US20070104721A1 - Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 - Google Patents
Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 Download PDFInfo
- Publication number
- US20070104721A1 US20070104721A1 US11/592,066 US59206606A US2007104721A1 US 20070104721 A1 US20070104721 A1 US 20070104721A1 US 59206606 A US59206606 A US 59206606A US 2007104721 A1 US2007104721 A1 US 2007104721A1
- Authority
- US
- United States
- Prior art keywords
- herceptin
- hki
- rapamycin
- mammal
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- JWNPDZNEKVCWMY-VQHVLOKHSA-N CCOC1=C(NC(=O)/C=C/CN(C)C)C=C2C(=C1)N=CC(C#N)=C2NC1=CC=C(OCC2=CC=CC=N2)C(Cl)=C1 Chemical compound CCOC1=C(NC(=O)/C=C/CN(C)C)C=C2C(=C1)N=CC(C#N)=C2NC1=CC=C(OCC2=CC=CC=N2)C(Cl)=C1 JWNPDZNEKVCWMY-VQHVLOKHSA-N 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C Chemical compound CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
- 0 [1*]C.[2*]C[3*]C1=CC=C(NC2=C(C#N)C=NC3=CC(OC[5*])=C(NC(=O)/C=C/CN([4*])C)C=C32)C=C1 Chemical compound [1*]C.[2*]C[3*]C1=CC=C(NC2=C(C#N)C=NC3=CC(OC[5*])=C(NC(=O)/C=C/CN([4*])C)C=C32)C=C1 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Definitions
- FIG. 3 is a 3-dimensional contour plot with the plane at 0% representing additive interaction, and peaks and valleys representing areas of synergy or antagonism between the herceptin and HKI-272 in MDA-MB-361 [HER-2 + (non-amplified); adenocarcinoma; ATCC HTB 27] cells.
- an HKI-272 refers to a compound having the following core, or a derivative or pharmaceutically acceptable salt thereof. Suitable derivatives may include, e.g., an ester, ether, or carbamate.
- the core structure, HKI-272 has the chemical name (E)-N- ⁇ 4-[3-chloro-4-(2-pyridinylmethoxy) anilino]-3-cyano-7-ethoxy-6-quinolinyl ⁇ -4-(dimethylam ino)-2-butenamide.
- a pharmaceutical pack contains a course of treatment of a neoplasm for one individual mammal, wherein the pack contains units of an mTOR inhibitor in unit dosage form and units of herceptin in unit dosage form, optionally further in combination with units of an HKI-272 in unit dosage form.
- a pharmaceutical pack contains a course of treatment of a neoplasm for one individual mammal, wherein the pack contains units of an mTOR inhibitor in unit dosage form and units of HKI-272 in unit dosage form, optionally further in combination with units of herceptin in unit dosage form.
- herceptin single doses and multiple doses are contemplated.
- a single loading dose of herceptin is administered as a 90-minute intravenous infusion in a range of about 4-5 mg/kg on day 1, followed by about 2 mg/kg per week starting on day 8.
- 3 weeks is 1 cycle. From 1, to 2 to 3, weeks may be provided between cycles.
- Herceptin may also be given at a dose of 6 mg/kg once every 3-4 weeks.
- herceptin may also be given after completion of chemotherapy as maintenance therapy.
- a compound of the invention is in the form of a unit dose.
- Suitable unit dose forms include tablets, capsules and powders in sachets or vials.
- Such unit dose forms may contain from 0.1 to 300 mg of a compound of the invention and preferably from 2 to 100 mg.
- Still further preferred unit dosage forms contain 5 to 50 mg of a compound of the present invention.
- the compounds of the present invention can be administered at a dose range of about 0.01 to 100 mg/kg or preferably at a dose range of 0.1 to 10 mg/kg.
- the compounds are administered orally from 1 to 6 times a day, more usually from I to 4 times a day.
- the compounds may be administered through another suitable route, e.g., intravenous.
- Fludarabine (9-H-Purin-6-amine,2-fluoro-9-(5-O-phosphono-(beta)-D-a-rabinofuranosyl) is commercially available as a liquid injectable containing 50 mg/vial (FLUDARA).
- 6-Mercaptopurine (1,7-dihydro-6H-purine-6-thione) is commercially available in 50 mg oral tablets (PURINETHOL).
- the invention includes a product or pharmaceutical pack containing a course of an anti-neoplastic treatment for one individual mammal comprising one or more container(s) having one, one to four, or more unit(s) of an mTOR inhibitor (e.g., temsirolimus) in unit dosage form and, optionally, one, one to four, or more unit(s) of herceptin, and optionally, another active agent.
- an mTOR inhibitor e.g., temsirolimus
- Temsirolimus is administered IV weekly over a 30-minute period using an in-line filter and an automatic dispensing pump.
- antihistamine diphenhydramine, 25 to 50 mg IV or the equivalent
- temsirolimus infusion is administered.
- the Pritchard and Shipman method was modified to allow determination of the combination effects at different levels of statistical significance (p-values 0.05, 0.01, 0.001). A p-value of 0.05 is considered significant.
