pfizer Prod Inc |
Composições farmacêuticas de dispersões de drogas e polìmeros neutros
|
|
TNSN03137A1
(en)
|
2001-06-22 |
2005-12-23 |
Pfizer Prod Inc |
PHARMACEUTICAL COMPOSITIONS COMPRISING LOW SOLUBILITY AND / OR ACID SENSITIVE DRUGS AND NEUTRALIZED ACID POLYMERS.
|
|
US20060003012A9
(en)
|
2001-09-26 |
2006-01-05 |
Sean Brynjelsen |
Preparation of submicron solid particle suspensions by sonication of multiphase systems
|
|
JP2005504090A
(ja)
|
2001-09-26 |
2005-02-10 |
バクスター・インターナショナル・インコーポレイテッド |
分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
|
|
US7112340B2
(en)
|
2001-10-19 |
2006-09-26 |
Baxter International Inc. |
Compositions of and method for preparing stable particles in a frozen aqueous matrix
|
|
US20030139373A1
(en)
*
|
2001-11-20 |
2003-07-24 |
Breimer Lars Holger |
Method for cancer therapy
|
|
EP1469833B1
(en)
|
2002-02-01 |
2021-05-19 |
Bend Research, Inc. |
Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus
|
|
MXPA05000977A
(es)
|
2002-08-12 |
2005-05-16 |
Pfizer Prod Inc |
Composiciones farmaceuticas de farmacos semiordenados y polimeros.
|
|
DE10351087A1
(de)
*
|
2003-10-31 |
2005-05-25 |
Bayer Technology Services Gmbh |
Feste Wirkstoff-Formulierung
|
|
JP4947482B2
(ja)
*
|
2003-11-14 |
2012-06-06 |
味の素株式会社 |
フェニルアラニン誘導体の徐放性経口投与製剤
|
|
PL1683524T3
(pl)
|
2003-11-14 |
2011-06-30 |
Ea Pharma Co Ltd |
Stała dyspersja lub preparat farmaceutyczny stałej dyspersji pochodnej fenyloalaniny
|
|
RU2411043C2
(ru)
*
|
2004-04-01 |
2011-02-10 |
Юниверсите Де Льеж |
Фармацевтические композиции пиримидин-2,4,6-трионов
|
|
AR049915A1
(es)
*
|
2004-06-14 |
2006-09-13 |
Anacor Pharmaceuticals Inc |
Compuestos con contenido de boro y metodos de uso de los mismos
|
|
WO2006062980A2
(en)
*
|
2004-12-07 |
2006-06-15 |
Nektar Therapeutics |
Stable non-crystalline formulation comprising tiagabine
|
|
CN101115469A
(zh)
*
|
2004-12-28 |
2008-01-30 |
卫材R&D管理有限公司 |
速崩片及其制造方法
|
|
DK1848430T3
(da)
*
|
2004-12-31 |
2017-11-06 |
Dr Reddys Laboratories Ltd |
Nye benzylamin-derivativer som cetp-inhibitors
|
|
US8604055B2
(en)
|
2004-12-31 |
2013-12-10 |
Dr. Reddy's Laboratories Ltd. |
Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
|
|
TW200633723A
(en)
*
|
2005-01-27 |
2006-10-01 |
Corium Int Inc |
Hydrophilic biocompatible adhesive formulations and uses
|
|
EP1690528A1
(de)
*
|
2005-02-11 |
2006-08-16 |
Abbott GmbH & Co. KG |
Herstellung von Dosierungsformen mit einer festen Dispersion eines mikrokristallinen Wirkstoffs
|
|
WO2006123223A1
(en)
*
|
2005-05-19 |
2006-11-23 |
Pfizer Inc. |
Pharmaceutical compostions comprising an amorphous form of a vegf-r inhibitor
|
|
EP1767194A1
(de)
*
|
2005-06-09 |
2007-03-28 |
Helm AG |
Verfahren zur Herstellung von Adsorbaten des Drospirenons
|
|
UA95244C2
(ru)
*
|
2005-06-22 |
2011-07-25 |
Плексикон, Инк. |
