GR851643B - - Google Patents

Info

Publication number
GR851643B
GR851643B GR851643A GR850101643A GR851643B GR 851643 B GR851643 B GR 851643B GR 851643 A GR851643 A GR 851643A GR 850101643 A GR850101643 A GR 850101643A GR 851643 B GR851643 B GR 851643B
Authority
GR
Greece
Prior art keywords
csf
cdna
preparing
protein
rna
Prior art date
Application number
GR851643A
Other languages
English (en)
Inventor
Steven C Clark
Pandal J Kaufman
Gordon G Wong
Elizabeth A Wang
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27417446&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR851643(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of GR851643B publication Critical patent/GR851643B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
GR851643A 1984-07-06 1985-07-04 GR851643B (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62834284A 1984-07-06 1984-07-06
US65274284A 1984-09-19 1984-09-19
US65244784A 1984-09-19 1984-09-19

Publications (1)

Publication Number Publication Date
GR851643B true GR851643B (el) 1985-11-26

Family

ID=27417446

Family Applications (1)

Application Number Title Priority Date Filing Date
GR851643A GR851643B (el) 1984-07-06 1985-07-04

Country Status (28)

Country Link
EP (2) EP0188479B1 (el)
JP (4) JP2540509B2 (el)
KR (1) KR910001809B1 (el)
AT (2) ATE67244T1 (el)
AU (3) AU599572B2 (el)
CA (2) CA1341618C (el)
CY (1) CY1629A (el)
DE (3) DE3584089D1 (el)
DK (2) DK168709B1 (el)
ES (1) ES8701226A1 (el)
FI (1) FI108796B (el)
GR (1) GR851643B (el)
HK (2) HK111594A (el)
HU (1) HU208711B (el)
IE (2) IE930961L (el)
IL (2) IL75725A (el)
LU (1) LU88337I2 (el)
MY (1) MY102902A (el)
NL (1) NL930089I2 (el)
NO (4) NO179455C (el)
NZ (2) NZ212645A (el)
PL (1) PL153139B1 (el)
PT (1) PT80776B (el)
SA (1) SA94150015A (el)
SG (1) SG108991G (el)
SK (1) SK505985A3 (el)
UA (1) UA39161C2 (el)
WO (1) WO1986000639A1 (el)

