ATA901585A - Verfahren zur herstellung des neuen n-(2-(4-fluor-phenyl)-1-methyl)-aethyl-n-methyl-n- propinylamin und isomeren und salzen desselben - Google Patents

Verfahren zur herstellung des neuen n-(2-(4-fluor-phenyl)-1-methyl)-aethyl-n-methyl-n- propinylamin und isomeren und salzen desselben

Info

Publication number
ATA901585A
ATA901585A AT9015/85A AT901585A ATA901585A AT A901585 A ATA901585 A AT A901585A AT 9015/85 A AT9015/85 A AT 9015/85A AT 901585 A AT901585 A AT 901585A AT A901585 A ATA901585 A AT A901585A
Authority
AT
Austria
Prior art keywords
methyl
propinylamine
aethyl
fluor
isomeric
Prior art date
Application number
AT9015/85A
Other languages
English (en)
Other versions
AT394552B (de
Inventor
Zoltan Ecsery
Jozsef Knoll
Eva Somfai
Zoltan Toeroek
Eva Szinnyei
Karoly Mozsolics
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of ATA901585A publication Critical patent/ATA901585A/de
Application granted granted Critical
Publication of AT394552B publication Critical patent/AT394552B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT0901585A 1984-05-31 1985-05-31 Verfahren zur herstellung des neuen n-(2-(4-fluor-phenyl)-1-methyl)-aethyl-n-methyl- propinylamin und isomeren und salzen desselben AT394552B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU842124A HU207282B (en) 1984-05-31 1984-05-31 Process for producing phenyl-alkyl-amine derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
ATA901585A true ATA901585A (de) 1991-10-15
AT394552B AT394552B (de) 1992-05-11

Family

ID=10957881

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0901585A AT394552B (de) 1984-05-31 1985-05-31 Verfahren zur herstellung des neuen n-(2-(4-fluor-phenyl)-1-methyl)-aethyl-n-methyl- propinylamin und isomeren und salzen desselben

Country Status (23)

Country Link
US (2) US5008292A (de)
EP (1) EP0186680B1 (de)
JP (2) JPS61502259A (de)
AT (1) AT394552B (de)
AU (1) AU588757B2 (de)
BG (1) BG61318B2 (de)
CH (1) CH671574A5 (de)
CS (1) CS271313B2 (de)
DD (1) DD235065A5 (de)
DE (2) DE3590241C2 (de)
DK (1) DK166018C (de)
ES (2) ES8609204A1 (de)
FI (1) FI92053C (de)
GB (1) GB2171694B (de)
GE (3) GEP19970786B (de)
HU (1) HU207282B (de)
IL (1) IL75358A (de)
MX (1) MX9203090A (de)
PL (2) PL149288B1 (de)
PT (1) PT80574B (de)
SE (1) SE463261B (de)
SU (3) SU1487810A3 (de)
WO (1) WO1985005617A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582060D1 (de) * 1984-11-22 1991-04-11 Sandoz Ag Homopropargylamine.
US5225446A (en) * 1990-08-31 1993-07-06 Deprenyl Animal Health, Inc. Use of 1-deprenyl for retention of specific physiological functions
US5844003A (en) * 1991-04-04 1998-12-01 Innovations Foundation Use of deprenyl compounds to maintain, prevent loss, or recover nerve cell function
US5444095A (en) * 1991-04-04 1995-08-22 University Of Toronto, Innovations Foundation Use of deprenyl to rescue damaged nerve cells
US5767164A (en) * 1991-04-04 1998-06-16 Innovations Foundation Use of deprenyl to rescue damaged nerve cells
IL99759A (en) * 1991-10-16 1997-06-10 Teva Pharma Mono-fluorinated derivatives of n-propargyl-1-aminoindan, their preparation and pharmaceutical compositions containing them
HUT63579A (en) * 1991-12-20 1993-09-28 Chinoin Gyogyszer Es Vegyeszet Process for producing double-phase pharmaceutical compositions suitable for treating diseases occurring during neurodegenerative processes
US5169536A (en) * 1992-04-28 1992-12-08 Betz Laboratories, Inc. Detoxification agents for surfactant based biocides
IES61604B2 (en) * 1993-12-16 1994-11-16 Russinsky Ltd A process for producing pharmaceutical compounds
US5516747A (en) * 1994-04-18 1996-05-14 Henkel Corporation Pesticidal surfactant mixtures comprising alkyl polyglycosides and alkyl naphthalene sulfonates
WO1995033455A1 (en) 1994-06-03 1995-12-14 Elmaleh David R Meta substituted arylalkylamines and therapeutic and diagnostic uses thereof
HU218927B (hu) * 1994-11-22 2000-12-28 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Eljárás propargil-ammónium-klorid-származékok előállítására
AU723047B2 (en) 1995-02-10 2000-08-17 University Of Toronto Innovations Foundation, The Deprenyl compounds for treatment of glaucoma
JP3087891B2 (ja) 1998-03-31 2000-09-11 東洋紡績株式会社 電解質測定用試薬組成物
HUP9902482A2 (hu) * 1999-07-22 2002-04-29 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. P-fluoro-selegilin alkalmazása neuroprotektív gyógyszerkészítmények előállítására
CA2616918A1 (en) * 2005-07-01 2007-01-11 Jenrin Discovery Mao-b inhibitors useful for treating obesity
EP2053033A1 (de) * 2007-10-26 2009-04-29 Bayer Schering Pharma AG Verbindungen zur Verwendung bei der Abbildung, Diagnose und/oder Behandlung von Erkrankungen des zentralen Nervensystems oder von Tumoren
CN102180798B (zh) * 2011-03-18 2013-11-06 湖北汉星化工新材料有限公司 一步法催化合成n,n-二乙基丙炔胺的方法
WO2015087094A1 (en) * 2013-12-10 2015-06-18 Semmelweis Egyetem New arylalkenylpropargylamine derivatives exhibiting neuroprotective action for the treatment of neurodegenerative diseases

