MX9800538A - Separacion de 1-azabiciclo[2.2.2]octan-3-amina, 2-(difenilmetil)-n-[[2-metoxi-5(1-metiletil)fenil]metil]. - Google Patents

Separacion de 1-azabiciclo[2.2.2]octan-3-amina, 2-(difenilmetil)-n-[[2-metoxi-5(1-metiletil)fenil]metil].

Info

Publication number
MX9800538A
MX9800538A MX9800538A MX9800538A MX9800538A MX 9800538 A MX9800538 A MX 9800538A MX 9800538 A MX9800538 A MX 9800538A MX 9800538 A MX9800538 A MX 9800538A MX 9800538 A MX9800538 A MX 9800538A
Authority
MX
Mexico
Prior art keywords
octan
diphenylmethyl
azabicyclo
methylethyl
methoxy
Prior art date
Application number
MX9800538A
Other languages
English (en)
Other versions
MXPA98000538A (es
Inventor
Derek L Tickner
Morgan Meltz
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9800538A publication Critical patent/MX9800538A/es
Publication of MXPA98000538A publication Critical patent/MXPA98000538A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

Esta invencion se refiere a un procedimiento para separar 1-azabicíclico[2.2.2]octan-3-amina,2-(difenilmetil )-N-[[2-metoxi-5-(metiletil)fenil]metil] que comprende hacer reaccionar 1-azabiciclico[2.2.2]octan-3-amina,2-(difenilmetil )-N-[[2-metoxi-5-(1-meiletil)fenil]metil] con ácido 1R-(-)-10-canforsulfonico en un disolvente capaz de disolver ambos reactivos anteriores y disolver de forma selectiva la sal de ácido canforsulfonico del enantiomero (2R, 3R) correspondiente respecto al enantiomero (2S, 3S) para formar la sal del ácido canforsulfonico de (2S, 3S)-1-azabicíclico[2.2.2]octan-3-amina, 2-(difenilmetil)-N-[[2-metoxi-5-(1-metiletil)fenil ]metil], y seguidamente hidrolizar de forma opcional dicha sal para obtener la base libre del enantiomero (2S, 3S).
MXPA/A/1998/000538A 1995-07-17 1998-01-16 Separacion de 1-azabiciclo[2.2.2]octan-3-amina, 2-(difenilmetil)-n-[[2-metoxi-5(1-metiletil)fenil]metil] MXPA98000538A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US119195P 1995-07-17 1995-07-17
US001191 1995-07-17
PCT/IB1996/000648 WO1997003984A1 (en) 1995-07-17 1996-07-04 Resolution of 1-azabicyclo[2.2.2]octan-3-amine, 2-(diphenylmethyl)-n-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]

Publications (2)

Publication Number Publication Date
MX9800538A true MX9800538A (es) 1998-05-31
MXPA98000538A MXPA98000538A (es) 1998-10-23

Family

ID=

Also Published As

Publication number Publication date
JPH10511102A (ja) 1998-10-27
DK0840735T3 (da) 2004-02-09
AU697553B2 (en) 1998-10-08
US6008357A (en) 1999-12-28
CN1068598C (zh) 2001-07-18
EP0840735A1 (en) 1998-05-13
PL184261B1 (pl) 2002-09-30
NZ310539A (en) 1998-11-25
CA2227194C (en) 2002-02-12
AR002772A1 (es) 1998-04-29
PT840735E (pt) 2004-02-27
HUP9900238A2 (hu) 1999-05-28
JP3043074B2 (ja) 2000-05-22
WO1997003984A1 (en) 1997-02-06
HUP9900238A3 (en) 2001-08-28
CA2227194A1 (en) 1997-02-06
AU6134896A (en) 1997-02-18
NO980211D0 (no) 1998-01-16
KR19990029058A (ko) 1999-04-15
ATE250600T1 (de) 2003-10-15
PE8798A1 (es) 1998-03-02
MY115734A (en) 2003-08-30
CO4480720A1 (es) 1997-07-09
KR100276989B1 (ko) 2001-01-15
EP0840735B1 (en) 2003-09-24
RU2136681C1 (ru) 1999-09-10
DE69630123D1 (en) 2003-10-30
NO980211L (no) 1998-03-16
CN1190970A (zh) 1998-08-19
IL122655A0 (en) 1998-08-16
DE69630123T2 (de) 2004-04-08
CZ15098A3 (cs) 1999-02-17
ZA966026B (en) 1998-01-16
ES2205039T3 (es) 2004-05-01
HK1010195A1 (en) 1999-06-17
PL324610A1 (en) 1998-06-08

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