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EP0202300B1 (en) * 1984-11-20 1992-11-11 Schering Biotech Corporation Cdna clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity
DE3686794T2 (de) * 1985-02-05 1993-03-04 Cetus Oncology Corp Reinigung des natuerlichen kolonie-stimulierenden faktors-1.
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CA1295567C (en) * 1988-07-25 1992-02-11 Lawrence T. Malek Expression system for the secretion of bioactive human granulocyte, macrophage-colony stimulating factor (gm-csf) and other heterologous proteins from streptomyces
US5298603A (en) * 1985-12-21 1994-03-29 Hoechst Aktiengesellschaft GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
GR871029B (en) 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US5162111A (en) * 1986-07-30 1992-11-10 Grabstein Kenneth H Treatment of bacterial diseases with granulocyte-macrophage colony stimulating factor
AU7675487A (en) * 1986-08-11 1988-05-19 Cetus Corporation Expression of granulocyte colony-stimulating factor
GB8624899D0 (en) * 1986-10-17 1986-11-19 Sandoz Ltd Monoclonal antibodies
JPH0618781B2 (ja) * 1986-10-18 1994-03-16 中外製薬株式会社 感染症治療剤
EP0276846A3 (en) * 1987-01-29 1989-07-26 Zymogenetics, Inc. Colony-stimulating factor derivatives
JP2521094B2 (ja) * 1987-04-28 1996-07-31 アムジェン、インコーポレーテッド ヒト顆粒球マクロファ―ジコロニ―刺激因子をコ―ドする合成ｄｎａ、そのｄｎａを含むプラスミド、およびそのｄｎａで形質転換された大腸菌
ATE121134T1 (de) * 1987-06-25 1995-04-15 Immunex Corp Rinder granulocyt-makrophagenkolonie stimulierender faktor.
EP0368904A1 (en) * 1987-07-16 1990-05-23 Schering Corporation Purification of gm-csf
US5391706A (en) * 1987-07-16 1995-02-21 Schering Plough Corporation Purification of GM-CSF
AU626530B2 (en) * 1987-07-17 1992-08-06 Schering Biotech Corporation Human granulocyte-macrophage colony stimulating factor and muteins thereof
IE63514B1 (en) * 1987-07-17 1995-05-03 Schering Biotech Corp Expression vectors for the production of human granulocyte-macrophage colony stimulation factor in a mammalian cell host
WO1989001038A1 (en) * 1987-07-24 1989-02-09 Cetus Corporation PRODUCTION OF BIOLOGICALLY ACTIVE FORMS OF CSF USING A BACULOVIRUS (AcNPV)-INSECT CELL EXPRESSION SYSTEM
EP0452315A1 (en) * 1988-05-31 1991-10-23 Schering Biotech Corporation Method of treating myeloid leukemias
AU618283B2 (en) * 1988-10-10 1991-12-19 Instituto Nazionale Per Lo Studio E La Cura Dei Tumori The use of GM-CSF in the treatment of a patient requiring high-dose chemo- or radiotherapy for cancer
US5811523A (en) 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
JPH0322973A (ja) * 1989-01-19 1991-01-31 Wan Shen-Yuan ヒトヘパトーム細胞系によるコロニー形成促進因子（ＣＳＦｓ）の構成性産生
IL95061A0 (en) * 1989-07-14 1991-06-10 Schering Corp Antagonists of gm-csf derived from the carboxyl terminus
AU3657893A (en) 1992-02-28 1993-09-13 Board Of Regents, The University Of Texas System Compositions and methods for the treatment of thermal injury
US6004807A (en) * 1992-03-30 1999-12-21 Schering Corporation In vitro generation of human dendritic cells
US6361977B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Methods of using multivariant IL-3 hematopoiesis fusion protein
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6361976B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US6413509B1 (en) 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US6153183A (en) * 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US6403076B1 (en) 1992-11-24 2002-06-11 S. Christopher Bauer Compositions for increasing hematopoiesis with interleukin-3 mutants
EP1378572B1 (en) 1993-05-12 2006-10-25 Genetics Institute, LLC Bmp-11 compositions
EP0646643B1 (en) * 1993-06-30 2001-12-05 Lucky Ltd. Modified human granulocyte macrophage-colony stimulating factor gene and expression thereof in yeast
US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
US5599536A (en) * 1993-12-13 1997-02-04 Sandoz Ltd. Method for suppressing the acute phase response in a patient receiving IL-6 therapy
US5578301A (en) * 1993-12-14 1996-11-26 Sandoz Ltd. Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy
US6165748A (en) 1997-07-11 2000-12-26 Genetics Institute, Inc. Frazzled nucleotide sequences and expression products
US6676937B1 (en) 1998-03-09 2004-01-13 Caritas St. Elizabeth's Medical Center Of Boston Inc. Compositions and methods for modulating vascularization
DE19905501B4 (de) 1999-02-10 2005-05-19 MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
EP1150666B1 (en) * 1999-02-12 2009-10-28 Washington University Gm-csf for the treatment of crohn's disease
US6869762B1 (en) 1999-12-10 2005-03-22 Whitehead Institute For Biomedical Research Crohn's disease-related polymorphisms
AU2258601A (en) * 1999-12-10 2001-06-18 Ellipsis Biotherapeutics Corporation Ibd-related polymorphisms
US6689599B1 (en) 2000-10-20 2004-02-10 Genetics Institute, Llc Aggrecanase molecules
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
AU2002319703A1 (en) 2001-07-27 2003-02-17 Wyeth Aggrecanase molecules
CA2474908A1 (en) 2002-01-31 2003-08-07 Wyeth Aggrecanase molecules
JP2005516614A (ja) 2002-02-05 2005-06-09 ワイス 切断アグレカナーゼ分子
BR0313083A (pt) 2002-07-29 2007-07-17 Wyeth Corp moléculas de adamts4 modificadas,polinucleotìdeo, vetor, processos para produção, composição farmacêutica, bem como uso das mesmas

