WO2019234163A1 - Verfahren und system zum ermitteln der schallgeschwindigkeit in einem fluid im bereich eines implantierten, vaskulären unterstützungssystems - Google Patents

Verfahren und system zum ermitteln der schallgeschwindigkeit in einem fluid im bereich eines implantierten, vaskulären unterstützungssystems Download PDF

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Publication number
WO2019234163A1
WO2019234163A1 PCT/EP2019/064803 EP2019064803W WO2019234163A1 WO 2019234163 A1 WO2019234163 A1 WO 2019234163A1 EP 2019064803 W EP2019064803 W EP 2019064803W WO 2019234163 A1 WO2019234163 A1 WO 2019234163A1
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WIPO (PCT)
Prior art keywords
sound
reflector
fluid
speed
support system
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Ceased
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PCT/EP2019/064803
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German (de)
English (en)
French (fr)
Inventor
Thomas Alexander SCHLEBUSCH
Tobias Schmid
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Kardion GmbH
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Kardion GmbH
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Publication date
Application filed by Kardion GmbH filed Critical Kardion GmbH
Priority to EP19729271.7A priority Critical patent/EP3801281A1/de
Priority to CN201980047180.XA priority patent/CN112533543B/zh
Priority to JP2020567974A priority patent/JP7387180B2/ja
Priority to US15/734,322 priority patent/US12311160B2/en
Publication of WO2019234163A1 publication Critical patent/WO2019234163A1/de
Anticipated expiration legal-status Critical
Priority to US19/218,142 priority patent/US20250345590A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/538—Regulation using real-time blood pump operational parameter data, e.g. motor current
    • A61M60/546—Regulation using real-time blood pump operational parameter data, e.g. motor current of blood flow, e.g. by adapting rotor speed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/488—Diagnostic techniques involving Doppler signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0883—Clinical applications for diagnosis of the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/70—General characteristics of the apparatus with testing or calibration facilities
    • A61M2205/702—General characteristics of the apparatus with testing or calibration facilities automatically during use

Definitions

  • the invention relates to a method for determining the speed of sound in a fluid in the region of an implanted vascular support system, a system for determining the speed of sound in a fluid in the region of an implanted vascular support system and an implantable, vascular support system.
  • the invention finds particular application in (fully) implanted left heart assist systems (LVAD).
  • LVAD left heart assist systems
  • An ultrasound Doppler measurement is suitable as a measuring method in which only a single ultrasound transducer is required as a transmitting and receiving element, which saves above all space in the implant.
  • the flow velocity can be calculated by the frequency shift through the Doppler effect:
  • the object of the invention is to specify a method and to provide a system with which the speed of sound in a fluid, in particular the speed of sound of blood in the region of an implanted, vascular support system can be determined.
  • a method for determining the speed of sound in a fluid in the region of an implanted, vascular support system comprising the following steps:
  • the vascular support system is preferably a cardiac support system, more preferably a ventricular assist system. Regularly, the support system serves to aid in the delivery of blood in the bloodstream of a human, and possibly patient.
  • the Support system may be at least partially arranged in a blood vessel.
  • the blood vessel is, for example, the aorta, in particular a left heart support system, or the common trunk (trunk pulmonalis) in the two pulmonary arteries, in particular in a right heart support system, preferably around the aorta.
  • the support system is preferably located at the exit of the left ventricle of the heart or left ventricle. Particularly preferably, the support system is arranged in aortic valve position.
  • the method is preferably for measuring the speed of sound in blood by means of ultrasound in a cardiac assist system.
  • the method may be for determining a fluid flow rate and / or a fluid volume flow from a ventricle of a heart, in particular from a (left) ventricle of a heart to the aorta in the region of a (fully) implanted (left) ventricular (heart -) support system.
  • the fluid is usually blood.
  • the sound velocity is preferably determined in a fluid flow or fluid volume flow which flows through the support system.
  • the method advantageously makes it possible to determine the speed of sound in the blood required for a (Doppler) measurement of the blood flow or flow rate, even outside the surgical scenario, with high quality, in particular by the implanted support system self.
