TWI675032B - ＲＯＲ-γ之二氫吡咯并吡啶抑制劑 - Google Patents

ＲＯＲ-γ之二氫吡咯并吡啶抑制劑 Download PDF

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TWI675032B
TWI675032B TW104133670A TW104133670A TWI675032B TW I675032 B TWI675032 B TW I675032B TW 104133670 A TW104133670 A TW 104133670A TW 104133670 A TW104133670 A TW 104133670A TW I675032 B TWI675032 B TW I675032B
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compound
mixture
disease
mmol
pharmaceutically acceptable
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TW201629058A (zh
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大衛Ａ 克雷爾蒙
羅倫斯 韋恩 迪拉德
董成國
範怡
賈蘭齊
史黛芬Ｄ 羅退史特
安卓 馬兒克斯
蘇瑞奇Ｂ 席恩
科林Ｍ 泰斯
苑晶
趙偉
亞軍 鄭
凌航 庄
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美商維它藥物公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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TW104133670A 2014-10-14 2015-10-14 ＲＯＲ-γ之二氫吡咯并吡啶抑制劑 TWI675032B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US62/063,912 2014-10-14
US201462074406P 2014-11-03 2014-11-03
US62/074,406 2014-11-03

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TW201629058A TW201629058A (zh) 2016-08-16
TWI675032B true TWI675032B (zh) 2019-10-21

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US (3) US9796710B2 (enExample)
EP (1) EP3207043B3 (enExample)
JP (1) JP6564029B2 (enExample)
KR (1) KR20170066628A (enExample)
CN (1) CN107074852B (enExample)
AU (1) AU2015333610B2 (enExample)
BR (1) BR112017007460A2 (enExample)
CA (1) CA2963140A1 (enExample)
CL (1) CL2017000902A1 (enExample)
CO (1) CO2017004525A2 (enExample)
CY (1) CY1121413T1 (enExample)
DK (1) DK3207043T6 (enExample)
EA (1) EA031967B1 (enExample)
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MX (1) MX371304B (enExample)
MY (1) MY182454A (enExample)
PH (1) PH12017500583B1 (enExample)
PL (1) PL3207043T6 (enExample)
PT (1) PT3207043T (enExample)
SG (1) SG11201702362SA (enExample)
SI (1) SI3207043T1 (enExample)
TW (1) TWI675032B (enExample)
UA (1) UA118989C2 (enExample)
WO (1) WO2016061160A1 (enExample)
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PT2900669T (pt) 2012-09-25 2019-10-29 Hoffmann La Roche Derivados de hexahidropirrolo[3,4−c]pirrol e compostos relacionados enquanto inibidores da autotaxina (atx) e enquanto inibidores da produção de ácido lisofosfatídico (lpa) para o tratamento de, por exemplo, doenças renais
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
PL3074400T3 (pl) 2013-11-26 2018-03-30 F.Hoffmann-La Roche Ag Pochodne oktahydrocyklobuta[1,2-c;3,4-c']dipirolu jako inhibitory autotaksyny
SI3102576T1 (sl) 2014-02-03 2019-08-30 Vitae Pharmaceuticals, Llc Inhibitorji dihidropirolopiridina ROR-gama
CN106029667B (zh) 2014-03-26 2019-08-23 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的稠合[1,4]二氮杂*化合物
MA39792B1 (fr) 2014-03-26 2019-12-31 Hoffmann La Roche Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
TWI675032B (zh) 2014-10-14 2019-10-21 美商維它藥物公司 ＲＯＲ-γ之二氫吡咯并吡啶抑制劑
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
SMT202100286T1 (it) 2015-05-15 2021-07-12 Aurigene Discovery Tech Ltd Composti di tetraidrochinolinone sostituito come modulatori ror-gamma
WO2016200851A1 (en) 2015-06-09 2016-12-15 Abbvie Inc. Nuclear receptor modulators
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
WO2017037146A1 (en) 2015-09-04 2017-03-09 F. Hoffmann-La Roche Ag Phenoxymethyl derivatives
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
MX372962B (es) 2015-09-24 2020-03-27 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
EP3353176B1 (en) 2015-09-24 2022-01-19 F. Hoffmann-La Roche AG Bicyclic compounds as atx inhibitors
EP3353180B1 (en) 2015-09-24 2022-03-16 F. Hoffmann-La Roche AG Bicyclic compounds as atx inhibitors
KR20180086221A (ko) 2015-11-20 2018-07-30 비타이 파마슈티컬즈, 인코포레이티드 Ror-감마의 조절물질
ES2927631T3 (es) 2015-12-15 2022-11-08 Astrazeneca Ab Compuestos de isoindol
TWI757266B (zh) * 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
JP2020524660A (ja) 2017-06-14 2020-08-20 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｒｏｒ−ガンマモジュレーターとして有用な２，３−ジヒドロイソインドール−１−カルボキサミド
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
TW201906816A (zh) 2017-07-06 2019-02-16 大陸商江蘇恆瑞醫藥股份有限公司 吲哚甲醯胺類衍生物、其製備方法及其在醫藥上的應用
AU2018307919B2 (en) 2017-07-24 2022-12-01 Vitae Pharmaceuticals, Llc Inhibitors of RORϒ
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