PE20070832A1 - Derivados de piridazinona como inhibidores de la tirosina quinasa - Google Patents
Derivados de piridazinona como inhibidores de la tirosina quinasaInfo
- Publication number
- PE20070832A1 PE20070832A1 PE2006001553A PE2006001553A PE20070832A1 PE 20070832 A1 PE20070832 A1 PE 20070832A1 PE 2006001553 A PE2006001553 A PE 2006001553A PE 2006001553 A PE2006001553 A PE 2006001553A PE 20070832 A1 PE20070832 A1 PE 20070832A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- atoms
- inhibitors
- kinase
- naphthylus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES Ar1, Het; R2 ES Ar2, Het2; R3 ES H, A; A ES ALQUILO NO RAMIFICADO O RAMIFICADO QUE TIENE 1-10 ATOMOS DE C, EN DONE 1-7 ATOMOS DE H PUEDEN ESTAR REEMPLAZADOS POR F, Cl, ENTRE OTROS; Ar1 ES FENILO, NAFTILO, BIFENILO, ENTRE OTROS; Ar2 ES FENILO, NAFTILO, BIFENILO, ENTRE OTROS; Het Y Het2 SON CADA UNO HETEROCICLO SATURADO, INSATURADO O AROMATICO MONO-, BI- O TRICICLICO QUE TIENE 1-4 ATOMOS DE N, O, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-ETIL-3-{3-[3-(3-HIDROXIFENIL)-6-OXO-6H-PIRIDAZIN-1-ILMETIL]FENIL}UREA; 1-(3-{3-[3-(2-DIMETILAMINOETOXI)FENIL]-6-OXO-6H-PIRAZIDIN-1-ILMETIL}FENIL)-3-ETILUREA, CLORHIDRATO; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS ACTUAN COMO INHIBIDORES DE LAS TIROSINA QUINASAS EN ESPECIAL LA MET-QUINASA, UTILES PAR EL TRATAMIENTO DE TUMORES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005057924A DE102005057924A1 (de) | 2005-12-05 | 2005-12-05 | Pyridazinonderivate |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070832A1 true PE20070832A1 (es) | 2007-08-27 |
Family
ID=37775213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001553A PE20070832A1 (es) | 2005-12-05 | 2006-12-05 | Derivados de piridazinona como inhibidores de la tirosina quinasa |
Country Status (28)
Country | Link |
---|---|
US (1) | US8173653B2 (es) |
EP (1) | EP1960370B1 (es) |
JP (1) | JP5210172B2 (es) |
KR (1) | KR101367447B1 (es) |
CN (1) | CN101326167B (es) |
AR (1) | AR057214A1 (es) |
AT (1) | ATE527241T1 (es) |
AU (1) | AU2006322364B2 (es) |
BR (1) | BRPI0619407A2 (es) |
CA (1) | CA2632217C (es) |
CY (1) | CY1112206T1 (es) |
DE (1) | DE102005057924A1 (es) |
DK (1) | DK1960370T3 (es) |
EA (1) | EA014667B1 (es) |
EC (1) | ECSP088598A (es) |
ES (1) | ES2373117T3 (es) |
HK (1) | HK1127489A1 (es) |
IL (1) | IL191832A (es) |
MY (1) | MY153261A (es) |
NZ (1) | NZ569568A (es) |
PE (1) | PE20070832A1 (es) |
PL (1) | PL1960370T3 (es) |
PT (1) | PT1960370E (es) |
SI (1) | SI1960370T1 (es) |
TW (1) | TWI395741B (es) |
UA (1) | UA95934C2 (es) |
WO (1) | WO2007065518A1 (es) |
ZA (1) | ZA200805877B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS52626B (en) * | 2006-07-25 | 2013-06-28 | Cephalon Inc. | PYRIDIZINONA DERIVATIVES |
DE102006037478A1 (de) * | 2006-08-10 | 2008-02-14 | Merck Patent Gmbh | 2-(Heterocyclylbenzyl)-pyridazinonderivate |
CA2672601A1 (en) * | 2006-12-14 | 2008-06-19 | Astellas Pharma Inc. | Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents |
CN101668732A (zh) * | 2007-04-02 | 2010-03-10 | 同一世界健康研究院 | Cftr抑制剂化合物及其用途 |
DE102007025717A1 (de) * | 2007-06-01 | 2008-12-11 | Merck Patent Gmbh | Arylether-pyridazinonderivate |
DE102007025718A1 (de) * | 2007-06-01 | 2008-12-04 | Merck Patent Gmbh | Pyridazinonderivate |
DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
DE102007038957A1 (de) * | 2007-08-17 | 2009-02-19 | Merck Patent Gmbh | 6-Thioxo-pyridazinderivate |
