WO1988002756A3 - Derives peptidiques - Google Patents

Derives peptidiques Download PDF

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Publication number
WO1988002756A3
WO1988002756A3 PCT/EP1987/000593 EP8700593W WO8802756A3 WO 1988002756 A3 WO1988002756 A3 WO 1988002756A3 EP 8700593 W EP8700593 W EP 8700593W WO 8802756 A3 WO8802756 A3 WO 8802756A3
Authority
WO
WIPO (PCT)
Prior art keywords
sugar
peptide
coupling
amino acid
derivative
Prior art date
Application number
PCT/EP1987/000593
Other languages
English (en)
Other versions
WO1988002756A2 (fr
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to DE3790635A priority Critical patent/DE3790635B4/de
Publication of WO1988002756A2 publication Critical patent/WO1988002756A2/fr
Publication of WO1988002756A3 publication Critical patent/WO1988002756A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Dérivé de sucre d'un peptide biologiquement actif, lequel dérivé présente une durée d'action prolongée par comparaison avec le peptide non modifié par du sucre, et renferme, au moins sur l'une des unités amino-acides, un résidu de sucre qui est fixé à un groupe amino desdites unités par un couplage autre qu'une liaison directe N-glycosidique, et en outre, lorsqu'il s'agit d'un produit de condensation d'un groupe carboxyle contenant du sucre et un peptide avec moins de 8 unités amino-acides, par un couplage autre qu'une liaison directe avec un amide.
PCT/EP1987/000593 1986-10-13 1987-10-12 Derives peptidiques WO1988002756A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3790635A DE3790635B4 (de) 1986-10-13 1987-10-12 Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DEP3634797.3 1986-10-13
DEP3634825.2 1986-10-13
DE3634826 1986-10-13
DE3634825 1986-10-13
DE3634797 1986-10-13
DEP3634826.0 1986-10-13
DEP3712626.1 1987-04-14
DE3712626 1987-04-14
CH3153/87-6 1987-08-17
CH315387 1987-08-17

Publications (2)

Publication Number Publication Date
WO1988002756A2 WO1988002756A2 (fr) 1988-04-21
WO1988002756A3 true WO1988002756A3 (fr) 1988-07-14

Family

ID=27509117

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1987/000593 WO1988002756A2 (fr) 1986-10-13 1987-10-12 Derives peptidiques

Country Status (23)

Country Link
US (1) US5656721A (fr)
JP (2) JPH0645639B2 (fr)
KR (1) KR960016861B1 (fr)
AU (2) AU617986B2 (fr)
BE (1) BE1003752A4 (fr)
CA (1) CA1340985C (fr)
CH (2) CH682632A5 (fr)
DE (1) DE3790635T1 (fr)
DK (1) DK174337B1 (fr)
ES (1) ES2007418A6 (fr)
FI (1) FI874495A (fr)
FR (1) FR2609991A1 (fr)
GB (2) GB2199829B (fr)
GR (1) GR871567B (fr)
HU (3) HU906340D0 (fr)
IE (1) IE912442A1 (fr)
LU (1) LU87014A1 (fr)
NL (1) NL194729C (fr)
NZ (1) NZ222133A (fr)
PL (1) PL157156B1 (fr)
PT (1) PT85904B (fr)
SE (2) SE8703938L (fr)
WO (1) WO1988002756A2 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
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HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
EP0329295A1 (fr) * 1988-02-01 1989-08-23 The Upjohn Company Peptides inhibant la rénine avec des groupes terminaux polaires
GB2218102B (en) * 1988-04-08 1992-09-16 Sandoz Ltd Calcitonin peptide derivatives
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (fr) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
ATE284413T1 (de) * 1993-08-09 2004-12-15 Sod Conseils Rech Applic Therapeutische peptid derivate
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) * 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
DE69816808T2 (de) 1997-05-13 2004-04-15 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatin agoniste zur reduzierung von körpergewicht
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
EP0981364B1 (fr) 1997-05-13 2006-03-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Procede et compositions pour traiter l'hyperlipidemie
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US7589061B2 (en) * 2001-04-23 2009-09-15 Mallinckrodt Inc. Tc and Re labeler radioactive glycosylated octreotide derivatives
DK1401863T3 (da) 2001-06-08 2009-05-25 Ipsen Pharma Kimære somatostatin-dopamin-analoge
DE60309847T2 (de) * 2002-02-27 2007-10-18 Ferring B.V. Zwischenprodukte und verfahren zur herstellung von heptapeptid-oxytocinanaloga
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2009506076A (ja) 2005-08-26 2009-02-12 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ 三叉神経疼痛のための薬物送達のための治療手順
EP1787658B1 (fr) 2005-11-10 2012-03-14 CHEMI S.p.A. Formulations à libération prolongée contenant des inhibiteurs de l'hormone de croissance analogues de la somatostatine
WO2008011168A2 (fr) * 2006-07-21 2008-01-24 Amgen Inc. Antagonistes peptidiques glycosylés du récepteur de la bradykinine de type b1
WO2008095063A1 (fr) 2007-01-31 2008-08-07 Dana-Farber Cancer Institute, Inc. Peptides p53 stabilisés et utilisations de ceux-ci
EP2508531B1 (fr) 2007-03-28 2016-10-19 President and Fellows of Harvard College Polypeptides piqués
WO2009040363A1 (fr) 2007-09-25 2009-04-02 Glycom Aps Glycoprotéines et cellules glycosylées, et procédé pour les préparer
AU2008323683B2 (en) * 2007-11-09 2014-10-02 University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for oral administration
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
EP2719392B1 (fr) 2008-06-12 2019-07-24 Ipsen Bioinnovation Limited Protéines de fusion pour leur utilisation dans le traitement de l'acromégalie
WO2010089757A2 (fr) * 2008-11-07 2010-08-12 Usv Limited Procédé amélioré de synthèse d'un octapeptide cyclique
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EP3713545A1 (fr) 2017-11-22 2020-09-30 Dauntless 1, Inc. Formulations de composé thérapeutique
EP3713660A1 (fr) 2017-11-22 2020-09-30 Dauntless 1, Inc. Dispositif d'émulsification de membrane pour la création de microsphères
WO2020005842A1 (fr) 2018-06-25 2020-01-02 Dauntless 2, Inc. Dispositif d'émulsification membranaire avec impulseur pour la création de microsphères
CN114026107A (zh) 2019-04-16 2022-02-08 巴克姆股份公司 二硫键肽的生产
CA3199254A1 (fr) * 2020-10-22 2022-04-28 The Trustees Of Indiana University Conceptions moleculaires d'analogues d'insuline sensibles au glucose et clivables par le glucose

