TR199802385T2 - TNF inhibit�rleri ve FDE-IV inhibit�rleri olarak kinolin karboksamidler. - Google Patents

TNF inhibit�rleri ve FDE-IV inhibit�rleri olarak kinolin karboksamidler.

Info

Publication number
TR199802385T2
TR199802385T2 TR1998/02385T TR9802385T TR199802385T2 TR 199802385 T2 TR199802385 T2 TR 199802385T2 TR 1998/02385 T TR1998/02385 T TR 1998/02385T TR 9802385 T TR9802385 T TR 9802385T TR 199802385 T2 TR199802385 T2 TR 199802385T2
Authority
TR
Turkey
Prior art keywords
inhibitors
fde
subject invention
compounds
tnf
Prior art date
Application number
TR1998/02385T
Other languages
English (en)
Turkish (tr)
Inventor
Joan Dyke Hazel
Gary Montana John
Lowe Christopher
Jayne Kendall Hannah
Margaret Sabin Verity
Original Assignee
Darwin Discovery Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9610506.9A external-priority patent/GB9610506D0/en
Priority claimed from GBGB9623234.3A external-priority patent/GB9623234D0/en
Priority claimed from GBGB9626883.4A external-priority patent/GB9626883D0/en
Priority claimed from GBGB9708072.5A external-priority patent/GB9708072D0/en
Application filed by Darwin Discovery Limited filed Critical Darwin Discovery Limited
Publication of TR199802385T2 publication Critical patent/TR199802385T2/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
TR1998/02385T 1996-05-20 1997-05-20 TNF inhibit�rleri ve FDE-IV inhibit�rleri olarak kinolin karboksamidler. TR199802385T2 (xx)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9610506.9A GB9610506D0 (en) 1996-05-20 1996-05-20 Novel compounds
GBGB9623234.3A GB9623234D0 (en) 1996-11-07 1996-11-07 Novel compounds
GBGB9626883.4A GB9626883D0 (en) 1996-12-24 1996-12-24 Compounds
GBGB9708072.5A GB9708072D0 (en) 1997-04-22 1997-04-22 Compounds

Publications (1)

Publication Number Publication Date
TR199802385T2 true TR199802385T2 (xx) 1999-04-21

Family

ID=27451451

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/02385T TR199802385T2 (xx) 1996-05-20 1997-05-20 TNF inhibit�rleri ve FDE-IV inhibit�rleri olarak kinolin karboksamidler.

Country Status (19)

Country Link
US (1) US5804588A (enExample)
EP (1) EP0952832B1 (enExample)
JP (1) JP2000510865A (enExample)
KR (1) KR20000065219A (enExample)
CN (1) CN1148189C (enExample)
AT (1) ATE406163T1 (enExample)
AU (1) AU722472B2 (enExample)
BR (1) BR9709015A (enExample)
CA (1) CA2252531A1 (enExample)
CZ (1) CZ296163B6 (enExample)
DE (1) DE69738949D1 (enExample)
IL (1) IL126557A (enExample)
NO (1) NO312099B1 (enExample)
NZ (1) NZ332341A (enExample)
PL (1) PL329922A1 (enExample)
RU (1) RU2170730C2 (enExample)
SK (1) SK283162B6 (enExample)
TR (1) TR199802385T2 (enExample)
WO (1) WO1997044036A1 (enExample)

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CN1219131A (zh) 1999-06-09
CZ365198A3 (cs) 1999-03-17
PL329922A1 (en) 1999-04-26
ATE406163T1 (de) 2008-09-15
CZ296163B6 (cs) 2006-01-11
CN1148189C (zh) 2004-05-05
CA2252531A1 (en) 1997-11-27
IL126557A (en) 2002-09-12
BR9709015A (pt) 1999-08-03
KR20000065219A (ko) 2000-11-06
EP0952832B1 (en) 2008-08-27
US5804588A (en) 1998-09-08
WO1997044036A1 (en) 1997-11-27
DE69738949D1 (de) 2008-10-09
NO985376L (no) 1998-11-19
AU2905897A (en) 1997-12-09
SK160598A3 (en) 1999-12-10
JP2000510865A (ja) 2000-08-22
NO312099B1 (no) 2002-03-18
RU2170730C2 (ru) 2001-07-20
NZ332341A (en) 2000-05-26
IL126557A0 (en) 1999-08-17
NO985376D0 (no) 1998-11-19
EP0952832A1 (en) 1999-11-03
AU722472B2 (en) 2000-08-03

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