Соединения и способ модулирования активности киназ, и показания для их применения
|
|
US20080031944A1
(en)
*
|
2006-08-04 |
2008-02-07 |
Cima Labs Inc. |
Stabilization of lorazepam
|
|
TW200815033A
(en)
*
|
2006-08-10 |
2008-04-01 |
Cipla Ltd |
Antiretroviral solid oral composition
|
|
US20080107725A1
(en)
*
|
2006-10-13 |
2008-05-08 |
Albano Antonio A |
Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
WO2008079909A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
PE20081581A1
(es)
*
|
2006-12-21 |
2008-11-12 |
Plexxikon Inc |
COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
|
|
WO2008081829A1
(ja)
|
2006-12-27 |
2008-07-10 |
Astellas Pharma Inc. |
難水溶性薬物の溶解性維持用アミノアルキルメタアクリレートコポリマーe
|
|
EP2155166A2
(en)
*
|
2007-05-11 |
2010-02-24 |
F. Hoffmann-Roche AG |
Pharmaceutical compositions for poorly soluble drugs
|
|
US8426467B2
(en)
|
2007-05-22 |
2013-04-23 |
Baxter International Inc. |
Colored esmolol concentrate
|
|
US8722736B2
(en)
|
2007-05-22 |
2014-05-13 |
Baxter International Inc. |
Multi-dose concentrate esmolol with benzyl alcohol
|
|
EP1997479A1
(en)
*
|
2007-05-31 |
2008-12-03 |
Helm AG |
Stabilized amorphous candesartan cilexetil compositions for oral administration
|
|
BRPI0814423B1
(pt)
|
2007-07-17 |
2022-04-19 |
Plexxikon, Inc |
Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
|
|
AU2008312321A1
(en)
*
|
2007-10-19 |
2009-04-23 |
Purdue Research Foundation |
Solid formulations of crystalline compounds
|
|
US8632805B2
(en)
*
|
2008-06-20 |
2014-01-21 |
Mutual Pharmaceutical Company, Inc. |
Controlled-release formulations, method of manufacture, and use thereof
|
|
US7794750B2
(en)
*
|
2008-06-20 |
2010-09-14 |
Mutual Pharmaceutical Company, Inc. |
Controlled-release formulations, method of manufacture, and use thereof
|
|
US20100099696A1
(en)
*
|
2008-10-16 |
2010-04-22 |
Anthony Edward Soscia |
Tamper resistant oral dosage forms containing an embolizing agent
|
|
KR20100073454A
(ko)
*
|
2008-12-23 |
2010-07-01 |
국립암센터 |
트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물
|
|
MY160737A
(en)
*
|
2009-04-03 |
2017-03-15 |
Hoffmann La Roche |
Propane-i-sulfonic acid {3- [5-(4-chloro-phenyl) -1h -pyrrolo [2, 3-b] pyridine-3-carbonyl] -2,4 difluoro-phenyl} - amide compositions and uses thereof
|
|
US8329724B2
(en)
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
JP2013510166A
(ja)
|
2009-11-06 |
2013-03-21 |
プレキシコン インコーポレーテッド |
キナーゼ調節のための化合物、方法およびその適用
|
|
WO2011152297A1
(ja)
*
|
2010-05-31 |
2011-12-08 |
アステラス製薬株式会社 |
トリアゾール化合物の固体分散体
|
|
US9624213B2
(en)
|
2011-02-07 |
2017-04-18 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
MX2013008476A
(es)
|
2011-02-17 |
2013-08-12 |
Hoffmann La Roche |
Proceso para cristalizacion controlada de un ingrediente farmaceutico activo a partir del estado liquido superenfriado por extrusion de fusion en caliente.
