JP2015500387A5 - - Google Patents

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Publication number
JP2015500387A5
JP2015500387A5 JP2014547145A JP2014547145A JP2015500387A5 JP 2015500387 A5 JP2015500387 A5 JP 2015500387A5 JP 2014547145 A JP2014547145 A JP 2014547145A JP 2014547145 A JP2014547145 A JP 2014547145A JP 2015500387 A5 JP2015500387 A5 JP 2015500387A5
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JP
Japan
Prior art keywords
chemically modified
kda
molecular weight
modified heparin
heparin
Prior art date
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JP2014547145A
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English (en)
Japanese (ja)
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JP2015500387A (ja
JP6703806B2 (ja
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Priority claimed from PCT/SE2011/051538 external-priority patent/WO2013095215A1/en
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Publication of JP2015500387A publication Critical patent/JP2015500387A/ja
Publication of JP2015500387A5 publication Critical patent/JP2015500387A5/ja
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Publication of JP6703806B2 publication Critical patent/JP6703806B2/ja
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JP2014547145A 2011-12-19 2012-12-19 低抗凝固剤ヘパリン Active JP6703806B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SEPCT/SE2011/051538 2011-12-19
PCT/SE2011/051538 WO2013095215A1 (en) 2011-12-19 2011-12-19 Low anticoagulant heparins
PCT/SE2012/051428 WO2013095276A1 (en) 2011-12-19 2012-12-19 Low anticoagulant heparins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018112162A Division JP2018154848A (ja) 2011-12-19 2018-06-12 低抗凝固剤ヘパリン

Publications (3)

Publication Number Publication Date
JP2015500387A JP2015500387A (ja) 2015-01-05
JP2015500387A5 true JP2015500387A5 (enExample) 2016-12-01
JP6703806B2 JP6703806B2 (ja) 2020-06-03

Family

ID=48668926

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014547145A Active JP6703806B2 (ja) 2011-12-19 2012-12-19 低抗凝固剤ヘパリン
JP2018112162A Pending JP2018154848A (ja) 2011-12-19 2018-06-12 低抗凝固剤ヘパリン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2018112162A Pending JP2018154848A (ja) 2011-12-19 2018-06-12 低抗凝固剤ヘパリン

Country Status (26)

Country Link
US (2) US9480702B2 (enExample)
EP (2) EP2794666B1 (enExample)
JP (2) JP6703806B2 (enExample)
CN (1) CN104053675B (enExample)
AU (1) AU2012354226B2 (enExample)
BR (1) BR112014014673B1 (enExample)
CA (2) CA2856918C (enExample)
CY (2) CY1120194T1 (enExample)
DK (2) DK2794667T3 (enExample)
ES (2) ES2668273T3 (enExample)
HR (2) HRP20180726T1 (enExample)
HU (2) HUE037555T2 (enExample)
IL (1) IL232903A (enExample)
IN (1) IN2014MN01056A (enExample)
MX (1) MX358439B (enExample)
MY (1) MY170069A (enExample)
NO (2) NO2794666T3 (enExample)
PH (1) PH12014501387A1 (enExample)
PL (2) PL2794666T3 (enExample)
PT (2) PT2794667T (enExample)
RS (2) RS57213B1 (enExample)
SI (2) SI2794667T1 (enExample)
SM (2) SMT201800217T1 (enExample)
TN (2) TN2014000236A1 (enExample)
WO (3) WO2013095215A1 (enExample)
ZA (1) ZA201403654B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2856492C (en) 2011-12-19 2017-01-10 Dilafor Ab Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
GB2515315A (en) 2013-06-19 2014-12-24 Dilafor Ab New Processes
EP2965764A1 (en) * 2014-07-11 2016-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treating vaso-occlusive crisis
ES2749076T3 (es) * 2014-04-30 2020-03-19 Inst Nat Sante Rech Med DNasa para uso en el tratamiento de crisis vaso-oclusivas
CN105504097B (zh) * 2015-12-30 2018-07-03 深圳市海普瑞药业集团股份有限公司 一种硫酸化肝素寡糖及其制备方法和应用
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
US12220500B2 (en) * 2018-04-13 2025-02-11 University Of Virginia Patent Foundation Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels
CN109481692A (zh) * 2018-11-30 2019-03-19 东南大学 一种青蒿琥酯肝素衍生物及其药物组合物和应用
US20250205392A1 (en) * 2022-03-29 2025-06-26 The Penn State Research Foundation Device and method for accelerating and guiding vascularization
WO2023215594A1 (en) 2022-05-05 2023-11-09 Venture Health Studio, Llc Magnetic power distribution assembly
EP4536248A4 (en) * 2022-06-06 2026-02-11 Ihp Therapeutics Inc CHEMICALLY MODIFIED HEPARIN
US20250360161A1 (en) * 2022-06-06 2025-11-27 Ihp Therapeutics Inc. Chemically modified heparin
CN115448994B (zh) * 2022-09-28 2023-08-01 山东大学 一种可中和抗凝低分子量肝素及其制备方法和应用
CN120112299A (zh) 2022-09-29 2025-06-06 爱多拉动物健康公司 用于治疗疼痛和其他医学病症的硫酸化糖胺聚糖及其衍生片段的储存稳定的制剂
GB2625581A (en) 2022-12-21 2024-06-26 Modus Therapeutics Ab New medical use
GB2627263A (en) * 2023-02-17 2024-08-21 Modus Therapeutics Ab New medical use
EP4665360A1 (en) 2023-02-17 2025-12-24 Modus Therapeutics AB New medical use of sevuparin in the treatment of endotoxemia
CN116854838A (zh) * 2023-06-30 2023-10-10 重庆望业药物研究有限公司 低分子多糖及其制备方法与应用
GB202407366D0 (en) * 2024-05-23 2024-07-10 Glycos Biomedical Ltd Preparation of medium molecular weight heparin

