AU2015333610B2 - Dihydropyrrolopyridine inhibitors of ROR-gamma - Google Patents

Dihydropyrrolopyridine inhibitors of ROR-gamma Download PDF

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Publication number
AU2015333610B2
AU2015333610B2 AU2015333610A AU2015333610A AU2015333610B2 AU 2015333610 B2 AU2015333610 B2 AU 2015333610B2 AU 2015333610 A AU2015333610 A AU 2015333610A AU 2015333610 A AU2015333610 A AU 2015333610A AU 2015333610 B2 AU2015333610 B2 AU 2015333610B2
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Prior art keywords
compound
mixture
mmol
disease
pharmaceutically acceptable
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AU2015333610A1 (en
Inventor
David A. Claremon
Lawrence Wayne Dillard
Chengguo DONG
Yi Fan
Lanqi Jia
Stephen D. Lotesta
Andrew Marcus
Suresh B. Singh
Colin M. Tice
Jing Yuan
Wei Zhao
Yajun Zheng
Linghang Zhuang
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Vitae Pharmaceuticals LLC
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Vitae Pharmaceuticals LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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AU2015333610A 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ROR-gamma Ceased AU2015333610B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462063912P 2014-10-14 2014-10-14
US62/063,912 2014-10-14
US201462074406P 2014-11-03 2014-11-03
US62/074,406 2014-11-03
PCT/US2015/055420 WO2016061160A1 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (2)

Publication Number Publication Date
AU2015333610A1 AU2015333610A1 (en) 2017-04-06
AU2015333610B2 true AU2015333610B2 (en) 2019-11-07

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Application Number Title Priority Date Filing Date
AU2015333610A Ceased AU2015333610B2 (en) 2014-10-14 2015-10-14 Dihydropyrrolopyridine inhibitors of ROR-gamma

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US (3) US9796710B2 (enExample)
EP (1) EP3207043B3 (enExample)
JP (1) JP6564029B2 (enExample)
KR (1) KR20170066628A (enExample)
CN (1) CN107074852B (enExample)
AU (1) AU2015333610B2 (enExample)
BR (1) BR112017007460A2 (enExample)
CA (1) CA2963140A1 (enExample)
CL (1) CL2017000902A1 (enExample)
CO (1) CO2017004525A2 (enExample)
CY (1) CY1121413T1 (enExample)
DK (1) DK3207043T6 (enExample)
EA (1) EA031967B1 (enExample)
EC (1) ECSP17029371A (enExample)
ES (1) ES2715458T7 (enExample)
HU (1) HUE042335T2 (enExample)
IL (1) IL251584B (enExample)
MX (1) MX371304B (enExample)
MY (1) MY182454A (enExample)
PH (1) PH12017500583B1 (enExample)
PL (1) PL3207043T6 (enExample)
PT (1) PT3207043T (enExample)
SG (1) SG11201702362SA (enExample)
SI (1) SI3207043T1 (enExample)
TW (1) TWI675032B (enExample)
UA (1) UA118989C2 (enExample)
WO (1) WO2016061160A1 (enExample)
ZA (1) ZA201702237B (enExample)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
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CR20160418A (es) 2014-03-26 2016-11-07 Hoffmann La Roche Nuevos compuestos biciclicos de 7 eslabones
MA50635A (fr) 2014-03-26 2020-08-12 Hoffmann La Roche Nouveaux composés bicycliques comme inhibiteurs de la production d'autotaxin (atx) et de l'acide lysophosphatidique
SI3207043T1 (sl) 2014-10-14 2019-04-30 Vitae Pharmaceuticals, Inc. Dihidropirolopiridinovi inhibitorji za ROR-gama
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MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
KR102702236B1 (ko) 2015-05-15 2024-09-04 오리진 온콜로지 리미티드 Ror 감마 조절제로서의 치환된 테트라하이드로퀴놀리논 화합물
JP6549735B2 (ja) 2015-06-09 2019-07-24 アッヴィ・インコーポレイテッド 核内受容体調節剤
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
EP3344619B1 (en) 2015-09-04 2020-10-28 H. Hoffnabb-La Roche Ag Phenoxymethyl derivatives
WO2017050747A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag New bicyclic compounds as dual atx/ca inhibitors
MA42918A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
AU2016328437A1 (en) 2015-09-24 2018-01-25 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
BR112018006080A2 (pt) 2015-09-24 2018-10-09 F. Hoffmann-La Roche Ag novos compostos bicíclicos como inibidores de dupla ação de atx/ca
EP3868750A1 (en) 2015-11-20 2021-08-25 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
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TWI757266B (zh) 2016-01-29 2022-03-11 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
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JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
RU2742770C1 (ru) 2017-07-06 2021-02-10 Цзянсу Хэнжуй Медицин Ко., Лтд. Производное индола и формамида, способ его получения и применение в медицине
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CN115716826A (zh) 2017-07-24 2023-02-28 生命医药有限责任公司 RORγ的抑制剂
CN110945002B (zh) 2017-08-01 2021-12-24 正大天晴药业集团股份有限公司 作为RORγ抑制剂的双环化合物
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