- the method of estimating statistical variability within each experiment was also modified. Variability was determined across all compound combinations, whereas in the original version, variability was estimated separately for each compound combination. It is believed that better estimates of the variability are obtained with the modified approach. In general, single points of synergy or antagonism are not considered representative of either synergistic or antagonistic activity. Thus, single point peaks or valleys are disregarded in the analysis.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/592,066 US20070104721A1 (en) | 2005-11-04 | 2006-11-02 | Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 |
US12/539,914 US20090297519A1 (en) | 2005-11-04 | 2009-08-12 | ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272 |
US13/454,768 US20120308560A1 (en) | 2005-11-04 | 2012-04-24 | Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272 |
US13/874,147 US10729672B2 (en) | 2005-11-04 | 2013-04-30 | Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272 |
US17/548,340 US20220354820A1 (en) | 2005-11-04 | 2021-12-10 | Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272 |
US17/871,397 US20230201155A1 (en) | 2005-11-04 | 2022-07-22 | Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73356205P | 2005-11-04 | 2005-11-04 | |
US83750906P | 2006-08-14 | 2006-08-14 | |
US11/592,066 US20070104721A1 (en) | 2005-11-04 | 2006-11-02 | Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/539,914 Division US20090297519A1 (en) | 2005-11-04 | 2009-08-12 | ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272 |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070104721A1 true US20070104721A1 (en) | 2007-05-10 |
Family
ID=37845244
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/592,066 Abandoned US20070104721A1 (en) | 2005-11-04 | 2006-11-02 | Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272 |
US12/539,914 Abandoned US20090297519A1 (en) | 2005-11-04 | 2009-08-12 | ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272 |
US13/454,768 Abandoned US20120308560A1 (en) | 2005-11-04 | 2012-04-24 | Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272 |
US13/874,147 Active 2027-02-14 US10729672B2 (en) | 2005-11-04 | 2013-04-30 | Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272 |
US17/548,340 Pending US20220354820A1 (en) | 2005-11-04 | 2021-12-10 | Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272 |
US17/871,397 Pending US20230201155A1 (en) | 2005-11-04 | 2022-07-22 | Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272 |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/539,914 Abandoned US20090297519A1 (en) | 2005-11-04 | 2009-08-12 | ANTINEOPLASTIC COMBINATIONS WITH mTOR INHIBITOR, TRASTUZUMAB, AND/OR HKI-272 |
US13/454,768 Abandoned US20120308560A1 (en) | 2005-11-04 | 2012-04-24 | Antineoplastic Combinations with mTOR Inhibitor, Trastuzumab and/or HKI-272 |
US13/874,147 Active 2027-02-14 US10729672B2 (en) | 2005-11-04 | 2013-04-30 | Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272 |
US17/548,340 Pending US20220354820A1 (en) | 2005-11-04 | 2021-12-10 | Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272 |
US17/871,397 Pending US20230201155A1 (en) | 2005-11-04 | 2022-07-22 | Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272 |
Country Status (17)
Country | Link |
---|---|
US (6) | US20070104721A1 (es) |
EP (2) | EP1942937A1 (es) |
JP (7) | JP2009514870A (es) |
KR (1) | KR101354828B1 (es) |
CN (1) | CN103110948A (es) |
AR (1) | AR057854A1 (es) |
AU (1) | AU2006311877A1 (es) |
BR (1) | BRPI0618042A2 (es) |
CA (1) | CA2626326C (es) |
CR (1) | CR9901A (es) |
EC (1) | ECSP088423A (es) |
IL (1) | IL190805A (es) |
NO (1) | NO20081837L (es) |
PE (1) | PE20070763A1 (es) |
RU (2) | RU2451524C2 (es) |
TW (1) | TW200803892A (es) |
WO (1) | WO2007056118A1 (es) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009054001A1 (en) * | 2007-10-22 | 2009-04-30 | Biocon Limited | A pharmaceutical composition and a process thereof |
US20090312360A1 (en) * | 2008-06-17 | 2009-12-17 | Wyeth | Antineoplastic Combinations Containing HKI-272 and Vinorelbine |
US20100081681A1 (en) * | 2006-08-16 | 2010-04-01 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
US20100087482A1 (en) * | 2005-02-03 | 2010-04-08 | Haber Daniel A | Method for Treating Gefitinib Resistant Cancer |
US20100113474A1 (en) * | 2008-08-04 | 2010-05-06 | Wyeth | Antineoplastic Combinations of 4-Anilino-3-Cyanoquinolines and Capecitabine |
US20100260733A1 (en) * | 2009-04-10 | 2010-10-14 | Haiyan Qi | Novel anti aging agents and methods to identify them |
WO2010117633A1 (en) | 2009-04-06 | 2010-10-14 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
US20110111059A1 (en) * | 2008-05-21 | 2011-05-12 | Jianhui Guo | Compositions Comprising Quinazoline Derivatives, Preparation Methods and Uses Thereof |
WO2011070499A1 (en) | 2009-12-11 | 2011-06-16 | Wyeth Llc | Phosphatidylinositol-3-kinase pathway biomarkers |
US20110165257A1 (en) * | 2009-11-09 | 2011-07-07 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
WO2011087926A1 (en) | 2010-01-13 | 2011-07-21 | Wyeth Llc | A CUT-POINT IN PTEN PROTEIN EXPRESSION THAT ACCURATELY IDENTIFIES TUMORS AND IS PREDICTIVE OF DRUG RESPONSE TO A PAN-ErbB INHIBITOR |
US9139558B2 (en) | 2007-10-17 | 2015-09-22 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-Chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
WO2018133838A1 (zh) * | 2017-01-22 | 2018-07-26 | 江苏恒瑞医药股份有限公司 | Egfr/her2抑制剂联合嘧啶类抗代谢药物的用途 |
US10729672B2 (en) | 2005-11-04 | 2020-08-04 | Wyeth Llc | Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272 |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
EP2591775A1 (en) * | 2006-04-05 | 2013-05-15 | Novartis AG | Combinations comprising mtor inhibitors for treating cancer |
WO2008121467A2 (en) * | 2007-02-28 | 2008-10-09 | Dana-Farber Cancer Institute, Inc. | Combination therapy for treating cancer |
