WO1988002756A3 - Derives peptidiques - Google Patents

Derives peptidiques Download PDF

Info

Publication number
WO1988002756A3
WO1988002756A3 PCT/EP1987/000593 EP8700593W WO8802756A3 WO 1988002756 A3 WO1988002756 A3 WO 1988002756A3 EP 8700593 W EP8700593 W EP 8700593W WO 8802756 A3 WO8802756 A3 WO 8802756A3
Authority
WO
WIPO (PCT)
Prior art keywords
sugar
peptide
coupling
amino acid
derivative
Prior art date
Application number
PCT/EP1987/000593
Other languages
English (en)
Other versions
WO1988002756A2 (fr
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to DE3790635A priority Critical patent/DE3790635B4/de
Publication of WO1988002756A2 publication Critical patent/WO1988002756A2/fr
Publication of WO1988002756A3 publication Critical patent/WO1988002756A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Dérivé de sucre d'un peptide biologiquement actif, lequel dérivé présente une durée d'action prolongée par comparaison avec le peptide non modifié par du sucre, et renferme, au moins sur l'une des unités amino-acides, un résidu de sucre qui est fixé à un groupe amino desdites unités par un couplage autre qu'une liaison directe N-glycosidique, et en outre, lorsqu'il s'agit d'un produit de condensation d'un groupe carboxyle contenant du sucre et un peptide avec moins de 8 unités amino-acides, par un couplage autre qu'une liaison directe avec un amide.
PCT/EP1987/000593 1986-10-13 1987-10-12 Derives peptidiques WO1988002756A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3790635A DE3790635B4 (de) 1986-10-13 1987-10-12 Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE3634797 1986-10-13
DEP3634825.2 1986-10-13
DE3634825 1986-10-13
DE3634826 1986-10-13
DEP3634826.0 1986-10-13
DEP3634797.3 1986-10-13
DE3712626 1987-04-14
DEP3712626.1 1987-04-14
CH315387 1987-08-17
CH3153/87-6 1987-08-17

Publications (2)

Publication Number Publication Date
WO1988002756A2 WO1988002756A2 (fr) 1988-04-21
WO1988002756A3 true WO1988002756A3 (fr) 1988-07-14

Family

ID=27509117

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1987/000593 WO1988002756A2 (fr) 1986-10-13 1987-10-12 Derives peptidiques

Country Status (23)

Country Link
US (1) US5656721A (fr)
JP (2) JPH0645639B2 (fr)
KR (1) KR960016861B1 (fr)
AU (2) AU617986B2 (fr)
BE (1) BE1003752A4 (fr)
CA (1) CA1340985C (fr)
CH (2) CH682632A5 (fr)
DE (1) DE3790635T1 (fr)
DK (1) DK174337B1 (fr)
ES (1) ES2007418A6 (fr)
FI (1) FI874495A (fr)
FR (1) FR2609991A1 (fr)
GB (2) GB2199829B (fr)
GR (1) GR871567B (fr)
HU (3) HU906341D0 (fr)
IE (1) IE912442A1 (fr)
LU (1) LU87014A1 (fr)
NL (1) NL194729C (fr)
NZ (1) NZ222133A (fr)
PL (1) PL157156B1 (fr)
PT (1) PT85904B (fr)
SE (2) SE8703938L (fr)
WO (1) WO1988002756A2 (fr)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
DE3822557C2 (de) * 1987-07-10 1998-07-02 Ciba Geigy Ag Arzneimittel, enthaltend Somatostatine
WO1989007109A1 (fr) * 1988-02-01 1989-08-10 The Upjohn Company Peptides inhibiteur de renine avec groupes terminaux polaires
GB2218102B (en) * 1988-04-08 1992-09-16 Sandoz Ltd Calcitonin peptide derivatives
DE3910667A1 (de) * 1988-04-11 1989-10-19 Sandoz Ag Peptidderivate
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
BE1003762A3 (fr) * 1988-11-11 1992-06-09 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives.
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
IT1229514B (it) * 1989-01-30 1991-09-03 Farmhispania S A A Montme Glicoconiugati anfifilici sintetici per impiego neurologico.
DK111489D0 (da) * 1989-03-08 1989-03-08 Novo Nordisk As Peptider
DE4206858A1 (de) * 1992-03-05 1993-09-09 Behringwerke Ag Glycopeptid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
IT1260156B (it) * 1992-08-03 1996-03-28 Fidia Spa Derivati dell'acido neuraminico
TW263437B (fr) * 1992-09-24 1995-11-21 Takeda Pharm Industry Co Ltd
US5710244A (en) * 1992-12-31 1998-01-20 Labroo; Virender M. Derivatized calcitonins
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
ATE284413T1 (de) * 1993-08-09 2004-12-15 Sod Conseils Rech Applic Therapeutische peptid derivate
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
IL119029A0 (en) 1996-08-07 1996-11-14 Yeda Res & Dev Long-acting drugs and pharamaceutical compositions comprising them
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
WO1998051331A1 (fr) 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Somatostatine et agonistes de somatostatine servant a la reduction du poids corporel
US7026289B2 (en) 1997-05-13 2006-04-11 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Method and compositions for treating hyperlipidemia and other conditions
WO1999040928A1 (fr) * 1998-02-13 1999-08-19 Amylin Pharmaceuticals, Inc. Nouveaux composes a activite mixte par rapport a l'amyline
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US20050037490A1 (en) * 1999-10-29 2005-02-17 Lawrence Rosenberg Medium for preparing dedifferentiated cells
US7589061B2 (en) * 2001-04-23 2009-09-15 Mallinckrodt Inc. Tc and Re labeler radioactive glycosylated octreotide derivatives
JP3996897B2 (ja) 2001-06-08 2007-10-24 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス ソマトスタチン−ドーパミンキメラ類似体
EP1480998B1 (fr) * 2002-02-27 2006-11-22 Ferring BV Intermediaires et procedes destines a fabriquer des analogues d'oxytocine heptapeptide
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20070093420A1 (en) 2005-08-26 2007-04-26 Yeomans David C Therapy procedure for drug delivery for trigeminal pain
ES2383303T3 (es) 2005-11-10 2012-06-20 Chemi S.P.A. Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
WO2008011168A2 (fr) * 2006-07-21 2008-01-24 Amgen Inc. Antagonistes peptidiques glycosylés du récepteur de la bradykinine de type b1
DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
ES2610531T3 (es) 2007-03-28 2017-04-28 President And Fellows Of Harvard College Polipéptidos cosidos
EP2190857A1 (fr) 2007-09-25 2010-06-02 Glycom A/S Glycoprotéines et cellules glycosylées, et procédé pour les préparer
WO2009062200A1 (fr) * 2007-11-09 2009-05-14 University Of Tennessee Research Foundation Dérivés anti-inflammatoires de l'acide quinique pour une administration par voie orale
JP5799397B2 (ja) 2008-06-12 2015-10-28 イプセン・バイオイノベーション・リミテッドＩｐｓｅｎ Ｂｉｏｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ 癌の抑制
EP3590956A1 (fr) 2008-06-12 2020-01-08 Ipsen Bioinnovation Limited Suppression de maladies neuroendocrines
US8377891B2 (en) 2008-11-07 2013-02-19 Usv, Ltd. Process for synthesis of cyclic octapeptide
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
CN107522779B (zh) 2011-09-04 2021-10-26 株式会社糖锁工学研究所 附加糖链的多肽和含有该多肽的医药组合物
CN103946234B (zh) 2011-09-04 2017-06-30 株式会社糖锁工学研究所 附加糖链的多肽和含有该多肽的医药组合物
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
MX362492B (es) 2012-02-15 2019-01-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos.
JP6450192B2 (ja) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物
AU2013337388B2 (en) 2012-11-01 2018-08-02 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
AU2014280847B2 (en) 2013-06-13 2019-07-04 Antisense Therapeutics Ltd Combination therapy
KR20170058424A (ko) 2014-09-24 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
AU2016205225A1 (en) 2015-01-07 2017-08-17 Trigemina, Inc. Magnesium-containing oxytocin formulations and methods of use
EP3294318A4 (fr) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
US20200353419A1 (en) 2017-11-22 2020-11-12 Dauntless 1, Inc. Membrane emulsification device for microsphere creation
EP3713545A1 (fr) 2017-11-22 2020-09-30 Dauntless 1, Inc. Formulations de composé thérapeutique
WO2020005842A1 (fr) 2018-06-25 2020-01-02 Dauntless 2, Inc. Dispositif d'émulsification membranaire avec impulseur pour la création de microsphères
JP2022529774A (ja) 2019-04-16 2022-06-24 バッヘン・ホールディング・アクチエンゲゼルシャフト ジスルフィド結合ペプチドの製造
US20230399373A1 (en) * 2020-10-22 2023-12-14 The Trustees Of Indiana University Molecular designs of glucose-responsive and glucose-cleavable insulin analogues

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089290A1 (fr) * 1982-03-15 1983-09-21 ANVAR Agence Nationale de Valorisation de la Recherche Conjugués d'haptènes et de muramyl-peptides, doués d'activité immunogène et compositions les contenant
EP0157753A1 (fr) * 1984-03-26 1985-10-09 TECHLAND, Société Anonyme Dérivés de la somatostatine, procédés de synthèse, préparation pour usage vétérinaire contenant ces dérivés et méthode pour le traitement d'animaux
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254023A (en) * 1979-10-16 1981-03-03 Pennwalt Corporation Synthesis of peptide alcohols by the solid phase method
US4280953A (en) * 1979-11-08 1981-07-28 The Salk Institute For Biological Studies Glycosylated analogs of somatostatin
CY1327A (en) * 1979-11-27 1986-06-27 Sandoz Ag Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use
US4444683A (en) * 1982-11-17 1984-04-24 University Of Utah Glycosylated insulin derivatives
US4483792A (en) * 1982-11-17 1984-11-20 Kim Wan S Glycosylated insulin derivatives
FR2546163B1 (fr) * 1983-05-16 1987-10-09 Centre Nat Rech Scient Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2548673B1 (fr) * 1983-07-05 1985-10-04 Essilor Int Polymeres supports de produits actifs relargables et leur procede de preparation
US4564998A (en) * 1984-10-19 1986-01-21 Westinghouse Electric Corp. Coil winding methods and apparatus
FI860708A (fi) * 1985-02-20 1986-08-21 Ciba Geigy Ag Acylerade hexosderivat och foerfarande foer deras framstaellning.
JPS61264260A (ja) * 1985-05-17 1986-11-22 Rikagaku Kenkyusho アルデヒド化多孔性高分子材料によるタンパク質の除去方法
CA1337041C (fr) * 1985-10-09 1995-09-19 Brett Alan Evans Compositions granulaires de detergent, a solubilite amelioree
SE8506094D0 (sv) * 1985-12-20 1985-12-20 Astra Laekemedel Ab New antibacterial agents and intermediates therefor
JPS63165410A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製造方法
JPS63165411A (ja) * 1986-09-11 1988-07-08 Tokyo Organ Chem Ind Ltd アルデヒド基を有する架橋共重合体の製法
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
US4859736A (en) * 1987-03-30 1989-08-22 Ciba-Geigy Corporation Synthetic polystyrene resin and its use in solid phase peptide synthesis
CH679045A5 (fr) * 1987-06-29 1991-12-13 Sandoz Ag

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089290A1 (fr) * 1982-03-15 1983-09-21 ANVAR Agence Nationale de Valorisation de la Recherche Conjugués d'haptènes et de muramyl-peptides, doués d'activité immunogène et compositions les contenant
EP0157753A1 (fr) * 1984-03-26 1985-10-09 TECHLAND, Société Anonyme Dérivés de la somatostatine, procédés de synthèse, préparation pour usage vétérinaire contenant ces dérivés et méthode pour le traitement d'animaux
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin

Also Published As

Publication number Publication date
FI874495A0 (fi) 1987-10-12
WO1988002756A2 (fr) 1988-04-21
HUT46710A (en) 1988-11-28
JPH0314599A (ja) 1991-01-23
BE1003752A4 (fr) 1992-06-09
PL157156B1 (pl) 1992-05-29
FR2609991A1 (fr) 1988-07-29
SE518630C2 (sv) 2002-11-05
DK532787A (da) 1988-04-14
NL194729C (nl) 2003-01-07
FR2609991B1 (fr) 1995-03-10
KR880005153A (ko) 1988-06-28
HU206890B (en) 1993-01-28
SE8703938D0 (sv) 1987-10-12
AU8015091A (en) 1991-10-31
CH680512A5 (fr) 1992-09-15
DK174337B1 (da) 2002-12-16
IE912442L (en) 1988-04-13
CH682632A5 (de) 1993-10-29
GR871567B (en) 1988-02-16
JPH0645639B2 (ja) 1994-06-15
DE3790635T1 (fr) 1988-10-06
PT85904A (en) 1987-11-01
DK532787D0 (da) 1987-10-12
HU906341D0 (en) 1991-04-29
AU617986B2 (en) 1991-12-12
AU634664B2 (en) 1993-02-25
GB2199831B (en) 1991-04-17
NL8702345A (nl) 1988-05-02
HU906340D0 (en) 1991-04-29
GB8800537D0 (en) 1988-02-10
NL194729B (nl) 2002-09-02
ES2007418A6 (es) 1989-06-16
GB2199829A (en) 1988-07-20
AU7956487A (en) 1988-04-14
IE912442A1 (en) 1992-02-12
CA1340985C (fr) 2000-05-09
FI874495A (fi) 1988-04-14
SE9301172L (fr) 1900-01-01
JPS63101399A (ja) 1988-05-06
JP2744910B2 (ja) 1998-04-28
GB2199829B (en) 1991-04-17
KR960016861B1 (ko) 1996-12-23
LU87014A1 (fr) 1988-05-03
PL268173A1 (en) 1988-09-01
GB8723737D0 (en) 1987-11-11
SE9301172D0 (sv) 1993-04-07
GB2199831A (en) 1988-07-20
SE8703938L (sv) 1988-04-14
NZ222133A (en) 1993-02-25
US5656721A (en) 1997-08-12
PT85904B (pt) 1990-08-31

Similar Documents

Publication Publication Date Title
WO1988002756A3 (fr) Derives peptidiques
CA2155762A1 (fr) Mothode de modification de proteine
WO1995013297A3 (fr) Compositions immunogenes ameliorees agissant contre la gastrine humaine 17
GR3034416T3 (en) Polysaccharide derivative and drug carrier.
AU5707294A (en) 3,3 diphenyl prop-2-yl amino acid derivatives and their use as tachykinin antagonists
CA2168113A1 (fr) Derives de peptides, agents therapeutiques
CA2054268A1 (fr) Composition nutritive
EP0130779A3 (fr) Composition pharmaceutique pour résorption dans l'intestin
IL86782A (en) Amino acid derivatives, processes for the preparation thereof and pharmaceutical compositions comprising the same
CA2109322A1 (fr) Analogues de bombesine
HUP9800049A3 (en) Amino acid compositions and use thereof in clinical nutrition, and use of the said amino acids for preparing pharmaceutical compns. for the diminution of tnf
CA2073166A1 (fr) Procede pour corriger et optimiser la composition d'un aliment pour animaux
EP0365209A3 (fr) Séquence aminoacidique de l'anti-leu 3a
EP0334244A3 (fr) Peptides antagonistes de Bradykinine
CA2048425A1 (fr) Polypeptide ayant des proprietes d'interaction avec la thrombine
EP0225020A3 (fr) Peptides comprenant dans leur séquence des unités sélectionnées parmi les restes d'acides aminés 17 à 24 du VIP
NZ231353A (en) Pharmaceutical compositions comprising 3,5-dihydroxy-7-(1-acyloxyhexahydronaphth-8-yl)-heptanoic acid and lactone derivatives
AU6927087A (en) 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3- substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters
EP0791601A3 (fr) Agent améliorant la formation d'os et inhibitant la résorption osseuse
IL81800A0 (en) 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo(or oxo)-5-pyrimidine-carboxylic acids and esters and pharmaceutical compositions containing the same
EP0228192A3 (fr) Oligopeptides-inhibiteurs de la rénine, leur préparation et leur utilisation
IE873239L (en) Variants of hirudin
AU579672B2 (en) An improved chopper harvester for sugar cane and the like crops
CA2047802A1 (fr) Compositions pharmaceutiques
AU585167B2 (en) Novel substrate peptides

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AT CH DE

ENP Entry into the national phase

Ref document number: 1987 9028

Country of ref document: AT

Date of ref document: 19880421

Kind code of ref document: A

AK Designated states

Kind code of ref document: A3

Designated state(s): AT CH DE

RET De translation (de og part 6b)

Ref document number: 3790635

Country of ref document: DE

Date of ref document: 19881006

WWE Wipo information: entry into national phase

Ref document number: 3790635

Country of ref document: DE

REG Reference to national code

Ref country code: DE

Ref legal event code: 8607