AR033651A1 - Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento - Google Patents
Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamentoInfo
- Publication number
- AR033651A1 AR033651A1 ARP000105063A ARP000105063A AR033651A1 AR 033651 A1 AR033651 A1 AR 033651A1 AR P000105063 A ARP000105063 A AR P000105063A AR P000105063 A ARP000105063 A AR P000105063A AR 033651 A1 AR033651 A1 AR 033651A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyrimidine
- compounds
- manufacture
- pharmaceutical compositions
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados de pirimidina-2,4,6-triona que comprenden compuestos de fórmula 1 en la cual R1 representa un radical fenilo, fenoxilo, feniltio, fenilsulfinilo, fenilsulfonilo, fenilamino o fenilmetilo, en donde la parte fenilo puede estar sustituida con uno o más átomos de halógeno, hidroxilo, alcoxilo de 1 a 6 átomos de carbono, alquilo de 1 a 6 átomos de carbono, ciano o grupos nitro y R2 representa un radical arilo o heteroarilo, opcionalmente substituido, con actividad como inhibidor de la metalo-proteinasa; composiciones farmacéuticas y el empleo de los mismos para la manufactura de un medicamento con actividad antitumoral y/o antimetastásica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99119506 | 1999-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR033651A1 true AR033651A1 (es) | 2004-01-07 |
Family
ID=8239103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000105063A AR033651A1 (es) | 1999-10-01 | 2000-09-27 | Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6498252B1 (es) |
| EP (1) | EP1226128B1 (es) |
| JP (1) | JP3848160B2 (es) |
| KR (1) | KR100459975B1 (es) |
| CN (1) | CN1157382C (es) |
| AR (1) | AR033651A1 (es) |
| AT (1) | ATE289595T1 (es) |
| AU (1) | AU768309B2 (es) |
| BR (1) | BR0014678A (es) |
| CA (1) | CA2385863C (es) |
| CO (1) | CO5210860A1 (es) |
| CZ (1) | CZ20021535A3 (es) |
| DE (1) | DE60018301T2 (es) |
| ES (1) | ES2235955T3 (es) |
| HK (1) | HK1050198A1 (es) |
| HU (1) | HUP0202832A3 (es) |
| IL (1) | IL148573A0 (es) |
| MA (1) | MA26823A1 (es) |
| MX (1) | MXPA02003192A (es) |
| NO (1) | NO20021380D0 (es) |
| NZ (1) | NZ517635A (es) |
| PE (1) | PE20010659A1 (es) |
| PL (1) | PL202680B1 (es) |
| RU (1) | RU2248971C2 (es) |
| TR (1) | TR200200858T2 (es) |
| UY (1) | UY26362A1 (es) |
| WO (1) | WO2001025217A1 (es) |
| YU (1) | YU22102A (es) |
| ZA (1) | ZA200201754B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6716845B2 (en) * | 2001-03-30 | 2004-04-06 | Hoffmann-La Roche Inc. | Barbituric acid derivatives |
| AU2002346729A1 (en) | 2001-12-20 | 2003-07-09 | Bristol-Myers Squibb Company | Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases |
| WO2004084903A1 (en) * | 2003-03-27 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis |
| WO2004084902A1 (en) * | 2003-03-28 | 2004-10-07 | F. Hoffmann-La Roche Ag | Use of a trioxopyrimidine for the treatment of chronic wounds |
| RU2402329C2 (ru) * | 2004-04-01 | 2010-10-27 | Юниверсите Де-Льеж | Применение триоксопиримидина для лечения и предупреждения воспалительных заболеваний бронхов |
| RU2411043C2 (ru) * | 2004-04-01 | 2011-02-10 | Юниверсите Де Льеж | Фармацевтические композиции пиримидин-2,4,6-трионов |
| EP1632489A1 (en) * | 2004-08-24 | 2006-03-08 | University of Liege | 5-(1,1'-Biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-trione derivatives, as inhibitors of zinc metallondopeptidases, their preparation and use. |
