UA6329A1 - Спосіб одержання 3-[2-(діметіламіно)-етіл]-n-метіл-1н-індол-5-метансульфонаміда або його солей, або сольватів - Google Patents

Спосіб одержання 3-[2-(діметіламіно)-етіл]-n-метіл-1н-індол-5-метансульфонаміда або його солей, або сольватів

Info

Publication number
UA6329A1
UA6329A1 UA3935745A UA3935745A UA6329A1 UA 6329 A1 UA6329 A1 UA 6329A1 UA 3935745 A UA3935745 A UA 3935745A UA 3935745 A UA3935745 A UA 3935745A UA 6329 A1 UA6329 A1 UA 6329A1
Authority
UA
Ukraine
Prior art keywords
methanesulfonamide
indol
methyl
solvates
dimethylamino
Prior art date
Application number
UA3935745A
Other languages
English (en)
Russian (ru)
Inventor
Вілльям Оксфорд Алєксандр
Original Assignee
Глексо Груп Лімітед
Глексо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10564759&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA6329(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глексо Груп Лімітед, Глексо Груп Лимитед filed Critical Глексо Груп Лімітед
Publication of UA6329A1 publication Critical patent/UA6329A1/uk

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Abstract

Спосіб одержання 3-[2-(диметиламіно)-етил]-N-метил-1Н-індол-5-метансульфонаміду формули або його солей, або сольватів. 3-(2-аминоетил)-N-метил-1Н-індол-5-метан-сульфонамід піддають взаємодії с формальдегідом і боргідридом або ціанборгідридом натрію с подальшим виділенням цільового продукту у вільному виді, або у виді солі, або сольвату.
UA3935745A 1984-08-01 1985-08-01 Спосіб одержання 3-[2-(діметіламіно)-етіл]-n-метіл-1н-індол-5-метансульфонаміда або його солей, або сольватів UA6329A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848419575A GB8419575D0 (en) 1984-08-01 1984-08-01 Chemical compounds

Publications (1)

Publication Number Publication Date
UA6329A1 true UA6329A1 (uk) 1994-12-29

Family

ID=10564759

Family Applications (1)

Application Number Title Priority Date Filing Date
UA3935745A UA6329A1 (uk) 1984-08-01 1985-08-01 Спосіб одержання 3-[2-(діметіламіно)-етіл]-n-метіл-1н-індол-5-метансульфонаміда або його солей, або сольватів

Country Status (42)

Country Link
US (1) US5037845A (uk)
JP (1) JPH0623197B2 (uk)
KR (1) KR930003759B1 (uk)
AT (1) AT386196B (uk)
AU (1) AU573878B2 (uk)
BE (1) BE903006A (uk)
CA (1) CA1241004A (uk)
CH (1) CH666026A5 (uk)
CZ (1) CZ280530B6 (uk)
DE (1) DE3527648A1 (uk)
DK (1) DK158942C (uk)
DO (1) DOP1989004759A (uk)
EC (1) ECSP941096A (uk)
EG (1) EG17283A (uk)
ES (6) ES8700234A1 (uk)
FI (1) FI78466C (uk)
FR (1) FR2568571B1 (uk)
GB (1) GB8419575D0 (uk)
GR (1) GR851850B (uk)
HK (1) HK33289A (uk)
HU (1) HU201738B (uk)
IE (1) IE58122B1 (uk)
IL (1) IL75986A (uk)
IS (1) IS1430B6 (uk)
IT (1) IT1207325B (uk)
JO (1) JO1379B1 (uk)
KE (1) KE3858A (uk)
LU (2) LU86032A1 (uk)
MA (1) MA20499A1 (uk)
MX (2) MX159672A (uk)
NL (2) NL188642C (uk)
NO (2) NO164653C (uk)
NZ (1) NZ212948A (uk)
PH (2) PH22850A (uk)
PL (1) PL146005B1 (uk)
PT (1) PT80900B (uk)
SE (1) SE452460B (uk)
SK (1) SK277952B6 (uk)
SU (1) SU1498386A3 (uk)
UA (1) UA6329A1 (uk)
ZA (1) ZA855818B (uk)
ZW (1) ZW12485A1 (uk)

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Also Published As

Publication number Publication date
SK404191A3 (en) 1995-09-13
ES545810A0 (es) 1986-10-16
MX159672A (es) 1989-08-02
JO1379B1 (en) 1986-11-30
ZA855818B (en) 1986-04-30
DE3527648C2 (uk) 1993-08-26
FI852969L (fi) 1986-02-02
ZW12485A1 (en) 1986-02-26
GB8419575D0 (en) 1984-09-05
KE3858A (en) 1989-06-02
CZ404191A3 (en) 1993-04-14
AT386196B (de) 1988-07-11
MA20499A1 (fr) 1986-04-01
KR930003759B1 (ko) 1993-05-10
FI852969A0 (fi) 1985-08-01
NO164653B (no) 1990-07-23
DK158942B (da) 1990-08-06
IE851918L (en) 1986-02-01
NL8502171A (nl) 1986-03-03
PH22850A (en) 1989-01-19
ES557482A0 (es) 1988-03-01
ES8700234A1 (es) 1986-10-16
NZ212948A (en) 1989-05-29
SU1498386A3 (ru) 1989-07-30
IT8548435A0 (it) 1985-08-01
ES552047A0 (es) 1987-12-16
LU86032A1 (fr) 1986-02-18
SE8503680L (sv) 1986-02-02
SE8503680D0 (sv) 1985-08-01
FR2568571A1 (fr) 1986-02-07
ES557480A0 (es) 1988-02-16
HK33289A (en) 1989-04-28
EG17283A (en) 1992-06-30
ES8801789A1 (es) 1988-02-16
PT80900B (pt) 1987-12-30
IL75986A0 (en) 1985-12-31
ES8801788A1 (es) 1988-02-16
CH666026A5 (fr) 1988-06-30
HU201738B (en) 1990-12-28
PT80900A (en) 1985-09-01
SE452460B (sv) 1987-11-30
LU88266I2 (uk) 1994-02-03
JPS6147464A (ja) 1986-03-07
AU573878B2 (en) 1988-06-23
NO1994023I1 (no) 1994-11-09
IS3034A7 (is) 1986-02-02
ES557481A0 (es) 1988-02-16
CZ280530B6 (cs) 1996-02-14
FI78466B (fi) 1989-04-28
FR2568571B1 (fr) 1988-09-23
PH24117A (en) 1990-03-05
NL930065I1 (nl) 1993-09-01
DK158942C (da) 1991-01-21
DE3527648A1 (de) 1986-02-13
KR860001788A (ko) 1986-03-22
DOP1989004759A (es) 1999-02-06
FI78466C (fi) 1989-08-10
ECSP941096A (es) 1995-01-16
PL146005B1 (en) 1988-12-31
JPH0623197B2 (ja) 1994-03-30
AU4568985A (en) 1986-02-06
DK351185A (da) 1986-02-02
NL930065I2 (nl) 1993-10-01
IT1207325B (it) 1989-05-17
ES557483A0 (es) 1988-02-16
NO853046L (no) 1986-02-03
SK277952B6 (en) 1995-09-13
NO164653C (no) 1990-11-07
BE903006A (fr) 1986-02-03
MX14221A (es) 1993-10-01
IS1430B6 (is) 1990-07-16
ES8801790A1 (es) 1988-02-16
IL75986A (en) 1989-02-28
IE58122B1 (en) 1993-07-14
ES8801204A1 (es) 1987-12-16
ES8801900A1 (es) 1988-03-01
NL188642C (nl) 1992-08-17
GR851850B (uk) 1985-11-26
DK351185D0 (da) 1985-08-01
HUT40077A (en) 1986-11-28
US5037845A (en) 1991-08-06
ATA226685A (de) 1987-12-15
CA1241004A (en) 1988-08-23
PL254800A1 (en) 1986-10-21

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