  • FMCW (frequency modulated approach) -based analysis algorithm allows the explicit determination of the speed of sound so that the accuracy of the Doppler-based blood flow measurement is not affected by any uncertainty in the speed of sound.
  • the solution presented here is based, in particular, on supplementing a cardiac support system integrated Doppler volume flow sensor by one or more reflectors in a defined distance to the ultrasonic element, so that from the geometrically defined and known distance between the ultrasonic element and reflector and the measured pulse duration and / or beat frequency (so-called beat frequency) on the Sound velocity can be closed.
  • an ultrasound signal is emitted by means of an ultrasound sensor.
  • the ultrasound sensor preferably has an ultrasound element which, for example due to its oscillation, is designed to be able to emit one or more ultrasound signals.
  • the ultrasonic element is a piezoelectric element.
  • the ultrasonic sensor is preferably oriented so that an angle between the ultrasonic sound path and the main flow direction of the fluid is less than 5 °. It is also advantageous if the ultrasonic sensor is embodied in the manner of an ultrasound transducer which is set up both for transmitting and for receiving ultrasound signals, for example in that an ultrasound element can function as a transmitting and receiving element.
  • the emitted ultrasonic signal can also be referred to as a transmission signal and generally has a specific frequency and / or amplitude.
  • the transmission signal can also be pulsed or have at least one (in) pulse (in the pulse transit time approach).
  • the transmission signal can be influenced by frequency modulation, in particular for the determination of beat frequencies (in the FMCW approach).
  • the ultrasound signal is reflected on at least one sound reflector, which is in the field of view of the ultrasound sensor and at a (pre-) defined distance to the ultrasound sensor and / or to another sound (also arranged in the field of vision of the ultrasound sensor).
  • Reflector is arranged.
  • the field of view of the ultrasonic sensor is usually determined or clamped by its emission characteristic.
  • the Sound reflector arranged circumferentially along an inner circumference of a flow channel of the support system.
  • the at least one sound reflector projects at least partially into a flow path of the fluid or flow channel for the fluid through the support system. This flow path or channel can run, for example, through an (inlet) cannula or be formed by it.
  • the at least one sound reflector rotates along an (inner) surface of the cannula.
  • This defined distance between the ultrasonic sensor and the acoustic reflector is preferably in the range from 5 to 35 mm, in particular from 5 to 30 mm.
  • the at least one sound reflector may have at least one air-filled cavity.
  • the at least one sound reflector is preferably designed and / or aligned in such a way that it effects (only) a reflection or (only) reflection in the direction of the ultrasound sensor.
  • the at least one sound reflector is set up and / or aligned in such a way that it reflects incident ultrasonic waves or signals, in particular directly and / or only towards the ultrasonic sensor.
  • the at least one sound reflector is aligned so that a surface of the reflector is parallel to the incident ultrasonic wavefront.
  • the at least one sound reflector is a separate component to the further components (eg channel inner wall) of the support system which come into contact with the fluid.
  • the at least one sound reflector is attached or attached to a channel inner wall of the support system.
  • the reflected ultrasound signal is received.
  • the reflected ultrasound signal is received by means of the ultrasound sensor.
  • the received ultrasound signal can also be referred to as receive signal.
  • several reflected ultrasonic signals can also be received in step c).
  • the speed of sound in the fluid is determined using the reflected ultrasound signal.
  • the ultrasound signal can be evaluated or analyzed, for example, by means of an evaluation unit of the assistance system, in particular of the ultrasound sensor. In this case, a (pulse) runtime-based approach and / or a so-called FMCW-based approach can be exercised.
  • the ultrasound signal is reflected at at least two sound reflectors, which are arranged at different distances from the ultrasound sensor.
  • the two sound reflectors have a (pre-) defined distance from one another. This distance is preferably in the range of 1 to 10 mm.
  • the use of at least two reflectors at different distances advantageously makes it possible to further increase the accuracy, in particular since this makes it possible to compensate for uncertainties in the speed of sound of the impedance matching layer of the ultrasound transducer as well as tissue deposits possibly present thereon.
  • the at least one sound reflector has an acoustic impedance that is greater than the largest acoustic impedance of the fluid or less than the smallest acoustic impedance of the fluid.
  • the at least one sound reflector has an acoustic impedance that differs from the acoustic impedance of the fluid by at least 5 MRayl. If several sound reflectors are provided, they may have the same acoustic impedance or different acoustic impedances from each other.
  • the at least one sound reflector should have an acoustic impedance that is greater than the largest acoustic impedance of the fluid or less than the smallest acoustic impedance of the fluid.
  • the at least one sound reflector preferably has an acoustic impedance in the range from 2 to 80 MRayl. Further preferred is the at least one acoustic reflector with one or more of the following materials formed: titanium, medical grade stainless steel z. MP35N, platinum-iridium, NiTiNol.
  • the at least one sound reflector preferably has a reflection factor which is greater than the largest reflection factor of the fluid.
  • a reflection factor of the sound reflector is understood in particular to be the reflection factor of the boundary layer between the material of the sound reflector and the fluid.
  • a reflection factor of the fluid is understood to mean, in particular, the reflection factor of the boundary layer between blood cells and blood serum. If several sound reflectors are provided, they may have the same reflection factor or different reflection factors from each other. However, all existing sound reflectors should have a reflection factor that is greater than the largest reflection factor of the fluid.
  • the reflection factor of the at least one sound reflector is in the range of 0.3 to 0.99.
  • the at least one sound reflector is embedded in an embedding material.
  • the potting material preferably has an acoustic impedance that substantially corresponds to the acoustic impedance of the fluid.
  • a silicone may be used as the embedding material.
  • the embedding material preferably surrounds at least partially, preferably completely, the surface of the acoustic reflector facing towards the fluid.
  • the at least one sound reflector (by means of the embedding material) is embedded in a flat and / or smooth surface.
  • the at least one sound reflector is embedded (by means of the embedding material) in a surface whose maximum pitch is smaller than the maximum pitch of the outer surface of the sound reflector.
  • the sound velocity using a (pulse) runtime-based Evaluation algorithm is determined.
  • the speed of sound is preferably determined as a function of the defined distance at least between the ultrasonic sensor and the sound reflector or between two sound reflectors and at least one (measured) signal propagation time.
  • a cross-correlation in particular of the transmission pulse (pulse of the transmitted ultrasound signal) with the reception pulses (pulses of the received, reflected pulses reflected at the sound reflectors) delayed by the transit time (s), is particularly preferred. reflected ultrasound signals).
  • the sound velocity is determined using an FMCW-based evaluation algorithm.
  • FMCW stands for frequency-modulated continuous wave.
  • the sound velocity is preferably determined as a function of the defined distance at least between the ultrasonic sensor and the sound reflector or between two sound reflectors, a change in a frequency of an ultrasonic signal and at least one (resulting) beat frequency.
  • the speed of sound is determined as a function of the defined distance between the ultrasonic sensor and the sound reflector and / or between two sound reflectors, the slope of a frequency ramp and at least one (resulting) beat frequency.
  • a beat frequency is determined in the case of or for the FMCW-based evaluation algorithm.
  • the beat frequency can also be referred to as difference frequency and / or beat frequency.
  • the beat frequency from a superposition of the of the Ultrasonic sensor emitted ultrasonic signal (transmission signal) with the received from the ultrasonic sensor reflected ultrasonic signal (received signal) determines.
  • the number of dominant beat frequencies to be determined or determined corresponds to the number of (ultra) sound reflectors.
  • a discrete Fourier transformation (DFT) or fast Fourier transformation (FFT) can be used to determine the beat frequency.
  • a system for determining sound velocity in a fluid in the region of an implanted vascular support system comprising:
  • At least one sound reflector which is arranged in the field of view of the ultrasound sensor and at a defined distance at least to the ultrasound sensor or to another sound reflector.
