TN2010000256A1 - Organic compound - Google Patents
Organic compoundInfo
- Publication number
- TN2010000256A1 TN2010000256A1 TN2010000256A TN2010000256A TN2010000256A1 TN 2010000256 A1 TN2010000256 A1 TN 2010000256A1 TN 2010000256 A TN2010000256 A TN 2010000256A TN 2010000256 A TN2010000256 A TN 2010000256A TN 2010000256 A1 TN2010000256 A1 TN 2010000256A1
- Authority
- TN
- Tunisia
- Prior art keywords
- blockade
- respond
- compounds
- sodium channel
- organic compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Image Analysis (AREA)
- Image Processing (AREA)
- Pyridine Compounds (AREA)
- Processing Or Creating Images (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07122739 | 2007-12-10 | ||
PCT/EP2008/067110 WO2009074575A2 (fr) | 2007-12-10 | 2008-12-09 | Composés organiques |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000256A1 true TN2010000256A1 (en) | 2011-11-11 |
Family
ID=39322745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TN2010000256A TN2010000256A1 (en) | 2007-12-10 | 2010-06-04 | Organic compound |
Country Status (30)
Country | Link |
---|---|
US (5) | US8039472B2 (fr) |
EP (3) | EP2444120B1 (fr) |
JP (1) | JP5455922B2 (fr) |
KR (1) | KR101578235B1 (fr) |
CN (1) | CN101939054B (fr) |
AR (1) | AR069637A1 (fr) |
AU (1) | AU2008334629B2 (fr) |
BR (1) | BRPI0820669A2 (fr) |
CA (1) | CA2707857C (fr) |
CL (1) | CL2008003651A1 (fr) |
CO (1) | CO6310968A2 (fr) |
CR (1) | CR11470A (fr) |
CU (1) | CU23967B1 (fr) |
EA (1) | EA017919B1 (fr) |
EC (1) | ECSP10010242A (fr) |
ES (2) | ES2602331T3 (fr) |
HN (1) | HN2010001165A (fr) |
IL (1) | IL206165A0 (fr) |
MA (1) | MA31894B1 (fr) |
MX (1) | MX2010006421A (fr) |
MY (1) | MY152955A (fr) |
NZ (1) | NZ585789A (fr) |
PE (1) | PE20091096A1 (fr) |
PL (1) | PL2444120T3 (fr) |
PT (1) | PT2444120T (fr) |
TN (1) | TN2010000256A1 (fr) |
TW (1) | TWI439462B (fr) |
UA (1) | UA104997C2 (fr) |
WO (1) | WO2009074575A2 (fr) |
ZA (1) | ZA201003837B (fr) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
MX2010006421A (es) * | 2007-12-10 | 2010-06-25 | Novartis Ag | Compuestos organicos. |
AU2009246799B2 (en) | 2008-02-26 | 2014-02-27 | Parion Sciences, Inc. | Poly aromatic pyrazinoylguanidine sodium channel blockers |
UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
EP2421532A4 (fr) * | 2008-10-02 | 2012-07-04 | Univ Johns Hopkins | Dérivés de spipérone et méthodes de traitement de troubles |
TWI465449B (zh) | 2008-10-23 | 2014-12-21 | Vertex Pharma | 囊腫性纖維化跨膜傳導調節因子之調控因子 |
DK2433940T3 (en) * | 2009-04-28 | 2015-01-12 | Chugai Pharmaceutical Co Ltd | Spiroimidazolonderivat |
US9549967B2 (en) | 2009-05-29 | 2017-01-24 | The University Of North Carolina At Chapel Hill | Regulation of sodium channels by PLUNC proteins |
EP2490687A1 (fr) * | 2009-10-22 | 2012-08-29 | Vertex Pharmaceuticals Incorporated | Compositions destinées au traitement de la mucoviscidose et d'autres maladies chroniques |
MX2012004791A (es) | 2009-10-23 | 2013-02-01 | Vertex Pharma | Formas sólidas de n-(4-(7-azabiciclo[2.2.1]heptan-7-il)-2-(trifluo rometil)fenil)-4-oxo-5-(trifluorometil)-1,4-dihidroquinolina-3-ca rboxamida. |
BR112012009583A2 (pt) | 2009-10-23 | 2015-09-29 | Vertex Pharma | processo para preparação de moduladores de regulador de condutância de transmembrana de fibrose cística |
WO2011146886A1 (fr) | 2010-05-20 | 2011-11-24 | Vertex Pharmaceuticals Incorporated | Procédés de production de modulateurs du régulateur de conductance transmembranaire de la fibrose kystique |
US8372845B2 (en) * | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
US9050339B2 (en) | 2010-09-17 | 2015-06-09 | Novartis Ag | Pyrazine derivatives as ENaC blockers |
AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
WO2013030803A1 (fr) | 2011-09-02 | 2013-03-07 | Novartis Ag | Sel de choline d'un composé anti-inflammatoire à base de cyclobutènedione substitué |
US8759349B2 (en) | 2011-11-02 | 2014-06-24 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
