TN2010000293A1 - Thiazole derivatives used as pi 3 kinase inhibitors - Google Patents

Thiazole derivatives used as pi 3 kinase inhibitors

Info

Publication number
TN2010000293A1
TN2010000293A1 TN2010000293A TN2010000293A TN2010000293A1 TN 2010000293 A1 TN2010000293 A1 TN 2010000293A1 TN 2010000293 A TN2010000293 A TN 2010000293A TN 2010000293 A TN2010000293 A TN 2010000293A TN 2010000293 A1 TN2010000293 A1 TN 2010000293A1
Authority
TN
Tunisia
Prior art keywords
kinase inhibitors
derivatives used
thiazole derivatives
compounds
kinase
Prior art date
Application number
TN2010000293A
Other languages
English (en)
Inventor
Giorgio Caravatti
Robin Alec Fairhurst
Pascal Furet
Vito Guagnano
Patricia Imbach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TN2010000293A1 publication Critical patent/TN2010000293A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TN2010000293A 2007-12-20 2010-06-18 Thiazole derivatives used as pi 3 kinase inhibitors TN2010000293A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07150228 2007-12-20
PCT/EP2008/067859 WO2009080694A1 (fr) 2007-12-20 2008-12-18 Dérivés de thiazole utilisés comme inhibiteur de la pi 3 kinase

Publications (1)

Publication Number Publication Date
TN2010000293A1 true TN2010000293A1 (en) 2011-11-11

Family

ID=39273277

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2010000293A TN2010000293A1 (en) 2007-12-20 2010-06-18 Thiazole derivatives used as pi 3 kinase inhibitors

Country Status (28)

Country Link
US (1) US8940771B2 (fr)
EP (1) EP2240475B1 (fr)
JP (1) JP2011506560A (fr)
KR (1) KR20100093129A (fr)
CN (1) CN101952282A (fr)
AR (1) AR069798A1 (fr)
AU (1) AU2008340053A1 (fr)
BR (1) BRPI0820722A2 (fr)
CA (1) CA2710122A1 (fr)
CL (1) CL2008003822A1 (fr)
CO (1) CO6321276A2 (fr)
CR (1) CR11491A (fr)
DO (1) DOP2010000183A (fr)
EA (1) EA201000947A1 (fr)
EC (1) ECSP10010271A (fr)
ES (1) ES2437595T3 (fr)
IL (1) IL206286A0 (fr)
MA (1) MA31903B1 (fr)
NI (1) NI201000107A (fr)
PA (1) PA8809001A1 (fr)
PE (1) PE20091523A1 (fr)
SM (1) SMP201000096B (fr)
SV (1) SV2010003598A (fr)
TN (1) TN2010000293A1 (fr)
TW (1) TW200930364A (fr)
UY (1) UY31545A1 (fr)
WO (1) WO2009080694A1 (fr)
ZA (1) ZA201003928B (fr)

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WO2009012421A1 (fr) 2007-07-17 2009-01-22 Rigel Pharmaceuticals, Inc. Pyrimidinediamines substituées par des amines cycliques utilisées en tant qu'inhibiteurs de la pkc
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AU2010268058A1 (en) * 2009-07-02 2012-01-19 Novartis Ag 2-carboxamide cycloamino ureas useful as PI3K inhibitors
EP2475668A1 (fr) 2009-09-10 2012-07-18 Novartis AG Dérivés éthers d'hétéroaryles bicycliques
US20120289501A1 (en) 2009-11-25 2012-11-15 Novartis Ag Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
US20130085161A1 (en) 2010-06-17 2013-04-04 Novartis Ag Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
JP2013528635A (ja) 2010-06-17 2013-07-11 ノバルティス アーゲー ビフェニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
WO2012062694A1 (fr) 2010-11-08 2012-05-18 Novartis Ag Utilisation de dérivés 2-carboxamide cycloamino urée dans le traitement de maladies dépendantes d'egfr ou de maladies qui ont acquis une résistance aux agents qui ciblent des membres de la famille d'egfr
UA112539C2 (uk) 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
EP2683722A1 (fr) 2011-03-08 2014-01-15 Novartis AG Composés hétéroaryliques bicycliques de type fluorophényle
EP2763532B1 (fr) * 2011-10-05 2018-09-19 The Board of Trustees of the Leland Stanford Junior University Inhibiteurs de pi-kinase à activité anti-infectieuse à large spectre
US9926309B2 (en) 2011-10-05 2018-03-27 The Board Of Trustees Of The Leland Stanford Junior University Pi-kinase inhibitors with anti-infective activity
US20150051252A1 (en) * 2012-03-30 2015-02-19 Xizhong Huang Compounds for use in the treatment of neuroblastoma, ewing's sarcoma or rhabdomyosarcoma
KR101761464B1 (ko) 2012-05-23 2017-07-25 에프. 호프만-라 로슈 아게 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
ES2686689T3 (es) * 2012-09-20 2018-10-19 Novartis Ag Combinación farmacéutica que comprende un inhibidor de fosfatidilinositol 3-quinasa y un inhibidor de aromatasa
CN103232406B (zh) * 2013-04-26 2015-07-29 北京大学 一种1,3-噻唑衍生物
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CN105294546B (zh) * 2015-10-29 2017-12-08 天津市斯芬克司药物研发有限公司 一种吡啶化合物及其制备方法
US11091472B2 (en) 2016-02-26 2021-08-17 The Regents Of The University Of California PI-kinase inhibitors with anti-infective activity
CN109111439B (zh) * 2017-06-26 2020-09-18 深圳市塔吉瑞生物医药有限公司 一种酰胺类化合物及包含该化合物的组合物及其用途
CA3115103A1 (fr) * 2018-10-05 2020-04-09 Sloan-Kettering Institute For Cancer Research Inhibiteurs de pi3k et leurs utilisations
CN110759900B (zh) * 2019-10-25 2021-07-30 沈阳药科大学 噻吩类化合物的制备方法和用途
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WO2024089272A1 (fr) * 2022-10-28 2024-05-02 Institut National De La Sante Et De La Recherche Medicale Nouveaux inhibiteurs de la phosphatidylinositol 3-kinase

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NI201000107A (es) 2011-03-15
DOP2010000183A (es) 2010-07-31
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CO6321276A2 (es) 2011-09-20
PE20091523A1 (es) 2009-10-29
EP2240475A1 (fr) 2010-10-20
ZA201003928B (en) 2011-04-28
CA2710122A1 (fr) 2009-07-02
UY31545A1 (es) 2009-08-03
MA31903B1 (fr) 2010-12-01
CR11491A (es) 2010-08-05
IL206286A0 (en) 2010-12-30
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CN101952282A (zh) 2011-01-19
US20090163469A1 (en) 2009-06-25
CL2008003822A1 (es) 2009-06-26
EP2240475B1 (fr) 2013-09-25
SV2010003598A (es) 2011-03-23
ES2437595T3 (es) 2014-01-13
WO2009080694A1 (fr) 2009-07-02
US8940771B2 (en) 2015-01-27
ECSP10010271A (es) 2010-07-30
AU2008340053A1 (en) 2009-07-02
PA8809001A1 (es) 2009-07-23
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SMAP201000096A (it) 2010-09-10
BRPI0820722A2 (pt) 2015-06-16

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