AR042658A1 - Derivados de 1,5-diaril-pirrol-3-carboxamida y su uso como moduladores de receptores canabinoides - Google Patents

Derivados de 1,5-diaril-pirrol-3-carboxamida y su uso como moduladores de receptores canabinoides

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Publication number
AR042658A1
AR042658A1 ARP030104797A ARP030104797A AR042658A1 AR 042658 A1 AR042658 A1 AR 042658A1 AR P030104797 A ARP030104797 A AR P030104797A AR P030104797 A ARP030104797 A AR P030104797A AR 042658 A1 AR042658 A1 AR 042658A1
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Argentina
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group
alkyl
optionally substituted
alkyl group
groups
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ARP030104797A
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English (en)
Inventor
Anna Ingrid Kristina Berggren
Stig Jonas Bostrom
Leifeng Cheng
Stig Thomas Elebring
Peter Greasley
Mats Nagard
Johan Michael Wilstermann
Emma Terricabras
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Astrazeneca Ab
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Publication of AR042658A1 publication Critical patent/AR042658A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • Diabetes (AREA)
  • Epidemiology (AREA)
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  • Obesity (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
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  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto de fórmula (1), procesos para preparar tales compuestos, su uso en el tratamiento de obesidad, trastornos psiquiátricos y neurológicos, particularmente obesidad, métodos para su uso terapéutico y composiciones farmacéuticas que los contienen. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1), y sales, profármacos y solvatos aceptables para uso farmacéutico del mismo, en donde R1 y R2 representan en forma independiente fenilo, tienilo o piridilo cada uno de los cuales está opcionalmente sustituido por uno, dos o tres grupos representados por Z; Z representa un grupo alquilo C1-3, un grupo alcoxi C1-3, hidroxi, halo, trifluorometilo, trifluorometiltio, difluorometoxi, trifluorometoxi, trifluorometilsulfonilo, amino, mono o di-alquilamino (C1-3), mono o di-alquilamido (C1-3), alquilsulfonilo C1-3, alcoxicarbonilo C1-3, carboxi, ciano, carbamoílo, mono o di-alquilo (C1-3) carbamoílo, sulfamoilo y acetilo; y R3 es H, un grupo alquilo C1-3, un grupo alcoximetilo C1-3, trifluorometilo, un grupo amino-alquilo (C1-3), un grupo hidroxi-alquilo (C1-3), alcoxicarbonilo C1-3, carboxi, ciano, carbamoílo, mono o di-alquilcrbamoilo (C1-3), acetilo, o hidrazinocarbonilo de fórmula -CONHNRaRb donde Ra y Rb son como se define para R4 y R5 respectivamente y; X es CO o SO2; Y está ausente o representa NH opcionalmente sustituido con un grupo alquilo C1-3; R4 y R5 representan en forma independiente un grupo alquilo C1-6; un grupo (amino)alquilo C1-4 en donde el amino está opcionalmente sustituido con uno o más grupos alquilo C1-3; un grupo carbocíclico C3-15 no aromático opcionalmente sustituido; un grupo cicloalquil(C3-12)-alquilo(C1-3); un grupo -(CH2)r(fenil)s en donde r es 0, 1, 2, 3 ó 4, s es 1 cuando r es 0, caso contrario, s es 1 ó 2 y los grupos fenilo están sustituidos opcionalmente en forma independiente por uno, dos o tres grupos representados por Z; naftilo; antracenilo; un grupo heterocíclico saturado de 5 a 8 miembros que contiene un nitrógeno y opcionalmente uno de los siguientes: oxígeno, azufre o un nitrógeno adicional donde el grupo heterocíclico está opcionalmente sustituido con uno o más grupos alquilo C1-3, hidroxi o bencilo; 1-adamantilmetilo; un grupo -(CH2)thet en donde t es 0, 1, 2, 3 ó 4, y la cadena alquileno está opcionalmente sustituida por uno o más grupos alquilo C1-3 y Het representa un heterociclo aromático opcionalmente sustituido por uno, dos o tres grupos seleccionados entre un grupo alquilo C1-6; un grupo alcoxi C1-6 o halo; o R4 representa H y R5 tiene los valores que se han definido; o R4 y R5 junto con el átomo de nitrógeno al cual están unidos representan un grupo heterocíclico saturado de 5 a 8 miembros que contiene un nitrógeno y opcionalmente uno de los siguientes: oxígeno, azufre o un nitrógeno adicional; donde el grupo heterocíclico está opcionalmente sustituido con uno o más grupos alquilo C1-3, hidroxi o bencilo; R6 es H, un grupo alquilo C1-3, un grupo alcoximetilo C1-3, trifluorometilo, un grupo hidroxi-alquilo (C1-3), alcoxicarbonilo C1-3, carboxi, ciano, carbamoílo, mono o di-alquilcarbamoilo (C1-3), acetilo, o hidrazinocarbonilo de fórmula -CONHRaRb donde Ra y Rb son como se define para R4 y R5 respectivamente y; con la salvedad de que cuando R6 es metilo entonces el grupo X-Y-NR4R5 no representa CONHC6H13, CONHC12H25, CONH2, CONHCH3, CON(CH3)2, o un resto de fórmula (2), y con la salvedad adicional de que cuando R1 y R2 representan en forma independiente fenilo entonces Z no es un grupo ortometilo.
ARP030104797A 2002-12-24 2003-12-22 Derivados de 1,5-diaril-pirrol-3-carboxamida y su uso como moduladores de receptores canabinoides AR042658A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0230088.7A GB0230088D0 (en) 2002-12-24 2002-12-24 Therapeutic agents

Publications (1)

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AR042658A1 true AR042658A1 (es) 2005-06-29

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ARP030104797A AR042658A1 (es) 2002-12-24 2003-12-22 Derivados de 1,5-diaril-pirrol-3-carboxamida y su uso como moduladores de receptores canabinoides

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Country Link
US (1) US20060122230A1 (es)
EP (1) EP1578417A1 (es)
JP (1) JP2006513201A (es)
KR (1) KR20050086931A (es)
CN (1) CN1753668A (es)
AR (1) AR042658A1 (es)
AU (1) AU2003290292A1 (es)
BR (1) BR0317705A (es)
CA (1) CA2511601A1 (es)
CL (1) CL2003002720A1 (es)
GB (1) GB0230088D0 (es)
IS (1) IS7944A (es)
MX (1) MXPA05006919A (es)
NO (1) NO20052995L (es)
PL (1) PL377296A1 (es)
RU (1) RU2005117783A (es)
TW (1) TW200503692A (es)
UY (1) UY28144A1 (es)
WO (1) WO2004058249A1 (es)
ZA (1) ZA200504822B (es)

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CA2511601A1 (en) 2004-07-15
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