CA2677108A1 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her inhibitor |
NZ589269A (en) * | 2008-05-16 | 2013-03-28 | Pharma Mar Sa | Combination therapy with an antitumor alkaloid |
WO2010070117A1 (en) * | 2008-12-18 | 2010-06-24 | Universite Libre De Bruxelles | Treatment method by the administration of anti-her2 targeted active compounds to patients with early breast cancer and her2-negative primary tumor |
NZ619375A (en) | 2009-04-28 | 2015-03-27 | Proteus Digital Health Inc | Highly reliable ingestible event markers and methods for using the same |
WO2011127252A2 (en) | 2010-04-07 | 2011-10-13 | Proteus Biomedical, Inc. | Miniature ingestible device |
EP2642983A4 (en) | 2010-11-22 | 2014-03-12 | Proteus Digital Health Inc | DEVICE INGREABLE WITH PHARMACEUTICAL PRODUCT |
WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
US11149123B2 (en) | 2013-01-29 | 2021-10-19 | Otsuka Pharmaceutical Co., Ltd. | Highly-swellable polymeric films and compositions comprising the same |
WO2014144738A1 (en) | 2013-03-15 | 2014-09-18 | Proteus Digital Health, Inc. | Metal detector apparatus, system, and method |
TWI482782B (zh) | 2013-05-31 | 2015-05-01 | Univ Nat Chiao Tung | 架接抗體之雙乳化核殼奈米結構 |
WO2015017728A1 (en) | 2013-07-31 | 2015-02-05 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
US11446516B2 (en) | 2013-08-09 | 2022-09-20 | The Trustees Of The University Of Pennsylvania | Methods of increasing response to cancer radiation therapy |
US20180057603A1 (en) * | 2013-08-09 | 2018-03-01 | The Trustees Of The University Of Pennsylvania | Combination of IFN-gamma with Anti-ERBB Antibody for the Treatment of Cancers |
LT3033086T (lt) * | 2013-08-14 | 2021-12-27 | Novartis Ag | Kombinuota terapija vėžiui gydyti |
US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
US10187121B2 (en) | 2016-07-22 | 2019-01-22 | Proteus Digital Health, Inc. | Electromagnetic sensing and detection of ingestible event markers |
TWI735689B (zh) | 2016-10-26 | 2021-08-11 | 日商大塚製藥股份有限公司 | 製造含有可攝食性事件標記之膠囊之方法 |
RU2648642C1 (ru) * | 2017-06-06 | 2018-03-26 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ неоадъювантного лечения больных местно-распространенным раком шейки матки |
JP7317343B2 (ja) * | 2019-03-20 | 2023-07-31 | 公立大学法人大阪 | 乳がんの予防又は治療剤及び乳がん細胞の増殖抑制剤 |
WO2022076917A1 (en) * | 2020-10-08 | 2022-04-14 | Kumquat Biosciences Inc. | Modulators of cell proliferation and uses thereof |
GB202111193D0 (en) | 2021-08-03 | 2021-09-15 | Phoremost Ltd | Pharmaceutical compounds |
Citations (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5705151A (en) * | 1995-05-18 | 1998-01-06 | National Jewish Center For Immunology & Respiratory Medicine | Gene therapy for T cell regulation |
US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6387371B1 (en) * | 1988-01-12 | 2002-05-14 | Genentech, Inc. | Monoclonal antibodies directed to the HER2 receptor |
US20020183240A1 (en) * | 2001-04-06 | 2002-12-05 | Wyeth | Antineoplastic combinations |
US20020198137A1 (en) * | 2001-06-01 | 2002-12-26 | Wyeth | Antineoplastic combinations |
US6511986B2 (en) * | 2000-08-11 | 2003-01-28 | Wyeth | Method of treating estrogen receptor positive carcinoma |
US20030153593A1 (en) * | 2000-11-15 | 2003-08-14 | Wyeth | Use of CCI-779 as an antineoplastic agent |
US6617333B2 (en) * | 2001-08-07 | 2003-09-09 | Wyeth | Antineoplastic combinations comprising |
US20040039010A1 (en) * | 2002-05-30 | 2004-02-26 | Grupp Stephan A. | Methods for treatment of acute lymphocytic leukemia |
US20040176339A1 (en) * | 2003-03-05 | 2004-09-09 | Wyeth | Antineoplastic combinations |
US6821515B1 (en) * | 1995-07-27 | 2004-11-23 | Genentech, Inc. | Protein formulation |
US20040258662A1 (en) * | 2003-04-22 | 2004-12-23 | Wyeth | Antineoplastic agents |
US20050032825A1 (en) * | 2002-02-01 | 2005-02-10 | Metcalf Chester A. | Phosphorus-containing compounds and uses thereof |
US20050059678A1 (en) * | 2003-09-15 | 2005-03-17 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
US20050272758A1 (en) * | 2004-03-11 | 2005-12-08 | Wyeth | Antineoplastic combinations of CCI-779 and rituximab |
US20060035904A1 (en) * | 2001-04-06 | 2006-02-16 | Wyeth | Antineoplastic combinations |
US20060094674A1 (en) * | 2002-07-05 | 2006-05-04 | Neel Benjamin G | Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms |
US7306801B2 (en) * | 2000-05-15 | 2007-12-11 | Health Research, Inc. | Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein |
Family Cites Families (196)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
CA1327358C (en) | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
US5023264A (en) | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
US5221670A (en) | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
US5233036A (en) | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
US5162333A (en) | 1991-09-11 | 1992-11-10 | American Home Products Corporation | Aminodiesters of rapamycin |
US5177203A (en) | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
US5256790A (en) | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5489680A (en) | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
US5302584A (en) | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
US5480989A (en) | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5480988A (en) | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5434260A (en) | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
US5411967A (en) | 1992-10-13 | 1995-05-02 | American Home Products Corporation | Carbamates of rapamycin |
US5262423A (en) | 1992-10-29 | 1993-11-16 | American Home Products Corporation | Rapamycin arylcarbonyl and alkoxycarbonyl carbamates as immunosuppressive and antifungal agents |
US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
US5260300A (en) | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
TW254946B (es) | 1992-12-18 | 1995-08-21 | Hoffmann La Roche | |
AU671491B2 (en) | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
