ZA201702237B - Dihydropyrrolopyridine inhibitors of ror-gamma - Google Patents

Dihydropyrrolopyridine inhibitors of ror-gamma

Info

Publication number
ZA201702237B
ZA201702237B ZA2017/02237A ZA201702237A ZA201702237B ZA 201702237 B ZA201702237 B ZA 201702237B ZA 2017/02237 A ZA2017/02237 A ZA 2017/02237A ZA 201702237 A ZA201702237 A ZA 201702237A ZA 201702237 B ZA201702237 B ZA 201702237B
Authority
ZA
South Africa
Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
Prior art date
Application number
ZA2017/02237A
Other languages
English (en)
Inventor
David A Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Stephen D Lotesta
Andrew Marcus
Suresh B Singh
Colin M Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
Original Assignee
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitae Pharmaceuticals Inc filed Critical Vitae Pharmaceuticals Inc
Publication of ZA201702237B publication Critical patent/ZA201702237B/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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ZA2017/02237A 2014-10-14 2017-03-30 Dihydropyrrolopyridine inhibitors of ror-gamma ZA201702237B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US201462074406P 2014-11-03 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (1)

Publication Number Publication Date
ZA201702237B true ZA201702237B (en) 2019-09-25

Family

ID=54352515

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Application Number Title Priority Date Filing Date
ZA2017/02237A ZA201702237B (en) 2014-10-14 2017-03-30 Dihydropyrrolopyridine inhibitors of ror-gamma

Country Status (28)

Country Link
US (3) US9796710B2 (enExample)
EP (1) EP3207043B3 (enExample)
JP (1) JP6564029B2 (enExample)
KR (1) KR20170066628A (enExample)
CN (1) CN107074852B (enExample)
AU (1) AU2015333610B2 (enExample)
BR (1) BR112017007460A2 (enExample)
CA (1) CA2963140A1 (enExample)
CL (1) CL2017000902A1 (enExample)
CO (1) CO2017004525A2 (enExample)
CY (1) CY1121413T1 (enExample)
DK (1) DK3207043T6 (enExample)
EA (1) EA031967B1 (enExample)
EC (1) ECSP17029371A (enExample)
ES (1) ES2715458T7 (enExample)
HU (1) HUE042335T2 (enExample)
IL (1) IL251584B (enExample)
MX (1) MX371304B (enExample)
MY (1) MY182454A (enExample)
PH (1) PH12017500583B1 (enExample)
PL (1) PL3207043T6 (enExample)
PT (1) PT3207043T (enExample)
SG (1) SG11201702362SA (enExample)
SI (1) SI3207043T1 (enExample)
TW (1) TWI675032B (enExample)
UA (1) UA118989C2 (enExample)
WO (1) WO2016061160A1 (enExample)
ZA (1) ZA201702237B (enExample)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
PL3074400T3 (pl) 2013-11-26 2018-03-30 F.Hoffmann-La Roche Ag Pochodne oktahydrocyklobuta[1,2-c;3,4-c']dipirolu jako inhibitory autotaksyny
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MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
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EP3353176B1 (en) 2015-09-24 2022-01-19 F. Hoffmann-La Roche AG Bicyclic compounds as atx inhibitors
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KR20180086221A (ko) 2015-11-20 2018-07-30 비타이 파마슈티컬즈, 인코포레이티드 Ror-감마의 조절물질
ES2927631T3 (es) 2015-12-15 2022-11-08 Astrazeneca Ab Compuestos de isoindol
TWI757266B (zh) * 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
JP2020524660A (ja) 2017-06-14 2020-08-20 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｒｏｒ−ガンマモジュレーターとして有用な２，３−ジヒドロイソインドール−１−カルボキサミド
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
TW201906816A (zh) 2017-07-06 2019-02-16 大陸商江蘇恆瑞醫藥股份有限公司 吲哚甲醯胺類衍生物、其製備方法及其在醫藥上的應用
AU2018307919B2 (en) 2017-07-24 2022-12-01 Vitae Pharmaceuticals, Llc Inhibitors of RORϒ
WO2019018975A1 (en) * 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
WO2019024809A1 (zh) 2017-08-01 2019-02-07 正大天晴药业集团股份有限公司 作为RORγ抑制剂的双环化合物
CN109384711A (zh) * 2017-08-07 2019-02-26 南京柯菲平盛辉制药有限公司 一类茚满-5-甲酰胺RORγ调节剂及其用途
US11396503B2 (en) 2017-09-30 2022-07-26 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Sulfonyl substituted bicyclic compound which acts as ROR inhibitor
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