EA201400522A1 (ru) | 2011-11-02 | 2014-10-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новый способ получения ацилгуанидинов и ацилтиомочевин |
US8809340B2 (en) * | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
WO2013155406A1 (fr) * | 2012-04-12 | 2013-10-17 | The Chinese University Of Hong Kong | Contragestion et traitement d'une inflammation par la modulation de l'activité d'un canal sodique dans l'épithélium |
EP2838882A1 (fr) | 2012-04-20 | 2015-02-25 | Vertex Pharmaceuticals Incorporated | Formes solides de n-[2,4-bis(1,1-diméthyléthyle)-5-hydroxyphényle]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
JP6072920B2 (ja) * | 2012-09-24 | 2017-02-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 複素環化合物、前記化合物を含む薬物、これらの使用及びこれらの調製方法 |
HRP20181740T4 (hr) | 2012-11-02 | 2024-01-05 | Vertex Pharmaceuticals Incorporated | Farmaceutski pripravci za liječenje bolesti koje su posredovane s cftr |
NZ707946A (en) | 2012-12-10 | 2019-11-29 | Chugai Pharmaceutical Co Ltd | Hydantoin derivative |
CA2895512C (fr) | 2012-12-17 | 2021-10-19 | Parion Sciences, Inc. | Derives de chloro-pyrazine carboxamide utiles dans le traitement de maladies favorisees par une hydratation insuffisante des muqueuses |
ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
CA2914178C (fr) | 2013-01-07 | 2023-06-13 | University Of Southern California | Inhibiteurs de la desoxyuridine triphosphatase |
DE202013000888U1 (de) | 2013-01-29 | 2014-05-05 | WKW Erbslöh Automotive GmbH | Vorrichtung zur Abdeckung eines in Längsrichtung eines Kraftfahrzeuges verlaufenden Dachkanals |
WO2014141064A1 (fr) | 2013-03-13 | 2014-09-18 | Novartis Ag | Molécules de liaison à notch2 pour le traitement de maladies respiratoires |
EP2991981B1 (fr) * | 2013-04-30 | 2017-03-01 | Boehringer Ingelheim International GmbH | Composés de diaminopyrazine, médicaments contenant lesdits composés, leur utilisation et leurs procédés de préparation |
EP2815749A1 (fr) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Forme solide de 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione ayant un réseau de diffraction de rayons X spécifique |
WO2015003083A1 (fr) * | 2013-07-02 | 2015-01-08 | The California Institute For Biomedical Research | Composés destinés au traitement de la mucosviscidose |
US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
WO2015103489A1 (fr) | 2014-01-03 | 2015-07-09 | University Of Southern California | Hétéroatome contenant des inhibiteurs de la désoxyuridine triphosphatase |
UY36034A (es) | 2014-03-18 | 2015-09-30 | Astrazeneca Ab | Derivados de 3,5-diamino-6-cloro-pirazina-2-carboxamida y sales farmaceuticamente aceptables de estos |
EP2932966A1 (fr) | 2014-04-16 | 2015-10-21 | Novartis AG | Inhibiteurs de la gamma sécrétase pour traiter des maladies respiratoires |
MX371090B (es) | 2014-06-09 | 2020-01-16 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica que contiene derivado de hidantoina. |
RU2017115994A (ru) * | 2014-10-08 | 2018-11-12 | Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл | Улучшенные пептидные ингибиторы натриевых каналов |
BR112017009194A2 (pt) | 2014-10-31 | 2017-12-26 | Abbvie Sarl | tetra-hidropiranos substituídos e método de uso |
US9932324B2 (en) * | 2015-01-12 | 2018-04-03 | Boehringer Ingelheim International Gmbh | Substituted benzimidazolium compounds useful in the treatment of respiratory diseases |
JP6667537B2 (ja) * | 2015-01-12 | 2020-03-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系疾患の治療に有用な四置換及び五置換ベンズイミダゾリウム化合物 |
WO2016113167A1 (fr) * | 2015-01-12 | 2016-07-21 | Boehringer Ingelheim International Gmbh | Composés subtitués à base de benzimidazolium utilisables dans le traitement de maladies respiratoires |
US10047051B2 (en) | 2015-06-02 | 2018-08-14 | Abbvie S.Á.R.L. | Substituted pyridines and method of use |
FR3038605B1 (fr) * | 2015-07-06 | 2018-08-24 | Universite Amiens Picardie Jules Verne | Diamines primaires vicinales associees a des motifs chelateurs de metaux et/ou de radicaux libres, actives contre les stress carbonyle et oxydant et leur utilisation |