  • At least two sound reflectors are arranged at different distances from the ultrasonic sensor. Furthermore, it is also preferred in the system when the at least one sound reflector is embedded in an embedding material.
  • an evaluation unit in which a pulse duration-based evaluation algorithm is stored.
  • an evaluation unit can be provided, in which an FMCW-based evaluation algorithm is stored.
  • the evaluation unit is preferably part of the support system, in particular of the ultrasonic sensor. Further preferably, the evaluation unit is set up to carry out a method proposed here.
  • the evaluation unit can have a memory in which the pulse duration-based evaluation algorithm and / or the FMCW-based evaluation algorithm is / are stored.
  • the evaluation unit a Microprocessor, which can access the memory.
  • the processing unit preferably receives data from an ultrasound element of the ultrasound sensor.
  • an implantable vascular support system comprising a system for determining the speed of sound proposed herein.
  • the support system is preferably a left ventricular cardiac assist system (LVAD) or a percutaneous, minimally invasive left ventricular assist system.
  • LVAD left ventricular cardiac assist system
  • this is preferably fully implantable.
  • the support system is located completely in the body of the patient and remains there.
  • the support system is set up or suitable for being able to be arranged at least partially in a ventricle, preferably the left ventricle of a heart and / or an aorta, in particular in the aortic valve position.
  • the support system comprises a cannula, in particular inlet cannula and a turbomachine, such as a pump.
  • the support system may further comprise an electric motor, which is regularly a part of the turbomachine.
  • the (inlet) cannula is preferably arranged so that it can lead fluid in the implanted state from a (left) ventricle of a heart to the flow machine.
  • the support system is preferably elongate and / or tubular.
  • the inlet cannula and the turbomachine are arranged in the region of opposite ends of the support system.
  • FIG. 2a is a detailed view of an implantable vascular support system
  • FIG. 2b is a detailed view of another implantable vascular support system
  • FIG. 4 shows an illustration of a system presented here
  • FIG. 5 shows an illustration of a pulse transit time-based approach that can be used here
  • FIG. 5 shows an illustration of a pulse transit time-based approach that can be used here
  • Fig. 6 is an illustration of an FMCW-based one usable here
  • FIG. 7 shows exemplary courses of real parts of impedances
  • Fig. 8a is a detail view of a system presented here
  • Fig. 8b is a detail view of another system presented here.
  • Fig. 1 shows schematically a flow of a method presented here in a regular operation.
  • the illustrated sequence of method steps a), b), c) and d) with the blocks 110, 120, 130 and 140 is merely exemplary.
  • an ultrasound signal is emitted by means of an ultrasound sensor.
  • the ultrasound signal is reflected on at least one sound reflector, which is arranged in the field of view of the ultrashort sensor and at a defined distance from the ultrasound sensor.
  • the reflected ultrasound signal is received.
  • the speed of sound in the fluid is determined using the reflected ultrasound signal.
  • the method steps a), b), and c) can also run at least partially in parallel or at the same time.
  • 2a schematically shows a detailed view of an implantable vascular support system 2.
  • FIG. 2b schematically shows a detailed view of another implantable vascular support system 2.
  • FIGS. 2a and 2b will be explained together below. The reference numbers are used uniformly.
  • FIG. 2 a shows the integration into a left ventricular microaxial pump in the aortic valve position and, in FIG. 2 b, the integration into an apically placed radial support system 2.
  • the flow direction of the fluid 1 is entered in Figures 2a and 2b by arrows.
  • an ultrasonic sensor 4 is provided, which is arranged in or on the support system 2.
  • the ultrasonic sensors 4 are exemplified in FIGS. 2a and 2b as ultrasonic transducers.
  • circumferential sound reflectors 5 are provided, which are arranged in the field of view 6 of the ultrasonic sensor 4 and each at a defined distance 7 to the ultrasonic sensor 4.
  • the flow channel can be formed in the interior of a (inlet) cannula (not shown here) of the support system 2.
  • the detailed view according to FIG. 2 a shows a tip of a support system 2 accommodating the ultrasonic sensor 4 with a micro-axial pump (not shown here).