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089290A1 (fr) * 1982-03-15 1983-09-21 ANVAR Agence Nationale de Valorisation de la Recherche Conjugués d'haptènes et de muramyl-peptides, doués d'activité immunogène et compositions les contenant
EP0157753A1 (fr) * 1984-03-26 1985-10-09 TECHLAND, Société Anonyme Dérivés de la somatostatine, procédés de synthèse, préparation pour usage vétérinaire contenant ces dérivés et méthode pour le traitement d'animaux
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin

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US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
DE19375086I2 (de) * 1979-11-27 2003-01-09 Novartis Ag Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
EP0192611A3 (fr) * 1985-02-20 1988-05-11 Ciba-Geigy Ag Dérivés d'hexoses acylées et leur méthode de préparation
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
CA1337041C (fr) * 1985-10-09 1995-09-19 Brett Alan Evans Compositions granulaires de detergent, a solubilite amelioree
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
HU906340D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Synthesis in solid phase for producing peptonic alcohols
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (fr) * 1987-06-29 1991-12-13 Sandoz Ag

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089290A1 (fr) * 1982-03-15 1983-09-21 ANVAR Agence Nationale de Valorisation de la Recherche Conjugués d'haptènes et de muramyl-peptides, doués d'activité immunogène et compositions les contenant
EP0157753A1 (fr) * 1984-03-26 1985-10-09 TECHLAND, Société Anonyme Dérivés de la somatostatine, procédés de synthèse, préparation pour usage vétérinaire contenant ces dérivés et méthode pour le traitement d'animaux
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin

Also Published As

Publication number Publication date
FR2609991B1 (fr) 1995-03-10
LU87014A1 (fr) 1988-05-03
GB2199831B (en) 1991-04-17
NL194729C (nl) 2003-01-07
HU906340D0 (en) 1991-04-29
ES2007418A6 (es) 1989-06-16
JP2744910B2 (ja) 1998-04-28
KR880005153A (ko) 1988-06-28
NL194729B (nl) 2002-09-02
DE3790635T1 (fr) 1988-10-06
AU617986B2 (en) 1991-12-12
GB2199829A (en) 1988-07-20
AU8015091A (en) 1991-10-31
JPS63101399A (ja) 1988-05-06
CH682632A5 (de) 1993-10-29
NL8702345A (nl) 1988-05-02
KR960016861B1 (ko) 1996-12-23
CH680512A5 (fr) 1992-09-15
HUT46710A (en) 1988-11-28
JPH0314599A (ja) 1991-01-23
PT85904A (en) 1987-11-01
IE912442L (en) 1988-04-13
JPH0645639B2 (ja) 1994-06-15
SE518630C2 (sv) 2002-11-05
AU634664B2 (en) 1993-02-25
FR2609991A1 (fr) 1988-07-29
US5656721A (en) 1997-08-12
GR871567B (en) 1988-02-16
GB8800537D0 (en) 1988-02-10
HU206890B (en) 1993-01-28
DK532787D0 (da) 1987-10-12
SE8703938L (sv) 1988-04-14
SE8703938D0 (sv) 1987-10-12
FI874495A (fi) 1988-04-14
GB2199831A (en) 1988-07-20
DK174337B1 (da) 2002-12-16
SE9301172D0 (sv) 1993-04-07
DK532787A (da) 1988-04-14
PT85904B (pt) 1990-08-31
PL268173A1 (en) 1988-09-01
BE1003752A4 (fr) 1992-06-09
CA1340985C (fr) 2000-05-09
PL157156B1 (pl) 1992-05-29
WO1988002756A2 (fr) 1988-04-21
SE9301172L (fr) 1900-01-01
FI874495A0 (fi) 1987-10-12
NZ222133A (en) 1993-02-25
GB8723737D0 (en) 1987-11-11
AU7956487A (en) 1988-04-14
GB2199829B (en) 1991-04-17
HU906341D0 (en) 1991-04-29
IE912442A1 (en) 1992-02-12

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