| RU2449994C1 (ru) * | 2011-03-10 | 2012-05-10 | Светлана Алексеевна Мещерякова | 6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность |
| RU2598607C1 (ru) * | 2015-07-16 | 2016-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный университет" (Астраханский государственный университет) | Способ получения 5-гетарилметиленпиримидин-2,4,6-трионов |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1246743B (de) * | 1965-01-12 | 1967-08-10 | Dresden Arzneimittel | Verfahren zur Herstellung von 5-Phenyl-5-piperidinobarbitursaeuren |
| US4595700A (en) | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
| GB8726714D0 (en) | 1987-11-14 | 1987-12-16 | Beecham Group Plc | Compounds |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| US5239078A (en) | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
| DK0489579T3 (da) | 1990-12-03 | 1995-06-12 | Celltech Therapeutics Ltd | Peptidylderivater |
| CA2058797A1 (en) | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
| US5789434A (en) | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
| AU725831C (en) | 1995-12-08 | 2002-10-17 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
| DE19548624A1 (de) | 1995-12-23 | 1997-06-26 | Boehringer Mannheim Gmbh | Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
-
2000
- 2000-09-27 PE PE2000001013A patent/PE20010659A1/es not_active Application Discontinuation
- 2000-09-27 CO CO00073355A patent/CO5210860A1/es not_active Application Discontinuation
- 2000-09-27 AR ARP000105063A patent/AR033651A1/es not_active Application Discontinuation
- 2000-09-29 MX MXPA02003192A patent/MXPA02003192A/es active IP Right Grant
- 2000-09-29 NZ NZ517635A patent/NZ517635A/en unknown
- 2000-09-29 KR KR10-2002-7003979A patent/KR100459975B1/ko not_active IP Right Cessation
- 2000-09-29 EP EP00967823A patent/EP1226128B1/en not_active Expired - Lifetime
- 2000-09-29 WO PCT/EP2000/009535 patent/WO2001025217A1/en active IP Right Grant
- 2000-09-29 PL PL357385A patent/PL202680B1/pl not_active IP Right Cessation
- 2000-09-29 CA CA002385863A patent/CA2385863C/en not_active Expired - Fee Related
- 2000-09-29 RU RU2002110106/04A patent/RU2248971C2/ru not_active IP Right Cessation
- 2000-09-29 TR TR2002/00858T patent/TR200200858T2/xx unknown
- 2000-09-29 US US09/675,935 patent/US6498252B1/en not_active Expired - Fee Related
- 2000-09-29 AT AT00967823T patent/ATE289595T1/de not_active IP Right Cessation
- 2000-09-29 YU YU22102A patent/YU22102A/sh unknown
- 2000-09-29 BR BR0014678-1A patent/BR0014678A/pt not_active Application Discontinuation
- 2000-09-29 HU HU0202832A patent/HUP0202832A3/hu unknown
- 2000-09-29 IL IL14857300A patent/IL148573A0/xx unknown
- 2000-09-29 JP JP2001528163A patent/JP3848160B2/ja not_active Expired - Fee Related
- 2000-09-29 ES ES00967823T patent/ES2235955T3/es not_active Expired - Lifetime
- 2000-09-29 UY UY26362A patent/UY26362A1/es not_active Application Discontinuation
- 2000-09-29 CN CNB00813006XA patent/CN1157382C/zh not_active Expired - Fee Related
- 2000-09-29 DE DE60018301T patent/DE60018301T2/de not_active Expired - Lifetime
- 2000-09-29 AU AU77849/00A patent/AU768309B2/en not_active Ceased
- 2000-09-29 CZ CZ20021535A patent/CZ20021535A3/cs unknown
-
2002
- 2002-03-01 ZA ZA200201754A patent/ZA200201754B/en unknown
- 2002-03-20 NO NO20021380A patent/NO20021380D0/no not_active Application Discontinuation
- 2002-04-01 MA MA26578A patent/MA26823A1/fr unknown
-
2003
- 2003-04-03 HK HK03102405A patent/HK1050198A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |