TWI325866B - Camptothecins with a modified lactone ring - Google Patents

Camptothecins with a modified lactone ring Download PDF

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Publication number
TWI325866B
TWI325866B TW092114164A TW92114164A TWI325866B TW I325866 B TWI325866 B TW I325866B TW 092114164 A TW092114164 A TW 092114164A TW 92114164 A TW92114164 A TW 92114164A TW I325866 B TWI325866 B TW I325866B
Authority
TW
Taiwan
Prior art keywords
group
isocamptothecin
compound
branched
ring
Prior art date
Application number
TW092114164A
Other languages
English (en)
Chinese (zh)
Other versions
TW200404806A (en
Inventor
Mauro Marzi
Elena Marastoni
Sergio Penco
Claudio Pisano
Maria Ornella Tinti
Loredana Vesci
Franco Zunino
Domenico Vergani
Walter Cabri
Marco Alpegiani
Marting Gomez Patricio
Tamara Danelli
Original Assignee
Sigma Tau Ind Farmaceuti
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Ist Naz Stud Cura Dei Tumori filed Critical Sigma Tau Ind Farmaceuti
Publication of TW200404806A publication Critical patent/TW200404806A/zh
Application granted granted Critical
Publication of TWI325866B publication Critical patent/TWI325866B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
TW092114164A 2002-05-31 2003-05-26 Camptothecins with a modified lactone ring TWI325866B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.

Publications (2)

Publication Number Publication Date
TW200404806A TW200404806A (en) 2004-04-01
TWI325866B true TWI325866B (en) 2010-06-11

Family

ID=11456338

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092114164A TWI325866B (en) 2002-05-31 2003-05-26 Camptothecins with a modified lactone ring

Country Status (22)

Country Link
US (1) US7273873B2 (enExample)
EP (2) EP1719775B1 (enExample)
JP (1) JP4693410B2 (enExample)
KR (1) KR101042042B1 (enExample)
CN (1) CN1656100A (enExample)
AR (1) AR040139A1 (enExample)
AT (2) ATE403659T1 (enExample)
AU (2) AU2003241160B2 (enExample)
BR (2) BR0311333A (enExample)
CA (2) CA2485201C (enExample)
CY (2) CY1107311T1 (enExample)
DE (2) DE60322754D1 (enExample)
DK (2) DK1719775T3 (enExample)
ES (2) ES2273002T7 (enExample)
IT (1) ITRM20020305A1 (enExample)
MX (1) MXPA04011682A (enExample)
PE (1) PE20050120A1 (enExample)
PL (1) PL374346A1 (enExample)
PT (2) PT1511752E (enExample)
SI (2) SI1511752T1 (enExample)
TW (1) TWI325866B (enExample)
WO (1) WO2003101995A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) * 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
PL2170900T3 (pl) * 2007-08-01 2013-04-30 Sigma Tau Ind Farmaceuti Krystaliczna forma II 7-(dimetoksymetylo)kamptotecyny, jej zastosowanie jako związek pośredni oraz otrzymane z niej produkty
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
CN112566666A (zh) 2018-05-14 2021-03-26 努瓦申生物公司 靶向抗癌核激素受体的化合物
AU2020274113A1 (en) 2019-05-14 2021-11-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
TW202131930A (zh) 2019-11-13 2021-09-01 美商諾維雪碧歐公司 抗癌核荷爾蒙受體標靶化合物
IL306010A (en) 2021-03-23 2023-11-01 Nuvation Bio Inc Anticancer compounds against the nuclear hormone receptor
CA3218577A1 (en) 2021-05-03 2022-11-10 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
WO2024073626A2 (en) * 2022-09-28 2024-04-04 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
EP1251125B1 (fr) * 1995-06-21 2005-12-07 Société de Conseils et de Recherches d'Applications Scientifiques (S.C.R.A.S.) Nouveaux analogues de la camptoth-cine, des proc-d-s de pr-paration, leur application comme m-dicaments et les compositions pharmaceutiques les contenant
DK1044977T3 (da) * 1999-03-09 2002-07-08 Sigma Tau Ind Farmaceuti Camptothecinderivater med antitumoraktivitet

Also Published As

Publication number Publication date
ES2273002T7 (es) 2011-08-01
EP1719775B1 (en) 2008-08-06
WO2003101995A2 (en) 2003-12-11
PT1719775E (pt) 2008-09-30
SI1511752T1 (sl) 2007-02-28
EP1719775A1 (en) 2006-11-08
BR0311329A (pt) 2005-02-22
AU2009236044A1 (en) 2009-12-03
EP1511752A2 (en) 2005-03-09
ITRM20020305A1 (it) 2003-12-01
AU2003241160A1 (en) 2003-12-19
JP2005531602A (ja) 2005-10-20
CY1108793T1 (el) 2014-04-09
AU2009236044B2 (en) 2011-03-24
AU2009236044A8 (en) 2011-07-21
DE60308368T3 (de) 2010-09-16
EP1511752B3 (en) 2010-03-10
EP1511752B8 (en) 2007-04-18
ES2312090T3 (es) 2009-02-16
DE60308368D1 (de) 2006-10-26
EP1511752B1 (en) 2006-09-13
ATE339422T1 (de) 2006-10-15
AU2009236044B8 (en) 2011-07-21
PL374346A1 (en) 2005-10-17
WO2003101995A8 (en) 2004-12-23
ATE403659T1 (de) 2008-08-15
SI1719775T1 (sl) 2009-04-30
CA2485201A1 (en) 2003-12-11
JP4693410B2 (ja) 2011-06-01
US20050154003A1 (en) 2005-07-14
DK1511752T5 (da) 2010-06-14
DE60322754D1 (de) 2008-09-18
BR0311333A (pt) 2005-03-15
PT1511752E (pt) 2007-01-31
CY1107311T1 (el) 2012-11-21
ITRM20020305A0 (it) 2002-05-31
TW200404806A (en) 2004-04-01
CA2706635A1 (en) 2003-12-11
PE20050120A1 (es) 2005-03-04
CN1656100A (zh) 2005-08-17
KR20050036909A (ko) 2005-04-20
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
CA2485201C (en) 2010-11-02
AU2003241160B2 (en) 2009-08-20
ES2273002T3 (es) 2007-05-01
KR101042042B1 (ko) 2011-06-16
AR040139A1 (es) 2005-03-16
MXPA04011682A (es) 2005-03-31
WO2003101995A3 (en) 2004-02-19
US7273873B2 (en) 2007-09-25
DK1511752T3 (da) 2007-01-29

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MM4A Annulment or lapse of patent due to non-payment of fees