DE69605800T2 - Maleinsäuresalz des (r)-(z)-azabycyclo(2.2.1)heptan-3-one,0-(3-(3-methoxyphenyl)-2-propynyl)oxims - Google Patents
Maleinsäuresalz des (r)-(z)-azabycyclo(2.2.1)heptan-3-one,0-(3-(3-methoxyphenyl)-2-propynyl)oximsInfo
- Publication number
- DE69605800T2 DE69605800T2 DE69605800T DE69605800T DE69605800T2 DE 69605800 T2 DE69605800 T2 DE 69605800T2 DE 69605800 T DE69605800 T DE 69605800T DE 69605800 T DE69605800 T DE 69605800T DE 69605800 T2 DE69605800 T2 DE 69605800T2
- Authority
- DE
- Germany
- Prior art keywords
- heptan
- propynyl
- methoxyphenyl
- azabycyclo
- oxims
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/474,622 US5534522A (en) | 1995-06-07 | 1995-06-07 | (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent |
PCT/US1996/006814 WO1996040687A1 (en) | 1995-06-07 | 1996-05-13 | (r)-(z)-1-azabicyclo[2.2.1]heptan-3-one,o-[3-(3-methoxyphenyl)-2-propynyl]oxime maleate as a pharmaceutical agent |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69605800D1 DE69605800D1 (de) | 2000-01-27 |
DE69605800T2 true DE69605800T2 (de) | 2000-11-16 |
Family
ID=23884337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69605800T Expired - Fee Related DE69605800T2 (de) | 1995-06-07 | 1996-05-13 | Maleinsäuresalz des (r)-(z)-azabycyclo(2.2.1)heptan-3-one,0-(3-(3-methoxyphenyl)-2-propynyl)oxims |
Country Status (25)
Country | Link |
---|---|
US (1) | US5534522A (de) |
EP (1) | EP0839148B1 (de) |
JP (1) | JPH11506723A (de) |
KR (1) | KR100383031B1 (de) |
CN (1) | CN1063181C (de) |
AT (1) | ATE187967T1 (de) |
BG (1) | BG63571B1 (de) |
CA (1) | CA2219753A1 (de) |
CZ (1) | CZ286528B6 (de) |
DE (1) | DE69605800T2 (de) |
DK (1) | DK0839148T3 (de) |
EA (1) | EA000381B1 (de) |
EE (1) | EE03971B1 (de) |
ES (1) | ES2142586T3 (de) |
GE (1) | GEP19991874B (de) |
GR (1) | GR3032772T3 (de) |
HK (1) | HK1018055A1 (de) |
HU (1) | HUP9802499A3 (de) |
NO (1) | NO308901B1 (de) |
NZ (1) | NZ307946A (de) |
PL (1) | PL323796A1 (de) |
SK (1) | SK282824B6 (de) |
UA (1) | UA46032C2 (de) |
WO (1) | WO1996040687A1 (de) |
ZA (1) | ZA964764B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9601909A (pt) * | 1995-07-13 | 1999-10-13 | Smithkline Beecham Corp | N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato |
US6528529B1 (en) * | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
CA2540639C (en) * | 2003-10-02 | 2010-08-31 | Pharmacia & Upjohn Company Llc | Salts and polymorphs of a pyrrole-substituted indolinone compound |
US7741358B2 (en) * | 2005-04-14 | 2010-06-22 | N.V. Organon | Crystal form of asenapine maleate |
WO2006131923A2 (en) * | 2005-06-07 | 2006-12-14 | Ramot At Tel Aviv University Ltd. | Novel salts of conjugated psychotropic drugs and processes of preparing same |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
CA2620333A1 (en) * | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2051735B1 (de) | 2006-07-17 | 2012-08-29 | Ramot, at Tel Aviv University Ltd. | Konjugate mit einem psychotropische heilmittel oder einem gaba agonist und eine organische säure und ihre behandlung von schmerzen und andere erkrankungen des zns |
MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US8207369B2 (en) | 2008-02-11 | 2012-06-26 | Ramot At Tel-Aviv University Ltd. | Conjugates for treating neurodegenerative diseases and disorders |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
BR112012013639A2 (pt) | 2009-12-09 | 2017-04-04 | Bar-Ilan Univ | "métodos pára melhorar funções congnitivas" |
CN102858345A (zh) | 2010-02-24 | 2013-01-02 | 雷蒙特亚特特拉维夫大学有限公司 | 奋乃静-gaba的三甲磺酸盐的晶型及其制备方法 |
WO2012038963A1 (en) | 2010-09-22 | 2012-03-29 | Ramot At Tel-Aviv University Ltd. | An acid addition salt of a nortriptyline-gaba conjugate and a process of preparing same |
JP5997931B2 (ja) * | 2011-05-25 | 2016-09-28 | 石原産業株式会社 | 農園芸用殺菌剤組成物及び植物病害の防除方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5346911A (en) * | 1990-03-06 | 1994-09-13 | Warner-Lambert Company | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment |
US5306718A (en) * | 1990-03-06 | 1994-04-26 | Warner-Lambert Company | Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment |
-
1995
- 1995-06-07 US US08/474,622 patent/US5534522A/en not_active Expired - Fee Related
-
1996
- 1996-05-13 ES ES96915757T patent/ES2142586T3/es not_active Expired - Lifetime
- 1996-05-13 DE DE69605800T patent/DE69605800T2/de not_active Expired - Fee Related
- 1996-05-13 EP EP96915757A patent/EP0839148B1/de not_active Expired - Lifetime
- 1996-05-13 WO PCT/US1996/006814 patent/WO1996040687A1/en active IP Right Grant
- 1996-05-13 DK DK96915757T patent/DK0839148T3/da active
- 1996-05-13 PL PL96323796A patent/PL323796A1/xx unknown
- 1996-05-13 CN CN96194436A patent/CN1063181C/zh not_active Expired - Fee Related
- 1996-05-13 SK SK1644-97A patent/SK282824B6/sk unknown
- 1996-05-13 AT AT96915757T patent/ATE187967T1/de not_active IP Right Cessation
- 1996-05-13 GE GEAP19964088A patent/GEP19991874B/en unknown
- 1996-05-13 EE EE9700316A patent/EE03971B1/xx not_active IP Right Cessation
- 1996-05-13 EA EA199800007A patent/EA000381B1/ru not_active IP Right Cessation
- 1996-05-13 CA CA002219753A patent/CA2219753A1/en not_active Abandoned
- 1996-05-13 JP JP9500555A patent/JPH11506723A/ja active Pending
- 1996-05-13 KR KR1019970709053A patent/KR100383031B1/ko not_active IP Right Cessation
- 1996-05-13 CZ CZ19973817A patent/CZ286528B6/cs not_active IP Right Cessation
- 1996-05-13 HU HU9802499A patent/HUP9802499A3/hu unknown
- 1996-05-13 NZ NZ307946A patent/NZ307946A/en unknown
- 1996-05-13 UA UA98010040A patent/UA46032C2/uk unknown
- 1996-06-06 ZA ZA964764A patent/ZA964764B/xx unknown
-
1997
- 1997-11-27 BG BG102078A patent/BG63571B1/bg unknown
- 1997-12-05 NO NO975704A patent/NO308901B1/no not_active IP Right Cessation
-
1998
- 1998-12-15 HK HK98113383A patent/HK1018055A1/xx not_active IP Right Cessation
-
2000
- 2000-02-28 GR GR20000400474T patent/GR3032772T3/el not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |