SK404191A3 - Indole derivatives, method of their production and pharmaceutical preparation with their contents - Google Patents

Indole derivatives, method of their production and pharmaceutical preparation with their contents Download PDF

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Publication number
SK404191A3
SK404191A3 SK4041-91A SK404191A SK404191A3 SK 404191 A3 SK404191 A3 SK 404191A3 SK 404191 A SK404191 A SK 404191A SK 404191 A3 SK404191 A3 SK 404191A3
Authority
SK
Slovakia
Prior art keywords
compound
formula
group
active ingredient
formulated
Prior art date
Application number
SK4041-91A
Other languages
English (en)
Slovak (sk)
Other versions
SK277952B6 (en
Inventor
Alexander W Oxford
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK404191(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SK404191A3 publication Critical patent/SK404191A3/sk
Publication of SK277952B6 publication Critical patent/SK277952B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK4041-91A 1984-08-01 1991-12-23 Indole derivatives, method of their production and pharmaceutical preparation with their contents SK277952B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419575A GB8419575D0 (en) 1984-08-01 1984-08-01 Chemical compounds

Publications (2)

Publication Number Publication Date
SK404191A3 true SK404191A3 (en) 1995-09-13
SK277952B6 SK277952B6 (en) 1995-09-13

Family

ID=10564759

Family Applications (1)

Application Number Title Priority Date Filing Date
SK4041-91A SK277952B6 (en) 1984-08-01 1991-12-23 Indole derivatives, method of their production and pharmaceutical preparation with their contents

Country Status (42)

Country Link
US (1) US5037845A (fr)
JP (1) JPH0623197B2 (fr)
KR (1) KR930003759B1 (fr)
AT (1) AT386196B (fr)
AU (1) AU573878B2 (fr)
BE (1) BE903006A (fr)
CA (1) CA1241004A (fr)
CH (1) CH666026A5 (fr)
CZ (1) CZ280530B6 (fr)
DE (1) DE3527648A1 (fr)
DK (1) DK158942C (fr)
DO (1) DOP1989004759A (fr)
EC (1) ECSP941096A (fr)
EG (1) EG17283A (fr)
ES (6) ES8700234A1 (fr)
FI (1) FI78466C (fr)
FR (1) FR2568571B1 (fr)
GB (1) GB8419575D0 (fr)
GR (1) GR851850B (fr)
HK (1) HK33289A (fr)
HU (1) HU201738B (fr)
IE (1) IE58122B1 (fr)
IL (1) IL75986A (fr)
IS (1) IS1430B6 (fr)
IT (1) IT1207325B (fr)
JO (1) JO1379B1 (fr)
KE (1) KE3858A (fr)
LU (2) LU86032A1 (fr)
MA (1) MA20499A1 (fr)
MX (2) MX159672A (fr)
NL (2) NL188642C (fr)
NO (2) NO164653C (fr)
NZ (1) NZ212948A (fr)
PH (2) PH22850A (fr)
PL (1) PL146005B1 (fr)
PT (1) PT80900B (fr)
SE (1) SE452460B (fr)
SK (1) SK277952B6 (fr)
SU (1) SU1498386A3 (fr)
UA (1) UA6329A1 (fr)
ZA (1) ZA855818B (fr)
ZW (1) ZW12485A1 (fr)

Families Citing this family (65)

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US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
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US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
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ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
AT399871B (de) * 1993-02-15 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 2-carboxy-3-(2- (dimethylamino)ethyl)-n-methyl-1h-indol-5- methansulfonamid und dessen niederalkylestern
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US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
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US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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CA2529528A1 (fr) * 2003-06-20 2004-12-29 Ronald Aung-Din Therapie locale pour le traitement des migraines, des claquages musculaires, des spasmes musculaires, de la spasticite et d'etats apparentes
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CN102432520B (zh) * 2011-11-21 2013-10-09 山东新华制药股份有限公司 3-[2-（二甲氨基）乙基]-n-甲基吲哚-5-甲烷磺酰胺琥珀酸盐的制备方法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
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Also Published As