  • a flow guide body 10 is placed here by way of example. This is not spaced apart from the ultrasound sensor 4 and is permeable to ultrasound signals.
  • the fluid 1 flows here in the direction of the pump.
  • the tip of the support system 2 shown in the detailed view according to FIG. 2 a can protrude into a ventricle (not shown here) of a heart in a preferred arrangement with the end shown here on the left, the pump at least partially in the aorta (not here) can be arranged). In this arrangement, the support system thus penetrates an aortic valve (not shown here).
  • FIG. 2b The detailed view of Fig. 2b relates to a support system 2, which is also referred to as apical radial pump.
  • the support system 2 has a turbomachine 1 1 (here pump), which discharges the fluid 1 in the radial direction as shown.
  • FIG. 3 shows schematically a radiation characteristic 12 of an ultrasonic element (not shown here).
  • FIG. 3 illustrates the field of view 6 of the ultrasound sensor (not shown here).
  • a field of view width 13 and along the abscissa (x-axis) a field of view length 14 can be measured.
  • the system comprises an ultrasound sensor 4 and two sound reflectors 5, which are arranged at different (defined) distance 7 from the ultrasound sensor 4.
  • the reflectors 5 protrude into the fluid 1 by way of example.
  • Each boundary layer between two acoustic impedances has a reflection factor at which a part of the sound energy is reflected in accordance with the quantity G.
  • the slightly different acoustic impedance of red blood cells and blood serum provides the reflected signal, which is usually used to calculate the Doppler frequency shift, from which the flow rate of the blood can be determined.
  • An (additional) reflector proposed here should preferably have the highest possible reflec- tion factor, which can be achieved in particular by an impedance mismatch with the blood, ie the acoustic impedance of the reflector should differ as clearly as possible from blood, for example by the reflector from an air-filled reflector Cavity or a metal is executed.
  • the method with only one reflector 5 can be faulty as soon as there is more than one unknown medium between the ultrasonic sensor 4 and the reflector 5.
  • the acoustic impedance (formula symbol: Zwi) and thus the speed of sound (symbol: Ci) of the matching layers 15 could change over the years due to water diffusion or it could lead to deposits 16 of cell layers (with their own acoustic impedance Zw 2 and sonic velocity C 2 ) on the ultrasonic sensor 4, so that an additional material layer of unknown thickness and / or unknown speed of sound is formed, as is illustrated in more detail in FIG. 4.
  • the differing sound velocities of the various media are entered by way of example in FIG. 4, namely the speed of sound Ci of the adaptation layers 15, the speed of sound C 2 of the deposits 16 and the speed of sound C3 of the fluid 1 (here: blood).
  • FIG. 5 schematically shows an illustration of a pulse duration-based approach that can be used here.
  • the pulse transit time-based approach reference will also be made to the depiction of the system according to FIG. 4.
  • the pulse transit time of the ultrasonic sensor 4 to the reflector 5 and back to the ultrasonic sensor 4 calculate. Since the mechanical structure of the (cardiac) support system 2 and thus the (defined) distance 7 between the ultrasound sensor 4 and the reflector 5 are known, it is possible according to the formula with the known (defined) distance 7 between the ultrasonic sensor 4 and the reflector 5 and t of the measured signal propagation time, the sought sound velocity c can be determined.
  • the sound velocity C 3 can be determined independently of the influence of additional layers between the ultrasonic sensor 4 and the reflector 5.
  • One possibility for determining the transit times t Ri and t R2 or t Ri -t R2 is the calculation of the cross-correlation 17 of the transmit pulse 3 (pulse of the transmitted ultrasound signal 3) with the delays delayed by the transit times t Ri or t R2 , at the ultrasonic reflectors 5 reflected receiving pulses 8 (pulses of the received, reflected ultrasonic signals 8).
  • the time-discrete cross-correlation 17 can be calculated for energy signal as follows: With R xy [n] the discrete cross-correlation at time n, the operator "star” as shorthand for the cross-correlation, x * [m] the conjugate complex transmission signal over all time shifts m and y [m + n] the received signal at time n all time shifts m.
