NO20021380D0 - Nye pyrimidin-2,4,6-trion-derivater, fremgangsmåter for deres fremstilling og farmasöytiske midler inneholdende dem - Google Patents

Nye pyrimidin-2,4,6-trion-derivater, fremgangsmåter for deres fremstilling og farmasöytiske midler inneholdende dem

Info

Publication number
NO20021380D0
NO20021380D0 NO20021380A NO20021380A NO20021380D0 NO 20021380 D0 NO20021380 D0 NO 20021380D0 NO 20021380 A NO20021380 A NO 20021380A NO 20021380 A NO20021380 A NO 20021380A NO 20021380 D0 NO20021380 D0 NO 20021380D0
Authority
NO
Norway
Prior art keywords
preparation
methods
pharmaceutical agents
agents containing
new pyrimidine
Prior art date
Application number
NO20021380A
Other languages
English (en)
Norwegian (no)
Other versions
NO20021380L (no
Inventor
Frank Grams
Hans-Willi Krell
Herbert Leinert
Ernesto Menta
Gerd Zimmermann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20021380L publication Critical patent/NO20021380L/no
Publication of NO20021380D0 publication Critical patent/NO20021380D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20021380A 1999-10-01 2002-03-20 Nye pyrimidin-2,4,6-trion-derivater, fremgangsmåter for deres fremstilling og farmasöytiske midler inneholdende dem NO20021380D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99119506 1999-10-01
PCT/EP2000/009535 WO2001025217A1 (en) 1999-10-01 2000-09-29 New pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds

Publications (2)

Publication Number Publication Date
NO20021380L NO20021380L (no) 2002-03-20
NO20021380D0 true NO20021380D0 (no) 2002-03-20

Family

ID=8239103

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021380A NO20021380D0 (no) 1999-10-01 2002-03-20 Nye pyrimidin-2,4,6-trion-derivater, fremgangsmåter for deres fremstilling og farmasöytiske midler inneholdende dem

Country Status (29)

Country Link
US (1) US6498252B1 (es)
EP (1) EP1226128B1 (es)
JP (1) JP3848160B2 (es)
KR (1) KR100459975B1 (es)
CN (1) CN1157382C (es)
AR (1) AR033651A1 (es)
AT (1) ATE289595T1 (es)
AU (1) AU768309B2 (es)
BR (1) BR0014678A (es)
CA (1) CA2385863C (es)
CO (1) CO5210860A1 (es)
CZ (1) CZ20021535A3 (es)
DE (1) DE60018301T2 (es)
ES (1) ES2235955T3 (es)
HK (1) HK1050198A1 (es)
HU (1) HUP0202832A3 (es)
IL (1) IL148573A0 (es)
MA (1) MA26823A1 (es)
MX (1) MXPA02003192A (es)
NO (1) NO20021380D0 (es)
NZ (1) NZ517635A (es)
PE (1) PE20010659A1 (es)
PL (1) PL202680B1 (es)
RU (1) RU2248971C2 (es)
TR (1) TR200200858T2 (es)
UY (1) UY26362A1 (es)
WO (1) WO2001025217A1 (es)
YU (1) YU22102A (es)
ZA (1) ZA200201754B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716845B2 (en) * 2001-03-30 2004-04-06 Hoffmann-La Roche Inc. Barbituric acid derivatives
AU2002346729A1 (en) 2001-12-20 2003-07-09 Bristol-Myers Squibb Company Barbituric acid derivatives as inhibitors of tnf-$g(a) converting enzyme (tace) and/or matrix metalloproteinases
WO2004084903A1 (en) * 2003-03-27 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment and prevention of ocular pathologic angiogenesis
WO2004084902A1 (en) * 2003-03-28 2004-10-07 F. Hoffmann-La Roche Ag Use of a trioxopyrimidine for the treatment of chronic wounds
RU2402329C2 (ru) * 2004-04-01 2010-10-27 Юниверсите Де-Льеж Применение триоксопиримидина для лечения и предупреждения воспалительных заболеваний бронхов
RU2411043C2 (ru) * 2004-04-01 2011-02-10 Юниверсите Де Льеж Фармацевтические композиции пиримидин-2,4,6-трионов
EP1632489A1 (en) * 2004-08-24 2006-03-08 University of Liege 5-(1,1'-Biphenyl)-4-yl-5-(4-(4-aminoacylphenyl)-piperazin)-1-yl-pyrimidine-2,4,6-trione derivatives, as inhibitors of zinc metallondopeptidases, their preparation and use.
RU2449994C1 (ru) * 2011-03-10 2012-05-10 Светлана Алексеевна Мещерякова 6-(4-бензилпиперазино)-1,3-диметилурацила дигидрохлорид, проявляющий биологическую активность
RU2598607C1 (ru) * 2015-07-16 2016-09-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Астраханский государственный университет" (Астраханский государственный университет) Способ получения 5-гетарилметиленпиримидин-2,4,6-трионов

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1246743B (de) * 1965-01-12 1967-08-10 Dresden Arzneimittel Verfahren zur Herstellung von 5-Phenyl-5-piperidinobarbitursaeuren
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8726714D0 (en) 1987-11-14 1987-12-16 Beecham Group Plc Compounds
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5239078A (en) 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
DK0489579T3 (da) 1990-12-03 1995-06-12 Celltech Therapeutics Ltd Peptidylderivater
CA2058797A1 (en) 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
US5789434A (en) 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
AU725831C (en) 1995-12-08 2002-10-17 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation
DE19548624A1 (de) 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers

Also Published As

Publication number Publication date
PE20010659A1 (es) 2001-06-20
DE60018301D1 (de) 2005-03-31
IL148573A0 (en) 2002-09-12
TR200200858T2 (tr) 2002-07-22
CN1374954A (zh) 2002-10-16
DE60018301T2 (de) 2006-04-06
NO20021380L (no) 2002-03-20
CN1157382C (zh) 2004-07-14
ES2235955T3 (es) 2005-07-16
AU768309B2 (en) 2003-12-04
HUP0202832A2 (hu) 2003-02-28
PL202680B1 (pl) 2009-07-31
MXPA02003192A (es) 2002-09-30
RU2248971C2 (ru) 2005-03-27
MA26823A1 (fr) 2004-12-20
AR033651A1 (es) 2004-01-07
BR0014678A (pt) 2002-07-23
HK1050198A1 (en) 2003-06-13
WO2001025217A1 (en) 2001-04-12
CZ20021535A3 (cs) 2002-11-13
KR100459975B1 (ko) 2004-12-03
YU22102A (sh) 2004-11-25
JP3848160B2 (ja) 2006-11-22
ATE289595T1 (de) 2005-03-15
CA2385863A1 (en) 2001-04-12
CA2385863C (en) 2009-04-14
HUP0202832A3 (en) 2003-03-28
EP1226128B1 (en) 2005-02-23
ZA200201754B (en) 2003-06-02
JP2003511376A (ja) 2003-03-25
US6498252B1 (en) 2002-12-24
KR20020039356A (ko) 2002-05-25
PL357385A1 (en) 2004-07-26
CO5210860A1 (es) 2002-10-30
UY26362A1 (es) 2001-04-30
NZ517635A (en) 2003-11-28
AU7784900A (en) 2001-05-10
EP1226128A1 (en) 2002-07-31

Similar Documents

Publication Publication Date Title
HUP0400708A3 (en) Substituted 1,3,5-triazine and pyrimidine derivatives, their use and pharmaceutical compositions containing them
HUP0301722A3 (en) Pyrimidine derivatives, pharmaceutical compositions containing them and their use
NO20014013D0 (no) 16-halogenepotilonderivater, fremgangsmater for fremstilling av dem og deres farmasoytiske anvendelse
HUP0202501A3 (en) Pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use
EE05181B1 (et) Prasolo[4,3-d]primidiini derivaadid, neid sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja meetodid nende valmistamiseks
DK1345910T3 (da) Quinazolinderivater, lægemidler indeholdende forbindelserne, deres anvendelse og fremgangsmåde til fremstilling deraf
HUP0202795A3 (en) Pyrimidine and pyrazine derivatives, pharmaceutical compositions containing them and their use
NO20024175D0 (no) Azetidinderivater, deres fremstilling og farmasöytiske forbindelser inneholdende de samme
NO20024176L (no) Farmasöytiske preparater inneholder derivater av 3-amino- azetidin, de nye derivater og deres fremstilling
HUP0302337A3 (en) Pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use
NO20014102D0 (no) Nye tricykliske forbindelser og deres anvendelse innenfor medisin, fremgangsmate for deres fremstilling og farmasoytisksammensetning inneholdende dem
HUP0105114A3 (en) Quinazolinone derivatives, pharmaceutical compositions containing them, their use and process for their preparation
NO20014702D0 (no) Diarylderivater og deres anvendelse som medikamenter
NO963506D0 (no) 4-Heterocyklyl-substituerte kinazolin-derivater, fremgangsmåte for fremstilling derav og deres anvendelse som anti-kreftmidler
DK1202965T3 (da) Indolderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende disse og deres medicinske anvendelse
DK1337529T3 (da) Heterocyclylalkylpiperidinderivater, deres fremstilling og præparater indeholdende dem
DK1083171T3 (da) Pyrazolinderivater, deres fremstilling og anvendelse som medikamenter
NO985368D0 (no) Substituerte imidazolidinderivater, deres fremstilling, deres anvendelse og farmas°ytiske preparater inneholdende forbindelsene
NO981522L (no) Aminosyrederivater, deres fremstilling og anvendelse som endotelinantagonister
NO20022021D0 (no) Indeno-, nafto- og benzocyklohepta-dihydrotiazolderivater, fremstilling av de samme og deres anvendelse somanoreksilegemidler
NO984309D0 (no) Nye imidazolidinderivater, deres fremstilling, deres anvendelse og farmas°ytiske preparater inneholdende disse
NO20021380L (no) Nye pyrimidin-2,4,6-trion-derivater, fremgangsmåter for deres fremstilling og farmasöytiske midler inneholdende dem
NO20016247D0 (no) Streptograminderivater, deres fremstilling og preparater inneholdende derivatene
HUP0303364A3 (en) Pyrimidine derivatives of arylalkane-sulfonamides having endothelin-antagonist activity, pharmaceutical compositions containing them and their use
HUP0303045A3 (en) Pyrimidine derivatives, process for their preparation, pharmaceutical compositions containing them and their use

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application