US5391730A (en) | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
US5373014A (en) | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
US5378836A (en) | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5385909A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
US5385910A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
US5385908A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
US5389639A (en) | 1993-12-29 | 1995-02-14 | American Home Products Company | Amino alkanoic esters of rapamycin |
US5463048A (en) | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
PL181304B1 (pl) | 1994-07-22 | 2001-07-31 | Lilly Co Eli | Preparat farmaceutyczny do hamowania zmniejszania masy kosci PL PL PL PL PL PL PL PL PL PL |
US5476932A (en) | 1994-08-26 | 1995-12-19 | Hoffmann-La Roche Inc. | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives |
US5491231A (en) | 1994-11-28 | 1996-02-13 | American Home Products Corporation | Hindered N-oxide esters of rapamycin |
US5563145A (en) | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
JP3437685B2 (ja) | 1995-09-12 | 2003-08-18 | 株式会社東芝 | 交直変換装置の制御保護システム |
DE69622183D1 (de) | 1995-11-07 | 2002-08-08 | Kirin Brewery | Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen |
US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
EP0937082A2 (en) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
US6426383B1 (en) | 1997-05-28 | 2002-07-30 | Nalco Chemical Company | Preparation of water soluble polymer dispersions from vinylamide monomers |
US6251912B1 (en) | 1997-08-01 | 2001-06-26 | American Cyanamid Company | Substituted quinazoline derivatives |
TW557297B (en) | 1997-09-26 | 2003-10-11 | Abbott Lab | Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same |
EP1117659B1 (en) | 1998-09-29 | 2003-12-03 | Wyeth Holdings Corporation | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
ES2219388T3 (es) | 1999-08-24 | 2004-12-01 | Ariad Gene Therapeutics, Inc. | 28-epi-rapalogos. |
TWI256395B (en) | 1999-09-29 | 2006-06-11 | Wyeth Corp | Regioselective synthesis of rapamycin derivatives |
KR20020071931A (ko) | 2000-01-07 | 2002-09-13 | 트렌스폼 파마수티컬스 인코퍼레이티드 | 다양한 고체-형태들의 고도의 자료 처리 편성, 확인 및분석 |
US6384051B1 (en) | 2000-03-13 | 2002-05-07 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
GB0008368D0 (en) | 2000-04-06 | 2000-05-24 | Astrazeneca Ab | Combination product |
IL157898A0 (en) * | 2001-04-06 | 2004-03-28 | Wyeth Corp | Antineoplastic combinations such as rapamycin together with gemcitabine or fluorouracil |
PL392652A1 (pl) * | 2001-05-16 | 2010-12-06 | Novartis Ag | Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację |
SG153647A1 (en) * | 2001-06-01 | 2009-07-29 | Wyeth Corp | Antineoplastic combinations |
US7521175B2 (en) | 2001-06-14 | 2009-04-21 | The Regents Of The University Of California | Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571 |
KR20050044599A (ko) | 2001-11-27 | 2005-05-12 | 와이어쓰 홀딩스 코포레이션 | Egf-r 및 her2 키나아제의 억제제로서의3-시아노퀴놀린 |
TWI275390B (en) | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
WO2003103676A2 (en) | 2002-06-05 | 2003-12-18 | Cedars-Sinai Medical Center | Method of treating cancer using kinase inhibitors |
DK1553940T3 (da) | 2002-07-30 | 2008-06-02 | Wyeth Corp | Patenterale formuleringer indeholdende en rapamycin-hydroxyester |
CN100415233C (zh) | 2002-09-17 | 2008-09-03 | 惠氏公司 | 口服制剂 |
US20040209930A1 (en) | 2002-10-02 | 2004-10-21 | Carboni Joan M. | Synergistic methods and compositions for treating cancer |
CL2004000016A1 (es) | 2003-01-21 | 2005-04-15 | Wyeth Corp | Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina. |
CN1437942A (zh) | 2003-02-08 | 2003-08-27 | 杭州华卫制药技术开发有限公司 | 注射用长春瑞滨粉针剂及制备方法 |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
ES2297490T3 (es) | 2003-07-23 | 2008-05-01 | Bayer Pharmaceuticals Corporation | Omega-carboxiarildifenilurea fluoro sustituida para el tratamiento y prevencion de enfermadades y afecciones. |
US20050025825A1 (en) | 2003-07-31 | 2005-02-03 | Xanodyne Pharmacal, Inc. | Tranexamic acid formulations with reduced adverse effects |
BRPI0413255A (pt) | 2003-08-01 | 2006-10-03 | Wyeth Corp | uso de uma combinação de um inibidor de quinase do receptor do fator de crescimento epidérmico e agentes citotóxicos para tratamento e inibição do cáncer |
RU2339639C2 (ru) | 2003-08-07 | 2008-11-27 | Уайт | Региоселективный синтез cci-779 |
MXPA06001590A (es) | 2003-08-19 | 2006-05-19 | Wyeth Corp | Proceso para la preparacion de 4-amino-3-quinolincarbonitrilos. |
AU2003304497B2 (en) | 2003-09-15 | 2010-06-24 | Wyeth Llc | Substituted quinolines as protein tyrosine kinase enzyme inhibitors |
TWI372066B (en) | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
US20050142192A1 (en) | 2003-10-15 | 2005-06-30 | Wyeth | Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives |
WO2005049021A1 (en) | 2003-11-03 | 2005-06-02 | Oy Helsinki Transplantation R & D Ltd | Materials and methods for inhibiting neointimal hyperplasia |
CA2566823A1 (en) | 2003-11-05 | 2005-05-19 | Board Of Regents, The University Of Texas System | Diagnostic and therapeutic methods and compositions involving pten and breast cancer |
TW200526684A (en) * | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
US7235564B2 (en) | 2003-12-04 | 2007-06-26 | Amr Technology, Inc. | Vinorelbine derivatives |
US9016221B2 (en) | 2004-02-17 | 2015-04-28 | University Of Florida Research Foundation, Inc. | Surface topographies for non-toxic bioadhesion control |
CN104774931B (zh) | 2004-03-31 | 2017-11-10 | 综合医院公司 | 测定癌症对表皮生长因子受体靶向性治疗反应性的方法 |
WO2005118876A2 (en) | 2004-06-04 | 2005-12-15 | Genentech, Inc. | Egfr mutations |
MX2007000944A (es) | 2004-07-23 | 2007-04-13 | Astrazeneca Ab | Metodo para pronosticar la sensibilidad de un tumor a farmacos del receptor erbb. |
US20060058311A1 (en) | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
TW200616612A (en) | 2004-10-08 | 2006-06-01 | Wyeth Corp | Method for the teatment of polycystic kidney disease field of invention |
TW200626610A (en) | 2004-10-13 | 2006-08-01 | Wyeth Corp | Analogs of 17-hydroxywortmannin as PI3K inhibitors |
WO2006044748A2 (en) | 2004-10-15 | 2006-04-27 | Monogram Biosciences, Inc. | RESPONSE PREDICTORS FOR ErbB PATHWAY-SPECIFIC DRUGS |
US20060084666A1 (en) | 2004-10-18 | 2006-04-20 | Harari Paul M | Combined treatment with radiation and an epidermal growth factor receptor kinase inhibitor |
US20080268034A1 (en) | 2005-01-07 | 2008-10-30 | Girish Karanth | Solid Oral Dosage Forms of Ziprasidone Containing Colloidal Silicone Dioxide |
GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
AU2006210572B2 (en) | 2005-02-03 | 2011-08-04 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
WO2006081985A1 (en) | 2005-02-04 | 2006-08-10 | F. Hoffmann-La Roche Ag | Combined treatment with an n4-(substituted-oxycarbonyl)-5’-deoxy-5-fluorocytidine derivative and an epidermal growth factor receptor kinase inhibitor |
SI1859793T1 (sl) | 2005-02-28 | 2011-08-31 | Eisai R&D Man Co Ltd | Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka |
US8828429B2 (en) | 2005-03-03 | 2014-09-09 | Takeda Pharmaceutical Company Limited | Release-control composition |
WO2006098978A1 (en) | 2005-03-09 | 2006-09-21 | Abbott Laboratories | Diagnostics method for identifying candidate patients for the treatment with trastuzumab |
GB0504994D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
US20060235006A1 (en) | 2005-04-13 | 2006-10-19 | Lee Francis Y | Combinations, methods and compositions for treating cancer |
KR20080002826A (ko) * | 2005-04-14 | 2008-01-04 | 와이어쓰 | 게피티니브 내성 환자에서의 표피 성장 인자 수용체(egfr) 키나제 억제제의 용도 |
US20110045459A1 (en) | 2005-04-21 | 2011-02-24 | Mischel Paul S | Molecular determinants of EGFR kinase inhibitor response in glioblastoma |
ATE460937T1 (de) | 2005-04-28 | 2010-04-15 | Wyeth Corp | Mikronisierte tanaproget zusammensetzungen und verfahren zu ihrer herstellung |
US20080193448A1 (en) | 2005-05-12 | 2008-08-14 | Pfizer Inc. | Combinations and Methods of Using an Indolinone Compound |
WO2006127205A2 (en) | 2005-05-25 | 2006-11-30 | Wyeth | Methods of preparing 3-cyano-quinolines and intermediates made thereby |
BRPI0610147A2 (pt) | 2005-05-25 | 2010-06-01 | Wyeth Corp | método para preparar e sintetizar 3-cianoquinolinas substituìdas e 4-amino-3-cianoquinolinas |
DE102005053679A1 (de) | 2005-06-24 | 2006-12-28 | Bayer Healthcare Ag | Therapeutischer Einsatz von Moxifloxacin zur Rekonstruktion von Funktionsstörungen des Immunsystems |
WO2007011619A2 (en) | 2005-07-15 | 2007-01-25 | Wyeth | Highly bioavailable oral delayed release dosage forms of o-desmethylvenlafaxine succinate |
WO2007015569A1 (ja) | 2005-08-01 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を予測する方法 |
EP1925676A4 (en) | 2005-08-02 | 2010-11-10 | Eisai R&D Man Co Ltd | TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR |
CA2624613A1 (en) | 2005-10-05 | 2007-04-12 | Astrazeneca Uk Limited | Method to predict or monitor the response of a patient to an erbb receptor drug |
US20110052570A1 (en) | 2005-10-26 | 2011-03-03 | Children's Medical Center Corporation | Method to prognose response to anti-egfr therapeutics |
WO2007056117A1 (en) | 2005-11-04 | 2007-05-18 | Wyeth | Antineoplastic combinations of temsirolimus and sunitinib malate |
AU2006311877A1 (en) | 2005-11-04 | 2007-05-18 | Wyeth Llc | Antineoplastic combinations with mTOR inhibitor, herceptin, and/orHKI-272 |
DK1948180T3 (da) | 2005-11-11 | 2013-05-27 | Boehringer Ingelheim Int | Kombinationsbehandling af cancer omfattende EGFR/HER2 inhibitorer |
CN101312737B (zh) | 2005-11-24 | 2012-11-14 | 爱库里斯股份有限两合公司 | 副痘病毒与传统细胞毒性化疗剂联合作为治疗癌症的生化治疗 |
JP2007145745A (ja) | 2005-11-25 | 2007-06-14 | Osaka Univ | 変異型EGFR下流シグナルを抑制するSrcファミリーチロシンキナーゼ阻害剤を含む肺癌治療剤およびその利用 |
CA2632213A1 (en) | 2005-12-22 | 2007-07-05 | Wyeth | Oral formulations comprising tigecycline |
WO2007095038A2 (en) | 2006-02-09 | 2007-08-23 | Novartis Ag | Mutations and polymorphisms of erbb2 |
CA2644841C (en) | 2006-04-07 | 2013-07-16 | Novartis Ag | Use of c-src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia |
TW200806282A (en) | 2006-05-05 | 2008-02-01 | Wyeth Corp | Solid dosage formulations |
IL282783B2 (en) | 2006-05-18 | 2023-09-01 | Caris Mpi Inc | A system and method for determining a personalized medical intervention for a disease stage |
TW200808728A (en) | 2006-05-23 | 2008-02-16 | Wyeth Corp | Method of preparing 4-halogenated quinoline intermediates |
EP2032989B2 (en) | 2006-06-30 | 2015-10-28 | Merck Sharp & Dohme Corp. | Igfbp2 biomarker |
ES2385613T3 (es) | 2006-09-18 | 2012-07-27 | Boehringer Ingelheim International Gmbh | Método para tratar cánceres que portan mutaciones de EGFR |
CA2664697A1 (en) | 2006-09-28 | 2008-04-10 | Follica, Inc. | Methods, kits, and compositions for generating new hair follicles and growing hair |
US20090317456A1 (en) | 2006-10-13 | 2009-12-24 | Medigene Ag | Use of oncolytic viruses and antiangiogenic agents in the treatment of cancer |
WO2008076257A2 (en) | 2006-12-13 | 2008-06-26 | Schering Corporation | Treating cancer with anti-igflr antibody 19d12 = sch 717454 |
NZ578329A (en) | 2006-12-13 | 2012-05-25 | Schering Corp | Igf1r inhibitors for treating cancer |
WO2008076415A1 (en) | 2006-12-14 | 2008-06-26 | Exelixis, Inc. | Methods of using mek inhibitors |
WO2008076143A1 (en) | 2006-12-18 | 2008-06-26 | Osi Pharmaceuticals, Inc. | Combination of igfr inhibitor and anti-cancer agent |
JP5406039B2 (ja) | 2006-12-21 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼ阻害剤として有用な5−シアノ−4−(ピロロ[2,3b]ピリジン−3−イル)−ピリミジン誘導体 |
CN101631536A (zh) | 2007-01-12 | 2010-01-20 | 惠氏公司 | 片中片组合物 |
CN104013956B (zh) | 2007-01-25 | 2018-12-18 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
ES2639854T3 (es) | 2007-02-01 | 2017-10-30 | Takeda Pharmaceutical Company Limited | Preparación de comprimidos sin causar problemas de fabricación de comprimidos |
WO2008121467A2 (en) | 2007-02-28 | 2008-10-09 | Dana-Farber Cancer Institute, Inc. | Combination therapy for treating cancer |
