MX2010005343A - Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina. - Google Patents

Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina.

Info

Publication number
MX2010005343A
MX2010005343A MX2010005343A MX2010005343A MX2010005343A MX 2010005343 A MX2010005343 A MX 2010005343A MX 2010005343 A MX2010005343 A MX 2010005343A MX 2010005343 A MX2010005343 A MX 2010005343A MX 2010005343 A MX2010005343 A MX 2010005343A
Authority
MX
Mexico
Prior art keywords
nos
inhibitory activity
substituted indole
indole compounds
norepinephrine reuptake
Prior art date
Application number
MX2010005343A
Other languages
English (en)
Inventor
Shawn Maddaford
Jailall Ramnauth
Suman Rakhit
Paul Renton
Subhash C Annedi
John S Andrews
Gabriela Miladenova
Original Assignee
Neuraxon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuraxon Inc filed Critical Neuraxon Inc
Publication of MX2010005343A publication Critical patent/MX2010005343A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

La presente invención se refiere a compuestos de indola 3,5-sustituidos de la Fórmula (I) teniendo actividad inhibitoria de sintasa de óxido nítrico (NOS), particularmente aquellos que inhiben selectivamente sintasa de óxido nítrico neuronal (nNos) en preferencia a otras isoformas de eNos. Los inhibidores de NOS de la invención, solos o en combinación con otros agentes farmacéuticamente activos, pueden usarse para tratar o prevenir condiciones tales como dolor crónico y desórdenes psiquiátricos.
MX2010005343A 2007-11-16 2008-11-17 Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina. MX2010005343A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98874107P 2007-11-16 2007-11-16
US13397508P 2008-07-03 2008-07-03
PCT/CA2008/002033 WO2009062318A1 (en) 2007-11-16 2008-11-17 3,5-substituted indole compounds having nos and norepinephrine reuptake inhibitory activity

Publications (1)

Publication Number Publication Date
MX2010005343A true MX2010005343A (es) 2010-08-09

Family

ID=40638298

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010005343A MX2010005343A (es) 2007-11-16 2008-11-17 Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina.

Country Status (5)

Country Link
US (1) US20090131503A1 (es)
EP (1) EP2220074A4 (es)
CA (1) CA2705833A1 (es)
MX (1) MX2010005343A (es)
WO (1) WO2009062318A1 (es)

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US20090131503A1 (en) 2009-05-21
CA2705833A1 (en) 2009-05-22
EP2220074A4 (en) 2012-01-04
EP2220074A1 (en) 2010-08-25
WO2009062318A1 (en) 2009-05-22

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