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
CA2837820C
(en)
|
2011-06-20 |
2019-02-19 |
H. Lundbeck A/S |
Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia
|
|
JP5964965B2
(ja)
|
2011-08-18 |
2016-08-03 |
ドクター レディズ ラボラトリーズ リミテッド |
コレステリルエステル転送タンパク質(cetp)インヒビターとしての置換複素環式アミン化合物
|
|
WO2013037396A1
(en)
*
|
2011-09-12 |
2013-03-21 |
Bioneer A/S |
Solution of polymer in api for a solid dosage form
|
|
EP2760864B1
(en)
|
2011-09-27 |
2018-01-24 |
Dr. Reddy's Laboratories Ltd. |
5-BENZYLAMINOMETHYL-6-AMINOPYRAZOLO[3,4-b]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS
|
|
WO2013056108A2
(en)
*
|
2011-10-14 |
2013-04-18 |
Array Biopharma Inc. |
Solid dispersion
|
|
RU2672575C2
(ru)
*
|
2012-03-23 |
2018-11-16 |
Эррэй Биофарма Инк. |
Лечение рака головного мозга
|
|
US20140128431A1
(en)
|
2012-04-03 |
2014-05-08 |
Hoffmann-Laroche Inc. |
Pharmaceutical composition with improved bioavailability, safety and tolerability
|
|
EP2649989B1
(en)
|
2012-04-13 |
2017-10-18 |
King Saud University |
Method for preparing a solid dispersion, solid dispersion obtained thereby and use thereof
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
JO3339B1
(ar)
*
|
2012-09-11 |
2019-03-13 |
Shanghai Inst Pharmaceutical Ind |
شكل مستقر غير متبلور من الأغوميلاتين وعملية تحضيره والتركيبات الدوائية التي تحتوي عليه
|
|
CN104918608A
(zh)
|
2012-11-19 |
2015-09-16 |
雷迪博士实验室有限公司 |
Cetp抑制剂的药物组合物
|
|
CA3053189A1
(en)
|
2012-12-20 |
2014-06-26 |
Kashiv Biosciences, Llc |
Orally disintegrating tablet formulation for enhanced bioavailability
|
|
CA2892025C
(en)
|
2013-01-22 |
2022-02-15 |
F. Hoffmann-La Roche Ag |
Solid dispersions comprising 4-{[(2r, 3s, 4r, 5s)-4-(4-chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3- methoxy -benzoic acid and pharmaceutical compositions comprising same with improved bioavailability
|
|
TWI615157B
(zh)
|
2013-02-06 |
2018-02-21 |
大塚製藥股份有限公司 |
包括不定形西洛他唑的固體分散劑
|
|
WO2015038376A1
(en)
*
|
2013-09-11 |
2015-03-19 |
3M Innovative Properties Company |
Coating compositions, dental structures thereof and methods for generating contrast
|
|
WO2015082562A1
(en)
*
|
2013-12-05 |
2015-06-11 |
Alrise Biosystems Gmbh |
Process for the production of drug formulations for oral administration
|
|
PT107846B
(pt)
*
|
2014-08-01 |
2019-03-22 |
Hovione Farm S A |
Produção de nano- partículas de dispersões sólidas amorfas por co-precipitação controlada
|
|
BR112017025739A2
(pt)
*
|
2015-05-29 |
2018-08-07 |
Sun Pharmaceutical Ind Ltd |
composição farmacêutica oral de isotretinoína que tem biodisponibilidade aumentada, processo para preparar a mesma e método de tratamento
|
|
CA3041155C
(en)
*
|
2016-12-13 |
2021-12-14 |
Nanjing Transthera Biosciences Co., Ltd. |
Multi-kinase inhibitor compound, and crystal form and use thereof
|
|
SG11201909676WA
(en)
|
2017-04-28 |
2019-11-28 |
Seattle Genetics Inc |
Treatment of her2 positive cancers
|
|
KR102082775B1
(ko)
*
|
2017-05-02 |
2020-02-28 |
주식회사 삼양바이오팜 |
수용해도 및 생체이용율이 개선된 조성물
|
|
RU2725879C2
(ru)
*
|
2018-07-26 |
2020-07-07 |
Федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский Государственный медицинский университет" Министерства здравоохранения Российской Федерации |
Интерполимерный носитель для пероральных систем контролируемой доставки активных фармацевтических ингредиентов
|
|
US11535600B2
(en)
|
2018-12-03 |
2022-12-27 |
H. Lundbeck A/S |
Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine
|
|
JP7738961B2
(ja)
|
2020-01-24 |
2025-09-16 |
ハンダ セラピューティクス リミテッド ライアビリティ カンパニー |
ダサチニブの非晶質固体分散体及びその使用
|
|
JP2023513045A
(ja)
|
2020-01-31 |
2023-03-30 |
ナノコピーア リミテッド ライアビリティ カンパニー |
非晶質ニロチニブ微粒子及びその使用
|
|
JP7705715B2
(ja)
|
2020-03-03 |
2025-07-10 |
デクセリアルズ株式会社 |
画像表示装置の製造方法
|
|
CA3181361A1
(en)
|
2020-04-30 |
2021-11-04 |
Nanocopoeia, Llc |
Orally disintegrating tablet comprising amorphous solid dispersion of nilotinib
|
|
US11980619B2
(en)
|
2021-07-28 |
2024-05-14 |
Nanocopoeia, Llc |
Pharmaceutical compositions and crushable tablets including amorphous solid dispersions of dasatinib and uses
|