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US4428632A (en) * 1979-08-10 1984-01-31 Thomas & Betts Corporation Coaxial cable transition connector
JPS6030654B2 (ja) * 1980-12-31 1985-07-17 株式会社林原生物化学研究所 ヒトコロニ−刺激因子の製造方法
US4438032A (en) 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
JPH0751511B2 (ja) * 1982-03-15 1995-06-05 味の素株式会社 インターロイキン２を含有してなる癌治療剤
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene

Also Published As

Publication number Publication date
SG108991G (en) 1992-03-20
JP2540509B2 (ja) 1996-10-02
DK102886A (da) 1986-03-06
PL254400A1 (en) 1986-06-17
UA39161C2 (uk) 2001-06-15
NO179455C (no) 1996-10-09
WO1986000639A1 (en) 1986-01-30
DE3584089D1 (de) 1991-10-17
SK280265B6 (sk) 1999-10-08
ES544868A0 (es) 1986-11-16
EP0188479A1 (en) 1986-07-30
NZ212645A (en) 1990-02-26
HUT38675A (en) 1986-06-30
JP2594744B2 (ja) 1997-03-26
NO961452L (no) 1996-04-12
NZ228031A (en) 1991-12-23
FI860308A (fi) 1986-01-22
SA94150015B1 (ar) 2004-09-04
EP0337359A2 (en) 1989-10-18
HK1011709A1 (en) 1999-07-16
CA1340852C (en) 1999-12-14
NO314941B1 (no) 2003-06-16
JP2594743B2 (ja) 1997-03-26
AU628069B2 (en) 1992-09-10
PT80776A (en) 1985-08-01
ATE172494T1 (de) 1998-11-15
PT80776B (pt) 1987-09-30
KR910001809B1 (ko) 1991-03-26
AU5497690A (en) 1990-09-13
ES8701226A1 (es) 1986-11-16
EP0337359A3 (en) 1990-02-07
EP0337359B1 (en) 1998-10-21
IL75725A (en) 1993-02-21
HK111594A (en) 1994-10-21
DE3588199T2 (de) 1999-04-08
DK172679B1 (da) 1999-05-17
JPS61502682A (ja) 1986-11-20
IE60819B1 (en) 1994-08-10
DK59493A (da) 1993-05-21
MY102902A (en) 1993-03-31
AU644359B2 (en) 1993-12-09
FI860308A0 (fi) 1986-01-22
IE851695L (en) 1986-01-06
NO943300L (no) 1986-03-13
AU4545685A (en) 1986-02-10
JPH06319557A (ja) 1994-11-22
FI108796B (fi) 2002-03-28
AU4009089A (en) 1989-12-07
NL930089I2 (nl) 1994-07-01
HU208711B (en) 1993-12-28
DK168709B1 (da) 1994-05-24
NO1996016I1 (no) 1996-12-18
CY1629A (en) 1992-07-10
IE930961L (en) 1986-01-06
CA1341618C (en) 2011-07-19
DE188479T1 (de) 1987-05-21
NO307348B1 (no) 2000-03-20
LU88337I2 (fr) 1994-05-04
SK505985A3 (en) 1999-10-08
NO961452D0 (no) 1996-04-12
JPH07163351A (ja) 1995-06-27
ATE67244T1 (de) 1991-09-15
SA94150015A (ar) 2005-12-03
PL153139B1 (en) 1991-03-29
DK59493D0 (da) 1993-05-21
KR860700264A (ko) 1986-08-01
NO943300D0 (no) 1994-09-07
NO179455B (no) 1996-07-01
JPH06199897A (ja) 1994-07-19
JP2594768B2 (ja) 1997-03-26
NO860775L (no) 1986-03-13
DE3588199D1 (de) 1998-11-26
AU599572B2 (en) 1990-07-26
NL930089I1 (nl) 1993-10-01
EP0188479B1 (en) 1991-09-11
DK102886D0 (da) 1986-03-06
IL75725A0 (en) 1985-11-29
IL94754A0 (en) 1991-04-15

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