CN107922330A (zh) * | 2015-07-08 | 2018-04-17 | Cv6治疗(Ni)有限公司 | 含乙内酰脲的脱氧尿苷三磷酸酶抑制剂 |
WO2017006283A1 (fr) | 2015-07-08 | 2017-01-12 | Cv6 Therapeutics (Ni) Limited | Inhibiteurs de désoxyuridine triphosphatase contenant une liaison cyclopropano |
US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
WO2017006271A1 (fr) | 2015-07-08 | 2017-01-12 | University Of Southern California | Inhibiteurs de désoxyuridine triphosphatase contenant une liaison sulfonyle aminée |
US9840513B2 (en) | 2015-07-16 | 2017-12-12 | Abbvie S.Á.R.L. | Substituted tricyclics and method of use |
ES2829636T3 (es) | 2015-10-09 | 2021-06-01 | Abbvie Overseas Sarl | Pirazolo[3,4-b]piridin-6-carboxamidas N-sulfoniladas y método de uso |
CA3001094A1 (fr) | 2015-10-09 | 2017-04-13 | Abbvie S.A.R.L. | Acides pyrazolo[3,4-b]pyridin-6-carboxyliques substitues et leur utilisation |
CA3000802A1 (fr) | 2015-10-09 | 2017-04-13 | Abbvie S.A.R.L. | Nouveaux composes destines au traitement de la fibrose kystique |
US10372306B2 (en) * | 2016-04-16 | 2019-08-06 | Apple Inc. | Organized timeline |
BR112018072047A2 (pt) | 2016-04-26 | 2019-02-12 | AbbVie S.à.r.l. | moduladores da proteína reguladora de condutância transmembranar de fibrose cística |
US10138227B2 (en) | 2016-06-03 | 2018-11-27 | Abbvie S.Á.R.L. | Heteroaryl substituted pyridines and methods of use |
GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
US9981910B2 (en) | 2016-10-07 | 2018-05-29 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
US10399940B2 (en) | 2016-10-07 | 2019-09-03 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
WO2018098208A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Inhibiteurs de désoxyuridine triphosphatase liés à un cycle azote |
US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
WO2018098204A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Isostères d'uracile à 6 chaînons |
US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
WO2018098209A1 (fr) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Composés aminosulfonyle |
US20200123137A1 (en) | 2016-12-20 | 2020-04-23 | AbbVie S.à.r.l. | Deuterated cftr modulators and methods of use |
US11247984B2 (en) | 2017-01-05 | 2022-02-15 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
TW201831471A (zh) | 2017-02-24 | 2018-09-01 | 盧森堡商艾伯維公司 | 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法 |
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AU2006279810B2 (en) | 2005-08-11 | 2011-10-27 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
NL2000284C2 (nl) | 2005-11-04 | 2007-09-28 | Pfizer Ltd | Pyrazine-derivaten. |
GB0526240D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
GB0526244D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
CL2006003737A1 (es) | 2005-12-29 | 2008-02-08 | Janssen Pharmaceutica Nv | Uso de compuestos derivados de triazina o pirimidina sustituida, para tratar o prevenir enfermedades mediadas por los receptores de prokineticina 2 tales como trastornos gastrointestinales. |
NZ577603A (en) | 2006-12-14 | 2012-04-27 | Janssen Pharmaceutica Nv | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
US8450348B2 (en) | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
MX2010006421A (es) | 2007-12-10 | 2010-06-25 | Novartis Ag | Compuestos organicos. |
CL2008003667A1 (es) | 2007-12-10 | 2010-06-04 | Synthon Bv | Proceso de preparacion de etil-6,7,8,9-tetrahidro-9-hidroxi-2-metil-4h-pirido[1,2-a]piridin-4-ona; y uno de los intermediarios considerados en el proceso descrito; util en la preparacion de paliperidona. |
JPWO2010027002A1 (ja) | 2008-09-05 | 2012-02-02 | 塩野義製薬株式会社 | Pi3k阻害活性を有する縮環モルホリン誘導体 |
EP2493888B1 (fr) | 2009-10-29 | 2016-04-06 | GlaxoSmithKline LLC | Pyridines bicycliques et analogues en tant que modulateurs de la sirtuine |
AU2014338549B2 (en) | 2013-10-25 | 2017-05-25 | Novartis Ag | Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors |
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