YU47097B - Hinuklidin derivati i postupak za njihovo dobijanje - Google Patents

Hinuklidin derivati i postupak za njihovo dobijanje

Info

Publication number
YU47097B
YU47097B YU222289A YU222289A YU47097B YU 47097 B YU47097 B YU 47097B YU 222289 A YU222289 A YU 222289A YU 222289 A YU222289 A YU 222289A YU 47097 B YU47097 B YU 47097B
Authority
YU
Yugoslavia
Prior art keywords
carbon atoms
formula
thienyl
alkyl
alkoxy
Prior art date
Application number
YU222289A
Other languages
English (en)
Other versions
YU222289A (en
Inventor
J.A. Lowe
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU222289A publication Critical patent/YU222289A/xx
Publication of YU47097B publication Critical patent/YU47097B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Postupak za dobijanje hinulkidin derivata formule: ili njegove farmaceutski prihvatljive soli, u kojoj Ar je tienil, fenil, fluorofenil, hlorofenil ili bromofenil; R' je cikloalkil koji ima od pet do sedam ugljenikovih atoma, norbornil, 2,3-dihidrobenzofuranil, tienil, alkoksitienil sa jedan do tri ugljenikova atoma u alkoksi ostatku, piridil, hidroksipiridil, hinolinil, indolil, naftil, alkoksinaftil sa jedan do tri ugljenikova atoma u alkoksi ostatku, bifenil, 2,3-metilendioksifenil ili fenil opciono supstituisan sa jedan ili dva supstituenta odabranih od nitro, amino, N-monoalkilamino sa jedan do tri ugljenikova atoma u alkil ostatku, fluor, hlor, brom, tri-fluorometil, alkil sa jedan do tri ugljenikova atoma, benzil, alkoksi sa jedan do tri ugljenikova atoma, aliloksi, hidroksi, hidroksimetil, karboksi, hidroksietoksi, alkoksikarbonil i alkoksikarbonilmetoksi svaki sa jedan do tri ugljenika u alkoksi ostatku, karboksimetoksi, i R" je alkil racvastog niza sa tri do cetiri ugljenikova atoma, alkenil racvastog niza alkenil sa pet do sest ugljenikovih atoma, cikloalkil sa pet do sedam ugljenikovih atoma, furil, tienil, piridil, bifenil, ili fenil opciono supstituisan sa do dva supstituenta odabranih izmedju fluora, hlora, broma, trifluorometil, alkila sa do tri ugljenikova atoma, benzil, alkoksi sa jedan do tri ugljenikova atoma, ili karboksi, pod uslovom sto je pomenuti R" uvek razlicit od nesupstituisanog fenil grupe, fluorofenil, hlorofenil, bromofenil ili alkilfenila kada je R' nesupstituisani fenil, ili tienil a Ar je razliciti od tienil grupe, i pod daljim uslovom da je najmanje jedan od Ar, R' i R". uvek razlicit od nesupstituisanog fenila, naznacen time, sto obuhvata: (a) kondenzaciju odgovarajuceg 2-/(alfa-supstituisanog)aril-metil/hinuklidin-3-on jedinjenja formule IV: u kojoj Ar, R i R" su svaki definisan kao gore, sa (ciklicnim) metilaminom formule R'CH2, NH2, gde R' je takodje kao sto je gore definisano, radi obrazovanja -eljenog iminskog finalnog proizvoda strukturne formule II; (b) kondenzaciju odgovarajuceg 3-amino-2-/(alfa-supstituisanog)fenilmetil/hinuklidin jedinjenja formule V: u kojoj Ar, R i R" su svaki kao sto je gore definisano, sa odgovarajucim ciklicnim aldehidnim jedinjenjem formule R'CHO, pri cemu R' je takodje kao sto je definisano gore, radi obrazovanja zeljenog metilenaminskog finalnog proizvoda strukturne formule III; ili (c) kondenzaciju 3-aminohinuklidin jedinjenja formule V sa aktiviranim derivatom karboksilne kiseline formule R'COOH radi obrazovanja odgovarajuceg 3-/(ciklicno)karbonilamino(2-2/(alfa-supstituisanog)arilmetil/hinuklidin jedinjenje formule VI u kojoj R, R' i R" svi imaju isto znacenje kao gore; i d) Posle toga izlaganja jedinjenja formule II, III ili VI selektivnom redukcionom dejstvu pogodnog metalo redukcionog sredstva radi obrazovanja 3-aminohinuklidin finalnog proizvoda struktura formule I; i e) Posle toga, po potrebi, pretvaranje jedinjenja strukturne formule I u kojoj R' je nitrofenil u odgo
YU222289A 1988-11-23 1989-11-22 Hinuklidin derivati i postupak za njihovo dobijanje YU47097B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/004205 WO1990005525A1 (en) 1988-11-23 1988-11-23 Quinuclidine derivatives as substance p antagonists

Publications (2)

Publication Number Publication Date
YU222289A YU222289A (en) 1991-04-30
YU47097B true YU47097B (sh) 1994-12-28

Family

ID=22209014

Family Applications (1)

Application Number Title Priority Date Filing Date
YU222289A YU47097B (sh) 1988-11-23 1989-11-22 Hinuklidin derivati i postupak za njihovo dobijanje

Country Status (29)

Country Link
US (1) US5162339A (sh)
EP (1) EP0409931B1 (sh)
JP (1) JPH0647589B2 (sh)
KR (1) KR900701782A (sh)
CN (1) CN1026111C (sh)
AP (1) AP120A (sh)
AR (1) AR246522A1 (sh)
AT (1) ATE101608T1 (sh)
AU (1) AU617906B2 (sh)
CA (1) CA2003441C (sh)
DD (1) DD285605A5 (sh)
DE (1) DE68913194T2 (sh)
EG (1) EG19301A (sh)
ES (1) ES2062504T3 (sh)
FI (1) FI903656A0 (sh)
HU (1) HU900517D0 (sh)
IE (1) IE893730L (sh)
IL (1) IL92336A0 (sh)
MA (1) MA21682A1 (sh)
MX (1) MX18467A (sh)
MY (1) MY105061A (sh)
NZ (1) NZ231461A (sh)
OA (1) OA10023A (sh)
PH (1) PH26590A (sh)
PL (1) PL161864B1 (sh)
PT (1) PT92361B (sh)
WO (2) WO1990005525A1 (sh)
YU (1) YU47097B (sh)
ZA (1) ZA898901B (sh)

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DE68913194T2 (de) 1994-05-19
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WO1990005525A1 (en) 1990-05-31
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MY105061A (en) 1994-07-30
AU4661989A (en) 1990-06-12
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IL92336A0 (en) 1990-07-26
PL161864B1 (pl) 1993-08-31
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