IS3034A7 - Afleiða af indóli - Google Patents

Afleiða af indóli

Info

Publication number
IS3034A7
IS3034A7 IS3034A IS3034A IS3034A7 IS 3034 A7 IS3034 A7 IS 3034A7 IS 3034 A IS3034 A IS 3034A IS 3034 A IS3034 A IS 3034A IS 3034 A7 IS3034 A7 IS 3034A7
Authority
IS
Iceland
Prior art keywords
indole
derivation
Prior art date
Application number
IS3034A
Other languages
English (en)
Other versions
IS1430B6 (is
Inventor
William Oxford Alexander
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS3034(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of IS3034A7 publication Critical patent/IS3034A7/is
Publication of IS1430B6 publication Critical patent/IS1430B6/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IS3034A 1984-08-01 1985-07-31 Afleiða af indóli IS1430B6 (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419575A GB8419575D0 (en) 1984-08-01 1984-08-01 Chemical compounds

Publications (2)

Publication Number Publication Date
IS3034A7 true IS3034A7 (is) 1986-02-02
IS1430B6 IS1430B6 (is) 1990-07-16

Family

ID=10564759

Family Applications (1)

Application Number Title Priority Date Filing Date
IS3034A IS1430B6 (is) 1984-08-01 1985-07-31 Afleiða af indóli

Country Status (42)

Country Link
US (1) US5037845A (is)
JP (1) JPH0623197B2 (is)
KR (1) KR930003759B1 (is)
AT (1) AT386196B (is)
AU (1) AU573878B2 (is)
BE (1) BE903006A (is)
CA (1) CA1241004A (is)
CH (1) CH666026A5 (is)
CZ (1) CZ280530B6 (is)
DE (1) DE3527648A1 (is)
DK (1) DK158942C (is)
DO (1) DOP1989004759A (is)
EC (1) ECSP941096A (is)
EG (1) EG17283A (is)
ES (6) ES8700234A1 (is)
FI (1) FI78466C (is)
FR (1) FR2568571B1 (is)
GB (1) GB8419575D0 (is)
GR (1) GR851850B (is)
HK (1) HK33289A (is)
HU (1) HU201738B (is)
IE (1) IE58122B1 (is)
IL (1) IL75986A (is)
IS (1) IS1430B6 (is)
IT (1) IT1207325B (is)
JO (1) JO1379B1 (is)
KE (1) KE3858A (is)
LU (2) LU86032A1 (is)
MA (1) MA20499A1 (is)
MX (2) MX159672A (is)
NL (2) NL188642C (is)
NO (2) NO164653C (is)
NZ (1) NZ212948A (is)
PH (2) PH22850A (is)
PL (1) PL146005B1 (is)
PT (1) PT80900B (is)
SE (1) SE452460B (is)
SK (1) SK404191A3 (is)
SU (1) SU1498386A3 (is)
UA (1) UA6329A1 (is)
ZA (1) ZA855818B (is)
ZW (1) ZW12485A1 (is)

Families Citing this family (65)

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US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
GB9102579D0 (en) * 1991-01-24 1991-03-27 Glaxo Group Ltd Compositions
GB9101592D0 (en) * 1991-01-24 1991-03-06 Glaxo Group Ltd Compositions
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
GB9104890D0 (en) 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions
AT399870B (de) * 1991-06-06 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 3-(2-(dimethylamino)ethyl)-n-methyl-1h-indol-5- ethansulfonamid
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
ES2059236B1 (es) * 1992-06-18 1995-06-16 Imidex S A Procedimiento para la sintesis de la 3-(2-dimetilamino) etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
AT399871B (de) * 1993-02-15 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 2-carboxy-3-(2- (dimethylamino)ethyl)-n-methyl-1h-indol-5- methansulfonamid und dessen niederalkylestern
US5807571A (en) * 1993-05-06 1998-09-15 Lts Lohmann Therapie-Systeme Gmbh Transdermal therapeutic systems for administering indole serotonin agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
ES2084560B1 (es) * 1994-03-09 1997-01-16 Almirall Lab Procedimiento de preparacion de derivados el indol.
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
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US5521197A (en) 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
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US5792763A (en) * 1996-10-08 1998-08-11 Eli Lilly And Company Serotonin 5-HT1F agonists
GB9714383D0 (en) * 1997-07-08 1997-09-10 Pfizer Ltd Improved process
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
AT500063A1 (de) * 1999-11-23 2005-10-15 Sandoz Ag Beschichtete tablettenkerne
WO2002076426A2 (en) * 2001-03-27 2002-10-03 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
EP1435945B1 (en) * 2001-06-05 2008-08-13 Aung-din, Ronald Topical migraine therapy
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
FR2827287B1 (fr) * 2001-07-13 2003-10-31 Servier Lab Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
US20060106227A1 (en) * 2002-06-13 2006-05-18 Dr Reddy's Laboratories Limited 3-'2-(Dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
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US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
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US20070054953A1 (en) * 2003-05-12 2007-03-08 Potluri Ramesh B A novel process for preparation of indole derivatives
KR20060015641A (ko) * 2003-06-06 2006-02-17 글락소 그룹 리미티드 트립탄 및 ｎｓａｉｄ를 포함하는 조성물
US20070065463A1 (en) * 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
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US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
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EP2219449A4 (en) * 2007-11-16 2010-10-27 Univ Arizona State METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING
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US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
KR101517415B1 (ko) * 2008-05-14 2015-05-07 에스케이바이오팜 주식회사 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물
EP2296652B1 (en) * 2008-06-30 2017-11-08 Afgin Pharma, Llc Topical regional neuro-affective therapy
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US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
JP5660817B2 (ja) * 2010-07-21 2015-01-28 高田製薬株式会社 スマトリプタンコハク酸塩を含有する内用液剤
CN102432520B (zh) * 2011-11-21 2013-10-09 山东新华制药股份有限公司 3-[2-（二甲氨基）乙基]-n-甲基吲哚-5-甲烷磺酰胺琥珀酸盐的制备方法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
CN107530318A (zh) 2015-03-02 2018-01-02 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
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Also Published As