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1311843A (fr) * 1961-09-06 1962-12-14 Abbott Lab Procédé de préparation de nu-halobenzyl-nu-méthyl-2-propynylamines
US3142554A (en) * 1961-10-10 1964-07-28 Monsanto Co Controlling vegetation with aryl thioalkylamines
GB1027611A (en) * 1962-01-04 1966-04-27 May & Baker Ltd Phenoxy- and phenylthio-alkylamines and acid addition salts thereof
GB1031425A (en) * 1962-03-30 1966-06-02 Chinoin Gyogyszer Es Vegyeszet New aralkylamines and their preparation
DE1227447B (de) * 1962-03-30 1966-10-27 Chinoin Gyogyszer Es Vegyeszet Verfahren zur Herstellung von Phenylisopropylaminen
GB1121857A (en) * 1965-01-05 1968-07-31 Science Union & Cie New phenylisopropylamine derivatives and process for their preparation and pharmaceutical preparations of such derivatives
CH551943A (en) * 1965-02-08 1974-07-31 Chinoin Gyogyszer Es Vegyeszet N-(Lower alkyl)-phenylisopropylamines
US3485874A (en) * 1966-05-04 1969-12-23 Chinoin Gyogyszer Es Vegyeszet Ortho and para bromophenyl isopropyl methylamines
US3496195A (en) * 1966-05-11 1970-02-17 Chinoin Gyogyszer Es Vegyeszet D-o-bromo-phenyl-isopropyl-methylpropinylamine and its salts
US4137328A (en) * 1970-07-18 1979-01-30 Pfizer Inc. Phenyl-alkanolamine, alkylamine and α-aminoalkyl ketone derivatives as heart stimulants
US3689504A (en) * 1970-12-24 1972-09-05 Abbott Lab N-substituted -alpha-methyl-3,4-(methylenedioxy) phenethylamines
US4314081A (en) * 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines
US4105695A (en) * 1975-12-11 1978-08-08 Bristol-Myers Company 2-Amino-1-(2,5-dimethoxyphenyl)-butanes
US4156017A (en) * 1977-02-22 1979-05-22 Schering Aktiengesellschaft Pesticides
US4200654A (en) * 1978-11-24 1980-04-29 Abbott Laboratories Ovicides
FR2486074A1 (fr) * 1979-12-14 1982-01-08 Lafon Labor Derives de fluorophenacyl-amine, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
DD235065A5 (de) 1986-04-23
SE8600413D0 (sv) 1986-01-30
DK45786A (da) 1986-01-30
PL149288B1 (en) 1990-01-31
AT394552B (de) 1992-05-11
FI92053C (fi) 1994-09-26
CS389585A2 (en) 1989-12-13
GB8602394D0 (en) 1986-03-05
CS271313B2 (en) 1990-09-12
SU1609443A3 (ru) 1990-11-23
JPH0564942B2 (de) 1993-09-16
SU1549477A3 (ru) 1990-03-07
FI860101A (fi) 1986-01-09
EP0186680A1 (de) 1986-07-09
AU4437585A (en) 1985-12-31
US4960797A (en) 1990-10-02
DK45786D0 (da) 1986-01-30
DE3590241T (de) 1986-06-26
EP0186680B1 (de) 1988-03-30
HUT37385A (en) 1985-12-28
SU1487810A3 (ru) 1989-06-15
ES544400A0 (es) 1986-09-01
SE463261B (sv) 1990-10-29
US5008292A (en) 1991-04-16
DK166018B (da) 1993-03-01
JPS61502259A (ja) 1986-10-09
HU207282B (en) 1993-03-29
MX9203090A (es) 1992-07-01
DK166018C (da) 1993-07-12
GEP19970786B (en) 1997-01-20
WO1985005617A1 (en) 1985-12-19
PT80574A (en) 1985-06-01
AU588757B2 (en) 1989-09-21
DE3590241C2 (de) 1991-08-01
GB2171694B (en) 1987-12-09
JPH0819057B2 (ja) 1996-02-28
GB2171694A (en) 1986-09-03
CH671574A5 (de) 1989-09-15
PL253737A1 (en) 1987-02-23
SE8600413L (sv) 1986-01-30
FI92053B (fi) 1994-06-15
JPH0687798A (ja) 1994-03-29
GEP19970818B (en) 1997-01-30
ES8704445A1 (es) 1987-04-16
IL75358A (en) 1988-10-31
PL150477B1 (en) 1990-05-31
PT80574B (pt) 1987-08-19
ES552827A0 (es) 1987-04-16
GEP19960459B (en) 1996-07-15
FI860101A0 (fi) 1986-01-09
ES8609204A1 (es) 1986-09-01
BG61318B2 (bg) 1997-05-30

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