  • FIG. 5 shows by way of example the result of this calculation.
  • the pulse of the emitted ultrasonic signal 3 the pulses of the received, reflected ultrasonic signals 8 and the (time-discrete) cross-correlation 17 are plotted against time 18. From the distance between z. B. the two peaks (peaks) in the cross-correlation signal 17 can - after the recalculation of the discrete time steps - the time interval t Ri - t R2 are determined.
  • Fig. 6 shows schematically an illustration of an FMCW-based approach which can be used here. In order to explain the illustration according to FIG. 6 or the FMCW-based approach, reference is also made to the illustration of the system according to FIG. 4.
  • the (ultra) sound reflectors 5 represent, in particular because of their high reflection factor, the dominant targets in the emission area of the ultrasonic sensor 4. Therefore, their beat frequencies (so-called beat frequencies) can be clearly recognized in the calculated spectrum. Since the mechanical structure of the (cardiac) support system and thus the distance between the ultrasound sensor 4 and the reflector 5 (symbol x) is known, the formula
  • the resulting beat frequency (beating frequency) in the baseband, the desired Schalgeschwindig- speed c are determined.
  • the reflectors 5 are fixed in place, the resulting beat frequency is influenced only by their distance from the ultrasound sensor 4 and the corresponding transit time of the frequency ramp in the fluid (here: blood) and, in particular, contains no speed-dependent component.
  • the beat frequency f beat.Ri is accordingly the frequency ramp reflected at the first reflector and the beat frequency fbeat, R2 of the frequency ramp reflected at the second reflector with S1 the thickness of the matching layers 15, S2 the thickness of the deposits 16, S3 the distance between deposits 16 and the first (left) reflector 5 and s 4 the distance between the first (left) reflector 5 and second (right) reflector fifth and with Ci the speed of sound in the matching layers 15, C2 the speed of sound in the deposits 16, C3 the speed of sound in the fluid 1 (here: blood).
  • the speed of sound C3 can be determined independently of the influence of additional layers between the ultrasonic sensor 4 and the reflector 5.
  • the ultrasonic frequency f o is hereby influenced by frequency modulation as an example. Sinusoidal, sawtooth, triangular or rectangular modulation types can be used. It is particularly preferable if the ultrasonic sensor or the ultrasonic element of the sensor provides a broadband resonance and that the ramp duration (symbol: T) much larger than the running time (so-called "time of flight") of the frequency ramps from the ultrasonic sensor 4 (ultrasonic transducer or transducer) to the (ultra) sound reflectors 5 and back again. The echoes of the successively transmitted, modulated ultrasonic frequency ramps reflected at the reflectors 5 are mixed down (superimposed) with the instantaneous transmission frequency ramp. The baseband signal thus generated contains the beat frequencies to be determined. These are transformed by the transformation into the frequency range z. As determined by discrete Fourier transform (DFT) or fast Fourier transformation (FFT).
  • DFT discrete Fourier transform
  • FFT fast Fourier transformation
  • FIG. 6 a possible implementation of the above-described FMCW-based approach by means of sawtooth modulation is shown.
  • the course of the frequency 19 over the time 18 is plotted.
  • both the ultrasound signal 3 (transmission signal) emitted by the ultrasound sensor and the reflected ultrasound signals 8 (reception signals) received by the ultrasound sensor are shaped in the manner of a sawtooth.
  • three are applied to the transmission signal 3 and mutually shifted reception signals 8, which would be the case, for example, if three ultrasound reflectors arranged at different distances from the ultrasound sensor were used.
  • the FMCW approach regularly uses a periodic frequency modulation, here periodic sawtooth modulation, which should be as linear as possible in order to achieve a high degree of accuracy in the measurement.
  • the modulation is usually carried out cyclically.
  • Such a passage from the lowest to the highest frequency is also called a burst (so-called burst).
