SI2794667T1 - Low anticoagulant heparins - Google Patents
Low anticoagulant heparins Download PDFInfo
- Publication number
- SI2794667T1 SI2794667T1 SI201231283T SI201231283T SI2794667T1 SI 2794667 T1 SI2794667 T1 SI 2794667T1 SI 201231283 T SI201231283 T SI 201231283T SI 201231283 T SI201231283 T SI 201231283T SI 2794667 T1 SI2794667 T1 SI 2794667T1
- Authority
- SI
- Slovenia
- Prior art keywords
- chemically modified
- kda
- heparin
- modified heparin
- molecular weight
- Prior art date
Links
- 229920000669 heparin Polymers 0.000 title claims abstract 9
- 229960002897 heparin Drugs 0.000 title claims abstract 9
- 239000003146 anticoagulant agent Substances 0.000 title claims 2
- 229940127219 anticoagulant drug Drugs 0.000 title claims 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract 24
- 230000000694 effects Effects 0.000 claims abstract 6
- 238000000034 method Methods 0.000 claims abstract 5
- 201000004792 malaria Diseases 0.000 claims abstract 3
- 150000004676 glycans Polymers 0.000 claims 11
- 150000004804 polysaccharides Polymers 0.000 claims 11
- 150000002016 disaccharides Chemical class 0.000 claims 3
- 239000007800 oxidant agent Substances 0.000 claims 3
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical group O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- -1 disaccharide polysaccharide Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- IOTAOYHKWICOBK-UHFFFAOYSA-N 1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione;hydrochloride Chemical compound Cl.CC(C)N=C(N)\N=C(/N)NC1=CC=C(Cl)C=C1.O=C1C(=O)C2=CC=CC=C2C(O)=C1C(CC1)CCC1C1=CC=C(Cl)C=C1 IOTAOYHKWICOBK-UHFFFAOYSA-N 0.000 claims 1
- 238000005160 1H NMR spectroscopy Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- JPIJQSOTBSSVTP-STHAYSLISA-N L-threonic acid Chemical group OC[C@H](O)[C@@H](O)C(O)=O JPIJQSOTBSSVTP-STHAYSLISA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000002429 anti-coagulating effect Effects 0.000 claims 1
- 239000004019 antithrombin Substances 0.000 claims 1
- 229940114027 atovaquone / proguanil Drugs 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- IAJILQKETJEXLJ-LECHCGJUSA-N iduronic acid Chemical class O=C[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-LECHCGJUSA-N 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 abstract 1
- 229920000045 Dermatan sulfate Polymers 0.000 abstract 1
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 1
- 229920002971 Heparan sulfate Polymers 0.000 abstract 1
- 206010040642 Sickle cell anaemia with crisis Diseases 0.000 abstract 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 1
- 229940051593 dermatan sulfate Drugs 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SE2011/051538 WO2013095215A1 (en) | 2011-12-19 | 2011-12-19 | Low anticoagulant heparins |
| EP12860938.5A EP2794667B1 (en) | 2011-12-19 | 2012-12-19 | Low anticoagulant heparins |
| PCT/SE2012/051428 WO2013095276A1 (en) | 2011-12-19 | 2012-12-19 | Low anticoagulant heparins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2794667T1 true SI2794667T1 (en) | 2018-06-29 |
Family
ID=48668926
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231283T SI2794667T1 (en) | 2011-12-19 | 2012-12-19 | Low anticoagulant heparins |
| SI201231282T SI2794666T1 (en) | 2011-12-19 | 2012-12-19 | Use of chemically modified heparin derivatives in sickle cell disease |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201231282T SI2794666T1 (en) | 2011-12-19 | 2012-12-19 | Use of chemically modified heparin derivatives in sickle cell disease |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9480702B2 (enExample) |
| EP (2) | EP2794667B1 (enExample) |
| JP (2) | JP6703806B2 (enExample) |
| CN (1) | CN104053675B (enExample) |
| AU (1) | AU2012354226B2 (enExample) |
| BR (1) | BR112014014673B1 (enExample) |
| CA (2) | CA2856477C (enExample) |
| CY (2) | CY1120194T1 (enExample) |
| DK (2) | DK2794666T3 (enExample) |
| ES (2) | ES2669055T3 (enExample) |
| HR (2) | HRP20180725T1 (enExample) |
| HU (2) | HUE037554T2 (enExample) |
| IL (1) | IL232903A (enExample) |
| IN (1) | IN2014MN01056A (enExample) |