Publication number Publication date
MA20499A1 (fr) 1986-04-01
LU86032A1 (fr) 1986-02-18
FR2568571B1 (fr) 1988-09-23
ES557480A0 (es) 1988-02-16
IT8548435A0 (it) 1985-08-01
CZ280530B6 (cs) 1996-02-14
ES8801900A1 (es) 1988-03-01
KR860001788A (ko) 1986-03-22
NL930065I1 (nl) 1993-09-01
ES557482A0 (es) 1988-03-01
ATA226685A (de) 1987-12-15
CA1241004A (en) 1988-08-23
AU573878B2 (en) 1988-06-23
US5037845A (en) 1991-08-06
DE3527648A1 (de) 1986-02-13
NL188642C (nl) 1992-08-17
ES8801790A1 (es) 1988-02-16
IL75986A (en) 1989-02-28
FI852969A0 (fi) 1985-08-01
DK351185D0 (da) 1985-08-01
ES545810A0 (es) 1986-10-16
DK158942C (da) 1991-01-21
PT80900B (pt) 1987-12-30
GB8419575D0 (en) 1984-09-05
ZA855818B (en) 1986-04-30
PH24117A (en) 1990-03-05
KR930003759B1 (ko) 1993-05-10
AT386196B (de) 1988-07-11
UA6329A1 (uk) 1994-12-29
FI852969L (fi) 1986-02-02
SU1498386A3 (ru) 1989-07-30
FR2568571A1 (fr) 1986-02-07
HUT40077A (en) 1986-11-28
NZ212948A (en) 1989-05-29
JPH0623197B2 (ja) 1994-03-30
SE452460B (sv) 1987-11-30
PH22850A (en) 1989-01-19
NL930065I2 (nl) 1993-10-01
HK33289A (en) 1989-04-28
GR851850B (is) 1985-11-26
IS1430B6 (is) 1990-07-16
ES8801204A1 (es) 1987-12-16
FI78466C (fi) 1989-08-10
CZ404191A3 (en) 1993-04-14
SK277952B6 (en) 1995-09-13
SE8503680D0 (sv) 1985-08-01
MX159672A (es) 1989-08-02
DOP1989004759A (es) 1999-02-06
KE3858A (en) 1989-06-02
AU4568985A (en) 1986-02-06
NO853046L (no) 1986-02-03
NO164653B (no) 1990-07-23
ES8801789A1 (es) 1988-02-16
IE851918L (en) 1986-02-01
FI78466B (fi) 1989-04-28
DK158942B (da) 1990-08-06
EG17283A (en) 1992-06-30
JO1379B1 (en) 1986-11-30
PT80900A (en) 1985-09-01
ES552047A0 (es) 1987-12-16
SE8503680L (sv) 1986-02-02
LU88266I2 (is) 1994-02-03
ES557483A0 (es) 1988-02-16
PL254800A1 (en) 1986-10-21
BE903006A (fr) 1986-02-03
MX14221A (es) 1993-10-01
IT1207325B (it) 1989-05-17
DK351185A (da) 1986-02-02
NO1994023I1 (no) 1994-11-09
NO164653C (no) 1990-11-07
HU201738B (en) 1990-12-28
ES8700234A1 (es) 1986-10-16
ES8801788A1 (es) 1988-02-16
JPS6147464A (ja) 1986-03-07
IL75986A0 (en) 1985-12-31
ECSP941096A (es) 1995-01-16
SK404191A3 (en) 1995-09-13
NL8502171A (nl) 1986-03-03
IE58122B1 (en) 1993-07-14
DE3527648C2 (is) 1993-08-26
ES557481A0 (es) 1988-02-16
PL146005B1 (en) 1988-12-31
CH666026A5 (fr) 1988-06-30
ZW12485A1 (en) 1986-02-26

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