AR060451A1 - Compuestos de indol 1,5 y 3,6-sustituidos con actividad inhibitoria de nos - Google Patents
Compuestos de indol 1,5 y 3,6-sustituidos con actividad inhibitoria de nosInfo
- Publication number
- AR060451A1 AR060451A1 ARP070101584A ARP070101584A AR060451A1 AR 060451 A1 AR060451 A1 AR 060451A1 AR P070101584 A ARP070101584 A AR P070101584A AR P070101584 A ARP070101584 A AR P070101584A AR 060451 A1 AR060451 A1 AR 060451A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- heterocyclyl
- alkyl
- alkaryl
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Abstract
Compuestos de indol 1,5 y 3,6-sustituidos que actuan como inhibidores de oxido-nítrico sintetasa (NOS), particularmente los que inhiben selectivamente oxido nítrico sintetasa neuronal (nNOS) de preferencia con otras isoformas de NOS. Los inhibidores de NOS de la presente, solo o en combinacion con otros agentes farmacéuticamente activos, se pueden usar para tratar o prevenir condiciones tales como, por ejemplo, accidente cerebrovascular, lesion de reperfusion, neurodegeneracion, traumatismo de cabeza, CABG, cefalea migranosa con y sin aura, migrana con alodinia, dolor central posterior a accidente cerebrovascular (CPSP), dolor neuropático, y dolor cronico. Reivindicacion 1: Un compuesto que tiene la formula (1), o una de sus sales o profármacos farmacéuticamente aceptables, en donde: R1 es H, alquilo C1-6 opcionalmente sustituido, alcarilo C1-4 opcionalmente sustituido, alqheterociclilo C1-4 opcionalmente sustituido o heterociclilo C2-6 opcionalmente sustituido; cada uno de R2 y R3 es, de modo independiente, H, Hal, alquilo C1-6 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, alcarilo C1-6 opcionalmente sustituido, heterociclilo C2-9 opcionalmente sustituido o alqheterociclilo C1-4 opcionalmente sustituido; R4 es H, R4AC(NH)NH(CH2)r4 o R4ANHC(S)NH(CH2)r4, en donde r4 es un numero entero de 0 a 2, R4A es alquilo C1-6 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, alcarilo C1-4 opcionalmente sustituido, heterociclilo C2-9 opcionalmente sustituido, alqheterociclilo C1-4 opcionalmente sustituido, tioalcoxi C1-6 opcionalmente sustituido, tioalcarilo C1-4 opcionalmente sustituido, ariloílo opcionalmente sustituido, tioalqheterociclilo C1-4 opcionalmente sustituido o amino opcionalmente sustituido; y R5 es H, R5AC(NH)NH(CH2)r5 o R5ANHC(S)NH(CH2)r5, en donde r5 es un numero entero de 0 a 2, R5A es alquilo C1-6, arilo C6-10 opcionalmente sustituido, alcarilo C1-4 opcionalmente sustituido, heterociclilo C2-9 opcionalmente sustituido, alqheterociclilo C1-4 opcionalmente sustituido, tioalcoxi C1-6 opcionalmente sustituido, tioalcarilo C1-4 opcionalmente sustituido, ariloílo opcionalmente sustituido, tioalqheterociclilo C1-4 opcionalmente sustituido o amino opcionalmente sustituido; en donde uno, pero no ambos, de R4 y R5 es H, y cuando R4 es H, R1 es H, y cuando R5 es H, R3 es H.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79184606P | 2006-04-13 | 2006-04-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR060451A1 true AR060451A1 (es) | 2008-06-18 |
Family
ID=38608997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070101584A AR060451A1 (es) | 2006-04-13 | 2007-04-13 | Compuestos de indol 1,5 y 3,6-sustituidos con actividad inhibitoria de nos |
Country Status (10)
Country | Link |
---|---|
US (1) | US7989447B2 (es) |
EP (1) | EP2010527B1 (es) |
JP (1) | JP5350219B2 (es) |
CN (1) | CN101466709B (es) |
AR (1) | AR060451A1 (es) |