DE102007061963A1 (de) * | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
CN101537006B (zh) * | 2008-03-18 | 2012-06-06 | 中国科学院上海药物研究所 | 哒嗪酮类化合物在制备抗肿瘤药物中的用途 |
DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
DE102008037790A1 (de) | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
US8586599B2 (en) * | 2008-12-22 | 2013-11-19 | Merck Patent Gmbh | Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof |
DE102008062826A1 (de) | 2008-12-23 | 2010-07-01 | Merck Patent Gmbh | Pyridazinonderivate |
DE102009003954A1 (de) * | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
DE102009004061A1 (de) | 2009-01-08 | 2010-07-15 | Merck Patent Gmbh | Pyridazinonderivate |
SG10201504735QA (en) | 2009-01-08 | 2015-07-30 | Merck Patent Gmbh | Novel polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof |
CN102731409A (zh) * | 2011-04-08 | 2012-10-17 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物,其药物组合物、制备方法及用途 |
KR101842645B1 (ko) * | 2012-04-12 | 2018-03-29 | 한국화학연구원 | 신규한 히드라진온이 치환된 피리미딘 유도체 및 그의 용도 |
CA2890273C (en) * | 2012-11-02 | 2021-10-26 | Merck Patent Gmbh | A 6-oxo-1,6-dihydro-pyridazine derivative for the use for the treatment of hepatocellular carcinoma (hcc) |
FI3640241T3 (fi) * | 2013-10-18 | 2023-01-13 | Bromodomeeni-inhibiittorit | |
CN103772352B (zh) * | 2014-01-16 | 2017-01-18 | 四川百利药业有限责任公司 | 哒嗪酮类衍生物及其制备方法和用途 |
MX2017007374A (es) * | 2014-12-11 | 2017-11-06 | Merck Patent Gmbh | Combinacion de un derivado de 6-oxo-1,6-dihidro-piridazina que tiene actividad anti-cancer con un derivado de quinazolina. |
WO2018081381A1 (en) * | 2016-10-26 | 2018-05-03 | Proteostasis Therapeutics, Inc | Pyridazine derivatives, compositions and methods for modulating cftr |
CN107334767B (zh) * | 2017-06-08 | 2019-03-05 | 中国医学科学院医药生物技术研究所 | 一种哒嗪酮类化合物在肿瘤治疗中的应用 |
EP3679027A1 (en) | 2017-09-04 | 2020-07-15 | C4 Therapeutics, Inc. | Dihydrobenzimidazolones |
EA202191082A1 (ru) | 2018-11-06 | 2021-09-10 | Эджвайз Терапьютикс, Инк. | Соединения пиридазинонов и их применения |
WO2020097258A1 (en) * | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
CN113272291A (zh) | 2018-11-06 | 2021-08-17 | 艾知怀斯治疗学公司 | 哒嗪酮化合物及其用途 |
EP3935050A4 (en) | 2019-03-06 | 2023-01-04 | C4 Therapeutics, Inc. | HETEROCYCLIC COMPOUNDS FOR MEDICAL TREATMENT |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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RO79566A2 (ro) * | 1980-05-28 | 1982-08-17 | Institutul De Cercetari Chimico-Farmaceutice,Ro | Substante din clasa 2-(3'-aril-piridazonil-1'5-metil-5-aril-(alchil)amino-tiadiazolului |
RO79562A2 (ro) * | 1980-05-29 | 1982-08-17 | Institutul De Cercetari Chimico-Farmaceutice,Ro | Substante din clasa 3-(3'-aril-piridazonil-1'5-metil-4-aril(alchil)-5-mercapto-1,2,4-triazolului si procedeu de obtinere a acestora |
JPS5826802A (ja) * | 1981-08-10 | 1983-02-17 | Sankyo Co Ltd | 農園芸用殺菌剤 |
DE3321012A1 (de) * | 1983-06-10 | 1984-12-13 | A. Nattermann & Cie GmbH, 5000 Köln | Substituierte 4,5-dihydro-6-(thien-2-yl)-3(2h)-pyridazinone und 6-(thien-2-yl)-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung |
IE913310A1 (en) * | 1990-09-21 | 1992-02-25 | Rohm & Haas | Dihydropyridazinones, pyridazinones and related compounds as¹fungicides |
EP0478195B1 (en) | 1990-09-21 | 1999-05-26 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones as fungicides |
AU691673B2 (en) * | 1994-11-14 | 1998-05-21 | Dow Agrosciences Llc | Pyridazinones and their use as fungicides |