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136620A (en) 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
FR2614026B1 (fr) 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
DE68906345T2 (de) * 1988-10-07 1993-10-28 Hoechst Ag Antimalariazusammenstellungen, gebrauchmachend von Quinidin, Artemisinin und ihren Derivaten.
SE9002550D0 (sv) 1990-08-01 1990-08-01 Kabivitrum Ab Heparinfragment
SE9003181D0 (sv) 1990-10-04 1990-10-04 Kabivitrum Ab Use of heparin fraction
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
US5250519A (en) * 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
JPH0532703A (ja) * 1991-07-26 1993-02-09 Terumo Corp 低分子量ヘパリン誘導体の製造法
WO1994008595A1 (en) 1992-10-13 1994-04-28 Virginia Commonwealth University Use of non-anticoagulant heparin for treating ischemia/reperfusion injury
US5527785A (en) * 1993-05-14 1996-06-18 The Regents Of The University Of California Selectin receptor modulating compositions
DE69623840D1 (de) * 1995-03-31 2002-10-31 Hamilton Civic Hospitals Res Zusammensetzung zur Hemmung der Thromboseentstehung
US5993810A (en) 1996-03-15 1999-11-30 Lebovitz; Shamir Israel Method of softening or ripening the cervix of a female mammal using collagenase
US5767269A (en) 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
WO1998016559A1 (fr) 1996-10-15 1998-04-23 Toray Industries, Inc. Agent de maturation des canaux cervicaux
GB9711443D0 (en) 1997-06-03 1997-07-30 Leo Pharm Prod Ltd Chemical suppositions
JP3342007B2 (ja) * 1997-11-20 2002-11-05 郁男 山科 低分子ヘパリン修飾体及び皮膚潰瘍治療剤
US6596705B1 (en) 1998-02-09 2003-07-22 The Regents Of The University Of California Inhibition of L-selectin and P-selection mediated binding using heparin
US6498246B1 (en) 1998-02-26 2002-12-24 Seikagaku Corporation Glycosaminoglycan derivatives and processes for preparing same
US6028061A (en) * 1998-06-18 2000-02-22 Children's Medical Center Corp Angiogenesis inhibitors and use thereof
US6492503B1 (en) * 1998-07-31 2002-12-10 Seikagaku Corporation Glycosaminoglycan and drug compositions containing the same
JP2003504428A (ja) * 1999-06-30 2003-02-04 ハミルトン シビック ホスピタルズ リサーチ ディベロップメント インコーポレイテッド クロット関連凝固因子を阻害するヘパリン組成物
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
DE60138115D1 (de) * 2000-09-12 2009-05-07 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
SE521676C2 (sv) 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
US20040072796A1 (en) * 2002-04-18 2004-04-15 Embury Stephen H. Method and composition for preventing pain in sickle cell patients
US8071569B2 (en) * 2002-09-20 2011-12-06 Mousa Shaker A Oxidized heparin fractions and their use in inhibiting angiogenesis
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
EP1758557B1 (en) * 2004-05-11 2011-07-13 Egalet Ltd. Swellable dosage form comprising gellan gum
US20060040896A1 (en) * 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
US7741311B2 (en) * 2005-01-03 2010-06-22 Shaker Mousa Composition and method for treating occlusive vascular diseases, nerve regeneration, and wound healing
US20070021378A1 (en) * 2005-07-22 2007-01-25 The Regents Of The University Of California Heparin compositions and selectin inhibition
EP1906975A4 (en) * 2005-07-22 2010-10-06 Trf Pharma Inc METHOD FOR THE TREATMENT OF SICKLE CELL DISEASE AND CONSEQUENCES OF SICKLE CELL DISEASE
EP2447285A3 (en) * 2006-05-25 2013-01-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
ES2567079T3 (es) * 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009073184A1 (en) 2007-12-03 2009-06-11 Florida State University Research Foundation, Inc. Compositions for inducing labor and associated methods
JP5758797B2 (ja) * 2008-04-04 2015-08-05 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法
US20110206770A1 (en) * 2008-07-25 2011-08-25 Alphapharm Pty. Ltd. Atovaquone with a particle size diameter range (d90) of greater than 3 microns to about 10 microns
US20120183976A1 (en) 2009-04-16 2012-07-19 He Zhou Methods of assessing activity of a polysaccharide composition
AU2010268756A1 (en) * 2009-06-30 2012-01-19 The Walter And Eliza Hall Institute Of Medical Research Sulfated polysaccharides having antiplasmodial activity and methods and products for identifying antiplasmodial activity
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
CA2856492C (en) 2011-12-19 2017-01-10 Dilafor Ab Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use
RU2014143017A (ru) 2012-03-26 2016-05-20 Дилафор Аб Препараты для индукции родов
CA2868479A1 (en) 2012-03-26 2013-10-03 Dilafor Ab Method for treatment of labor arrest

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