HRP970307B1 - New benzimidazole derivatives with antihistaminic activity - Google Patents

New benzimidazole derivatives with antihistaminic activity

Info

Publication number
HRP970307B1
HRP970307B1 HR970307A HRP970307A HRP970307B1 HR P970307 B1 HRP970307 B1 HR P970307B1 HR 970307 A HR970307 A HR 970307A HR P970307 A HRP970307 A HR P970307A HR P970307 B1 HRP970307 B1 HR P970307B1
Authority
HR
Croatia
Prior art keywords
benzimidazole derivatives
antihistaminic activity
new benzimidazole
new
antihistaminic
Prior art date
Application number
HR970307A
Other languages
English (en)
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Publication of HRP970307A2 publication Critical patent/HRP970307A2/xx
Publication of HRP970307B1 publication Critical patent/HRP970307B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR970307A 1996-06-04 1997-06-03 New benzimidazole derivatives with antihistaminic activity HRP970307B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (2)

Publication Number Publication Date
HRP970307A2 HRP970307A2 (en) 1998-04-30
HRP970307B1 true HRP970307B1 (en) 2002-02-28

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970307A HRP970307B1 (en) 1996-06-04 1997-06-03 New benzimidazole derivatives with antihistaminic activity

Country Status (27)

Country Link
US (1) US5877187A (cg-RX-API-DMAC7.html)
EP (1) EP0818454B1 (cg-RX-API-DMAC7.html)
JP (1) JP4218991B2 (cg-RX-API-DMAC7.html)
CN (1) CN1105716C (cg-RX-API-DMAC7.html)
AR (1) AR008386A1 (cg-RX-API-DMAC7.html)
AT (1) ATE264317T1 (cg-RX-API-DMAC7.html)
AU (1) AU725700B2 (cg-RX-API-DMAC7.html)
BR (1) BR9703276A (cg-RX-API-DMAC7.html)
CA (1) CA2206754C (cg-RX-API-DMAC7.html)
CZ (1) CZ289278B6 (cg-RX-API-DMAC7.html)
DE (2) DE69728608T2 (cg-RX-API-DMAC7.html)
DK (1) DK0818454T3 (cg-RX-API-DMAC7.html)
ES (1) ES2124167B1 (cg-RX-API-DMAC7.html)
FR (1) FR11C0023I2 (cg-RX-API-DMAC7.html)
HR (1) HRP970307B1 (cg-RX-API-DMAC7.html)
HU (1) HU227598B1 (cg-RX-API-DMAC7.html)
IN (1) IN186319B (cg-RX-API-DMAC7.html)
LU (1) LU91798I2 (cg-RX-API-DMAC7.html)
MX (1) MXPA97004127A (cg-RX-API-DMAC7.html)
NO (2) NO313195B1 (cg-RX-API-DMAC7.html)
PL (1) PL188908B1 (cg-RX-API-DMAC7.html)
PT (1) PT818454E (cg-RX-API-DMAC7.html)
RU (1) RU2182150C2 (cg-RX-API-DMAC7.html)
SI (1) SI0818454T1 (cg-RX-API-DMAC7.html)
TR (1) TR199700464A3 (cg-RX-API-DMAC7.html)
TW (1) TW438794B (cg-RX-API-DMAC7.html)
ZA (1) ZA974893B (cg-RX-API-DMAC7.html)

