EA200970422A1 - Аналоги пиразола - Google Patents

Аналоги пиразола

Info

Publication number
EA200970422A1
EA200970422A1 EA200970422A EA200970422A EA200970422A1 EA 200970422 A1 EA200970422 A1 EA 200970422A1 EA 200970422 A EA200970422 A EA 200970422A EA 200970422 A EA200970422 A EA 200970422A EA 200970422 A1 EA200970422 A1 EA 200970422A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
pyrazole
analogue
disorders
preparation
Prior art date
Application number
EA200970422A
Other languages
English (en)
Other versions
EA016588B1 (ru
Inventor
Меттью Дж. Грането
Тодд Майкл Мэддакс
Джейме Л. Масферрер
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200970422A1 publication Critical patent/EA200970422A1/ru
Publication of EA016588B1 publication Critical patent/EA016588B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I) или их фармацевтически приемлемой соли и сольвату, где Rобозначает F или Н, и к способам их получения, к промежуточным соединениям, которые используются при их получении, к композициям, содержащим подобные соединения, и к использованию подобных соединений. Соединения по настоящему изобретению пригодны для использования при многочисленных заболеваниях, расстройствах и состояниях, в частности аллергических и респираторных заболеваниях, расстройствах и состояниях.
EA200970422A 2006-11-27 2007-11-14 Аналоги пиразола EA016588B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86733706P 2006-11-27 2006-11-27
PCT/IB2007/003518 WO2008065493A1 (en) 2006-11-27 2007-11-14 Pyrazole analogs

Publications (2)

Publication Number Publication Date
EA200970422A1 true EA200970422A1 (ru) 2009-12-30
EA016588B1 EA016588B1 (ru) 2012-06-29

Family

ID=39226772

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970422A EA016588B1 (ru) 2006-11-27 2007-11-14 Аналоги пиразола

Country Status (32)

Country Link
US (1) US7772269B2 (ru)
EP (1) EP2097407A1 (ru)
JP (1) JP4469924B2 (ru)
KR (1) KR20090074264A (ru)
CN (1) CN101541790A (ru)
AP (1) AP2009004849A0 (ru)
AR (1) AR063924A1 (ru)
AU (1) AU2007327004A1 (ru)
BR (1) BRPI0718672A2 (ru)
CA (1) CA2667566C (ru)
CL (1) CL2007003403A1 (ru)
CO (1) CO6180447A2 (ru)
CR (1) CR10745A (ru)
CU (1) CU23801B7 (ru)
DO (1) DOP2009000121A (ru)
EA (1) EA016588B1 (ru)
EC (1) ECSP099328A (ru)
GE (1) GEP20125386B (ru)
GT (1) GT200700104A (ru)
HN (1) HN2007000505A (ru)
IL (1) IL198412A0 (ru)
MA (1) MA30924B1 (ru)
MX (1) MX2009005526A (ru)
NO (1) NO20092413L (ru)
NZ (1) NZ576376A (ru)
PE (1) PE20081299A1 (ru)
RS (1) RS20090211A (ru)
TN (1) TN2009000205A1 (ru)
TW (1) TW200831495A (ru)
UA (1) UA92833C2 (ru)
UY (1) UY30743A1 (ru)
WO (1) WO2008065493A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2705729C (en) 2007-11-26 2012-09-18 Pfizer Inc. Pyrazole derivatives as 5-lo inhibitors
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
EP2563359A1 (en) * 2010-04-30 2013-03-06 Allergan, Inc. Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
EP0703913B1 (en) 1993-06-14 1997-06-11 Pfizer Inc. Imidazoles as lipoxygenase inhibitors
SK281577B6 (sk) * 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
US5883106A (en) 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
JP3400392B2 (ja) * 1994-10-18 2003-04-28 ファイザー製薬株式会社 ５−リポキシゲナーゼ阻害剤及び新規医薬組成物
PT863905E (pt) 1995-09-18 2001-03-30 Pfizer Novos inibidores da lipoxigenase do imidazolo
US6194585B1 (en) * 1998-12-22 2001-02-27 Pfizer Inc. Process for preparing 5-lipoxygenase inhibitors
JP2001100682A (ja) * 1999-09-28 2001-04-13 Sanyo Electric Co Ltd サインシステム
JP2001100686A (ja) * 1999-09-28 2001-04-13 Hitachi Kokusai Electric Inc 表示データ取込方法及び比較検査装置

Also Published As

Publication number Publication date
PE20081299A1 (es) 2008-09-17
TW200831495A (en) 2008-08-01
WO2008065493A1 (en) 2008-06-05
JP2010511601A (ja) 2010-04-15
TN2009000205A1 (fr) 2010-10-18
NO20092413L (no) 2009-07-20
AU2007327004A1 (en) 2008-06-05
MA30924B1 (fr) 2009-11-02
JP4469924B2 (ja) 2010-06-02
UA92833C2 (en) 2010-12-10
CL2007003403A1 (es) 2008-07-04
NZ576376A (en) 2011-02-25
CR10745A (es) 2009-05-22
CO6180447A2 (es) 2010-07-19
AR063924A1 (es) 2009-02-25
KR20090074264A (ko) 2009-07-06
ECSP099328A (es) 2009-06-30
HN2007000505A (es) 2010-06-09
DOP2009000121A (es) 2009-06-15
AP2009004849A0 (en) 2009-06-30
CA2667566A1 (en) 2008-06-05
RS20090211A (en) 2010-10-31
CA2667566C (en) 2012-01-03
CU23801B7 (es) 2012-03-15
US20080125474A1 (en) 2008-05-29
GT200700104A (es) 2011-04-13
BRPI0718672A2 (pt) 2013-11-26
IL198412A0 (en) 2010-02-17
EP2097407A1 (en) 2009-09-09
CN101541790A (zh) 2009-09-23
MX2009005526A (es) 2009-06-05
US7772269B2 (en) 2010-08-10
GEP20125386B (en) 2012-01-25
EA016588B1 (ru) 2012-06-29
UY30743A1 (es) 2008-07-03
CU20090083A7 (es) 2011-09-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU