SK288082B6 - Human antibodies that bind human IL-12, their use and methods for producing, pharmaceutical composition containing it, nucleic acid and recombinant vector, which they coded, and host cell - Google Patents

Human antibodies that bind human IL-12, their use and methods for producing, pharmaceutical composition containing it, nucleic acid and recombinant vector, which they coded, and host cell Download PDF

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Publication number
SK288082B6
SK288082B6 SK1367-2001A SK13672001A SK288082B6 SK 288082 B6 SK288082 B6 SK 288082B6 SK 13672001 A SK13672001 A SK 13672001A SK 288082 B6 SK288082 B6 SK 288082B6
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SK
Slovakia
Prior art keywords
antibody
amino acid
antigen
seq
acid sequence
Prior art date
Application number
SK1367-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK13672001A3 (sk
Inventor
Jochen G. Salfeld
Michael Roguska
Michael Paskind
Subhashis Banerjee
Daniel E. Tracey
Michael White
Zehra Kaymakcalan
Boris Labkovsky
Paul Sakorafas
Stuart Friedrich
Angela Myles
Geertruida M. Veldman
Amy Venturini
Nicholas W. Warne
Angela Widom
John G. Elvin
Alexander R. Duncan
Elaine J. Derbyshire
Sara Carmen
Stephen Smith
Thor Las Holtet
Fou Sarah L. Du
Original Assignee
Abbott Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22425740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK288082(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of SK13672001A3 publication Critical patent/SK13672001A3/sk
Publication of SK288082B6 publication Critical patent/SK288082B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
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SK1367-2001A 1999-03-25 2000-03-24 Human antibodies that bind human IL-12, their use and methods for producing, pharmaceutical composition containing it, nucleic acid and recombinant vector, which they coded, and host cell SK288082B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12660399P 1999-03-25 1999-03-25
PCT/US2000/007946 WO2000056772A1 (en) 1999-03-25 2000-03-24 Human antibodies that bind human il-12 and methods for producing

Publications (2)

Publication Number Publication Date
SK13672001A3 SK13672001A3 (sk) 2002-03-05
SK288082B6 true SK288082B6 (sk) 2013-06-03

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SK1367-2001A SK288082B6 (sk) 1999-03-25 2000-03-24 Human antibodies that bind human IL-12, their use and methods for producing, pharmaceutical composition containing it, nucleic acid and recombinant vector, which they coded, and host cell

Country Status (28)

Country Link
EP (4) EP2301970A1 (cs)
JP (3) JP4841038B2 (cs)
KR (6) KR100818066B1 (cs)
CN (4) CN101333256A (cs)
AR (3) AR043274A1 (cs)
AU (1) AU3921600A (cs)
BG (2) BG66399B1 (cs)
BR (1) BR0009323A (cs)
CA (3) CA2796140A1 (cs)
CY (2) CY1113326T1 (cs)
CZ (1) CZ303725B6 (cs)
DK (1) DK2168984T3 (cs)
ES (1) ES2390849T3 (cs)
HU (1) HUP0200575A3 (cs)
IL (3) IL145134A0 (cs)
LU (1) LU92159I2 (cs)
MX (1) MXPA01009645A (cs)
MY (2) MY142984A (cs)
NO (3) NO334828B1 (cs)
NZ (5) NZ513945A (cs)
PL (2) PL218748B1 (cs)
PT (1) PT2168984E (cs)
SI (1) SI2168984T1 (cs)
SK (1) SK288082B6 (cs)
TR (5) TR200603997T1 (cs)
TW (5) TWI280980B (cs)
WO (1) WO2000056772A1 (cs)
ZA (1) ZA200107774B (cs)

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7883704B2 (en) * 1999-03-25 2011-02-08 Abbott Gmbh & Co. Kg Methods for inhibiting the activity of the P40 subunit of human IL-12
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
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