DE60322754D1 - Camptothecine mit modifiziertem Lactonring - Google Patents

Camptothecine mit modifiziertem Lactonring

Info

Publication number
DE60322754D1
DE60322754D1 DE60322754T DE60322754T DE60322754D1 DE 60322754 D1 DE60322754 D1 DE 60322754D1 DE 60322754 T DE60322754 T DE 60322754T DE 60322754 T DE60322754 T DE 60322754T DE 60322754 D1 DE60322754 D1 DE 60322754D1
Authority
DE
Germany
Prior art keywords
camptothecine
lactone ring
modified lactone
modified
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60322754T
Other languages
German (de)
English (en)
Inventor
Mauro Marzi
Elena Marastoni
Sergio Penco
Claudio Pisano
Maria Ornella Tinti
Loredana Vesci
Franco Zunino
Domenico Vergani
Walter Cabri
Marco Alpegiani
Martin Patricio
Tamara Danelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale per lo Studio e la Cura die Tumori
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale per lo Studio e la Cura die Tumori, Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale per lo Studio e la Cura die Tumori
Application granted granted Critical
Publication of DE60322754D1 publication Critical patent/DE60322754D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
DE60322754T 2002-05-31 2003-05-28 Camptothecine mit modifiziertem Lactonring Expired - Lifetime DE60322754D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002RM000305A ITRM20020305A1 (it) 2002-05-31 2002-05-31 Camptotecine con anello lattonico modificato.

Publications (1)

Publication Number Publication Date
DE60322754D1 true DE60322754D1 (de) 2008-09-18

Family

ID=11456338

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60322754T Expired - Lifetime DE60322754D1 (de) 2002-05-31 2003-05-28 Camptothecine mit modifiziertem Lactonring
DE60308368T Expired - Lifetime DE60308368T3 (de) 2002-05-31 2003-05-28 Camptothecine mit modifiziertem lactonring

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60308368T Expired - Lifetime DE60308368T3 (de) 2002-05-31 2003-05-28 Camptothecine mit modifiziertem lactonring

Country Status (22)

Country Link
US (1) US7273873B2 (enExample)
EP (2) EP1511752B3 (enExample)
JP (1) JP4693410B2 (enExample)
KR (1) KR101042042B1 (enExample)
CN (1) CN1656100A (enExample)
AR (1) AR040139A1 (enExample)
AT (2) ATE403659T1 (enExample)
AU (2) AU2003241160B2 (enExample)
BR (2) BR0311333A (enExample)
CA (2) CA2485201C (enExample)
CY (2) CY1107311T1 (enExample)
DE (2) DE60322754D1 (enExample)
DK (2) DK1719775T3 (enExample)
ES (2) ES2312090T3 (enExample)
IT (1) ITRM20020305A1 (enExample)
MX (1) MXPA04011682A (enExample)
PE (1) PE20050120A1 (enExample)
PL (1) PL374346A1 (enExample)
PT (2) PT1719775E (enExample)
SI (2) SI1719775T1 (enExample)
TW (1) TWI325866B (enExample)
WO (1) WO2003101995A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
ITRM20030344A1 (it) 2003-07-14 2005-01-15 Ist Naz Stud Cura Dei Tumori 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi.
ES2400607T3 (es) * 2007-08-01 2013-04-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Forma cristalina ll de 7-(dimetoxi-metil)camptotecina, su uso como compuesto intermedio y productos obtenidos a partir de la misma
CN102746314B (zh) * 2011-04-18 2016-07-06 华东师范大学 含有稳定7元内酯环的喜树碱类化合物、制备方法和用途
CN104530066A (zh) * 2015-01-06 2015-04-22 华东师范大学 一类新型高喜树碱衍生物、制备方法和用途
WO2019222272A1 (en) 2018-05-14 2019-11-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
BR112021022008A2 (pt) 2019-05-14 2022-05-17 Nuvation Bio Inc Compostos de direcionamento a receptor de hormônio nuclear anticâncer
TW202131930A (zh) 2019-11-13 2021-09-01 美商諾維雪碧歐公司 抗癌核荷爾蒙受體標靶化合物
WO2022204184A1 (en) 2021-03-23 2022-09-29 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
AU2022269568A1 (en) 2021-05-03 2023-11-16 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
JP2025532843A (ja) * 2022-09-28 2025-10-03 ニューベイション・バイオ・インコーポレイテッド 抗がん核内ホルモン受容体標的化化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116076A (en) * 1981-01-09 1982-07-19 Yakult Honsha Co Ltd Novel camptothecin derivative and its preparation
US4399276A (en) * 1981-01-09 1983-08-16 Kabushiki Kaisha Yakult Honsha 7-Substituted camptothecin derivatives
FR2532591A1 (fr) 1982-09-02 1984-03-09 Hutchinson Nouveau dispositif de securite pour pneumatiques de vehicules ou autres engins
CN1114608C (zh) * 1995-06-21 2003-07-16 科学研究与运用咨询公司 喜树碱类似物、其制备方法和药物应用及其药物组合物
ES2175919T3 (es) * 1999-03-09 2002-11-16 Sigma Tau Ind Farmaceuti Derivados del camptothecin con actividad antitumoral.