Publication number Publication date
HU201738B (en) 1990-12-28
ES545810A0 (es) 1986-10-16
AU4568985A (en) 1986-02-06
ES557480A0 (es) 1988-02-16
ATA226685A (de) 1987-12-15
CA1241004A (fr) 1988-08-23
ES8801788A1 (es) 1988-02-16
NO164653C (no) 1990-11-07
FI78466C (fi) 1989-08-10
HK33289A (en) 1989-04-28
SE8503680L (sv) 1986-02-02
PL146005B1 (en) 1988-12-31
SE8503680D0 (sv) 1985-08-01
ZW12485A1 (en) 1986-02-26
LU86032A1 (fr) 1986-02-18
GB8419575D0 (en) 1984-09-05
DOP1989004759A (es) 1999-02-06
KE3858A (en) 1989-06-02
BE903006A (fr) 1986-02-03
EG17283A (en) 1992-06-30
IL75986A (en) 1989-02-28
IT1207325B (it) 1989-05-17
ZA855818B (en) 1986-04-30
SE452460B (sv) 1987-11-30
JPS6147464A (ja) 1986-03-07
MX159672A (es) 1989-08-02
PL254800A1 (en) 1986-10-21
ES557481A0 (es) 1988-02-16
NO164653B (no) 1990-07-23
NO1994023I1 (no) 1994-11-09
NL930065I1 (nl) 1993-09-01
IS1430B6 (is) 1990-07-16
CH666026A5 (fr) 1988-06-30
ES8801900A1 (es) 1988-03-01
SK277952B6 (en) 1995-09-13
SU1498386A3 (ru) 1989-07-30
ES557482A0 (es) 1988-03-01
UA6329A1 (uk) 1994-12-29
LU88266I2 (fr) 1994-02-03
IE851918L (en) 1986-02-01
IS3034A7 (is) 1986-02-02
ES8801204A1 (es) 1987-12-16
GR851850B (fr) 1985-11-26
FI78466B (fi) 1989-04-28
DK158942C (da) 1991-01-21
ECSP941096A (es) 1995-01-16
NO853046L (no) 1986-02-03
US5037845A (en) 1991-08-06
CZ280530B6 (cs) 1996-02-14
NL8502171A (nl) 1986-03-03
ES8801790A1 (es) 1988-02-16
KR930003759B1 (ko) 1993-05-10
AU573878B2 (en) 1988-06-23
MA20499A1 (fr) 1986-04-01
FR2568571B1 (fr) 1988-09-23
KR860001788A (ko) 1986-03-22
IT8548435A0 (it) 1985-08-01
MX14221A (es) 1993-10-01
AT386196B (de) 1988-07-11
ES552047A0 (es) 1987-12-16
DE3527648C2 (fr) 1993-08-26
JO1379B1 (en) 1986-11-30
DK351185A (da) 1986-02-02
HUT40077A (en) 1986-11-28
PH24117A (en) 1990-03-05
PT80900B (pt) 1987-12-30
DK351185D0 (da) 1985-08-01
ES557483A0 (es) 1988-02-16
CZ404191A3 (en) 1993-04-14
DE3527648A1 (de) 1986-02-13
NL188642C (nl) 1992-08-17
IE58122B1 (en) 1993-07-14
IL75986A0 (en) 1985-12-31
PT80900A (en) 1985-09-01
NZ212948A (en) 1989-05-29
ES8801789A1 (es) 1988-02-16
FR2568571A1 (fr) 1986-02-07
NL930065I2 (nl) 1993-10-01
PH22850A (en) 1989-01-19
FI852969L (fi) 1986-02-02
DK158942B (da) 1990-08-06
FI852969A0 (fi) 1985-08-01
ES8700234A1 (es) 1986-10-16
JPH0623197B2 (ja) 1994-03-30

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