DE3587669T2 - Menschliche IL-1-cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren. - Google Patents

Menschliche IL-1-cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren.

Info

Publication number
DE3587669T2
DE3587669T2 DE19853587669 DE3587669T DE3587669T2 DE 3587669 T2 DE3587669 T2 DE 3587669T2 DE 19853587669 DE19853587669 DE 19853587669 DE 3587669 T DE3587669 T DE 3587669T DE 3587669 T2 DE3587669 T2 DE 3587669T2
Authority
DE
Germany
Prior art keywords
human
proteins
biologically active
sequences encoding
cdna sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE19853587669
Other languages
English (en)
Other versions
DE3587669D1 (de
Inventor
Philip E Auron
Andrew C Webb
Lee Gehrke
Charles A Dinarello
Lanny J Rosenwasser
Alexander Rich
Sheldon M Wolff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New England Medical Center Hospitals Inc
Wellesley College
Massachusetts Institute of Technology
Tufts University
Original Assignee
New England Medical Center Hospitals Inc
Wellesley College
Massachusetts Institute of Technology
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/700,374 external-priority patent/US4762914A/en
Application filed by New England Medical Center Hospitals Inc, Wellesley College, Massachusetts Institute of Technology, Tufts University filed Critical New England Medical Center Hospitals Inc
Publication of DE3587669D1 publication Critical patent/DE3587669D1/de
Application granted granted Critical
Publication of DE3587669T2 publication Critical patent/DE3587669T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
DE19853587669 1984-05-18 1985-05-07 Menschliche IL-1-cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren. Expired - Lifetime DE3587669T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61166984A 1984-05-18 1984-05-18
US06/700,374 US4762914A (en) 1984-05-18 1985-02-11 Truncated protein of interleukin-1

Publications (2)

Publication Number Publication Date
DE3587669D1 DE3587669D1 (de) 1994-01-13
DE3587669T2 true DE3587669T2 (de) 1994-03-31

Family

ID=27086567

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19853588241 Expired - Lifetime DE3588241T2 (de) 1984-05-18 1985-05-07 Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DE19853587669 Expired - Lifetime DE3587669T2 (de) 1984-05-18 1985-05-07 Menschliche IL-1-cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19853588241 Expired - Lifetime DE3588241T2 (de) 1984-05-18 1985-05-07 Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren

Country Status (3)

Country Link
EP (1) EP0161901B1 (de)
JP (2) JP2650026B2 (de)
DE (2) DE3588241T2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859484A (en) * 1973-09-10 1975-01-07 Robert E Nelson Cyclic pressure switch with plural diaphrams
JPS617296A (ja) * 1984-06-19 1986-01-13 イミユネツクス、コ−ポレ−シヨン インタ−ロイキン１の遺伝子の精製、クロ−ニング及び特性づけ
CA1340978C (en) * 1984-06-19 2000-05-02 Douglas P. Cerretti Purification, cloning and characterization of the gene for interleukin 1
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
EP0188920B1 (de) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin-1 und dessen Derivat
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
JPS63123397A (ja) * 1986-11-14 1988-05-27 Kyowa Hakko Kogyo Co Ltd 新規ポリペプチド
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
FR2635113B1 (fr) * 1988-08-05 1992-07-24 Sanofi Sa Procede d'obtention d'interleukine-1 (beta) mature a partir de cellules d'e. coli transformees
GB9010356D0 (en) * 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
MX348154B (es) 2005-06-21 2017-05-30 Xoma (Us) Llc Anticuerpos de enlace a il-1-beta y fragmentos de los mismos.
JP5645409B2 (ja) 2006-12-20 2014-12-24 ゾーマ （ユーエス） リミテッド ライアビリティ カンパニー ＩＬ−１β関連疾患の治療方法
PL2391650T3 (pl) 2007-12-20 2015-03-31 Xoma Us Llc Sposoby leczenia dny
CA2735940A1 (en) 2008-09-05 2010-03-11 Xoma Technology Ltd. Methods for treating or preventing il-1.beta. related diseases
MX337586B (es) 2010-05-07 2016-03-11 Xoma Us Llc Anticuerpos anti-interleucina-1beta para usarse en el tratamiento de condiciones relacionadas con interleucina-1beta.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2519553A1 (en) * 1982-01-08 1983-07-18 Anvar Pyrogenic immunostimulant prepn. - by culture of cell lines with N:acetyl muramyl L:alanyl D:iso-glutamine
CA1340978C (en) * 1984-06-19 2000-05-02 Douglas P. Cerretti Purification, cloning and characterization of the gene for interleukin 1
EP0188920B1 (de) * 1984-12-25 1993-09-29 Dainippon Pharmaceutical Co., Ltd. Interleukin-1 und dessen Derivat
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene

Also Published As

Publication number Publication date
DE3588241T2 (de) 2002-12-05
JP2650026B2 (ja) 1997-09-03
DE3587669D1 (de) 1994-01-13
EP0161901B1 (de) 1993-12-01
EP0161901A2 (de) 1985-11-21
EP0161901A3 (en) 1987-03-04
JPH06315393A (ja) 1994-11-15
JPS61119191A (ja) 1986-06-06
DE3588241D1 (de) 2002-09-26
JP2805008B2 (ja) 1998-09-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN