PE8798A1 - Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil] - Google Patents

Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]

Info

Publication number
PE8798A1
PE8798A1 PE1996000507A PE00050796A PE8798A1 PE 8798 A1 PE8798 A1 PE 8798A1 PE 1996000507 A PE1996000507 A PE 1996000507A PE 00050796 A PE00050796 A PE 00050796A PE 8798 A1 PE8798 A1 PE 8798A1
Authority
PE
Peru
Prior art keywords
methyl
enantiomers
azabiciclo
metoxy
octan
Prior art date
Application number
PE1996000507A
Other languages
English (en)
Inventor
Derek L Tickner
Morgan Meltz
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE8798A1 publication Critical patent/PE8798A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

CARACTERIZADO PORQUE COMPRENDE: 1) HACER REACCIONAR EL RACEMATO CON EL ACIDO 1R-(-)-10-CANFORSULFONICO, EN PRESENCIA DE UN DISOLVENTE TAL COMO ACETONITRILO, ACETONA O ETANOL, HACIENDO POSIBLE DISOLVER EN FORMA SELECTIVA EL ENANTIOMERO (2S,3S) DEL ENANTIOMERO (2R,3R), DONDE TALES ENANTIOMEROS SE ENCUENTRAN EN FORMA DE SAL CANFORSULFONICO; 2) HIDROLIZAR LA SAL QUE PRECIPITA EN SOLUCION, PARA OBTENER LA BASE LIBRE DEL ENANTIOMERO (2S,3S). ES ANTAGONISTA DEL RECEPTOR DE LA SUSTANCIA P, SIENDO USADO EN EL TRATAMIENTO Y LA PREVENCION DE UNA AMPLIA GAMA DE TRANSTORNOS DEL SISTEMA NERVIOSO CENTRAL, GASTROINTESTINALES, ENTRE OTROS
PE1996000507A 1995-07-17 1996-07-03 Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil] PE8798A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US119195P 1995-07-17 1995-07-17

Publications (1)

Publication Number Publication Date
PE8798A1 true PE8798A1 (es) 1998-03-02

Family

ID=21694832

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000507A PE8798A1 (es) 1995-07-17 1996-07-03 Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]

Country Status (26)

Country Link
US (1) US6008357A (es)
EP (1) EP0840735B1 (es)
JP (1) JP3043074B2 (es)
KR (1) KR100276989B1 (es)
CN (1) CN1068598C (es)
AR (1) AR002772A1 (es)
AT (1) ATE250600T1 (es)
AU (1) AU697553B2 (es)
CA (1) CA2227194C (es)
CO (1) CO4480720A1 (es)
CZ (1) CZ15098A3 (es)
DE (1) DE69630123T2 (es)
DK (1) DK0840735T3 (es)
ES (1) ES2205039T3 (es)
HK (1) HK1010195A1 (es)
HU (1) HUP9900238A3 (es)
IL (1) IL122655A0 (es)
MY (1) MY115734A (es)
NO (1) NO980211L (es)
NZ (1) NZ310539A (es)
PE (1) PE8798A1 (es)
PL (1) PL184261B1 (es)
PT (1) PT840735E (es)
RU (1) RU2136681C1 (es)
WO (1) WO1997003984A1 (es)
ZA (1) ZA966026B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861526B2 (en) * 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
US20090099364A1 (en) * 2004-02-02 2009-04-16 Pfizer Inc. Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5- tert-butyl-2-methoxybenzyl)quinuclidin-3-amine
US20060100438A1 (en) * 2004-11-10 2006-05-11 Boehringer Ingelheim Chemicals, Inc. Process of making fentanyl intermediates
BRPI0922880A2 (pt) * 2008-12-09 2018-07-24 Univ Florida compostos inibidores de quinase
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
CN108341812A (zh) * 2017-01-23 2018-07-31 科贝源(北京)生物医药科技有限公司 一种含奎宁环化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
NO168529C (no) * 1989-09-15 1992-03-04 Chiron Lab As Fremgangsmaate for fremstilling av s-(-) og r-(+)-n-(quinuclidinyl-3)-amider.
RU2092486C1 (ru) * 1991-05-22 1997-10-10 Пфайзер Инк. Замещенные 3-аминохинуклидины
KR100214905B1 (ko) * 1991-05-31 1999-08-02 디. 제이. 우드, 스피겔 알렌 제이 퀴누클리딘 유도체
US5604241A (en) * 1992-10-21 1997-02-18 Pfizer Inc. Substituted benzylaminoquinuclidines as substance P antagonists

Also Published As

Publication number Publication date
NO980211D0 (no) 1998-01-16
MY115734A (en) 2003-08-30
WO1997003984A1 (en) 1997-02-06
HK1010195A1 (en) 1999-06-17
EP0840735B1 (en) 2003-09-24
US6008357A (en) 1999-12-28
ZA966026B (en) 1998-01-16
ES2205039T3 (es) 2004-05-01
AU6134896A (en) 1997-02-18
CN1068598C (zh) 2001-07-18
NO980211L (no) 1998-03-16
AR002772A1 (es) 1998-04-29
CA2227194C (en) 2002-02-12
PL324610A1 (en) 1998-06-08
IL122655A0 (en) 1998-08-16
AU697553B2 (en) 1998-10-08
JP3043074B2 (ja) 2000-05-22
HUP9900238A2 (hu) 1999-05-28
DE69630123D1 (en) 2003-10-30
HUP9900238A3 (en) 2001-08-28
CN1190970A (zh) 1998-08-19
MX9800538A (es) 1998-05-31
CA2227194A1 (en) 1997-02-06
CO4480720A1 (es) 1997-07-09
PL184261B1 (pl) 2002-09-30
CZ15098A3 (cs) 1999-02-17
DE69630123T2 (de) 2004-04-08
JPH10511102A (ja) 1998-10-27
KR19990029058A (ko) 1999-04-15
RU2136681C1 (ru) 1999-09-10
KR100276989B1 (ko) 2001-01-15
EP0840735A1 (en) 1998-05-13
PT840735E (pt) 2004-02-27
NZ310539A (en) 1998-11-25
ATE250600T1 (de) 2003-10-15
DK0840735T3 (da) 2004-02-09

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