GB0706633D0 (en) | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | Combination |
EP1978106A1 (en) | 2007-04-07 | 2008-10-08 | Universitätsklinikum Hamburg-Eppendorf | Detection of ESR1 amplification in endometrium cancer and ovary cancer |
US8715665B2 (en) | 2007-04-13 | 2014-05-06 | The General Hospital Corporation | Methods for treating cancer resistant to ErbB therapeutics |
CA2684265A1 (en) | 2007-04-19 | 2008-10-30 | Wellstat Biologics Corporation | Detection of elevated levels of her-2/neu protein from non-isolated circulating cancer cells and treatment |
WO2008136838A1 (en) | 2007-05-04 | 2008-11-13 | Trustees Of Dartmouth College | Novel amide derivatives of cddo and methods of use thereof |
US20110014117A1 (en) | 2007-06-28 | 2011-01-20 | Schering Corporation | Anti-igf1r |
ES2569215T3 (es) | 2007-09-10 | 2016-05-09 | Boston Biomedical, Inc. | Un nuevo grupo de inhibidores de la ruta de Stat3 e inhibidores de la ruta de las células madre del cáncer |
WO2009042613A1 (en) | 2007-09-24 | 2009-04-02 | Tragara Pharmaceuticals, Inc. | Combination therapy for the treatment of cancer using cox-2 inhibitors and dual inhibitors of egfr [erbb1] and her-2 [erbb2] |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
CN101918579A (zh) | 2007-10-22 | 2010-12-15 | 先灵公司 | 完全人抗-vegf抗体和使用方法 |
JP2011502571A (ja) | 2007-11-05 | 2011-01-27 | ピュアテック ベンチャーズ | 医薬化合物を投与するための方法、キット、および組成物 |
CN101185633A (zh) | 2007-12-14 | 2008-05-28 | 山东蓝金生物工程有限公司 | 一种治疗实体肿瘤的尼拉替尼缓释植入剂 |
MX2010006854A (es) | 2007-12-18 | 2010-09-09 | Schering Corp | Biomarcadores para sensibilidad a terapia anti-receptor-1 del factor de crecimiento tipo insulina. |
US20100297118A1 (en) | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
WO2009100176A2 (en) | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
WO2009105234A2 (en) | 2008-02-19 | 2009-08-27 | Combinatorx, Incorporated | Methods and compositions for the treatment of disorders associated with defects of the cystic fibrosis transmembrane conductance regulator gene or protein |
CA2716826C (en) | 2008-02-25 | 2017-05-09 | Prometheus Laboratories Inc. | Drug selection for breast cancer therapy using antibody-based arrays |
WO2009111073A2 (en) | 2008-03-06 | 2009-09-11 | Odyssey Thera, Inc. | High-content and high throughput assays for identification of lipid-regulating pathways, and novel therapeutic agents for lipid disorders |
EP2259797A2 (en) | 2008-03-25 | 2010-12-15 | Schering Corporation | Methods for treating or preventing colorectal cancer |
EP2279267A4 (en) | 2008-03-27 | 2012-01-18 | Vascular Biosciences Inc | METHOD FOR IDENTIFICATION OF NEW THERAPEUTIC CANDIDATES VIA GENE EXPRESSION ANALYSIS IN VASCULAR DISEASES |
US20090246198A1 (en) | 2008-03-31 | 2009-10-01 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
US20110182888A1 (en) | 2008-04-08 | 2011-07-28 | Peter Ordentlich | Administration of an Inhibitor of HDAC, an Inhibitor of HER-2, and a Selective Estrogen Receptor Modulator |
NZ588710A (en) | 2008-04-18 | 2012-12-21 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17 |
CN104250280A (zh) | 2008-04-18 | 2014-12-31 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物 |
WO2009129545A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring |
TW201004627A (en) | 2008-04-18 | 2010-02-01 | Reata Pharmaceuticals Inc | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
JP5564490B2 (ja) | 2008-04-18 | 2014-07-30 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗炎症性ファルマコアを含む化合物および使用法 |
MX2010012064A (es) | 2008-05-05 | 2010-12-06 | Schering Corp | Uso secuencial de agentes quimioterapeuticos citotoxicos para el tratamiento de cancer. |
WO2009151910A2 (en) | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
KR20180128078A (ko) | 2008-06-17 | 2018-11-30 | 와이어쓰 엘엘씨 | Hki-272 및 비노렐빈을 함유하는 항신생물성 조합물 |
JP5758801B2 (ja) | 2008-07-22 | 2015-08-05 | トラスティーズ・オブ・ダートマス・カレッジTrustees of Dartmouth College | 単環式シアノエノンおよびその使用方法説明 |
NZ590464A (en) | 2008-08-04 | 2012-10-26 | Wyeth Llc | Antineoplastic combinations of the 4-anilino-3-cyanoquinoline neratinib and capecitabine |
US20100069340A1 (en) | 2008-09-11 | 2010-03-18 | Wyeth | Pharmaceutical compositions of an src kinase inhibitor and an aromatase inhibitor |
EP3075864A1 (en) | 2008-10-14 | 2016-10-05 | Caris MPI, Inc. | Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type |
WO2010048477A2 (en) | 2008-10-24 | 2010-04-29 | Wyeth Llc | Improved process for preparation of coupled products from 4-amino-3-cyanoquinolines using stabilized intermediates |
CN102223886A (zh) | 2008-11-07 | 2011-10-19 | 安龙制药公司 | Erbb-3(her3)选择性组合疗法 |
WO2010085845A1 (en) | 2009-01-28 | 2010-08-05 | The University Of Queensland | Cancer therapy and/or diagnosis |
AU2010210636A1 (en) | 2009-02-04 | 2011-09-22 | Bipar Sciences, Inc. | Treatment of lung cancer with a nitrobenzamide compound in combination with a growth factor inhibitor |
WO2010098627A2 (ko) | 2009-02-27 | 2010-09-02 | 한올바이오파마주식회사 | 약제학적 제제 |
US9073916B2 (en) | 2009-03-11 | 2015-07-07 | Auckland Uniservices Limited | Prodrug forms of kinase inhibitors and their use in therapy |
HUE061640T2 (hu) | 2009-04-06 | 2023-07-28 | Wyeth Llc | Gyógykezelési rendszer mellrákhoz neratinib alkalmazásával |
AR076053A1 (es) | 2009-04-14 | 2011-05-18 | Schering Corp | Derivados de pirazolo[1,5-a]pirimidina como inhibidores de mtor |
WO2010124009A2 (en) | 2009-04-21 | 2010-10-28 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
ES2659725T3 (es) | 2009-05-05 | 2018-03-19 | Dana-Farber Cancer Institute, Inc. | Inhibidores de EGFR y procedimiento de tratamiento de trastornos |
CN102470109A (zh) | 2009-07-02 | 2012-05-23 | 惠氏有限责任公司 | 3-氰基喹啉片剂制剂及其应用 |
KR20110007985A (ko) | 2009-07-17 | 2011-01-25 | 한올바이오파마주식회사 | N,n―디메틸 이미도디카르본이미딕 디아미드의 부틸산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제 |
WO2011008053A2 (ko) | 2009-07-17 | 2011-01-20 | 한올바이오파마주식회사 | N,n-디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제 |