  • the duration of a corresponding passage is entered in the upper diagram of FIG. 6 as a so-called chirp duration (chirp duration) 22.
  • chirp duration 23 is marked.
  • the ultrasonic sensor transmits here by way of example a linearly frequency-modulated signal with a sawtooth-shaped change of the transmission frequency 3. The same signal is received by the ultrasonic sensor after reflection on one of the ultrasonic reflectors.
  • the received signal 8 differs once in time, wherein the time difference 21 between the frequency jumps is usually proportional to the distance of the reflecting ultrasonic I-reflector from the ultrasonic sensor.
  • the difference frequency 20 between the transmission signal 3 and the reception signal 8 is the same at every point in time and is therefore also a measure of the distance of the reflecting ultrasonic reflector. This frequency difference can be evaluated in particular in the frequency domain.
  • a frequency spectrum 25 is generated here, for example, by Fieruntermixing / multiplication with the instantaneous transmission signal and by means of downstream fast Fourier transformation 24, in which the difference frequencies 20 are entered in addition to the background noise 26 are.
  • this is a multiplication of the received signal with the instantaneous transmission signal and subsequent Fourier transformation of the baseband time signal, from which the difference frequencies 20 result, which are also referred to here as beat frequencies or beat frequencies.
  • the particularly advantageous linearity can be achieved over the desired frequency band.
  • real parts 27 of the impedances of 8 MFIz piezo elements are plotted as an example over the stimulation frequency 28.
  • FIG. 8a shows schematically a detail view of a system presented here.
  • Fig. 8b shows schematically a detailed view of another system presented here.
  • FIGS. 8a and 8b will be explained together below.
  • the reference numerals are used uniformly.
  • the surface of the reflector should be parallel to the incident ultrasonic wavefront. Since uneven surfaces such as applied reflectors can cause turbulence in the flow (disadvantageous for the Doppler ultrasound measurement), the formation of thrombi as well as by occurring shear forces to additional blood damage (flaemolysis), it is expedient, the reflectors 5 with to embed an embedding material 9, as exemplified in Figures 8a and 8b.
  • the embedding material 9 is used here by way of example to provide a surface which is smoother in comparison to the reflector surface or a surface without corners and / or edges. It is particularly preferred, the to embed at least one reflector 5, in particular by means of the embedding material 9 in a flat surface.
  • the embedding material 9 should have an acoustic impedance that is as similar as possible to the fluid 1 (here: blood) and should be as thin as possible, so that no additional reflections or diffractions of the sound impulse occur, unless this additional diffraction is desired.
  • the or each reflector 5 with acoustic impedance C 4 can be embedded in a silicone with acoustic impedance C 3 ' , where C 3' is similar to the acoustic impedance C 3 of blood.
  • the solution presented here enables one or more of the following advantages:
  • the speed of sound can be determined from the resulting pulse transit time and / or ramp runtime by the reflector.

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PCT/EP2019/064803 2018-06-06 2019-06-06 Verfahren und system zum ermitteln der schallgeschwindigkeit in einem fluid im bereich eines implantierten, vaskulären unterstützungssystems Ceased WO2019234163A1 (de)

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EP19729271.7A EP3801281A1 (de) 2018-06-06 2019-06-06 Verfahren und system zum ermitteln der schallgeschwindigkeit in einem fluid im bereich eines implantierten, vaskulären unterstützungssystems
CN201980047180.XA CN112533543B (zh) 2018-06-06 2019-06-06 用于确定植入式血管支持系统的区域中的流体中的声速的方法和系统
JP2020567974A JP7387180B2 (ja) 2018-06-06 2019-06-06 移植された血管補助システムの領域内の流体中の音速を決定するための方法およびシステム、ならびにそれを用いた血管補助システム
US15/734,322 US12311160B2 (en) 2018-06-06 2019-06-06 Method and system for determining the speed of sound in a fluid in the region of a cardiac support system
US19/218,142 US20250345590A1 (en) 2018-06-06 2025-05-23 Method and system for determining the speed of sound in a fluid in the region of a cardiac support system

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