UA39161C2 - Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують - Google Patents

Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують

Info

Publication number
UA39161C2
UA39161C2 UA4027096A UA4027096A UA39161C2 UA 39161 C2 UA39161 C2 UA 39161C2 UA 4027096 A UA4027096 A UA 4027096A UA 4027096 A UA4027096 A UA 4027096A UA 39161 C2 UA39161 C2 UA 39161C2
Authority
UA
Ukraine
Prior art keywords
csf
vector
granylocytes
macrophages
patients
Prior art date
Application number
UA4027096A
Other languages
English (en)
Russian (ru)
Inventor
Стівен К. Кларк
Стивен К. Кларк
Рандал Дж. Кауфман
Гордон Г. Вонг
Елізабет А. Ванг
Элизабет А. Ванг
Original Assignee
Новартіс Аг
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27417446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA39161(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартіс Аг, Новартис Аг filed Critical Новартіс Аг
Publication of UA39161C2 publication Critical patent/UA39161C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Abstract

Вектор містить ген, що кодує білок GM-CSF приматів, має амінокислотну послідовність, зазначену нижче після стрілки для CSF-Thr, CSF-lle або CSF-G. Його алельні або інші функціонально еквівалентні варіанти, в яких одну або декілька амінокислот додано, замінено або видалено без істотного впливу на активність GM-CSF приматів при аналізі кісткового мозку людини.
UA4027096A 1984-07-06 1985-07-04 Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують UA39161C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62834284A 1984-07-06 1984-07-06
US65244784A 1984-09-19 1984-09-19
US65274284A 1984-09-19 1984-09-19
PCT/EP1985/000326 WO1986000639A1 (en) 1984-07-06 1985-07-04 Lymphokine production and purification

Publications (1)

Publication Number Publication Date
UA39161C2 true UA39161C2 (uk) 2001-06-15

Family

ID=27417446

Family Applications (1)

Application Number Title Priority Date Filing Date
UA4027096A UA39161C2 (uk) 1984-07-06 1985-07-04 Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують

Country Status (28)

Country Link
EP (2) EP0188479B1 (uk)
JP (4) JP2540509B2 (uk)
KR (1) KR910001809B1 (uk)
AT (2) ATE67244T1 (uk)
AU (3) AU599572B2 (uk)
CA (2) CA1341618C (uk)
CY (1) CY1629A (uk)
DE (3) DE3584089D1 (uk)
DK (2) DK168709B1 (uk)
ES (1) ES8701226A1 (uk)
FI (1) FI108796B (uk)
GR (1) GR851643B (uk)
HK (2) HK111594A (uk)
HU (1) HU208711B (uk)
IE (2) IE60819B1 (uk)
IL (2) IL75725A (uk)
LU (1) LU88337I2 (uk)
MY (1) MY102902A (uk)
NL (1) NL930089I2 (uk)
NO (4) NO179455C (uk)
NZ (2) NZ228031A (uk)
PL (1) PL153139B1 (uk)
PT (1) PT80776B (uk)
SA (1) SA94150015A (uk)
SG (1) SG108991G (uk)
SK (1) SK505985A3 (uk)
UA (1) UA39161C2 (uk)
WO (1) WO1986000639A1 (uk)

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Also Published As

Publication number Publication date
IL94754A0 (en) 1991-04-15
JP2594744B2 (ja) 1997-03-26
NO860775L (no) 1986-03-13
AU599572B2 (en) 1990-07-26
SK280265B6 (sk) 1999-10-08
NL930089I2 (nl) 1994-07-01
DK102886A (da) 1986-03-06
CA1341618C (en) 2011-07-19
NZ228031A (en) 1991-12-23
MY102902A (en) 1993-03-31
LU88337I2 (fr) 1994-05-04
NO961452L (no) 1996-04-12
GR851643B (uk) 1985-11-26
KR910001809B1 (ko) 1991-03-26
IL75725A0 (en) 1985-11-29
EP0337359B1 (en) 1998-10-21
NO314941B1 (no) 2003-06-16
FI860308A0 (fi) 1986-01-22
SA94150015A (ar) 2005-12-03
HU208711B (en) 1993-12-28
FI108796B (fi) 2002-03-28
EP0188479B1 (en) 1991-09-11
NO179455B (no) 1996-07-01
IL75725A (en) 1993-02-21
PL254400A1 (en) 1986-06-17
SA94150015B1 (ar) 2004-09-04
PT80776B (pt) 1987-09-30
CY1629A (en) 1992-07-10
NO943300L (no) 1986-03-13
JP2594768B2 (ja) 1997-03-26
NO943300D0 (no) 1994-09-07
WO1986000639A1 (en) 1986-01-30
ES544868A0 (es) 1986-11-16
FI860308A (fi) 1986-01-22
KR860700264A (ko) 1986-08-01
IE930961L (en) 1986-01-06
HK111594A (en) 1994-10-21
AU5497690A (en) 1990-09-13
ATE172494T1 (de) 1998-11-15
IE851695L (en) 1986-01-06
NO307348B1 (no) 2000-03-20
EP0337359A2 (en) 1989-10-18
DK168709B1 (da) 1994-05-24
NO1996016I1 (no) 1996-12-18
PT80776A (en) 1985-08-01
NO179455C (no) 1996-10-09
DE3588199T2 (de) 1999-04-08
NL930089I1 (nl) 1993-10-01
HK1011709A1 (en) 1999-07-16
JPH06319557A (ja) 1994-11-22
EP0337359A3 (en) 1990-02-07
NZ212645A (en) 1990-02-26
JPH07163351A (ja) 1995-06-27
CA1340852C (en) 1999-12-14
EP0188479A1 (en) 1986-07-30
AU628069B2 (en) 1992-09-10
AU4009089A (en) 1989-12-07
JPH06199897A (ja) 1994-07-19
DE3588199D1 (de) 1998-11-26
JP2594743B2 (ja) 1997-03-26
SG108991G (en) 1992-03-20
DK59493A (da) 1993-05-21
JPS61502682A (ja) 1986-11-20
DK102886D0 (da) 1986-03-06
ES8701226A1 (es) 1986-11-16
IE60819B1 (en) 1994-08-10
NO961452D0 (no) 1996-04-12
SK505985A3 (en) 1999-10-08
AU4545685A (en) 1986-02-10
ATE67244T1 (de) 1991-09-15
DE188479T1 (de) 1987-05-21
AU644359B2 (en) 1993-12-09
JP2540509B2 (ja) 1996-10-02
DK172679B1 (da) 1999-05-17
DE3584089D1 (de) 1991-10-17
HUT38675A (en) 1986-06-30
PL153139B1 (en) 1991-03-29
DK59493D0 (da) 1993-05-21

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