AU2015333610B2 - Dihydropyrrolopyridine inhibitors of ROR-gamma - Google Patents

Dihydropyrrolopyridine inhibitors of ROR-gamma Download PDF

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Publication number
AU2015333610B2
AU2015333610B2 AU2015333610A AU2015333610A AU2015333610B2 AU 2015333610 B2 AU2015333610 B2 AU 2015333610B2 AU 2015333610 A AU2015333610 A AU 2015333610A AU 2015333610 A AU2015333610 A AU 2015333610A AU 2015333610 B2 AU2015333610 B2 AU 2015333610B2
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Prior art keywords
compound
mixture
mmol
disease
pharmaceutically acceptable
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AU2015333610A1 (en
Inventor
David A. Claremon
Lawrence Wayne Dillard
Chengguo DONG
Yi Fan
Lanqi Jia
Stephen D. Lotesta
Andrew Marcus
Suresh B. Singh
Colin M. Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
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Vitae Pharmaceuticals LLC
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Vitae Pharmaceuticals LLC
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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AU2015333610A 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ROR-gamma Ceased AU2015333610B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US62/063,912 2014-10-14
US201462074406P 2014-11-03 2014-11-03
US62/074,406 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

Publication Number Publication Date
AU2015333610A1 AU2015333610A1 (en) 2017-04-06
AU2015333610B2 true AU2015333610B2 (en) 2019-11-07

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AU2015333610A Ceased AU2015333610B2 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ROR-gamma

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US (3) US9796710B2 (enExample)
EP (1) EP3207043B3 (enExample)
JP (1) JP6564029B2 (enExample)
KR (1) KR20170066628A (enExample)
CN (1) CN107074852B (enExample)
AU (1) AU2015333610B2 (enExample)
BR (1) BR112017007460A2 (enExample)
CA (1) CA2963140A1 (enExample)
CL (1) CL2017000902A1 (enExample)
CO (1) CO2017004525A2 (enExample)
CY (1) CY1121413T1 (enExample)
DK (1) DK3207043T6 (enExample)
EA (1) EA031967B1 (enExample)
EC (1) ECSP17029371A (enExample)
ES (1) ES2715458T7 (enExample)
HU (1) HUE042335T2 (enExample)
IL (1) IL251584B (enExample)
MX (1) MX371304B (enExample)
MY (1) MY182454A (enExample)
PH (1) PH12017500583B1 (enExample)
PL (1) PL3207043T6 (enExample)
PT (1) PT3207043T (enExample)
SG (1) SG11201702362SA (enExample)
SI (1) SI3207043T1 (enExample)
TW (1) TWI675032B (enExample)
UA (1) UA118989C2 (enExample)
WO (1) WO2016061160A1 (enExample)
ZA (1) ZA201702237B (enExample)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
NO3074400T3 (enExample) 2013-11-26 2018-04-14
EP3527569B1 (en) 2014-02-03 2021-08-25 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma for use in treating drye eye
MA39792B1 (fr) 2014-03-26 2019-12-31 Hoffmann La Roche Composés bicycliques en tant qu'inhibiteurs de production d'autotaxine (atx) et d'acide lysophosphatidique (lpa)
EP3122751B1 (en) 2014-03-26 2019-10-30 F.Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
TWI675032B (zh) 2014-10-14 2019-10-21 美商維它藥物公司 ＲＯＲ-γ之二氫吡咯并吡啶抑制劑
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CU24487B1 (es) 2015-05-15 2020-11-30 Aurigene Discovery Tech Ltd Compuestos de tetrahidroquinolinona sustituidos como moduladores de gamma ror
HUE047988T2 (hu) 2015-06-09 2020-05-28 Abbvie Inc Nukleáris receptor modulátorok (ROR) gyulladásos és autoimmun betegségek kezelésére
ES2856931T3 (es) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc Moduladores de ROR-gamma
MX387736B (es) 2015-09-04 2025-03-18 Hoffmann La Roche Derivados de fenoximetilo.
PE20180451A1 (es) 2015-09-24 2018-03-05 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de atx
CN107635995B (zh) 2015-09-24 2022-08-19 豪夫迈·罗氏有限公司 作为atx抑制剂的二环化合物
KR20180054634A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
MX2017015034A (es) 2015-09-24 2018-04-13 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de autotaxina (atx)/anhidrasa carbonica (ca).
EP3868750A1 (en) 2015-11-20 2021-08-25 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TWI728017B (zh) 2015-12-15 2021-05-21 瑞典商阿斯特捷利康公司 異吲哚化合物、包含其之醫藥組成物及其用途
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
MA49879A (fr) 2017-03-16 2020-06-24 Hoffmann La Roche Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
EP3638661A1 (en) 2017-06-14 2020-04-22 Astrazeneca AB 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
CN109952298B (zh) 2017-07-06 2021-09-03 江苏恒瑞医药股份有限公司 吲哚甲酰胺类衍生物、其制备方法及其在医药上的应用
MA49685A (fr) 2017-07-24 2021-04-14 Vitae Pharmaceuticals Llc INHIBITEURS DE ROR gamma
WO2019018975A1 (en) * 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
EP3663299B1 (en) 2017-08-01 2023-03-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicyclic compound acting as ror gamma inhibitor
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