| MX (1) | MX358439B (enExample) |
| MY (1) | MY170069A (enExample) |
| NO (2) | NO2794667T3 (enExample) |
| PH (1) | PH12014501387B1 (enExample) |
| PL (2) | PL2794667T3 (enExample) |
| PT (2) | PT2794666T (enExample) |
| RS (2) | RS57214B1 (enExample) |
| SI (2) | SI2794667T1 (enExample) |
| SM (2) | SMT201800218T1 (enExample) |
| TN (2) | TN2014000237A1 (enExample) |
| WO (3) | WO2013095215A1 (enExample) |
| ZA (1) | ZA201403654B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| PT2794665T (pt) | 2011-12-19 | 2018-01-24 | Dilafor Ab | Glicosaminoglicanos não anticoagulativos que compreendem unidade repetitiva de dissacáridos e sua utilização médica |
| GB2515315A (en) | 2013-06-19 | 2014-12-24 | Dilafor Ab | New Processes |
| WO2015165944A1 (en) * | 2014-04-30 | 2015-11-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating vaso-occlusive crisis |
| EP2965764A1 (en) * | 2014-07-11 | 2016-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating vaso-occlusive crisis |
| CN105504097B (zh) * | 2015-12-30 | 2018-07-03 | 深圳市海普瑞药业集团股份有限公司 | 一种硫酸化肝素寡糖及其制备方法和应用 |
| CN108424474B (zh) * | 2017-02-15 | 2023-07-25 | 清华大学 | 去抗凝肝素衍生物及其用于炎症性肠病的治疗 |
| US12220500B2 (en) * | 2018-04-13 | 2025-02-11 | University Of Virginia Patent Foundation | Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels |
| CN109481692A (zh) * | 2018-11-30 | 2019-03-19 | 东南大学 | 一种青蒿琥酯肝素衍生物及其药物组合物和应用 |
| WO2023192343A1 (en) * | 2022-03-29 | 2023-10-05 | The Penn State Research Foundation | Bioactive granular hydrogel scaffolds and use thereof |
| US12444880B2 (en) | 2022-05-05 | 2025-10-14 | Tego Innovations, Inc. | Magnetic power distribution assembly |
| CA3257703A1 (en) * | 2022-06-06 | 2023-12-14 | Ihp Therapeutics Inc. | CHEMICALLY MODIFIED HEPARIN |
| CN119325383A (zh) * | 2022-06-06 | 2025-01-17 | Ihp治疗公司 | 经化学修饰的肝素 |
| CN115448994B (zh) * | 2022-09-28 | 2023-08-01 | 山东大学 | 一种可中和抗凝低分子量肝素及其制备方法和应用 |
| KR20250083499A (ko) * | 2022-09-29 | 2025-06-10 | 아도라 애니멀 헬스 코포레이션 | 통증 및 다른 의학적 병태의 치료를 위한 황화 글리코사미노글리칸 및 이것에서 유래한 단편의 저장에 안정한 제형 |
| GB2625581A (en) | 2022-12-21 | 2024-06-26 | Modus Therapeutics Ab | New medical use |
| GB2627263A (en) * | 2023-02-17 | 2024-08-21 | Modus Therapeutics Ab | New medical use |
| WO2024170746A1 (en) | 2023-02-17 | 2024-08-22 | Modus Therapeutics Ab | New medical use of sevuparin in the treatment of endotoxemia |
| CN116854838A (zh) * | 2023-06-30 | 2023-10-10 | 重庆望业药物研究有限公司 | 低分子多糖及其制备方法与应用 |
| GB202407366D0 (en) * | 2024-05-23 | 2024-07-10 | Glycos Biomedical Ltd | Preparation of medium molecular weight heparin |
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| CA1136620A (en) | 1979-01-08 | 1982-11-30 | Ulf P.F. Lindahl | Heparin fragments having selective anticoagulation activity |
| FR2614026B1 (fr) | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| ES2054975T3 (es) * | 1988-10-07 | 1994-08-16 | Hoechst Ag | Composiciones antimalaricas que emplean quinidina, artemisinina y sus derivados. |
| SE9002550D0 (sv) | 1990-08-01 | 1990-08-01 | Kabivitrum Ab | Heparinfragment |
| SE9003181D0 (sv) * | 1990-10-04 | 1990-10-04 | Kabivitrum Ab | Use of heparin fraction |
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| AU2010236222B2 (en) | 2009-04-16 | 2015-10-15 | Momenta Pharmaceuticals, Inc. | Methods of assessing activity of a polysaccharide composition |
| AU2010268756A1 (en) * | 2009-06-30 | 2012-01-19 | The Walter And Eliza Hall Institute Of Medical Research | Sulfated polysaccharides having antiplasmodial activity and methods and products for identifying antiplasmodial activity |
| PT2794665T (pt) | 2011-12-19 | 2018-01-24 | Dilafor Ab | Glicosaminoglicanos não anticoagulativos que compreendem unidade repetitiva de dissacáridos e sua utilização médica |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| UA117908C2 (uk) | 2012-03-26 | 2018-10-25 | Ділафор Аб | Застосування гепарину або гепарансульфату для індукції пологів |
| NZ631279A (en) | 2012-03-26 | 2016-06-24 | Dilafor Ab | Method for treatment of labor arrest |
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