AU (1) | AU2007240078B2 (es) |
CA (1) | CA2643822A1 (es) |
TW (1) | TW200808780A (es) |
WO (1) | WO2007118314A1 (es) |
ZA (1) | ZA200809659B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0607517A2 (pt) | 2005-04-13 | 2009-09-08 | Neuraxon Inc | compostos de indol substituìdo, composição farmacêutica compreendendo o mesmo, método para tratar e uso do mesmo |
WO2007118314A1 (en) | 2006-04-13 | 2007-10-25 | Neuraxon, Inc. | 1,5 and 3,6- substituted indole compounds having nos inhibitory activity |
EP2219449A4 (en) * | 2007-11-16 | 2010-10-27 | Univ Arizona State | METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING |
US20090131503A1 (en) * | 2007-11-16 | 2009-05-21 | Annedi Subhash C | 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity |
AU2008323526A1 (en) * | 2007-11-16 | 2009-05-22 | Neuraxon, Inc. | Indole compounds and methods for treating visceral pain |
UA105182C2 (ru) * | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
WO2010132072A1 (en) * | 2009-05-15 | 2010-11-18 | Neuraxon, Inc | Treatment or prevention of migraine by dosing at aura |
MA40759A (fr) | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
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WO2023177452A1 (en) * | 2022-03-14 | 2023-09-21 | Colorado Chromatography, Llc | Hydrogenation of cannabigerol and cannabichromene |
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BRPI0607517A2 (pt) * | 2005-04-13 | 2009-09-08 | Neuraxon Inc | compostos de indol substituìdo, composição farmacêutica compreendendo o mesmo, método para tratar e uso do mesmo |
WO2007118314A1 (en) | 2006-04-13 | 2007-10-25 | Neuraxon, Inc. | 1,5 and 3,6- substituted indole compounds having nos inhibitory activity |
EP2219449A4 (en) | 2007-11-16 | 2010-10-27 | Univ Arizona State | METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING |
AU2008323526A1 (en) | 2007-11-16 | 2009-05-22 | Neuraxon, Inc. | Indole compounds and methods for treating visceral pain |
US20090131503A1 (en) * | 2007-11-16 | 2009-05-21 | Annedi Subhash C | 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity |
-
2007
- 2007-04-13 WO PCT/CA2007/000617 patent/WO2007118314A1/en active Application Filing
- 2007-04-13 JP JP2009504540A patent/JP5350219B2/ja not_active Expired - Fee Related
- 2007-04-13 ZA ZA200809659A patent/ZA200809659B/xx unknown
- 2007-04-13 CN CN2007800222857A patent/CN101466709B/zh not_active Expired - Fee Related
- 2007-04-13 AR ARP070101584A patent/AR060451A1/es not_active Application Discontinuation
- 2007-04-13 CA CA002643822A patent/CA2643822A1/en not_active Abandoned
- 2007-04-13 TW TW096113005A patent/TW200808780A/zh unknown
- 2007-04-13 EP EP07719544.4A patent/EP2010527B1/en not_active Not-in-force
- 2007-04-13 US US11/787,167 patent/US7989447B2/en not_active Expired - Fee Related
- 2007-04-13 AU AU2007240078A patent/AU2007240078B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
CA2643822A1 (en) | 2007-10-25 |
US20070254940A1 (en) | 2007-11-01 |
JP5350219B2 (ja) | 2013-11-27 |
WO2007118314A1 (en) | 2007-10-25 |
EP2010527B1 (en) | 2013-08-14 |
TW200808780A (en) | 2008-02-16 |
ZA200809659B (en) | 2010-03-31 |
CN101466709A (zh) | 2009-06-24 |
CN101466709B (zh) | 2013-03-20 |
US7989447B2 (en) | 2011-08-02 |
JP2009533358A (ja) | 2009-09-17 |
EP2010527A1 (en) | 2009-01-07 |
AU2007240078B2 (en) | 2013-07-25 |
AU2007240078A1 (en) | 2007-10-25 |
EP2010527A4 (en) | 2010-02-10 |
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