UA78975C2 - Basic linear compounds with activity of tachykinin antagonists and their dosage forms - Google Patents
Basic linear compounds with activity of tachykinin antagonists and their dosage forms Download PDFInfo
- Publication number
- UA78975C2 UA78975C2 UA20040504087A UA20040504087A UA78975C2 UA 78975 C2 UA78975 C2 UA 78975C2 UA 20040504087 A UA20040504087 A UA 20040504087A UA 20040504087 A UA20040504087 A UA 20040504087A UA 78975 C2 UA78975 C2 UA 78975C2
- Authority
- UA
- Ukraine
- Prior art keywords
- carboxylic acid
- amide
- group
- ethylcarbamoyl
- phenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract description 47
- 239000005557 antagonist Substances 0.000 title abstract description 9
- 102000003141 Tachykinin Human genes 0.000 title abstract description 7
- 108060008037 tachykinin Proteins 0.000 title abstract description 7
- 230000000694 effects Effects 0.000 title description 5
- 239000002552 dosage form Substances 0.000 title description 4
- HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 abstract description 9
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 9
- 102400000097 Neurokinin A Human genes 0.000 abstract description 8
- 101800000399 Neurokinin A Proteins 0.000 abstract description 8
- 238000000034 method Methods 0.000 description 160
- -1 cyanomethyl Chemical group 0.000 description 126
- 238000001819 mass spectrum Methods 0.000 description 106
- 150000001408 amides Chemical class 0.000 description 80
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 76
- 125000005605 benzo group Chemical group 0.000 description 72
- 239000000243 solution Substances 0.000 description 58
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 48
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 42
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- 239000000047 product Substances 0.000 description 38
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 29
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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ITFI20010203 ITFI20010203A1 (it) | 2001-10-29 | 2001-10-29 | Composti lineari con caratteristiche basiche ad attivita' nk-2 antagonista,loro processi di sintesi e formulazioni che li contengono |
ITFI20020104 ITFI20020104A1 (it) | 2002-06-14 | 2002-06-14 | Composti lineari con caratteristiche basiche ed attivita' nk-2 antagonista, loro processi di sintesi e formulazioni che li contengono |
PCT/EP2002/012022 WO2003037916A2 (en) | 2001-10-29 | 2002-10-28 | Linear basic compounds having nk-2 antagonist activity and formulations thereof |
Publications (1)
Publication Number | Publication Date |
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UA78975C2 true UA78975C2 (en) | 2007-05-10 |
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UA20040504087A UA78975C2 (en) | 2001-10-29 | 2002-10-28 | Basic linear compounds with activity of tachykinin antagonists and their dosage forms |
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EP (1) | EP1442050B1 (sl) |
JP (1) | JP4511835B2 (sl) |
KR (1) | KR100958226B1 (sl) |
CN (1) | CN100413882C (sl) |
AR (1) | AR037044A1 (sl) |
AT (1) | ATE339439T1 (sl) |
AU (1) | AU2002351794B2 (sl) |
BR (2) | BRPI0213574B1 (sl) |
CA (1) | CA2464353C (sl) |
CO (1) | CO5580834A2 (sl) |
CY (1) | CY1105847T1 (sl) |
DE (1) | DE60214750T2 (sl) |
DK (1) | DK1442050T3 (sl) |
EA (1) | EA007855B1 (sl) |
EG (1) | EG24335A (sl) |
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HK (1) | HK1063326A1 (sl) |
HR (1) | HRP20040360B1 (sl) |
HU (1) | HUP0402081A3 (sl) |
IL (1) | IL161649A0 (sl) |
MX (1) | MXPA04003974A (sl) |
MY (1) | MY130373A (sl) |
NO (1) | NO331227B1 (sl) |
NZ (1) | NZ533097A (sl) |
PA (1) | PA8557201A1 (sl) |
PE (1) | PE20030611A1 (sl) |
PL (1) | PL209411B1 (sl) |
PT (1) | PT1442050E (sl) |
RS (1) | RS52290B (sl) |
SI (1) | SI1442050T1 (sl) |
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TN (1) | TNSN04077A1 (sl) |
UA (1) | UA78975C2 (sl) |
UY (1) | UY27514A1 (sl) |
WO (1) | WO2003037916A2 (sl) |
ZA (1) | ZA200404163B (sl) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2005243535A1 (en) * | 2004-05-13 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Novel substituted thiophenecarboxamides, their production and their use as medicaments |
ITFI20040221A1 (it) * | 2004-10-27 | 2005-01-27 | Guidotti & C Spa | Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico |
JP4012239B2 (ja) * | 2006-01-11 | 2007-11-21 | 生化学工業株式会社 | オキサゾロン誘導体 |
US20080227823A1 (en) * | 2007-03-12 | 2008-09-18 | Hassan Pajouhesh | Amide derivatives as calcium channel blockers |
IT1394304B1 (it) * | 2009-05-21 | 2012-06-06 | Malesci Sas | Processo per la preparazione di ibodutant (men15596) e relativi intermedi |
JP5929483B2 (ja) | 2011-05-10 | 2016-06-08 | 住友化学株式会社 | 植物の生長を促進する方法 |
BR112013033316A2 (pt) | 2011-06-24 | 2017-01-31 | Amgen Inc | antagonista de trpm8 e seu uso em tratamentos |
EP2723718A1 (en) | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
EP2671575A1 (en) * | 2012-06-04 | 2013-12-11 | Universität Regensburg | Ras inhibitors |
US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
KR20240035395A (ko) | 2021-06-14 | 2024-03-15 | 스코르피온 테라퓨틱스, 인코퍼레이티드 | 암 치료에 사용할 수 있는 요소 유도체 |
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DE3711335A1 (de) * | 1987-04-03 | 1988-10-20 | Merck Patent Gmbh | Aminosaeurederivate |
US5164372A (en) | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
ATE197793T1 (de) | 1992-08-13 | 2000-12-15 | Warner Lambert Co | Tachykinin antagonistes |
ITFI940009A1 (it) * | 1994-01-19 | 1995-07-19 | Menarini Farma Ind | Antagonisti delle tachichinine, loro preparazione e formulazioni farmaceutiche che li contengono. |
TW385308B (en) * | 1994-03-04 | 2000-03-21 | Merck & Co Inc | Prodrugs of morpholine tachykinin receptor antagonists |
CA2187531A1 (en) * | 1994-06-06 | 1995-12-14 | David Christopher Horwell | Tachykinin (nk1) receptor antagonists |
US5483070A (en) * | 1994-08-02 | 1996-01-09 | Packard Instrument Company | Scintillation counter |
IT1291776B1 (it) | 1997-02-07 | 1999-01-21 | Menarini Ricerche Spa | Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista |
IT1291823B1 (it) | 1997-04-08 | 1999-01-21 | Menarini Ricerche Spa | Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche |
WO1999000388A1 (fr) * | 1997-06-30 | 1999-01-07 | Nippon Kayaku Kabushiki Kaisha | Nouveaux derives de naphthyridine ou leurs sels |
US6740682B2 (en) * | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
EP1012166B1 (en) * | 1997-08-29 | 2003-10-29 | Tularik Limited | 1-amino-7-isoquinoline derivatives as serine protease inhibitors |
IT1304898B1 (it) * | 1998-09-08 | 2001-04-05 | Menarini Ricerche Spa | Prodotti con caratteristiche basiche aventi attivita' antagonista sulrecettore nk-1 e loro impiego in preparazioni farmaceutiche |
ATE303988T1 (de) * | 1999-06-14 | 2005-09-15 | Lilly Co Eli | Inhibitoren von serin proteasen |
IT1307809B1 (it) | 1999-10-21 | 2001-11-19 | Menarini Ricerche Spa | Composti monociclici basici ad azione nk-2 antagonista, processi difabbricazione e formulazioni che li contengono. |
GB0030303D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
GB0030305D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
US20050038692A1 (en) | 2003-08-14 | 2005-02-17 | Kane John Michael | System and method for facilitating centralized candidate selection and monitoring subject participation in clinical trial studies |
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