CA2216512A1 (en) * | 1996-10-11 | 1998-04-11 | Rohm And Haas Company | Dihydropyridazinones and pyridazinones their use as fungicides and insecticides |
ES2260846T3 (es) * | 1997-08-22 | 2006-11-01 | Abbott Laboratories | Inhibidores para la biosintesis de la prostaglandina h2 sintasa. |
WO1999025697A1 (fr) * | 1997-11-19 | 1999-05-27 | Kowa Co., Ltd. | Nouveaux derives de pyridazine et medicaments contenant ces composes comme principe actif |
US7060822B1 (en) | 1999-07-30 | 2006-06-13 | Abbott Gmbh & Co. Kg | 2-pyrazolin-5-ones |
IL147757A0 (en) * | 1999-07-30 | 2002-08-14 | Abbott Gmbh & Co Kg | 2-pyrazolin-5-ones |
AUPR606401A0 (en) * | 2001-07-02 | 2001-07-26 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
EP1463509A1 (en) * | 2001-10-31 | 2004-10-06 | MERCK PATENT GmbH | Type 4 phosphodiesterase inhibitors and uses thereof |
WO2003059891A1 (en) * | 2002-01-18 | 2003-07-24 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
WO2004022540A2 (en) * | 2002-09-06 | 2004-03-18 | Fujisawa Pharmaceutical Co., Ltd. | Pyridazinone and pyridone derivatives as adenosine antagonists |
NZ541064A (en) * | 2003-03-07 | 2007-09-28 | Kowa Co | Benzofuran derivative |
WO2004100960A2 (en) * | 2003-04-25 | 2004-11-25 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
CN101410120A (zh) | 2003-04-25 | 2009-04-15 | 吉里德科学公司 | 抗炎的膦酸酯化合物 |
WO2006095666A1 (ja) * | 2005-03-07 | 2006-09-14 | Kyorin Pharmaceutical Co., Ltd. | ピラゾロピリジン-4-イルピリダジノン誘導体とその付加塩及びそれらを有効成分とするpde阻害剤 |
-
2005
- 2005-12-05 DE DE102005057924A patent/DE102005057924A1/de not_active Withdrawn
-
2006
- 2006-11-07 PL PL06806700T patent/PL1960370T3/pl unknown
- 2006-11-07 NZ NZ569568A patent/NZ569568A/en not_active IP Right Cessation
- 2006-11-07 KR KR1020087016217A patent/KR101367447B1/ko active IP Right Grant
- 2006-11-07 BR BRPI0619407-9A patent/BRPI0619407A2/pt not_active Application Discontinuation
- 2006-11-07 EP EP06806700A patent/EP1960370B1/de active Active
- 2006-11-07 DK DK06806700.8T patent/DK1960370T3/da active
- 2006-11-07 CA CA2632217A patent/CA2632217C/en active Active
- 2006-11-07 CN CN2006800458935A patent/CN101326167B/zh active Active
- 2006-11-07 PT PT06806700T patent/PT1960370E/pt unknown
- 2006-11-07 US US12/096,079 patent/US8173653B2/en active Active
- 2006-11-07 UA UAA200808757A patent/UA95934C2/ru unknown
- 2006-11-07 AU AU2006322364A patent/AU2006322364B2/en active Active
- 2006-11-07 WO PCT/EP2006/010668 patent/WO2007065518A1/de active Application Filing
- 2006-11-07 EA EA200801428A patent/EA014667B1/ru not_active IP Right Cessation
- 2006-11-07 SI SI200631187T patent/SI1960370T1/sl unknown
- 2006-11-07 ES ES06806700T patent/ES2373117T3/es active Active
- 2006-11-07 JP JP2008543675A patent/JP5210172B2/ja not_active Expired - Fee Related
- 2006-11-07 MY MYPI20081936A patent/MY153261A/en unknown
- 2006-11-07 AT AT06806700T patent/ATE527241T1/de active
- 2006-12-01 AR ARP060105310A patent/AR057214A1/es active IP Right Grant
- 2006-12-04 TW TW095145046A patent/TWI395741B/zh not_active IP Right Cessation
- 2006-12-05 PE PE2006001553A patent/PE20070832A1/es active IP Right Grant
-
2008
- 2008-05-29 IL IL191832A patent/IL191832A/en active IP Right Grant
- 2008-07-02 EC EC2008008598A patent/ECSP088598A/es unknown
- 2008-07-04 ZA ZA200805877A patent/ZA200805877B/xx unknown
-
2009
- 2009-06-09 HK HK09105156.0A patent/HK1127489A1/xx not_active IP Right Cessation
-
2011
- 2011-12-14 CY CY20111101245T patent/CY1112206T1/el unknown
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