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HUP0200749A3 (en) 1998-11-27 2003-03-28 Basf Ag Substituted benzimidazoles and their use as parp inhibitors and process for their preparation
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
EP1505066B1 (en) * 2002-04-19 2006-12-06 Faes Farma, S.A. Polymorph of acid 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-il]-1-piperidinyl]ethyl]-alpha, alpha-dimethyl-benzeneacetic
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
EP1511482B1 (en) * 2002-06-13 2006-11-15 Vertex Pharmaceuticals Incorporated 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase iv inhibitors for the treatment of bacterial infections
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101123903B1 (ko) 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
WO2014149019A1 (en) * 2013-03-15 2014-09-25 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
ES2600827B9 (es) * 2015-07-24 2018-03-28 Urquima, S.A Formas cristalinas de bilastina y procedimientos para su preparación
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
DK3681475T3 (da) 2017-10-16 2021-02-01 Faes Farma Sa Vandige sammensætninger omfattende bilastin og mometason
PL3641735T3 (pl) 2017-12-18 2021-09-06 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Kompozycja farmaceutyczna tabletki zawierająca bilastynę w postaci 3 i rozpuszczalny w wodzie wypełniacz
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
EP3915539A1 (en) 2018-01-18 2021-12-01 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
EP4188339A1 (en) 2020-07-30 2023-06-07 Faes Farma, S.A. Decongestant drug delivery system
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
JP2023549381A (ja) 2020-11-18 2023-11-24 バイオファーマ・シナジーズ，エス．エル． 抗ヒスタミン活性化合物を含む口内分散性粉末組成物
CA3200779A1 (en) 2020-12-23 2022-06-30 Strusi ORAZIO LUCA A non-micronized bilastine composition
CA3243849A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. COMPOSITION OF BILASTIN FOR ONCE-DAILY PARENTERAL ADMINISTRATION
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

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GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
EP0525129A4 (en) * 1990-04-13 1993-03-24 Smith-Kline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
FI950467L (fi) * 1992-08-03 1995-03-31 Sepracor Inc Terfenadiinin metaboliitit ja niiden optisesti puhtaat isomeerit allergisten sairauksien hoitamiseksi
CN1168717C (zh) * 1993-06-25 2004-09-29 默里尔药物公司 用于制备抗组胺哌啶衍生物的新中间体

Also Published As

Publication number Publication date
PL320358A1 (en) 1997-12-08
PL188908B1 (pl) 2005-05-31
IN186319B (cg-RX-API-DMAC7.html) 2001-08-04
US5877187A (en) 1999-03-02
HU9700997D0 (en) 1997-07-28
EP0818454B1 (en) 2004-04-14
JPH1059961A (ja) 1998-03-03
CA2206754C (en) 2007-01-23
AU2467297A (en) 1997-12-11
EP0818454A1 (en) 1998-01-14
ES2124167A1 (es) 1999-01-16
BR9703276A (pt) 2004-08-17
MXPA97004127A (es) 2005-07-25
JP4218991B2 (ja) 2009-02-04
PT818454E (pt) 2004-08-31
TR199700464A2 (xx) 1997-12-21
SI0818454T1 (en) 2004-08-31
CN1105716C (zh) 2003-04-16
HU227598B1 (en) 2011-09-28
NO972525L (no) 1997-12-05
TR199700464A3 (tr) 1997-12-21
FR11C0023I2 (fr) 2012-03-16
AR008386A1 (es) 2000-01-19
HUP9700997A1 (hu) 1999-09-28
ES2124167B1 (es) 1999-09-16
NO2011008I2 (no) 2012-05-14
CZ172397A3 (en) 1997-12-17
ZA974893B (en) 1997-12-30
DE122011000006I1 (de) 2011-06-16
NO313195B1 (no) 2002-08-26
CZ289278B6 (cs) 2001-12-12
NO972525D0 (no) 1997-06-03
HRP970307A2 (en) 1998-04-30
DE69728608T2 (de) 2005-04-21
CA2206754A1 (en) 1997-12-04
TW438794B (en) 2001-06-07
ATE264317T1 (de) 2004-04-15
AU725700B2 (en) 2000-10-19
RU2182150C2 (ru) 2002-05-10
DE69728608D1 (de) 2004-05-19
FR11C0023I1 (cg-RX-API-DMAC7.html) 2011-08-19
CN1176964A (zh) 1998-03-25
LU91798I2 (fr) 2011-05-23
NO2011008I1 (no) 2011-06-06
DK0818454T3 (da) 2004-07-12

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: FAES FARMA, S.A., ES

ODRP Renewal fee for the maintenance of a patent

Payment date: 20160523

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20170603