WO1990012874A3 - Variantes de polypeptides par addition de cysteine, et leurs modifications chimiques - Google Patents
Variantes de polypeptides par addition de cysteine, et leurs modifications chimiques Download PDFInfo
- Publication number
- WO1990012874A3 WO1990012874A3 PCT/US1990/002144 US9002144W WO9012874A3 WO 1990012874 A3 WO1990012874 A3 WO 1990012874A3 US 9002144 W US9002144 W US 9002144W WO 9012874 A3 WO9012874 A3 WO 9012874A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polypeptides
- cysteine
- added variants
- chemical modifications
- modified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69027989T DE69027989T2 (de) | 1989-04-21 | 1990-04-19 | Il-3 MIT ZUSÄTZLICHEN CYSTEINRESTEN UND CHEMISCHE MODIFIKATIONEN DAVON |
EP90907849A EP0469074B1 (fr) | 1989-04-21 | 1990-04-19 | Variantes d'il-3 par addition de cysteine, et leurs modifications chimiques |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US341,990 | 1989-04-21 | ||
US07/341,990 US5166322A (en) | 1989-04-21 | 1989-04-21 | Cysteine added variants of interleukin-3 and chemical modifications thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1990012874A2 WO1990012874A2 (fr) | 1990-11-01 |
WO1990012874A3 true WO1990012874A3 (fr) | 1991-01-10 |
Family
ID=23339864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/002144 WO1990012874A2 (fr) | 1989-04-21 | 1990-04-19 | Variantes de polypeptides par addition de cysteine, et leurs modifications chimiques |
Country Status (9)
Country | Link |
---|---|
US (1) | US5166322A (fr) |
EP (3) | EP0668353A1 (fr) |
JP (1) | JP2557144B2 (fr) |
AT (1) | ATE140969T1 (fr) |
AU (1) | AU5553790A (fr) |
DE (1) | DE69027989T2 (fr) |
DK (1) | DK0469074T3 (fr) |
ES (1) | ES2090132T3 (fr) |
WO (1) | WO1990012874A2 (fr) |
Cited By (5)
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---|---|---|---|---|
US8840879B2 (en) | 2004-03-11 | 2014-09-23 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US8859497B2 (en) | 1997-07-14 | 2014-10-14 | Bolder Biotechnology, Inc. | Method of treatment using cysteine mutants of beta interferon |
US8916518B2 (en) | 2002-03-06 | 2014-12-23 | Fresenius Kabi Deutschland Gmbh | Coupling proteins to a modified polysaccharide |
US8957023B2 (en) | 1999-01-14 | 2015-02-17 | Bolder Biotechnology Inc. | Methods for making proteins containing free cysteine residues |
US11844839B2 (en) | 2016-03-25 | 2023-12-19 | Seagen Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
Families Citing this family (243)
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US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
GB8824591D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
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US5951972A (en) * | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
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KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
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AU3423293A (en) * | 1991-12-19 | 1993-07-19 | Baylor College Of Medicine | Pva or peg conjugates of peptides for epitope-specific immunosuppression |
US5578496A (en) * | 1991-12-19 | 1996-11-26 | Board Of Regents, Baylor College Of Medicine | Detection of autoantibodies associated with the disease myasthenia gravis |
US5705362A (en) * | 1992-05-25 | 1998-01-06 | Gist-Brocades, N.V. | Modified signal sequences |
DE69333243T2 (de) * | 1992-11-24 | 2004-08-19 | G.D. Searle & Co., Chicago | Mutierte polypeptide des interleukin-3(il-3) |
US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
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- 1989-04-21 US US07/341,990 patent/US5166322A/en not_active Expired - Lifetime
-
1990
- 1990-04-19 EP EP95103989A patent/EP0668353A1/fr not_active Withdrawn
- 1990-04-19 WO PCT/US1990/002144 patent/WO1990012874A2/fr active IP Right Grant
- 1990-04-19 AT AT90907849T patent/ATE140969T1/de not_active IP Right Cessation
- 1990-04-19 EP EP90907849A patent/EP0469074B1/fr not_active Expired - Lifetime
- 1990-04-19 DE DE69027989T patent/DE69027989T2/de not_active Expired - Fee Related
- 1990-04-19 ES ES90907849T patent/ES2090132T3/es not_active Expired - Lifetime
- 1990-04-19 EP EP95103990A patent/EP0668354A1/fr not_active Withdrawn
- 1990-04-19 AU AU55537/90A patent/AU5553790A/en not_active Abandoned
- 1990-04-19 DK DK90907849.5T patent/DK0469074T3/da active
- 1990-04-19 JP JP2507086A patent/JP2557144B2/ja not_active Expired - Fee Related
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EP0154316A2 (fr) * | 1984-03-06 | 1985-09-11 | Takeda Chemical Industries, Ltd. | Lymphokine chimiquement modifiée et son procédé de préparation |
WO1987000056A1 (fr) * | 1985-06-26 | 1987-01-15 | Cetus Corporation | Solubilisation de proteines pour des compositions pharmaceutiques utilisant une conjugaison de polymeres |
WO1989006546A1 (fr) * | 1988-01-20 | 1989-07-27 | Cetus Corporation | Conjugaison d'un polymere avec la proteine csf-1 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8859497B2 (en) | 1997-07-14 | 2014-10-14 | Bolder Biotechnology, Inc. | Method of treatment using cysteine mutants of beta interferon |
US8957023B2 (en) | 1999-01-14 | 2015-02-17 | Bolder Biotechnology Inc. | Methods for making proteins containing free cysteine residues |
US8916518B2 (en) | 2002-03-06 | 2014-12-23 | Fresenius Kabi Deutschland Gmbh | Coupling proteins to a modified polysaccharide |
US8840879B2 (en) | 2004-03-11 | 2014-09-23 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
US11844839B2 (en) | 2016-03-25 | 2023-12-19 | Seagen Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
Also Published As
Publication number | Publication date |
---|---|
EP0668354A1 (fr) | 1995-08-23 |
ATE140969T1 (de) | 1996-08-15 |
EP0469074B1 (fr) | 1996-07-31 |
DK0469074T3 (da) | 1996-08-26 |
EP0668353A1 (fr) | 1995-08-23 |
ES2090132T3 (es) | 1996-10-16 |
WO1990012874A2 (fr) | 1990-11-01 |
JP2557144B2 (ja) | 1996-11-27 |
DE69027989T2 (de) | 1997-02-20 |
AU5553790A (en) | 1990-11-16 |
US5166322A (en) | 1992-11-24 |
DE69027989D1 (de) | 1996-09-05 |
JPH04504801A (ja) | 1992-08-27 |
EP0469074A1 (fr) | 1992-02-05 |
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