TR199700464A3 - Antihistaminik etkili yeni benzimidazole türevleri. - Google Patents

Antihistaminik etkili yeni benzimidazole türevleri.

Info

Publication number
TR199700464A3
TR199700464A3 TR97/00464A TR9700464A TR199700464A3 TR 199700464 A3 TR199700464 A3 TR 199700464A3 TR 97/00464 A TR97/00464 A TR 97/00464A TR 9700464 A TR9700464 A TR 9700464A TR 199700464 A3 TR199700464 A3 TR 199700464A3
Authority
TR
Turkey
Prior art keywords
benzimidazole derivatives
antihistamine effect
new benzimidazole
new
antihistamine
Prior art date
Application number
TR97/00464A
Other languages
English (en)
Turkish (tr)
Other versions
TR199700464A2 (xx
Inventor
Orjales Aurelio
Rubio Victor
Bordell Maravillas
Original Assignee
Fabrica Espanola De Productos Quimicos Y Farmaceuticos,
S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola De Productos Quimicos Y Farmaceuticos,, S.A. filed Critical Fabrica Espanola De Productos Quimicos Y Farmaceuticos,
Publication of TR199700464A2 publication Critical patent/TR199700464A2/xx
Publication of TR199700464A3 publication Critical patent/TR199700464A3/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TR97/00464A 1996-06-04 1997-06-04 Antihistaminik etkili yeni benzimidazole türevleri. TR199700464A3 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (2)

Publication Number Publication Date
TR199700464A2 TR199700464A2 (xx) 1997-12-21
TR199700464A3 true TR199700464A3 (tr) 1997-12-21

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00464A TR199700464A3 (tr) 1996-06-04 1997-06-04 Antihistaminik etkili yeni benzimidazole türevleri.

Country Status (27)

Country Link
US (1) US5877187A (cg-RX-API-DMAC7.html)
EP (1) EP0818454B1 (cg-RX-API-DMAC7.html)
JP (1) JP4218991B2 (cg-RX-API-DMAC7.html)
CN (1) CN1105716C (cg-RX-API-DMAC7.html)
AR (1) AR008386A1 (cg-RX-API-DMAC7.html)
AT (1) ATE264317T1 (cg-RX-API-DMAC7.html)
AU (1) AU725700B2 (cg-RX-API-DMAC7.html)
BR (1) BR9703276A (cg-RX-API-DMAC7.html)
CA (1) CA2206754C (cg-RX-API-DMAC7.html)
CZ (1) CZ289278B6 (cg-RX-API-DMAC7.html)
DE (2) DE69728608T2 (cg-RX-API-DMAC7.html)
DK (1) DK0818454T3 (cg-RX-API-DMAC7.html)
ES (1) ES2124167B1 (cg-RX-API-DMAC7.html)
FR (1) FR11C0023I2 (cg-RX-API-DMAC7.html)
HR (1) HRP970307B1 (cg-RX-API-DMAC7.html)
HU (1) HU227598B1 (cg-RX-API-DMAC7.html)
IN (1) IN186319B (cg-RX-API-DMAC7.html)
LU (1) LU91798I2 (cg-RX-API-DMAC7.html)
MX (1) MXPA97004127A (cg-RX-API-DMAC7.html)
NO (2) NO313195B1 (cg-RX-API-DMAC7.html)
PL (1) PL188908B1 (cg-RX-API-DMAC7.html)
PT (1) PT818454E (cg-RX-API-DMAC7.html)
RU (1) RU2182150C2 (cg-RX-API-DMAC7.html)
SI (1) SI0818454T1 (cg-RX-API-DMAC7.html)
TR (1) TR199700464A3 (cg-RX-API-DMAC7.html)
TW (1) TW438794B (cg-RX-API-DMAC7.html)
ZA (1) ZA974893B (cg-RX-API-DMAC7.html)

