IN2014MN01056A - - Google Patents

Info

Publication number
IN2014MN01056A
IN2014MN01056A IN1056MUN2014A IN2014MN01056A IN 2014MN01056 A IN2014MN01056 A IN 2014MN01056A IN 1056MUN2014 A IN1056MUN2014 A IN 1056MUN2014A IN 2014MN01056 A IN2014MN01056 A IN 2014MN01056A
Authority
IN
India
Prior art keywords
antifactor
activity
less
heparin
malaria
Prior art date
Application number
Inventor
Hans Peter Ekre
Ulf Lindahl
Erik Holmer
Per Olov Eriksson
Anna Leitgeb
Mats Wahlgren
Stefania Tidia
Lino Liverani
Original Assignee
Dilaforette Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dilaforette Ab filed Critical Dilaforette Ab
Publication of IN2014MN01056A publication Critical patent/IN2014MN01056A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a chemically modified heparin with an antifactor II activity of less than 10 IU/mg an antifactor Xa activity of less than 10 IU/mg and an average molecular weight (Mw) between about 6.5 and 9.5 kDa. Also disclosed is a method of preparing the heparin and its medical use including treatment of malaria.
IN1056MUN2014 2011-12-19 2012-12-19 IN2014MN01056A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/SE2011/051538 WO2013095215A1 (en) 2011-12-19 2011-12-19 Low anticoagulant heparins
PCT/SE2012/051428 WO2013095276A1 (en) 2011-12-19 2012-12-19 Low anticoagulant heparins

Publications (1)

Publication Number Publication Date
IN2014MN01056A true IN2014MN01056A (en) 2015-05-01

Family

ID=48668926

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1056MUN2014 IN2014MN01056A (en) 2011-12-19 2012-12-19

Country Status (26)

Country Link
US (2) US9480701B2 (en)
EP (2) EP2794666B1 (en)
JP (2) JP6703806B2 (en)
CN (1) CN104053675B (en)
AU (1) AU2012354226B2 (en)
BR (1) BR112014014673B1 (en)
CA (2) CA2856918C (en)
CY (2) CY1120194T1 (en)
DK (2) DK2794666T3 (en)
ES (2) ES2669055T3 (en)
HK (2) HK1199893A1 (en)
HR (2) HRP20180726T1 (en)
HU (2) HUE037554T2 (en)
IL (1) IL232903A (en)
IN (1) IN2014MN01056A (en)
MX (1) MX358439B (en)
MY (1) MY170069A (en)
NO (2) NO2794666T3 (en)
PH (1) PH12014501387A1 (en)
PL (2) PL2794667T3 (en)
PT (2) PT2794667T (en)
RS (2) RS57213B1 (en)
SI (2) SI2794667T1 (en)
TN (2) TN2014000236A1 (en)
WO (3) WO2013095215A1 (en)
ZA (1) ZA201403654B (en)

Families Citing this family (15)

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GB2515315A (en) 2013-06-19 2014-12-24 Dilafor Ab New Processes
EP2965764A1 (en) * 2014-07-11 2016-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treating vaso-occlusive crisis
WO2015165944A1 (en) * 2014-04-30 2015-11-05 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for treating vaso-occlusive crisis
CN105504097B (en) * 2015-12-30 2018-07-03 深圳市海普瑞药业集团股份有限公司 A kind of sulfated heparin oligosaccharides and its preparation method and application
CN108424474B (en) * 2017-02-15 2023-07-25 清华大学 Deanticoagulated heparin derivatives and their use in the treatment of inflammatory bowel disease
US20210052779A1 (en) * 2018-04-13 2021-02-25 University Of Virginia Patent Foundation Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels
CN109481692A (en) * 2018-11-30 2019-03-19 东南大学 A kind of Artesunate heparin derivatives and its pharmaceutical composition and application
WO2023239711A1 (en) * 2022-06-06 2023-12-14 Ihp Therapeutics Inc. Chemically modified heparin
CN115448994B (en) * 2022-09-28 2023-08-01 山东大学 Low molecular weight heparin capable of neutralizing anticoagulation, preparation method and application thereof
WO2024072942A2 (en) * 2022-09-29 2024-04-04 Adora Animal Health Corporation Skin penetrating formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions
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GB2627263A (en) * 2023-02-17 2024-08-21 Modus Therapeutics Ab New medical use
WO2024170746A1 (en) 2023-02-17 2024-08-22 Modus Therapeutics Ab New medical use of sevuparin in the treatment of endotoxemia

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Also Published As

Publication number Publication date
HUE037555T2 (en) 2018-09-28
PT2794667T (en) 2018-05-16
TN2014000237A1 (en) 2015-09-30
JP2015500387A (en) 2015-01-05
US9480702B2 (en) 2016-11-01
CY1120197T1 (en) 2018-12-12
DK2794666T3 (en) 2018-04-23
HK1200471A1 (en) 2015-08-07
ZA201403654B (en) 2017-08-30
MX2014006956A (en) 2014-10-17
NO2794667T3 (en) 2018-07-21
EP2794666B1 (en) 2018-02-21
IL232903A0 (en) 2014-07-31
PH12014501387B1 (en) 2014-09-22
EP2794666A1 (en) 2014-10-29
TN2014000236A1 (en) 2015-09-30
HRP20180725T1 (en) 2018-06-29
JP6703806B2 (en) 2020-06-03
MX358439B (en) 2018-08-21
HUE037554T2 (en) 2018-09-28
EP2794667A1 (en) 2014-10-29
ES2668273T3 (en) 2018-05-17
CY1120194T1 (en) 2018-12-12
NZ625096A (en) 2016-07-29
NO2794666T3 (en) 2018-07-21
AU2012354226A1 (en) 2014-06-05
EP2794667B1 (en) 2018-02-21
CA2856477A1 (en) 2013-06-27
HK1199893A1 (en) 2015-07-24
RS57214B1 (en) 2018-07-31
AU2012354226B2 (en) 2017-01-12
EP2794667A4 (en) 2015-07-22
DK2794667T3 (en) 2018-04-23
HRP20180726T1 (en) 2018-06-15
PL2794666T3 (en) 2018-08-31
PH12014501387A1 (en) 2014-09-22
BR112014014673A2 (en) 2017-06-13
WO2013095277A1 (en) 2013-06-27
SI2794667T1 (en) 2018-06-29
ES2669055T3 (en) 2018-05-23
WO2013095276A1 (en) 2013-06-27
SI2794666T1 (en) 2018-06-29
PL2794667T3 (en) 2018-09-28
CN104053675A (en) 2014-09-17
MY170069A (en) 2019-07-03
RS57213B1 (en) 2018-07-31
CA2856918C (en) 2017-07-04
EP2794666A4 (en) 2015-07-22
WO2013095215A1 (en) 2013-06-27
JP2018154848A (en) 2018-10-04
US9480701B2 (en) 2016-11-01
US20140364369A1 (en) 2014-12-11
US20150031638A1 (en) 2015-01-29
IL232903A (en) 2017-02-28
BR112014014673B1 (en) 2021-02-17
CA2856918A1 (en) 2013-06-27
CA2856477C (en) 2017-06-27
PT2794666T (en) 2018-05-09
CN104053675B (en) 2016-10-12
BR112014014673A8 (en) 2017-07-04

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