ZA200201754B - New pyrimidine,2,4,6-trioe derivatives, processes for their production and pharmaceutical agents containing these compounds. - Google Patents

New pyrimidine,2,4,6-trioe derivatives, processes for their production and pharmaceutical agents containing these compounds. Download PDF

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Publication number
ZA200201754B
ZA200201754B ZA200201754A ZA200201754A ZA200201754B ZA 200201754 B ZA200201754 B ZA 200201754B ZA 200201754 A ZA200201754 A ZA 200201754A ZA 200201754 A ZA200201754 A ZA 200201754A ZA 200201754 B ZA200201754 B ZA 200201754B
Authority
ZA
South Africa
Prior art keywords
phenyl
phenoxy
piperazin
pyrimidin
trioxo
Prior art date
Application number
ZA200201754A
Other languages
English (en)
Inventor
Frank Grams
Herbert Leinert
Gerd Zimmermann
Hans-Willi Krell
Ernesto Menta
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200201754B publication Critical patent/ZA200201754B/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200201754A 1999-10-01 2002-03-01 New pyrimidine,2,4,6-trioe derivatives, processes for their production and pharmaceutical agents containing these compounds. ZA200201754B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99119506 1999-10-01

Publications (1)

Publication Number Publication Date
ZA200201754B true ZA200201754B (en) 2003-06-02

Family

ID=8239103

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200201754A ZA200201754B (en) 1999-10-01 2002-03-01 New pyrimidine,2,4,6-trioe derivatives, processes for their production and pharmaceutical agents containing these compounds.

Country Status (29)

Country Link
US (1) US6498252B1 (es)
EP (1) EP1226128B1 (es)
JP (1) JP3848160B2 (es)
KR (1) KR100459975B1 (es)
CN (1) CN1157382C (es)
AR (1) AR033651A1 (es)
AT (1) ATE289595T1 (es)
AU (1) AU768309B2 (es)
BR (1) BR0014678A (es)
CA (1) CA2385863C (es)
CO (1) CO5210860A1 (es)
CZ (1) CZ20021535A3 (es)
DE (1) DE60018301T2 (es)
ES (1) ES2235955T3 (es)
HK (1) HK1050198A1 (es)
HU (1) HUP0202832A3 (es)
IL (1) IL148573A0 (es)
MA (1) MA26823A1 (es)
MX (1) MXPA02003192A (es)
NO (1) NO20021380D0 (es)
NZ (1) NZ517635A (es)
PE (1) PE20010659A1 (es)
PL (1) PL202680B1 (es)
RU (1) RU2248971C2 (es)
TR (1) TR200200858T2 (es)
UY (1) UY26362A1 (es)
WO (1) WO2001025217A1 (es)
YU (1) YU22102A (es)
ZA (1) ZA200201754B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716845B2 (en) * 2001-03-30 2004-04-06 Hoffmann-La Roche Inc. Barbituric acid derivatives
AU2002346729A1 (en) 2001-12-20 2003-07-09 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
WO2004084903A1 (en) * 2003-03-27 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment of chronic wounds
RU2402329C2 (ru) * 2004-04-01 2010-10-27 Юниверсите Де-Льеж Применение триоксопиримидина для лечения и предупреждения воспалительных заболеваний бронхов
RU2411043C2 (ru) * 2004-04-01 2011-02-10 Юниверсите Де Льеж Фармацевтические композиции пиримидин-2,4,6-трионов
EP1632489A1 (en) * 2004-08-24 2006-03-08 University of Liege 5-(1,1'-Biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-trione derivatives, as inhibitors of zinc metallondopeptidases, their preparation and use.
RU2449994C1 (ru) * 2011-03-10 2012-05-10 Светлана Алексеевна Мещерякова 6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность
RU2598607C1 (ru) * 2015-07-16 2016-09-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный университет" (Астраханский государственный университет) Способ получения 5-гетарилметиленпиримидин-2,4,6-трионов

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1246743B (de) * 1965-01-12 1967-08-10 Dresden Arzneimittel Verfahren zur Herstellung von 5-Phenyl-5-piperidinobarbitursaeuren
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8726714D0 (en) 1987-11-14 1987-12-16 Beecham Group Plc Compounds
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5239078A (en) 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
DK0489579T3 (da) 1990-12-03 1995-06-12 Celltech Therapeutics Ltd Peptidylderivater
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
US5789434A (en) 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
AU725831C (en) 1995-12-08 2002-10-17 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
DE19548624A1 (de) 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers

Also Published As

Publication number Publication date
PE20010659A1 (es) 2001-06-20
DE60018301D1 (de) 2005-03-31
IL148573A0 (en) 2002-09-12
TR200200858T2 (tr) 2002-07-22
CN1374954A (zh) 2002-10-16
DE60018301T2 (de) 2006-04-06
NO20021380L (no) 2002-03-20
CN1157382C (zh) 2004-07-14
ES2235955T3 (es) 2005-07-16
AU768309B2 (en) 2003-12-04
HUP0202832A2 (hu) 2003-02-28
PL202680B1 (pl) 2009-07-31
MXPA02003192A (es) 2002-09-30
RU2248971C2 (ru) 2005-03-27
MA26823A1 (fr) 2004-12-20
AR033651A1 (es) 2004-01-07
BR0014678A (pt) 2002-07-23
HK1050198A1 (en) 2003-06-13
WO2001025217A1 (en) 2001-04-12
NO20021380D0 (no) 2002-03-20
CZ20021535A3 (cs) 2002-11-13
KR100459975B1 (ko) 2004-12-03
YU22102A (sh) 2004-11-25
JP3848160B2 (ja) 2006-11-22
ATE289595T1 (de) 2005-03-15
CA2385863A1 (en) 2001-04-12
CA2385863C (en) 2009-04-14
HUP0202832A3 (en) 2003-03-28
EP1226128B1 (en) 2005-02-23
JP2003511376A (ja) 2003-03-25
US6498252B1 (en) 2002-12-24
KR20020039356A (ko) 2002-05-25
PL357385A1 (en) 2004-07-26
CO5210860A1 (es) 2002-10-30
UY26362A1 (es) 2001-04-30
NZ517635A (en) 2003-11-28
AU7784900A (en) 2001-05-10
EP1226128A1 (en) 2002-07-31

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