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HUP0200749A3 (en) 1998-11-27 2003-03-28 Basf Ag Substituted benzimidazoles and their use as parp inhibitors and process for their preparation
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
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RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
EP1511482B1 (en) * 2002-06-13 2006-11-15 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101123903B1 (ko) 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
WO2014149019A1 (en) * 2013-03-15 2014-09-25 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
ES2600827B9 (es) * 2015-07-24 2018-03-28 Urquima, S.A Formas cristalinas de bilastina y procedimientos para su preparación
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
DK3681475T3 (da) 2017-10-16 2021-02-01 Faes Farma Sa Vandige sammensætninger omfattende bilastin og mometason
PL3641735T3 (pl) 2017-12-18 2021-09-06 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Kompozycja farmaceutyczna tabletki zawierająca bilastynę w postaci 3 i rozpuszczalny w wodzie wypełniacz
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
EP3915539A1 (en) 2018-01-18 2021-12-01 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
EP4188339A1 (en) 2020-07-30 2023-06-07 Faes Farma, S.A. Decongestant drug delivery system
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
JP2023549381A (ja) 2020-11-18 2023-11-24 バイオファーマ・シナジーズ，エス．エル． 抗ヒスタミン活性化合物を含む口内分散性粉末組成物
CA3200779A1 (en) 2020-12-23 2022-06-30 Strusi ORAZIO LUCA A non-micronized bilastine composition
CA3243849A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. COMPOSITION OF BILASTIN FOR ONCE-DAILY PARENTERAL ADMINISTRATION
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

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EP0525129A4 (en) * 1990-04-13 1993-03-24 Smith-Kline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
FI950467L (fi) * 1992-08-03 1995-03-31 Sepracor Inc Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit allergisten sairauksien hoitamiseksi
CN1168717C (zh) * 1993-06-25 2004-09-29 默里尔药物公司 用于制备抗组胺哌啶衍生物的新中间体

Also Published As

Publication number Publication date
PL320358A1 (en) 1997-12-08
PL188908B1 (pl) 2005-05-31
IN186319B (cg-RX-API-DMAC7.html) 2001-08-04
US5877187A (en) 1999-03-02
HU9700997D0 (en) 1997-07-28
EP0818454B1 (en) 2004-04-14
JPH1059961A (ja) 1998-03-03
CA2206754C (en) 2007-01-23
AU2467297A (en) 1997-12-11
EP0818454A1 (en) 1998-01-14
ES2124167A1 (es) 1999-01-16
BR9703276A (pt) 2004-08-17
MXPA97004127A (es) 2005-07-25
JP4218991B2 (ja) 2009-02-04
PT818454E (pt) 2004-08-31
TR199700464A2 (xx) 1997-12-21
SI0818454T1 (en) 2004-08-31
CN1105716C (zh) 2003-04-16
HRP970307B1 (en) 2002-02-28
HU227598B1 (en) 2011-09-28
NO972525L (no) 1997-12-05
FR11C0023I2 (fr) 2012-03-16
AR008386A1 (es) 2000-01-19
HUP9700997A1 (hu) 1999-09-28
ES2124167B1 (es) 1999-09-16
NO2011008I2 (no) 2012-05-14
CZ172397A3 (en) 1997-12-17
ZA974893B (en) 1997-12-30
DE122011000006I1 (de) 2011-06-16
NO313195B1 (no) 2002-08-26
CZ289278B6 (cs) 2001-12-12
NO972525D0 (no) 1997-06-03
HRP970307A2 (en) 1998-04-30
DE69728608T2 (de) 2005-04-21
CA2206754A1 (en) 1997-12-04
TW438794B (en) 2001-06-07
ATE264317T1 (de) 2004-04-15
AU725700B2 (en) 2000-10-19
RU2182150C2 (ru) 2002-05-10
DE69728608D1 (de) 2004-05-19
FR11C0023I1 (cg-RX-API-DMAC7.html) 2011-08-19
CN1176964A (zh) 1998-03-25
LU91798I2 (fr) 2011-05-23
NO2011008I1 (no) 2011-06-06
DK0818454T3 (da) 2004-07-12

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