ES557483A0 - Un procedimiento para la preparacion de derivados de indol - Google Patents

Un procedimiento para la preparacion de derivados de indol

Info

Publication number
ES557483A0
ES557483A0 ES557483A ES557483A ES557483A0 ES 557483 A0 ES557483 A0 ES 557483A0 ES 557483 A ES557483 A ES 557483A ES 557483 A ES557483 A ES 557483A ES 557483 A0 ES557483 A0 ES 557483A0
Authority
ES
Spain
Prior art keywords
procedure
preparation
indol derivatives
indol
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES557483A
Other languages
English (en)
Other versions
ES8801790A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES557483(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES557483A0 publication Critical patent/ES557483A0/es
Publication of ES8801790A1 publication Critical patent/ES8801790A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
ES557483A 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol Expired ES8801790A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419575A GB8419575D0 (en) 1984-08-01 1984-08-01 Chemical compounds

Publications (2)

Publication Number Publication Date
ES557483A0 true ES557483A0 (es) 1988-02-16
ES8801790A1 ES8801790A1 (es) 1988-02-16

Family

ID=10564759

Family Applications (6)

Application Number Title Priority Date Filing Date
ES545810A Expired ES8700234A1 (es) 1984-08-01 1985-08-01 Un procedimiento para la preparacion de derivados del indol.
ES552047A Expired ES8801204A1 (es) 1984-08-01 1986-02-14 Un procedimiento para la preparacion de derivados de indol
ES557481A Expired ES8801789A1 (es) 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol
ES557483A Expired ES8801790A1 (es) 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol
ES557482A Expired ES8801900A1 (es) 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol
ES557480A Expired ES8801788A1 (es) 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES545810A Expired ES8700234A1 (es) 1984-08-01 1985-08-01 Un procedimiento para la preparacion de derivados del indol.
ES552047A Expired ES8801204A1 (es) 1984-08-01 1986-02-14 Un procedimiento para la preparacion de derivados de indol
ES557481A Expired ES8801789A1 (es) 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES557482A Expired ES8801900A1 (es) 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol
ES557480A Expired ES8801788A1 (es) 1984-08-01 1987-03-31 Un procedimiento para la preparacion de derivados de indol

Country Status (42)

Country Link
US (1) US5037845A (es)
JP (1) JPH0623197B2 (es)
KR (1) KR930003759B1 (es)
AT (1) AT386196B (es)
AU (1) AU573878B2 (es)
BE (1) BE903006A (es)
CA (1) CA1241004A (es)
CH (1) CH666026A5 (es)
CZ (1) CZ280530B6 (es)
DE (1) DE3527648A1 (es)
DK (1) DK158942C (es)
DO (1) DOP1989004759A (es)
EC (1) ECSP941096A (es)
EG (1) EG17283A (es)
ES (6) ES8700234A1 (es)
FI (1) FI78466C (es)
FR (1) FR2568571B1 (es)
GB (1) GB8419575D0 (es)
GR (1) GR851850B (es)
HK (1) HK33289A (es)
HU (1) HU201738B (es)
IE (1) IE58122B1 (es)
IL (1) IL75986A (es)
IS (1) IS1430B6 (es)
IT (1) IT1207325B (es)
JO (1) JO1379B1 (es)
KE (1) KE3858A (es)
LU (2) LU88266I2 (es)
MA (1) MA20499A1 (es)
MX (2) MX159672A (es)
NL (2) NL188642C (es)
NO (2) NO164653C (es)
NZ (1) NZ212948A (es)
PH (2) PH22850A (es)
PL (1) PL146005B1 (es)
PT (1) PT80900B (es)
SE (1) SE452460B (es)
SK (1) SK404191A3 (es)
SU (1) SU1498386A3 (es)
UA (1) UA6329A1 (es)
ZA (1) ZA855818B (es)
ZW (1) ZW12485A1 (es)

Families Citing this family (65)