Also Published As

Publication number Publication date
ITRM20020305A0 (it) 2002-05-31
JP2005531602A (ja) 2005-10-20
EP1511752B1 (en) 2006-09-13
EP1511752B3 (en) 2010-03-10
WO2003101995A2 (en) 2003-12-11
DK1511752T5 (da) 2010-06-14
EP1511752B8 (en) 2007-04-18
DE60308368D1 (de) 2006-10-26
CY1107311T1 (el) 2012-11-21
ES2273002T7 (es) 2011-08-01
US20050154003A1 (en) 2005-07-14
TW200404806A (en) 2004-04-01
DE60308368T3 (de) 2010-09-16
ITRM20020305A1 (it) 2003-12-01
WO2003101995A3 (en) 2004-02-19
SI1719775T1 (sl) 2009-04-30
ATE339422T1 (de) 2006-10-15
AU2009236044B2 (en) 2011-03-24
PL374346A1 (en) 2005-10-17
WO2003101995A8 (en) 2004-12-23
PT1511752E (pt) 2007-01-31
BR0311333A (pt) 2005-03-15
BR0311329A (pt) 2005-02-22
TWI325866B (en) 2010-06-11
AU2003241160B2 (en) 2009-08-20
AR040139A1 (es) 2005-03-16
CA2706635A1 (en) 2003-12-11
JP4693410B2 (ja) 2011-06-01
MXPA04011682A (es) 2005-03-31
CA2485201A1 (en) 2003-12-11
CN1656100A (zh) 2005-08-17
EP1719775A1 (en) 2006-11-08
CA2485201C (en) 2010-11-02
EP1719775B1 (en) 2008-08-06
ES2312090T3 (es) 2009-02-16
KR101042042B1 (ko) 2011-06-16
AU2009236044B8 (en) 2011-07-21
PE20050120A1 (es) 2005-03-04
US7273873B2 (en) 2007-09-25
ES2273002T3 (es) 2007-05-01
SI1511752T1 (sl) 2007-02-28
ATE403659T1 (de) 2008-08-15
DE60308368T2 (de) 2007-09-06
DK1719775T3 (da) 2008-11-17
AU2003241160A1 (en) 2003-12-19
AU2009236044A8 (en) 2011-07-21
AU2009236044A1 (en) 2009-12-03
EP1511752A2 (en) 2005-03-09
PT1719775E (pt) 2008-09-30
DK1511752T3 (da) 2007-01-29
KR20050036909A (ko) 2005-04-20
CY1108793T1 (el) 2014-04-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition