JP6703806B2 - 低抗凝固剤ヘパリン - Google Patents

低抗凝固剤ヘパリン Download PDF

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Publication number
JP6703806B2
JP6703806B2 JP2014547145A JP2014547145A JP6703806B2 JP 6703806 B2 JP6703806 B2 JP 6703806B2 JP 2014547145 A JP2014547145 A JP 2014547145A JP 2014547145 A JP2014547145 A JP 2014547145A JP 6703806 B2 JP6703806 B2 JP 6703806B2
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JP
Japan
Prior art keywords
chemically modified
heparin
modified heparin
molecular weight
kda
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JP2014547145A
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English (en)
Japanese (ja)
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JP2015500387A (ja
JP2015500387A5 (enExample
Inventor
エイキュラ,ハンス−ペータ
リンダール,ウルフ
ホルマー,エリック
エリクソン,ペル−オルブ
ライトゲプ,アンナ
ボールグレーン,マッツ
ティーディア,ステファーニャ
リヴェラーニ,リーノ
Original Assignee
モーダス セラピューティクス アクチエボラゲット
モーダス セラピューティクス アクチエボラゲット
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Publication of JP2015500387A5 publication Critical patent/JP2015500387A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078Degradation products
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014547145A 2011-12-19 2012-12-19 低抗凝固剤ヘパリン Active JP6703806B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/SE2011/051538 WO2013095215A1 (en) 2011-12-19 2011-12-19 Low anticoagulant heparins
SEPCT/SE2011/051538 2011-12-19
PCT/SE2012/051428 WO2013095276A1 (en) 2011-12-19 2012-12-19 Low anticoagulant heparins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018112162A Division JP2018154848A (ja) 2011-12-19 2018-06-12 低抗凝固剤ヘパリン

Publications (3)

Publication Number Publication Date
JP2015500387A JP2015500387A (ja) 2015-01-05
JP2015500387A5 JP2015500387A5 (enExample) 2016-12-01
JP6703806B2 true JP6703806B2 (ja) 2020-06-03

Family

ID=48668926

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014547145A Active JP6703806B2 (ja) 2011-12-19 2012-12-19 低抗凝固剤ヘパリン
JP2018112162A Pending JP2018154848A (ja) 2011-12-19 2018-06-12 低抗凝固剤ヘパリン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018112162A Pending JP2018154848A (ja) 2011-12-19 2018-06-12 低抗凝固剤ヘパリン

Country Status (26)

Country Link
US (2) US9480702B2 (enExample)
EP (2) EP2794666B1 (enExample)
JP (2) JP6703806B2 (enExample)
CN (1) CN104053675B (enExample)
AU (1) AU2012354226B2 (enExample)
BR (1) BR112014014673B1 (enExample)
CA (2) CA2856918C (enExample)
CY (2) CY1120197T1 (enExample)
DK (2) DK2794667T3 (enExample)
ES (2) ES2669055T3 (enExample)
HR (2) HRP20180725T1 (enExample)
HU (2) HUE037555T2 (enExample)
IL (1) IL232903A (enExample)
IN (1) IN2014MN01056A (enExample)
MX (1) MX358439B (enExample)
MY (1) MY170069A (enExample)
NO (2) NO2794667T3 (enExample)
PH (1) PH12014501387A1 (enExample)
PL (2) PL2794666T3 (enExample)
PT (2) PT2794667T (enExample)
RS (2) RS57213B1 (enExample)
SI (2) SI2794667T1 (enExample)
SM (2) SMT201800217T1 (enExample)
TN (2) TN2014000237A1 (enExample)
WO (3) WO2013095215A1 (enExample)
ZA (1) ZA201403654B (enExample)

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JP6543467B2 (ja) 2011-12-19 2019-07-10 ディラホア アクチエボラゲット 二糖繰り返し単位を含んでいる非抗凝固グリコサミノグリカンおよびそれらの医療用途
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CN105504097B (zh) * 2015-12-30 2018-07-03 深圳市海普瑞药业集团股份有限公司 一种硫酸化肝素寡糖及其制备方法和应用
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JP6543467B2 (ja) 2011-12-19 2019-07-10 ディラホア アクチエボラゲット 二糖繰り返し単位を含んでいる非抗凝固グリコサミノグリカンおよびそれらの医療用途
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Also Published As

Publication number Publication date
IL232903A (en) 2017-02-28
JP2015500387A (ja) 2015-01-05
BR112014014673A8 (pt) 2017-07-04
AU2012354226A1 (en) 2014-06-05
MX358439B (es) 2018-08-21
HUE037554T2 (hu) 2018-09-28
EP2794667A1 (en) 2014-10-29
IL232903A0 (en) 2014-07-31
WO2013095276A1 (en) 2013-06-27
SI2794667T1 (en) 2018-06-29
CY1120197T1 (el) 2018-12-12
HK1199893A1 (en) 2015-07-24
HRP20180725T1 (hr) 2018-06-29
US9480701B2 (en) 2016-11-01
NZ625096A (en) 2016-07-29
SMT201800217T1 (it) 2018-05-02
IN2014MN01056A (enExample) 2015-05-01
WO2013095215A1 (en) 2013-06-27
SMT201800218T1 (it) 2018-05-02
PT2794667T (pt) 2018-05-16
PL2794666T3 (pl) 2018-08-31
PH12014501387B1 (en) 2014-09-22
CA2856918A1 (en) 2013-06-27
EP2794666A1 (en) 2014-10-29
US20140364369A1 (en) 2014-12-11
TN2014000236A1 (en) 2015-09-30
PH12014501387A1 (en) 2014-09-22
CN104053675B (zh) 2016-10-12
AU2012354226B2 (en) 2017-01-12
MX2014006956A (es) 2014-10-17
DK2794666T3 (en) 2018-04-23
EP2794666B1 (en) 2018-02-21
JP2018154848A (ja) 2018-10-04
ES2668273T3 (es) 2018-05-17
ES2669055T3 (es) 2018-05-23
NO2794667T3 (enExample) 2018-07-21
BR112014014673A2 (pt) 2017-06-13
BR112014014673B1 (pt) 2021-02-17
RS57213B1 (sr) 2018-07-31
CA2856477A1 (en) 2013-06-27
CA2856918C (en) 2017-07-04
ZA201403654B (en) 2017-08-30
MY170069A (en) 2019-07-03
HUE037555T2 (hu) 2018-09-28
TN2014000237A1 (en) 2015-09-30
DK2794667T3 (en) 2018-04-23
PL2794667T3 (pl) 2018-09-28
EP2794667A4 (en) 2015-07-22
CN104053675A (zh) 2014-09-17
US9480702B2 (en) 2016-11-01
EP2794667B1 (en) 2018-02-21
EP2794666A4 (en) 2015-07-22
CY1120194T1 (el) 2018-12-12
CA2856477C (en) 2017-06-27
WO2013095277A1 (en) 2013-06-27
RS57214B1 (sr) 2018-07-31
PT2794666T (pt) 2018-05-09
US20150031638A1 (en) 2015-01-29
HK1200471A1 (en) 2015-08-07
HRP20180726T1 (hr) 2018-06-15
SI2794666T1 (en) 2018-06-29
NO2794666T3 (enExample) 2018-07-21

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