TWI614016B - 以針對無調同源物１（ａｔｏｈ１）之天然反義轉錄本之抑制作用治療ａｔｏｈ１相關疾病 - Google Patents

以針對無調同源物１（ａｔｏｈ１）之天然反義轉錄本之抑制作用治療ａｔｏｈ１相關疾病 Download PDF

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TWI614016B
TWI614016B TW100118577A TW100118577A TWI614016B TW I614016 B TWI614016 B TW I614016B TW 100118577 A TW100118577 A TW 100118577A TW 100118577 A TW100118577 A TW 100118577A TW I614016 B TWI614016 B TW I614016B
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oligonucleotide
atoh1
antisense
nucleic acid
rna
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TW100118577A
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Chinese (zh)
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TW201200138A (en
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約瑟夫 柯拉德
Joseph Collard
薛曼 歐嘉 寇可維
Olga Khorkova Sherman
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可娜公司
Curna, Inc.
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TW100118577A 2010-05-26 2011-05-26 以針對無調同源物１（ａｔｏｈ１）之天然反義轉錄本之抑制作用治療ａｔｏｈ１相關疾病 TWI614016B (zh)

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US34865610P 2010-05-26 2010-05-26
US61/348,656 2010-05-26

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TW201200138A TW201200138A (en) 2012-01-01
TWI614016B true TWI614016B (zh) 2018-02-11

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TW100118577A TWI614016B (zh) 2010-05-26 2011-05-26 以針對無調同源物１（ａｔｏｈ１）之天然反義轉錄本之抑制作用治療ａｔｏｈ１相關疾病
TW105142300A TWI688391B (zh) 2010-05-26 2011-05-26 以針對無調同源物１（ａｔｏｈ１）之天然反義轉錄本之抑制作用治療ａｔｏｈ１相關疾病

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US (4) US8895528B2 (enExample)
EP (2) EP2576783B1 (enExample)
JP (2) JP5973996B2 (enExample)
KR (2) KR20180053419A (enExample)
CN (2) CN107412251A (enExample)
AR (1) AR081420A1 (enExample)
CA (1) CA2799207C (enExample)
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EP3702460A1 (en) 2010-11-12 2020-09-02 The General Hospital Corporation Polycomb-associated non-coding rnas
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
US10174315B2 (en) 2012-05-16 2019-01-08 The General Hospital Corporation Compositions and methods for modulating hemoglobin gene family expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
CN104540946A (zh) 2012-05-16 2015-04-22 Rana医疗有限公司 用于调节utrn表达的组合物和方法
EA201492120A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии atp2a2
JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
CN104583402A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节mecp2表达的组合物和方法
CN104583398A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节基因表达的组合物和方法
EP2892506B1 (en) 2012-09-07 2021-11-03 Massachusetts Eye & Ear Infirmary Treating hearing loss with the gamma-secretase inhibitor ly411575
WO2014071275A1 (en) * 2012-11-02 2014-05-08 Genesys Research Institute Compositions and methods for auditory therapy
WO2014145205A2 (en) * 2013-03-15 2014-09-18 St. Jude Children's Research Hospital Methods and compositions of p27kip1 transcription modulators
WO2016022776A2 (en) * 2014-08-06 2016-02-11 Massachusetts Eye And Ear Infirmary Increasing atoh1 life to drive sensorineural hair cell differentiantion
TWI710635B (zh) * 2014-10-09 2020-11-21 美商珍維克公司 編碼人類無調同源物-1(hath1)之腺病毒載體
WO2016070060A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
US10900036B2 (en) 2015-03-17 2021-01-26 The General Hospital Corporation RNA interactome of polycomb repressive complex 1 (PRC1)
CN108137595B (zh) 2015-06-18 2021-04-20 听治疗有限责任公司 预防和治疗听力损失的方法和组合物
WO2017096233A1 (en) 2015-12-04 2017-06-08 Massachusetts Eye And Ear Infirmary Treatment of hearing loss by inhibition of casein kinase 1
CN109219439B (zh) 2016-01-29 2022-09-20 马萨诸塞眼科耳科诊所 内耳支持细胞的扩增和分化及其使用方法
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
CN111655228B (zh) * 2017-05-03 2024-02-09 听治疗有限责任公司 预防和治疗听力损失的组合物和方法
CN111849968A (zh) 2019-04-30 2020-10-30 中美瑞康核酸技术(南通)研究院有限公司 寡核苷酸分子及其在急性间歇性卟啉症治疗中的应用
CA3145567A1 (en) * 2019-07-04 2021-01-07 Ractigen Therapeutics Oligomeric nucleic acid molecule activating atoh1 gene and use thereof
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
WO2021262919A2 (en) 2020-06-26 2021-12-30 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
WO2022020114A2 (en) 2020-07-10 2022-01-27 Ting Therapeutics Llc Methods for the prevention and treatment of hearing loss

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