DK351185A - Indolderivater - Google Patents

Indolderivater Download PDF

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Publication number
DK351185A
DK351185A DK351185A DK351185A DK351185A DK 351185 A DK351185 A DK 351185A DK 351185 A DK351185 A DK 351185A DK 351185 A DK351185 A DK 351185A DK 351185 A DK351185 A DK 351185A
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DK
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Prior art keywords
indole derivatives
indole
derivatives
Prior art date
Application number
DK351185A
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English (en)
Other versions
DK158942C (da
DK158942B (da
DK351185D0 (da
Inventor
Alexander William Oxford
Original Assignee
Glaxo Group Ltd
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK351185(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK351185D0 publication Critical patent/DK351185D0/da
Publication of DK351185A publication Critical patent/DK351185A/da
Publication of DK158942B publication Critical patent/DK158942B/da
Application granted granted Critical
Publication of DK158942C publication Critical patent/DK158942C/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK351185A 1984-08-01 1985-08-01 3-(2-(dimethylamino)ethyl)-n-methyl-1h-indol-5-methansulfonamid, farmaceutiske praeparater indeholdende denne forbindelse samt fremgangsmaader til fremstilling af forbindelsen DK158942C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8419575 1984-08-01
GB848419575A GB8419575D0 (en) 1984-08-01 1984-08-01 Chemical compounds

Publications (4)

Publication Number Publication Date
DK351185D0 DK351185D0 (da) 1985-08-01
DK351185A true DK351185A (da) 1986-02-02
DK158942B DK158942B (da) 1990-08-06
DK158942C DK158942C (da) 1991-01-21

Family

ID=10564759

Family Applications (1)

Application Number Title Priority Date Filing Date
DK351185A DK158942C (da) 1984-08-01 1985-08-01 3-(2-(dimethylamino)ethyl)-n-methyl-1h-indol-5-methansulfonamid, farmaceutiske praeparater indeholdende denne forbindelse samt fremgangsmaader til fremstilling af forbindelsen

Country Status (42)

Country Link
US (1) US5037845A (da)
JP (1) JPH0623197B2 (da)
KR (1) KR930003759B1 (da)
AT (1) AT386196B (da)
AU (1) AU573878B2 (da)
BE (1) BE903006A (da)
CA (1) CA1241004A (da)
CH (1) CH666026A5 (da)
CZ (1) CZ280530B6 (da)
DE (1) DE3527648A1 (da)
DK (1) DK158942C (da)
DO (1) DOP1989004759A (da)
EC (1) ECSP941096A (da)
EG (1) EG17283A (da)
ES (6) ES8700234A1 (da)
FI (1) FI78466C (da)
FR (1) FR2568571B1 (da)
GB (1) GB8419575D0 (da)
GR (1) GR851850B (da)
HK (1) HK33289A (da)
HU (1) HU201738B (da)
IE (1) IE58122B1 (da)
IL (1) IL75986A (da)
IS (1) IS1430B6 (da)
IT (1) IT1207325B (da)
JO (1) JO1379B1 (da)
KE (1) KE3858A (da)
LU (2) LU88266I2 (da)
MA (1) MA20499A1 (da)
MX (2) MX159672A (da)
NL (2) NL188642C (da)
NO (2) NO164653C (da)
NZ (1) NZ212948A (da)
PH (2) PH22850A (da)
PL (1) PL146005B1 (da)
PT (1) PT80900B (da)
SE (1) SE452460B (da)
SK (1) SK404191A3 (da)
SU (1) SU1498386A3 (da)
UA (1) UA6329A1 (da)
ZA (1) ZA855818B (da)
ZW (1) ZW12485A1 (da)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
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GB9104890D0 (en) 1991-03-08 1991-04-24 Glaxo Group Ltd Compositions
AT399870B (de) * 1991-06-06 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 3-(2-(dimethylamino)ethyl)-n-methyl-1h-indol-5- ethansulfonamid
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
ES2059236B1 (es) * 1992-06-18 1995-06-16 Imidex S A Procedimiento para la sintesis de la 3-(2-dimetilamino) etil)-n-metil-1h-indol-5-metanosulfonamida.
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
AT399871B (de) * 1993-02-15 1995-08-25 Vita Invest Sa Verfahren zur herstellung von 2-carboxy-3-(2- (dimethylamino)ethyl)-n-methyl-1h-indol-5- methansulfonamid und dessen niederalkylestern
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US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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US20060106227A1 (en) * 2002-06-13 2006-05-18 Dr Reddy's Laboratories Limited 3-'2-(Dimethylamino) ethyl!-n-methyl-1h-indole-5-methanesulfonamide and the succinate thereof
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JP2012506404A (ja) * 2008-10-22 2012-03-15 ノバルティス アーゲー 片頭痛処置用組み合わせ剤
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JP5660817B2 (ja) * 2010-07-21 2015-01-28 高田製薬株式会社 スマトリプタンコハク酸塩を含有する内用液剤
CN102432520B (zh) * 2011-11-21 2013-10-09 山东新华制药股份有限公司 3-[2-（二甲氨基）乙基]-n-甲基吲哚-5-甲烷磺酰胺琥珀酸盐的制备方法
CN107530318A (zh) 2015-03-02 2018-01-02 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
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HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds

Also Published As

Publication number Publication date
IT1207325B (it) 1989-05-17
ES8700234A1 (es) 1986-10-16
HK33289A (en) 1989-04-28
MX159672A (es) 1989-08-02
KE3858A (en) 1989-06-02
IS3034A7 (is) 1986-02-02
NL930065I1 (nl) 1993-09-01
ES557481A0 (es) 1988-02-16
GR851850B (da) 1985-11-26
SE8503680D0 (sv) 1985-08-01
JO1379B1 (en) 1986-11-30
ES552047A0 (es) 1987-12-16
IS1430B6 (is) 1990-07-16
NL188642C (nl) 1992-08-17
ES8801900A1 (es) 1988-03-01
ES545810A0 (es) 1986-10-16
PL254800A1 (en) 1986-10-21
ES8801204A1 (es) 1987-12-16
PH24117A (en) 1990-03-05
LU86032A1 (fr) 1986-02-18
NO1994023I1 (no) 1994-11-09
SK277952B6 (en) 1995-09-13
ES8801790A1 (es) 1988-02-16
IL75986A (en) 1989-02-28
PT80900B (pt) 1987-12-30
ES557482A0 (es) 1988-03-01
IE58122B1 (en) 1993-07-14
NZ212948A (en) 1989-05-29
ES557483A0 (es) 1988-02-16
KR930003759B1 (ko) 1993-05-10
NO164653B (no) 1990-07-23
FI852969L (fi) 1986-02-02
UA6329A1 (uk) 1994-12-29
CH666026A5 (fr) 1988-06-30
BE903006A (fr) 1986-02-03
CZ404191A3 (en) 1993-04-14
ES8801789A1 (es) 1988-02-16
DE3527648A1 (de) 1986-02-13
MA20499A1 (fr) 1986-04-01
ATA226685A (de) 1987-12-15
NL8502171A (nl) 1986-03-03
KR860001788A (ko) 1986-03-22
NO853046L (no) 1986-02-03
DK158942C (da) 1991-01-21
ES557480A0 (es) 1988-02-16
FI78466B (fi) 1989-04-28
ES8801788A1 (es) 1988-02-16
PT80900A (en) 1985-09-01
ECSP941096A (es) 1995-01-16
SU1498386A3 (ru) 1989-07-30
GB8419575D0 (en) 1984-09-05
PH22850A (en) 1989-01-19
HU201738B (en) 1990-12-28
LU88266I2 (da) 1994-02-03
FI78466C (fi) 1989-08-10
SE452460B (sv) 1987-11-30
FI852969A0 (fi) 1985-08-01
AU4568985A (en) 1986-02-06
AU573878B2 (en) 1988-06-23
EG17283A (en) 1992-06-30
NL930065I2 (nl) 1993-10-01
CA1241004A (en) 1988-08-23
FR2568571A1 (fr) 1986-02-07
JPH0623197B2 (ja) 1994-03-30
IE851918L (en) 1986-02-01
PL146005B1 (en) 1988-12-31
AT386196B (de) 1988-07-11
MX14221A (es) 1993-10-01
SK404191A3 (en) 1995-09-13
DK158942B (da) 1990-08-06
CZ280530B6 (cs) 1996-02-14
US5037845A (en) 1991-08-06
DE3527648C2 (da) 1993-08-26
HUT40077A (en) 1986-11-28
DK351185D0 (da) 1985-08-01
NO164653C (no) 1990-11-07
JPS6147464A (ja) 1986-03-07
SE8503680L (sv) 1986-02-02
IT8548435A0 (it) 1985-08-01
ZA855818B (en) 1986-04-30
IL75986A0 (en) 1985-12-31
DOP1989004759A (es) 1999-02-06
ZW12485A1 (en) 1986-02-26
FR2568571B1 (fr) 1988-09-23

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