CA2856918C - Use of chemically modified heparin derivates in sickle cell disease - Google Patents
Use of chemically modified heparin derivates in sickle cell disease Download PDFInfo
- Publication number
- CA2856918C CA2856918C CA2856918A CA2856918A CA2856918C CA 2856918 C CA2856918 C CA 2856918C CA 2856918 A CA2856918 A CA 2856918A CA 2856918 A CA2856918 A CA 2856918A CA 2856918 C CA2856918 C CA 2856918C
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- Prior art keywords
- heparin
- kda
- chemically modified
- polysaccharide chains
- use according
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- 230000035939 shock Effects 0.000 description 1
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- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
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- 230000004083 survival effect Effects 0.000 description 1
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- SYRHIZPPCHMRIT-UHFFFAOYSA-N tin(4+) Chemical compound [Sn+4] SYRHIZPPCHMRIT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SE2011/051538 WO2013095215A1 (en) | 2011-12-19 | 2011-12-19 | Low anticoagulant heparins |
| SEPCT/SE2011/051538 | 2011-12-19 | ||
| PCT/SE2012/051429 WO2013095277A1 (en) | 2011-12-19 | 2012-12-19 | Use of chemically modified heparin derivates in sickle cell disease |
Publications (2)
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|---|---|
| CA2856918A1 CA2856918A1 (en) | 2013-06-27 |
| CA2856918C true CA2856918C (en) | 2017-07-04 |
Family
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|---|---|---|---|
| CA2856918A Expired - Fee Related CA2856918C (en) | 2011-12-19 | 2012-12-19 | Use of chemically modified heparin derivates in sickle cell disease |
| CA2856477A Active CA2856477C (en) | 2011-12-19 | 2012-12-19 | Low anticoagulant heparins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2856477A Active CA2856477C (en) | 2011-12-19 | 2012-12-19 | Low anticoagulant heparins |
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| EP (2) | EP2794666B1 (enExample) |
| JP (2) | JP6703806B2 (enExample) |
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| HR (2) | HRP20180725T1 (enExample) |
| HU (2) | HUE037555T2 (enExample) |
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| IN (1) | IN2014MN01056A (enExample) |
| MX (1) | MX358439B (enExample) |
| MY (1) | MY170069A (enExample) |
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| PH (1) | PH12014501387A1 (enExample) |
| PL (2) | PL2794666T3 (enExample) |
| PT (2) | PT2794667T (enExample) |
| RS (2) | RS57213B1 (enExample) |
| SI (2) | SI2794667T1 (enExample) |
| SM (2) | SMT201800217T1 (enExample) |
| TN (2) | TN2014000237A1 (enExample) |
| WO (3) | WO2013095215A1 (enExample) |
| ZA (1) | ZA201403654B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6543467B2 (ja) | 2011-12-19 | 2019-07-10 | ディラホア アクチエボラゲット | 二糖繰り返し単位を含んでいる非抗凝固グリコサミノグリカンおよびそれらの医療用途 |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| GB2515315A (en) | 2013-06-19 | 2014-12-24 | Dilafor Ab | New Processes |
| US20170049862A1 (en) * | 2014-04-30 | 2017-02-23 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for treating vaso-occlusive crisis |
| EP2965764A1 (en) * | 2014-07-11 | 2016-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating vaso-occlusive crisis |
| CN105504097B (zh) * | 2015-12-30 | 2018-07-03 | 深圳市海普瑞药业集团股份有限公司 | 一种硫酸化肝素寡糖及其制备方法和应用 |
| CN108424474B (zh) * | 2017-02-15 | 2023-07-25 | 清华大学 | 去抗凝肝素衍生物及其用于炎症性肠病的治疗 |
| EP3773770B1 (en) * | 2018-04-13 | 2023-11-29 | University of Virginia Patent Foundation | Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels |
| CN109481692A (zh) * | 2018-11-30 | 2019-03-19 | 东南大学 | 一种青蒿琥酯肝素衍生物及其药物组合物和应用 |
| WO2023192344A1 (en) * | 2022-03-29 | 2023-10-05 | The Penn State Research Foundation | Device and method for accelerating and guiding vascularization |
| WO2023215594A1 (en) | 2022-05-05 | 2023-11-09 | Venture Health Studio, Llc | Magnetic power distribution assembly |
| EP4536248A1 (en) * | 2022-06-06 | 2025-04-16 | IHP Therapeutics Inc. | Chemically modified heparin |
| CN115448994B (zh) * | 2022-09-28 | 2023-08-01 | 山东大学 | 一种可中和抗凝低分子量肝素及其制备方法和应用 |
| US12059430B2 (en) | 2022-09-29 | 2024-08-13 | Adora Animal Health Corporation | Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions |
| GB2625581A (en) | 2022-12-21 | 2024-06-26 | Modus Therapeutics Ab | New medical use |
| WO2024170746A1 (en) | 2023-02-17 | 2024-08-22 | Modus Therapeutics Ab | New medical use of sevuparin in the treatment of endotoxemia |
| GB2627263A (en) * | 2023-02-17 | 2024-08-21 | Modus Therapeutics Ab | New medical use |
| CN116854838A (zh) * | 2023-06-30 | 2023-10-10 | 重庆望业药物研究有限公司 | 低分子多糖及其制备方法与应用 |
| GB202407366D0 (en) * | 2024-05-23 | 2024-07-10 | Glycos Biomedical Ltd | Preparation of medium molecular weight heparin |
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| SE9002550D0 (sv) | 1990-08-01 | 1990-08-01 | Kabivitrum Ab | Heparinfragment |
| SE9003181D0 (sv) | 1990-10-04 | 1990-10-04 | Kabivitrum Ab | Use of heparin fraction |
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| AU2010268756A1 (en) * | 2009-06-30 | 2012-01-19 | The Walter And Eliza Hall Institute Of Medical Research | Sulfated polysaccharides having antiplasmodial activity and methods and products for identifying antiplasmodial activity |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| JP6543467B2 (ja) | 2011-12-19 | 2019-07-10 | ディラホア アクチエボラゲット | 二糖繰り返し単位を含んでいる非抗凝固グリコサミノグリカンおよびそれらの医療用途 |
| MX2014011505A (es) | 2012-03-26 | 2014-12-05 | Dilafor Ab | Terapias para inducir el parto. |
| CN104244957B (zh) | 2012-03-26 | 2017-11-17 | 迪乐方有限责任公司 | 用于治疗分娩停止的方法 |
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- 2012-12-19 WO PCT/SE2012/051428 patent/WO2013095276A1/en not_active Ceased
- 2012-12-19 PT PT128593845T patent/PT2794666T/pt unknown
- 2012-12-19 ES ES12859384.5T patent/ES2668273T3/es active Active
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2014
- 2014-05-20 ZA ZA2014/03654A patent/ZA201403654B/en unknown
- 2014-05-29 TN TNP2014000237A patent/TN2014000237A1/en unknown
- 2014-05-29 TN TNP2014000236A patent/TN2014000236A1/en unknown
- 2014-06-01 IL IL232903A patent/IL232903A/en active IP Right Grant
- 2014-06-18 PH PH12014501387A patent/PH12014501387A1/en unknown
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2018
- 2018-05-10 CY CY20181100483T patent/CY1120197T1/el unknown
- 2018-05-10 CY CY20181100482T patent/CY1120194T1/el unknown
- 2018-06-12 JP JP2018112162A patent/JP2018154848A/ja active Pending
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| MKLA | Lapsed |
Effective date: 20191219 |