AR072471A1 - BENZOXACINAS Y BENZOTIACINAS CON ACTIVIDAD INHIBIDORA DE NOS, COMPOSICIoN FARMACÉUTICA QUE LAS COMPRENDE Y SU USO EN EL TRATAMIENTO DEL DOLOR. - Google Patents
BENZOXACINAS Y BENZOTIACINAS CON ACTIVIDAD INHIBIDORA DE NOS, COMPOSICIoN FARMACÉUTICA QUE LAS COMPRENDE Y SU USO EN EL TRATAMIENTO DEL DOLOR.Info
- Publication number
- AR072471A1 AR072471A1 ARP090102506A ARP090102506A AR072471A1 AR 072471 A1 AR072471 A1 AR 072471A1 AR P090102506 A ARP090102506 A AR P090102506A AR P090102506 A ARP090102506 A AR P090102506A AR 072471 A1 AR072471 A1 AR 072471A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- heterocyclyl
- alkyl
- r2nhc
- alkylaryl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Benzoxacinas, benzotiacinas y compuestos relacionados que inhiben la sintetasa oxido nítrico (NOS), particularmente aquellas que inhiben selectivamente la sintetasa de oxido nítrico neuronal (nNOS) preferentemente a otras isoformas de NOS. Estos inhibidores de NOS solos o en combinacion con otros agentes farmacéuticamente activos, pueden ser usados para el tratamiento o prevencion de diversas condiciones médicas relacionadas con el dolor. Reivindicacion 1: Un compuesto que tiene la formula (1) en donde: Q es O-(CHR6)1-3 o S-(CHR6)1-3; R1 y cada R6 es, de modo independiente, H, alquilo C1-6 opcionalmente sustituido, alquilarilo C1-4 opcionalmente sustituido, alquilheterociclilo C1-4 opcionalmente sustituido, o heterociclilo C2-9 opcionalmente sustituido, cicloalquilo C3-8 opcionalmente sustituido, alquilcicloalquilo C1-4 opcionalmente sustituido, o -(CR1AR1B)nNR1CR1D; R1A y R1B son, de modo independiente, H, hidroxi, halo, alquilo C1-6 opcionalmente sustituido, alcoxi C1-6 opcionalmente sustituido, alquilcicloalquilo C1-4 opcionalmente sustituido, alquilarilo C1-4 opcionalmente sustituido, alquilheterociclilo C1-4 opcionalmente sustituido, alquilheteroarilo C1-4 opcionalmente sustituido, cicloalquilo C3-8 opcionalmente sustituido, heterociclilo C2-9 opcionalmente sustituido o R1A y R1B se combinan para formar =O; R1C y R1D son, de modo independiente, H, alquilo C1-6 opcionalmente sustituido, alcoxi C1-6 opcionalmente sustituido, alquilcicloalquilo C1-4 opcionalmente sustituido, alquilarilo C1-4 opcionalmente sustituido, alquilheterociclilo C1-4 opcionalmente sustituido, alquilheteroarilo C1-4 opcionalmente sustituido, cicloalquilo C3-8 opcionalmente sustituido, heterociclilo C2-9 opcionalmente sustituido o un grupo protector de N, o R1C y R1D se combinan para formar un heterociclilo C2-9 opcionalmente sustituido o un grupo protector de N; n es un numero entero entre 1-6; cada de R2 y R3 es, independientemente, H, hal, alquilo C1-6 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, alquilarilo C1-6 opcionalmente sustituido, heterociclilo C2-9 opcionalmente sustituido, hidroxi, alcoxi C1-6 opcionalmente sustituido, tioalcoxi C1-6 opcionalmente sustituido, (CH2)r2NHC(NH)R2A, o (CH2)r2NHC(S)NHR2A, o alquilheterociclilo C1-4 opcionalmente sustituido, en donde r2 es un numero entero de 0 a 2, R2A es alquilo C1-6 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, alquilarilo C1-4 opcionalmente sustituido, heterociclilo C2-9, opcionalmente sustituido, alquilheterociclilo C1-4 opcionalmente sustituido, tioalcoxi C1-6 opcionalmente sustituido, tioalquilarilo C1-4 opcionalmente sustituido, ariloílo opcionalmente sustituido, tioalquilheterociclilo C1-4 opcionalmente sustituido, o amino opcionalmente sustituido; cada uno de R4 y R5 es independientemente H, hal, (CH2)r2NHC(NH)R2A, o (CH2)r2NHC(S)NHR2A; en donde Y1 e Y2 son cada uno H, o Y1 e Y2 en conjunto son =O, o Y1 e Y2 son independientemente H, alquilo C1-6 opcionalmente sustituido, arilo C6-10 opcionalmente sustituido, alquilarilo C1-6 opcionalmente sustituido, heterociclilo C2-9 opcionalmente sustituido, hidroxi, alcoxi C1-6 opcionalmente sustituido, tioalcoxi C1-6 opcionalmente sustituido, o alquilheterociclilo C1-4 opcionalmente sustituido; en donde solo una de R2, R3, R4, y R5 es (CH2)r2NHC(NH)R2A o (CH2)r2NHC(S)NHR2A; o una sal farmacéuticamente aceptable o un profármaco de la misma.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13388708P | 2008-07-03 | 2008-07-03 |
Publications (1)
Publication Number | Publication Date |
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AR072471A1 true AR072471A1 (es) | 2010-09-01 |
Family
ID=41465440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP090102506A AR072471A1 (es) | 2008-07-03 | 2009-07-03 | BENZOXACINAS Y BENZOTIACINAS CON ACTIVIDAD INHIBIDORA DE NOS, COMPOSICIoN FARMACÉUTICA QUE LAS COMPRENDE Y SU USO EN EL TRATAMIENTO DEL DOLOR. |
Country Status (20)
Country | Link |
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US (3) | US8106043B2 (es) |
EP (1) | EP2310386A4 (es) |
JP (1) | JP5572157B2 (es) |
KR (1) | KR20110036607A (es) |
CN (1) | CN102143961B (es) |
AR (1) | AR072471A1 (es) |
AU (1) | AU2009266386B2 (es) |
BR (1) | BRPI0913915A2 (es) |
CA (1) | CA2729246C (es) |
CL (1) | CL2010001633A1 (es) |
EA (1) | EA021798B1 (es) |
IL (1) | IL210195A (es) |
MX (1) | MX2011000124A (es) |
MY (1) | MY158796A (es) |
NZ (1) | NZ590727A (es) |
SG (1) | SG192470A1 (es) |
TW (1) | TWI458726B (es) |
UA (1) | UA105182C2 (es) |
WO (1) | WO2010000073A1 (es) |
ZA (1) | ZA201100436B (es) |
Families Citing this family (117)
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US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
CN101830894B (zh) * | 2010-06-01 | 2013-05-29 | 上海交通大学 | 一类苯并[d]噁唑化合物及其制备方法 |
WO2013076590A1 (en) * | 2011-11-23 | 2013-05-30 | Oxygen Healthcare Research Pvt. Ltd | Benzothiazine compounds as h3 receptor ligands |
CN102491919B (zh) * | 2011-12-15 | 2014-03-19 | 南京友杰医药科技有限公司 | 去甲维拉帕米的合成方法 |
WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
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DE19952147A1 (de) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE10020667A1 (de) * | 2000-04-19 | 2001-11-22 | Schering Ag | Neue Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
US20030082225A1 (en) | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
DK1539724T3 (da) | 2002-08-07 | 2008-02-11 | Neuraxon Inc | Aminobenzothiazolforbindelser med NOS-inhiberende aktivitet |
CN101247853B (zh) * | 2005-04-13 | 2014-11-12 | 轴突公司 | 具有nos抑制活性的取代的吲哚化合物 |
AR054045A1 (es) * | 2005-05-18 | 2007-05-30 | Neuraxon Inc | Compuestos benzoimidazol sustituidos con actividad dual no inhibitoria y mu opioide agonista |
US7700592B2 (en) * | 2005-08-25 | 2010-04-20 | Schering Corporation | α2C adrenoreceptor agonists |
DE602006016303D1 (de) * | 2005-08-25 | 2010-09-30 | Pharmacopeia Llc | 3,4-dihydro-2H-benzoÄ1,4Üoxazin- und 3,4-dihydro-2H-benzoÄ1,4Üthiazin-VERBINDUNGEN ALS ALPHA2C-ADRENOREZEPTOR-ANTAGONISTEN |
AR060451A1 (es) * | 2006-04-13 | 2008-06-18 | Neuraxon Inc | Compuestos de indol 1,5 y 3,6-sustituidos con actividad inhibitoria de nos |
CA2705833A1 (en) | 2007-11-16 | 2009-05-22 | Subhash C. Annedi | 3,5-substituted indole compounds having nos and norepinephrine reuptake inhibitory activity |
-
2009
- 2009-03-07 UA UAA201101136A patent/UA105182C2/ru unknown
- 2009-07-03 SG SG2013051644A patent/SG192470A1/en unknown
- 2009-07-03 AR ARP090102506A patent/AR072471A1/es unknown
- 2009-07-03 KR KR1020117002783A patent/KR20110036607A/ko not_active Application Discontinuation
- 2009-07-03 CA CA2729246A patent/CA2729246C/en not_active Expired - Fee Related
- 2009-07-03 NZ NZ590727A patent/NZ590727A/xx not_active IP Right Cessation
- 2009-07-03 JP JP2011515041A patent/JP5572157B2/ja not_active Expired - Fee Related
- 2009-07-03 WO PCT/CA2009/000923 patent/WO2010000073A1/en active Application Filing
- 2009-07-03 EP EP09771883A patent/EP2310386A4/en not_active Withdrawn
- 2009-07-03 MX MX2011000124A patent/MX2011000124A/es active IP Right Grant
- 2009-07-03 TW TW098122515A patent/TWI458726B/zh not_active IP Right Cessation
- 2009-07-03 AU AU2009266386A patent/AU2009266386B2/en not_active Ceased
- 2009-07-03 CN CN200980134295.9A patent/CN102143961B/zh not_active Expired - Fee Related
- 2009-07-03 EA EA201170130A patent/EA021798B1/ru not_active IP Right Cessation
- 2009-07-03 MY MYPI2010006341A patent/MY158796A/en unknown
- 2009-07-03 BR BRPI0913915A patent/BRPI0913915A2/pt not_active IP Right Cessation
- 2009-07-06 US US12/498,185 patent/US8106043B2/en not_active Expired - Fee Related
-
2010
- 2010-12-23 IL IL210195A patent/IL210195A/en not_active IP Right Cessation
- 2010-12-30 CL CL2010001633A patent/CL2010001633A1/es unknown
-
2011
- 2011-01-17 ZA ZA2011/00436A patent/ZA201100436B/en unknown
-
2012
- 2012-01-27 US US13/360,029 patent/US8618286B2/en not_active Expired - Fee Related
-
2013
- 2013-12-11 US US14/103,446 patent/US20140163016A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2011526251A (ja) | 2011-10-06 |
MY158796A (en) | 2016-11-15 |
US20120122855A1 (en) | 2012-05-17 |
US20140163016A1 (en) | 2014-06-12 |
CA2729246A1 (en) | 2010-01-07 |
EA201170130A1 (ru) | 2011-08-30 |
EA021798B1 (ru) | 2015-09-30 |
US8106043B2 (en) | 2012-01-31 |
EP2310386A4 (en) | 2012-04-11 |
US20100009975A1 (en) | 2010-01-14 |
KR20110036607A (ko) | 2011-04-07 |
BRPI0913915A2 (pt) | 2015-10-13 |
ZA201100436B (en) | 2012-10-31 |
TWI458726B (zh) | 2014-11-01 |
IL210195A (en) | 2015-08-31 |
US8618286B2 (en) | 2013-12-31 |
CN102143961B (zh) | 2014-11-05 |
CA2729246C (en) | 2018-08-21 |
UA105182C2 (ru) | 2014-04-25 |
IL210195A0 (en) | 2011-03-31 |
NZ590727A (en) | 2012-12-21 |
SG192470A1 (en) | 2013-08-30 |
MX2011000124A (es) | 2011-02-24 |
EP2310386A1 (en) | 2011-04-20 |
JP5572157B2 (ja) | 2014-08-13 |
AU2009266386A1 (en) | 2010-01-07 |
AU2009266386B2 (en) | 2015-02-19 |
CN102143961A (zh) | 2011-08-03 |
TW201002701A (en) | 2010-01-16 |
WO2010000073A1 (en) | 2010-01-07 |
CL2010001633A1 (es) | 2011-05-20 |
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