PE20081299A1 - Analogos de pirazol - Google Patents

Analogos de pirazol

Info

Publication number
PE20081299A1
PE20081299A1 PE2007001660A PE2007001660A PE20081299A1 PE 20081299 A1 PE20081299 A1 PE 20081299A1 PE 2007001660 A PE2007001660 A PE 2007001660A PE 2007001660 A PE2007001660 A PE 2007001660A PE 20081299 A1 PE20081299 A1 PE 20081299A1
Authority
PE
Peru
Prior art keywords
phenyl
pyran
carboxamide
tetrahydro
thio
Prior art date
Application number
PE2007001660A
Other languages
English (en)
Inventor
Matthew J Graneto
Todd Michael Maddux
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20081299A1 publication Critical patent/PE20081299A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES F, H. SON COMPUESTOS DE LA INVENCION: 4-(3-{[4-(1-METIL-1H-PIRAZOL-5-IL)FENIL]TIO}FENIL)TETRAHIDRO-2H-PIRAN-4-CARBOXAMIDA Y 4-(3-{[3-FLUORO-4-(1-METIL-1H-PIRAZOL-5-IL)FENIL]TIO}FENIL)TETRAHIDRO-2H-PIRAN-4-CARBOXAMIDA. REFERIDA TAMBIEN A UNA COMBINACION QUE CONTIENE ADEMAS: A) ANTAGONISTAS DE LEUCOTRIENO (LTRA), INCLUYENDO ANTAGONISTAS DE LTB4, LTC4, LTD4 Y LTE4; B) AGENTES SIMPATICOMIMETICOS VASOCONSTRICTORES; C) CROMOGLICANO DE SODIO; ENTRE OTROS. LOS COMPUESTOS DESCRITOS SON INHIBIDORES POTENTES Y SELECTIVOS DE 5-LO (RUTA DE 5-LIPOOXIGENASA), UTILES EN EL TRATAMIENTO DE TRASTORNOS Y AFECCIONES ALERGICOS Y RESPIRATORIOS
PE2007001660A 2006-11-27 2007-11-26 Analogos de pirazol PE20081299A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86733706P 2006-11-27 2006-11-27

Publications (1)

Publication Number Publication Date
PE20081299A1 true PE20081299A1 (es) 2008-09-17

Family

ID=39226772

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001660A PE20081299A1 (es) 2006-11-27 2007-11-26 Analogos de pirazol

Country Status (32)

Country Link
US (1) US7772269B2 (es)
EP (1) EP2097407A1 (es)
JP (1) JP4469924B2 (es)
KR (1) KR20090074264A (es)
CN (1) CN101541790A (es)
AP (1) AP2009004849A0 (es)
AR (1) AR063924A1 (es)
AU (1) AU2007327004A1 (es)
BR (1) BRPI0718672A2 (es)
CA (1) CA2667566C (es)
CL (1) CL2007003403A1 (es)
CO (1) CO6180447A2 (es)
CR (1) CR10745A (es)
CU (1) CU23801B7 (es)
DO (1) DOP2009000121A (es)
EA (1) EA016588B1 (es)
EC (1) ECSP099328A (es)
GE (1) GEP20125386B (es)
GT (1) GT200700104A (es)
HN (1) HN2007000505A (es)
IL (1) IL198412A0 (es)
MA (1) MA30924B1 (es)
MX (1) MX2009005526A (es)
NO (1) NO20092413L (es)
NZ (1) NZ576376A (es)
PE (1) PE20081299A1 (es)
RS (1) RS20090211A (es)
TN (1) TN2009000205A1 (es)
TW (1) TW200831495A (es)
UA (1) UA92833C2 (es)
UY (1) UY30743A1 (es)
WO (1) WO2008065493A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009069044A1 (en) 2007-11-26 2009-06-04 Pfizer Inc. Pyrazole derivatives as 5-lo inhibitors
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
WO2011137363A1 (en) * 2010-04-30 2011-11-03 Allergan, Inc. Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
US8759386B2 (en) * 2011-01-24 2014-06-24 Boehringer Ingelheim International Gmbh Pyrazole compounds as CRTH2 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
CA2163667C (en) 1993-06-14 1998-12-15 Rodney W. Stevens Imidazole lipoxygenase inhibitors
US5883106A (en) 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
SK281577B6 (sk) * 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
JP3400392B2 (ja) * 1994-10-18 2003-04-28 ファイザー製薬株式会社 ５−リポキシゲナーゼ阻害剤及び新規医薬組成物
DE69611101T2 (de) 1995-09-18 2001-04-05 Pfizer Imidazol lipoxygenase inhibitoren
US6194585B1 (en) * 1998-12-22 2001-02-27 Pfizer Inc. Process for preparing 5-lipoxygenase inhibitors
JP2001100686A (ja) * 1999-09-28 2001-04-13 Hitachi Kokusai Electric Inc 表示データ取込方法及び比較検査装置
JP2001100682A (ja) * 1999-09-28 2001-04-13 Sanyo Electric Co Ltd サインシステム

Also Published As

Publication number Publication date
AU2007327004A1 (en) 2008-06-05
JP4469924B2 (ja) 2010-06-02
MA30924B1 (fr) 2009-11-02
WO2008065493A1 (en) 2008-06-05
TW200831495A (en) 2008-08-01
US20080125474A1 (en) 2008-05-29
UY30743A1 (es) 2008-07-03
BRPI0718672A2 (pt) 2013-11-26
AR063924A1 (es) 2009-02-25
ECSP099328A (es) 2009-06-30
IL198412A0 (en) 2010-02-17
US7772269B2 (en) 2010-08-10
CN101541790A (zh) 2009-09-23
CU23801B7 (es) 2012-03-15
UA92833C2 (en) 2010-12-10
EP2097407A1 (en) 2009-09-09
TN2009000205A1 (fr) 2010-10-18
EA016588B1 (ru) 2012-06-29
KR20090074264A (ko) 2009-07-06
EA200970422A1 (ru) 2009-12-30
NO20092413L (no) 2009-07-20
GEP20125386B (en) 2012-01-25
DOP2009000121A (es) 2009-06-15
AP2009004849A0 (en) 2009-06-30
CL2007003403A1 (es) 2008-07-04
CA2667566C (en) 2012-01-03
HN2007000505A (es) 2010-06-09
CU20090083A7 (es) 2011-09-21
JP2010511601A (ja) 2010-04-15
NZ576376A (en) 2011-02-25
RS20090211A (en) 2010-10-31
CA2667566A1 (en) 2008-06-05
GT200700104A (es) 2011-04-13
MX2009005526A (es) 2009-06-05
CO6180447A2 (es) 2010-07-19
CR10745A (es) 2009-05-22

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