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US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
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GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
ES2059236B1 (es) * 1992-06-18 1995-06-16 Imidex S A Procedimiento para la sintesis de la 3-(2-dimetilamino) etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
AT399871B (de) * 1993-02-15 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 2-carboxy-3-(2- (dimethylamino)ethyl)-n-methyl-1h-indol-5- methansulfonamid und dessen niederalkylestern
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US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
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US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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CN102432520B (zh) * 2011-11-21 2013-10-09 山东新华制药股份有限公司 3-[2-（二甲氨基）乙基]-n-甲基吲哚-5-甲烷磺酰胺琥珀酸盐的制备方法
US10716766B2 (en) 2015-03-02 2020-07-21 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene

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Also Published As

Publication number Publication date
EG17283A (en) 1992-06-30
NL188642C (nl) 1992-08-17
SE8503680L (sv) 1986-02-02
LU86032A1 (fr) 1986-02-18
HU201738B (en) 1990-12-28
NZ212948A (en) 1989-05-29
JPH0623197B2 (ja) 1994-03-30
ZW12485A1 (en) 1986-02-26
MX14221A (es) 1993-10-01
ES545810A0 (es) 1986-10-16
GB8419575D0 (en) 1984-09-05
US5037845A (en) 1991-08-06
PH22850A (en) 1989-01-19
ZA855818B (en) 1986-04-30
AT386196B (de) 1988-07-11
SK277952B6 (en) 1995-09-13
SE8503680D0 (sv) 1985-08-01
HK33289A (en) 1989-04-28
AU573878B2 (en) 1988-06-23
PT80900B (pt) 1987-12-30
IS1430B6 (is) 1990-07-16
ES8801788A1 (es) 1988-02-16
ES557480A0 (es) 1988-02-16
FI852969A0 (fi) 1985-08-01
FR2568571B1 (fr) 1988-09-23
MX159672A (es) 1989-08-02
ES8801789A1 (es) 1988-02-16
DK351185D0 (da) 1985-08-01
DE3527648A1 (de) 1986-02-13
IT8548435A0 (it) 1985-08-01
UA6329A1 (uk) 1994-12-29
KR860001788A (ko) 1986-03-22
BE903006A (fr) 1986-02-03
PH24117A (en) 1990-03-05
DE3527648C2 (es) 1993-08-26
ES8700234A1 (es) 1986-10-16
IT1207325B (it) 1989-05-17
CZ404191A3 (en) 1993-04-14
KE3858A (en) 1989-06-02
ATA226685A (de) 1987-12-15
CA1241004A (en) 1988-08-23
DK158942C (da) 1991-01-21
ES552047A0 (es) 1987-12-16
AU4568985A (en) 1986-02-06
ECSP941096A (es) 1995-01-16
SK404191A3 (en) 1995-09-13
KR930003759B1 (ko) 1993-05-10
FI78466C (fi) 1989-08-10
JO1379B1 (en) 1986-11-30
NO164653B (no) 1990-07-23
ES8801900A1 (es) 1988-03-01
ES557481A0 (es) 1988-02-16
IS3034A7 (is) 1986-02-02
LU88266I2 (es) 1994-02-03
NL930065I1 (nl) 1993-09-01
IE58122B1 (en) 1993-07-14
DK351185A (da) 1986-02-02
DK158942B (da) 1990-08-06
ES8801204A1 (es) 1987-12-16
HUT40077A (en) 1986-11-28
DOP1989004759A (es) 1999-02-06
PL146005B1 (en) 1988-12-31
GR851850B (es) 1985-11-26
MA20499A1 (fr) 1986-04-01
CZ280530B6 (cs) 1996-02-14
IE851918L (en) 1986-02-01
NL930065I2 (nl) 1993-10-01
FI78466B (fi) 1989-04-28
FI852969L (fi) 1986-02-02
ES557482A0 (es) 1988-03-01
PL254800A1 (en) 1986-10-21
NL8502171A (nl) 1986-03-03
SE452460B (sv) 1987-11-30
NO164653C (no) 1990-11-07
IL75986A0 (en) 1985-12-31
CH666026A5 (fr) 1988-06-30
SU1498386A3 (ru) 1989-07-30
NO1994023I1 (no) 1994-11-09
PT80900A (en) 1985-09-01
NO853046L (no) 1986-02-03
JPS6147464A (ja) 1986-03-07
ES8801790A1 (es) 1988-02-16
IL75986A (en) 1989-02-28
FR2568571A1 (fr) 1986-02-07

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