KR101211227B1 (ko) | 2009-08-25 | 2012-12-11 | 한올바이오파마주식회사 | 메트포르민 아스코르브산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 |
WO2011025269A2 (ko) | 2009-08-25 | 2011-03-03 | 한올바이오파마주식회사 | 메트포르민 타우린염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 |
KR20110021691A (ko) | 2009-08-25 | 2011-03-04 | 한올바이오파마주식회사 | 메트포르민 메탄설폰산염, 그의 제조방법, 그를 포함하는 약학 조성물 및 그를 포함하는 복합제제 |
US20110055838A1 (en) | 2009-08-28 | 2011-03-03 | Moyes William A | Optimized thread scheduling via hardware performance monitoring |
WO2011038467A1 (en) | 2009-10-01 | 2011-04-07 | Csl Limited | Method of treatment of philadelphia chromosome positive leukaemia |
CN107441058A (zh) | 2009-11-09 | 2017-12-08 | 惠氏有限责任公司 | 包衣药物球状体及消除或减少病症如呕吐和腹泻的用途 |
PT2498756T (pt) | 2009-11-09 | 2019-11-26 | Wyeth Llc | Formulações de comprimidos de maleato de neratinib |
EP2896632B1 (en) | 2009-11-13 | 2017-10-25 | Daiichi Sankyo Europe GmbH | Material and methods for treating or preventing HER-3 associated diseases |
US20130012465A1 (en) | 2009-12-07 | 2013-01-10 | Boehringer Ingelheim International Gmbh | Bibw 2992 for use in the treatment of triple negative breast cancer |
EP2510121A1 (en) | 2009-12-11 | 2012-10-17 | Wyeth LLC | Phosphatidylinositol-3-kinase pathway biomarkers |
US8338456B2 (en) | 2010-01-13 | 2012-12-25 | Wyeth Llc | Cut-point in PTEN protein expression that accurately identifies tumors and is predictive of drug response to a pan-ErbB inhibitor |
-
2006
- 2006-11-02 AU AU2006311877A patent/AU2006311877A1/en not_active Abandoned
- 2006-11-02 WO PCT/US2006/042915 patent/WO2007056118A1/en active Application Filing
- 2006-11-02 AR ARP060104814A patent/AR057854A1/es unknown
- 2006-11-02 US US11/592,066 patent/US20070104721A1/en not_active Abandoned
- 2006-11-02 BR BRPI0618042-6A patent/BRPI0618042A2/pt not_active Application Discontinuation
- 2006-11-02 CN CN2012102875776A patent/CN103110948A/zh active Pending
- 2006-11-02 RU RU2008115454/15A patent/RU2451524C2/ru active
- 2006-11-02 EP EP06836862A patent/EP1942937A1/en not_active Ceased
- 2006-11-02 TW TW095140556A patent/TW200803892A/zh unknown
- 2006-11-02 PE PE2006001342A patent/PE20070763A1/es not_active Application Discontinuation
- 2006-11-02 EP EP18197238.1A patent/EP3488866A1/en active Pending
- 2006-11-02 KR KR1020087011508A patent/KR101354828B1/ko active IP Right Grant
- 2006-11-02 JP JP2008539047A patent/JP2009514870A/ja not_active Withdrawn
- 2006-11-02 CA CA2626326A patent/CA2626326C/en active Active
-
2008
- 2008-04-10 IL IL190805A patent/IL190805A/en active IP Right Grant
- 2008-04-16 NO NO20081837A patent/NO20081837L/no not_active Application Discontinuation
- 2008-04-18 CR CR9901A patent/CR9901A/es not_active Application Discontinuation
- 2008-05-05 EC EC2008008423A patent/ECSP088423A/es unknown
-
2009
- 2009-08-12 US US12/539,914 patent/US20090297519A1/en not_active Abandoned
-
2012
- 2012-01-13 RU RU2012100913A patent/RU2632104C2/ru active
- 2012-04-24 US US13/454,768 patent/US20120308560A1/en not_active Abandoned
- 2012-08-14 JP JP2012179873A patent/JP5952679B2/ja active Active
-
2013
- 2013-04-30 US US13/874,147 patent/US10729672B2/en active Active
-
2014
- 2014-02-28 JP JP2014038121A patent/JP2014098040A/ja not_active Withdrawn
-
2015
- 2015-12-28 JP JP2015255873A patent/JP6040303B2/ja active Active
-
2016
- 2016-04-13 JP JP2016080252A patent/JP6232463B2/ja active Active
-
2017
- 2017-07-10 JP JP2017134635A patent/JP6522056B2/ja active Active
-
2018
- 2018-10-04 JP JP2018188726A patent/JP2018203783A/ja active Pending
-
2021
- 2021-12-10 US US17/548,340 patent/US20220354820A1/en active Pending
-
2022
- 2022-07-22 US US17/871,397 patent/US20230201155A1/en active Pending
Patent Citations (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6387371B1 (en) * | 1988-01-12 | 2002-05-14 | Genentech, Inc. | Monoclonal antibodies directed to the HER2 receptor |
US6399063B1 (en) * | 1988-01-12 | 2002-06-04 | Genentech, Inc. | Monoclonal antibodies directed to the HER2 receptor |
US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5705151A (en) * | 1995-05-18 | 1998-01-06 | National Jewish Center For Immunology & Respiratory Medicine | Gene therapy for T cell regulation |
US6821515B1 (en) * | 1995-07-27 | 2004-11-23 | Genentech, Inc. | Protein formulation |
US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US7306801B2 (en) * | 2000-05-15 | 2007-12-11 | Health Research, Inc. | Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein |
US6511986B2 (en) * | 2000-08-11 | 2003-01-28 | Wyeth | Method of treating estrogen receptor positive carcinoma |
US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
US20030153593A1 (en) * | 2000-11-15 | 2003-08-14 | Wyeth | Use of CCI-779 as an antineoplastic agent |
US20020183240A1 (en) * | 2001-04-06 | 2002-12-05 | Wyeth | Antineoplastic combinations |
US20050187184A1 (en) * | 2001-04-06 | 2005-08-25 | Wyeth | Antineoplastic combinations |
US20060035904A1 (en) * | 2001-04-06 | 2006-02-16 | Wyeth | Antineoplastic combinations |
US20020198137A1 (en) * | 2001-06-01 | 2002-12-26 | Wyeth | Antineoplastic combinations |
US20060030547A1 (en) * | 2001-06-01 | 2006-02-09 | Wyeth | Antineoplastic combinations |
US6617333B2 (en) * | 2001-08-07 | 2003-09-09 | Wyeth | Antineoplastic combinations comprising |
US20050032825A1 (en) * | 2002-02-01 | 2005-02-10 | Metcalf Chester A. | Phosphorus-containing compounds and uses thereof |
US20040039010A1 (en) * | 2002-05-30 | 2004-02-26 | Grupp Stephan A. | Methods for treatment of acute lymphocytic leukemia |
US20060094674A1 (en) * | 2002-07-05 | 2006-05-04 | Neel Benjamin G | Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms |
US20040176339A1 (en) * | 2003-03-05 | 2004-09-09 | Wyeth | Antineoplastic combinations |
US20040258662A1 (en) * | 2003-04-22 | 2004-12-23 | Wyeth | Antineoplastic agents |
US20050059678A1 (en) * | 2003-09-15 | 2005-03-17 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
US20050272758A1 (en) * | 2004-03-11 | 2005-12-08 | Wyeth | Antineoplastic combinations of CCI-779 and rituximab |
