IT1291776B1 - Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista - Google Patents

Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista

Info

Publication number
IT1291776B1
IT1291776B1 IT97FI000020A ITFI970020A IT1291776B1 IT 1291776 B1 IT1291776 B1 IT 1291776B1 IT 97FI000020 A IT97FI000020 A IT 97FI000020A IT FI970020 A ITFI970020 A IT FI970020A IT 1291776 B1 IT1291776 B1 IT 1291776B1
Authority
IT
Italy
Prior art keywords
antagonist action
monocyclic compounds
bifunctional
residues
bifunctional residues
Prior art date
Application number
IT97FI000020A
Other languages
English (en)
Inventor
Raffaello Giorgi
Bugno Cristina Di
Danilo Giannotti
Carlo Alberto Maggi
Original Assignee
Menarini Ricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche Spa filed Critical Menarini Ricerche Spa
Publication of ITFI970020A0 publication Critical patent/ITFI970020A0/it
Priority to IT97FI000020A priority Critical patent/IT1291776B1/it
Priority to DE69816633T priority patent/DE69816633T2/de
Priority to AT98908055T priority patent/ATE245658T1/de
Priority to ES98908055T priority patent/ES2203934T3/es
Priority to EP98908055A priority patent/EP1017711B1/en
Priority to JP53375198A priority patent/JP2001511167A/ja
Priority to AU66201/98A priority patent/AU6620198A/en
Priority to CA002280228A priority patent/CA2280228A1/en
Priority to PCT/EP1998/000599 priority patent/WO1998034949A2/en
Priority to CNB988023601A priority patent/CN1227261C/zh
Priority to US09/355,210 priority patent/US6780968B1/en
Priority to ZA98931A priority patent/ZA98931B/xx
Priority to MYPI98000485A priority patent/MY117392A/en
Priority to ARP980100535A priority patent/AR011789A1/es
Publication of ITFI970020A1 publication Critical patent/ITFI970020A1/it
Application granted granted Critical
Publication of IT1291776B1 publication Critical patent/IT1291776B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IT97FI000020A 1997-02-07 1997-02-07 Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista IT1291776B1 (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT97FI000020A IT1291776B1 (it) 1997-02-07 1997-02-07 Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista
AU66201/98A AU6620198A (en) 1997-02-07 1998-02-04 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action
PCT/EP1998/000599 WO1998034949A2 (en) 1997-02-07 1998-02-04 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action
ES98908055T ES2203934T3 (es) 1997-02-07 1998-02-04 Compuestos monociclicos con cuatro restos bifuncionales que tienen accon antagonista en nk-2.
EP98908055A EP1017711B1 (en) 1997-02-07 1998-02-04 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action
JP53375198A JP2001511167A (ja) 1997-02-07 1998-02-04 Ｎｋ−２アンタゴニスト作用を有する４個の二官能性残基を含む単環式化合物
DE69816633T DE69816633T2 (de) 1997-02-07 1998-02-04 Monozyklische verbingungen mit vier bifunktionellen resten und nk-2 antagonistischer aktivität
CA002280228A CA2280228A1 (en) 1997-02-07 1998-02-04 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action
AT98908055T ATE245658T1 (de) 1997-02-07 1998-02-04 Monozyklische verbingungen mit vier bifunktionellen resten und nk-2 antagonistischer aktivität
CNB988023601A CN1227261C (zh) 1997-02-07 1998-02-04 具有nk－2拮抗作用的含有四个双官能基团的单环类化合物，其制法，药物组合物及用途
US09/355,210 US6780968B1 (en) 1997-02-07 1998-02-04 Monocyclic compounds with four bifunctional residues having NK-2 antagonist action
ZA98931A ZA98931B (en) 1997-02-07 1998-02-05 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action
MYPI98000485A MY117392A (en) 1997-02-07 1998-02-06 Monocyclic compounds with four bifunctional residues having nk-2 antagonist action
ARP980100535A AR011789A1 (es) 1997-02-07 1998-02-09 Compuestos monociclicos que contienen cuatro residuos bifuncionales unidos entre si via enlaces peptidos, o pseudopeptidos, usos de los mismos,composiciones farmaceuticas que los comprenden, y un procedimiento para la sintesis de un compuesto monociclico que contiene cuatro residuos bifuncionales

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97FI000020A IT1291776B1 (it) 1997-02-07 1997-02-07 Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista

Publications (3)

Publication Number Publication Date
ITFI970020A0 ITFI970020A0 (it) 1997-02-07
ITFI970020A1 ITFI970020A1 (it) 1998-08-07
IT1291776B1 true IT1291776B1 (it) 1999-01-21

Family

ID=11351932

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97FI000020A IT1291776B1 (it) 1997-02-07 1997-02-07 Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista

Country Status (14)

Country Link
US (1) US6780968B1 (it)
EP (1) EP1017711B1 (it)
JP (1) JP2001511167A (it)
CN (1) CN1227261C (it)
AR (1) AR011789A1 (it)
AT (1) ATE245658T1 (it)
AU (1) AU6620198A (it)
CA (1) CA2280228A1 (it)
DE (1) DE69816633T2 (it)
ES (1) ES2203934T3 (it)
IT (1) IT1291776B1 (it)
MY (1) MY117392A (it)
WO (1) WO1998034949A2 (it)
ZA (1) ZA98931B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
IT1307809B1 (it) 1999-10-21 2001-11-19 Menarini Ricerche Spa Composti monociclici basici ad azione nk-2 antagonista, processi difabbricazione e formulazioni che li contengono.
MY130373A (en) 2001-10-29 2007-06-29 Malesci Sas Linear basic compounds having nk-2 antagonist activity and formulations thereof
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4703034A (en) * 1986-04-28 1987-10-27 Merck & Co., Inc. Novel cyclic tetrapeptide
US5187156A (en) * 1988-03-16 1993-02-16 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
IT1262902B (it) 1992-04-15 1996-07-22 Menarini Farma Ind Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.
JPH06172385A (ja) * 1992-12-08 1994-06-21 Yamanouchi Pharmaceut Co Ltd 新規な環状ペプチド化合物及びその製造法
IT1277835B1 (it) * 1995-03-13 1997-11-12 Menarini Farma Ind Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche

Also Published As

Publication number Publication date
AR011789A1 (es) 2000-09-13
ATE245658T1 (de) 2003-08-15
ITFI970020A1 (it) 1998-08-07
WO1998034949A3 (en) 1998-10-22
ZA98931B (en) 1998-08-07
CN1246866A (zh) 2000-03-08
CA2280228A1 (en) 1998-08-13
US6780968B1 (en) 2004-08-24
EP1017711B1 (en) 2003-07-23
ITFI970020A0 (it) 1997-02-07
JP2001511167A (ja) 2001-08-07
CN1227261C (zh) 2005-11-16
WO1998034949A2 (en) 1998-08-13
DE69816633T2 (de) 2004-06-03
AU6620198A (en) 1998-08-26
MY117392A (en) 2004-06-30
ES2203934T3 (es) 2004-04-16
DE69816633D1 (de) 2003-08-28
EP1017711A2 (en) 2000-07-12

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