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10596162B2 (en) | 2005-02-03 | 2020-03-24 | Wyeth Llc | Method for treating gefitinib resistant cancer |
US20100087482A1 (en) * | 2005-02-03 | 2010-04-08 | Haber Daniel A | Method for Treating Gefitinib Resistant Cancer |
US10603314B2 (en) | 2005-02-03 | 2020-03-31 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
US10729672B2 (en) | 2005-11-04 | 2020-08-04 | Wyeth Llc | Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272 |
US20100081681A1 (en) * | 2006-08-16 | 2010-04-01 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
US10035788B2 (en) | 2007-10-17 | 2018-07-31 | Wyeth Llc | Maleate salts of (E)-N-{4[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
US9139558B2 (en) | 2007-10-17 | 2015-09-22 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-Chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
US9630946B2 (en) | 2007-10-17 | 2017-04-25 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
WO2009054001A1 (en) * | 2007-10-22 | 2009-04-30 | Biocon Limited | A pharmaceutical composition and a process thereof |
US20110111059A1 (en) * | 2008-05-21 | 2011-05-12 | Jianhui Guo | Compositions Comprising Quinazoline Derivatives, Preparation Methods and Uses Thereof |
US8507010B2 (en) * | 2008-05-21 | 2013-08-13 | Shanghai Allist Pharmaceuticals, Inc. | Compositions comprising quinazoline derivatives |
EP3443961A1 (en) | 2008-06-17 | 2019-02-20 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
US10111868B2 (en) | 2008-06-17 | 2018-10-30 | Wyeth Llc | Antineoplastic combinations containing HKI-272 and vinorelbine |
KR101922096B1 (ko) | 2008-06-17 | 2018-11-27 | 와이어쓰 엘엘씨 | Hki-272 및 비노렐빈을 함유하는 항신생물성 조합물 |
EP3730139A1 (en) | 2008-06-17 | 2020-10-28 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
EP3135285A1 (en) | 2008-06-17 | 2017-03-01 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
US9511063B2 (en) | 2008-06-17 | 2016-12-06 | Wyeth Llc | Antineoplastic combinations containing HKI-272 and vinorelbine |
EP2915532A1 (en) | 2008-06-17 | 2015-09-09 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
US20090312360A1 (en) * | 2008-06-17 | 2009-12-17 | Wyeth | Antineoplastic Combinations Containing HKI-272 and Vinorelbine |
US9265784B2 (en) | 2008-08-04 | 2016-02-23 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
EP3175853A1 (en) | 2008-08-04 | 2017-06-07 | Wyeth LLC | Antineoplastic combinations of neratinib and capecitabine |
EP4424375A2 (en) | 2008-08-04 | 2024-09-04 | Wyeth LLC | Antineoplastic combinations of neratinib and capecitabine |
US20100113474A1 (en) * | 2008-08-04 | 2010-05-06 | Wyeth | Antineoplastic Combinations of 4-Anilino-3-Cyanoquinolines and Capecitabine |
US8669273B2 (en) | 2008-08-04 | 2014-03-11 | Wyeth Llc | Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine |
EP4218760A2 (en) | 2009-04-06 | 2023-08-02 | Wyeth LLC | Treatment regimen utilizing neratinib for breast cancer |
EP3000467A1 (en) | 2009-04-06 | 2016-03-30 | Wyeth LLC | Treatment regimen utilizing neratinib for breast cancer |
WO2010117633A1 (en) | 2009-04-06 | 2010-10-14 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
CN105999264A (zh) * | 2009-04-06 | 2016-10-12 | 惠氏有限责任公司 | 用于乳腺癌的利用奈拉替尼的治疗方案 |
US9211291B2 (en) | 2009-04-06 | 2015-12-15 | Wyeth Llc | Treatment regimen utilizing neratinib for breast cancer |
US8492110B2 (en) | 2009-04-10 | 2013-07-23 | Haiyan Qi | Anti aging agents and methods to identify them |
EP2965763A1 (en) | 2009-04-10 | 2016-01-13 | Haiyan Qi | Anti-aging agents |
US9360471B2 (en) | 2009-04-10 | 2016-06-07 | Haiyan Qi | Anti-aging agents and methods to identify them |
US20100260733A1 (en) * | 2009-04-10 | 2010-10-14 | Haiyan Qi | Novel anti aging agents and methods to identify them |
US8524281B2 (en) * | 2009-11-09 | 2013-09-03 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
US20140004203A1 (en) * | 2009-11-09 | 2014-01-02 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
US9211264B2 (en) * | 2009-11-09 | 2015-12-15 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
US20110165257A1 (en) * | 2009-11-09 | 2011-07-07 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
US20160222467A1 (en) * | 2009-12-11 | 2016-08-04 | Wyeth Llc | Phosphatidylinositol-3-kinase pathway biomarkers |
WO2011070499A1 (en) | 2009-12-11 | 2011-06-16 | Wyeth Llc | Phosphatidylinositol-3-kinase pathway biomarkers |
EP3575413A1 (en) | 2009-12-11 | 2019-12-04 | Wyeth LLC | Phosphatidylinositol-3-kinase pathway biomarkers |
WO2011087926A1 (en) | 2010-01-13 | 2011-07-21 | Wyeth Llc | A CUT-POINT IN PTEN PROTEIN EXPRESSION THAT ACCURATELY IDENTIFIES TUMORS AND IS PREDICTIVE OF DRUG RESPONSE TO A PAN-ErbB INHIBITOR |
US8338456B2 (en) | 2010-01-13 | 2012-12-25 | Wyeth Llc | Cut-point in PTEN protein expression that accurately identifies tumors and is predictive of drug response to a pan-ErbB inhibitor |
CN108778275A (zh) * | 2017-01-22 | 2018-11-09 | 江苏恒瑞医药股份有限公司 | Egfr/her2抑制剂联合嘧啶类抗代谢药物的用途 |
WO2018133838A1 (zh) * | 2017-01-22 | 2018-07-26 | 江苏恒瑞医药股份有限公司 | Egfr/her2抑制剂联合嘧啶类抗代谢药物的用途 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220354820A1 (en) | Antineoplastic Combinations with m-TOR Inhibitor, Trastuzumab and/or HKI-272 | |
US20070105887A1 (en) | Antineoplastic combinations of temsirolimus and sunitinib malate | |
US20030008923A1 (en) | Antineoplastic combinations | |
DK2656844T3 (en) | ANTINEOPLASTIC COMBINATIONS CONTAINING HKI-272 AND VINORELBINE | |
AU2018217257B2 (en) | Antineoplastic combinations with mTOR inhibitor, herceptin, and/or HKI-272 | |
CN101300029A (zh) | mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合 | |
AU2013204788B2 (en) | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: WYETH, NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:MOORE, LAURENCE;ZACHARCHUK, CHARLES;RABINDRAN, SRIDHAR K.;REEL/FRAME:018507/0447;SIGNING DATES FROM 20061018 TO 20061020 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |