SI1337535T1 - Benzodiazepine derivatives as gaba a receptor modulators - Google Patents

Benzodiazepine derivatives as gaba a receptor modulators

Info

Publication number
SI1337535T1
SI1337535T1 SI200130125T SI200130125T SI1337535T1 SI 1337535 T1 SI1337535 T1 SI 1337535T1 SI 200130125 T SI200130125 T SI 200130125T SI 200130125 T SI200130125 T SI 200130125T SI 1337535 T1 SI1337535 T1 SI 1337535T1
Authority
SI
Slovenia
Prior art keywords
gaba
receptor modulators
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Application number
SI200130125T
Other languages
English (en)
Slovenian (sl)
Inventor
Raffaello Masciadri
Andrew William Thomas
Juergen Wichmann
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SI1337535T1 publication Critical patent/SI1337535T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200130125T 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators SI1337535T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00124332 2000-11-16
PCT/EP2001/012887 WO2002040487A2 (fr) 2000-11-16 2001-11-08 Derives de benzodiazepine comme modulateurs de recepteur gaba a
EP01996541A EP1337535B1 (fr) 2000-11-16 2001-11-08 Derives de benzodiazepine comme modulateurs de recepteur gaba a

Publications (1)

Publication Number Publication Date
SI1337535T1 true SI1337535T1 (en) 2004-10-31

Family

ID=8170315

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130125T SI1337535T1 (en) 2000-11-16 2001-11-08 Benzodiazepine derivatives as gaba a receptor modulators

Country Status (41)

Country Link
US (1) US6743789B2 (fr)
EP (1) EP1337535B1 (fr)
JP (1) JP4088151B2 (fr)
KR (1) KR100504300B1 (fr)
CN (1) CN1191255C (fr)
AR (1) AR031345A1 (fr)
AT (1) ATE268776T1 (fr)
AU (2) AU1700702A (fr)
BG (1) BG107817A (fr)
BR (1) BR0115393A (fr)
CA (1) CA2427576C (fr)
CZ (1) CZ295256B6 (fr)
DE (1) DE60103776T2 (fr)
DK (1) DK1337535T3 (fr)
EC (1) ECSP034607A (fr)
ES (1) ES2220831T3 (fr)
GC (1) GC0000375A (fr)
GT (1) GT200100230A (fr)
HK (1) HK1062442A1 (fr)
HR (1) HRP20030360A2 (fr)
HU (1) HUP0303281A3 (fr)
IL (1) IL155813A0 (fr)
JO (1) JO2359B1 (fr)
MA (1) MA26962A1 (fr)
MX (1) MXPA03004251A (fr)
MY (1) MY141675A (fr)
NO (1) NO324706B1 (fr)
NZ (1) NZ525413A (fr)
PA (1) PA8532401A1 (fr)
PE (1) PE20020583A1 (fr)
PL (1) PL362925A1 (fr)
PT (1) PT1337535E (fr)
RU (1) RU2278865C2 (fr)
SI (1) SI1337535T1 (fr)
SK (1) SK7232003A3 (fr)
TR (1) TR200402073T4 (fr)
TW (1) TWI239333B (fr)
UY (1) UY27026A1 (fr)
WO (1) WO2002040487A2 (fr)
YU (1) YU35603A (fr)
ZA (1) ZA200303435B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
EP1634879A4 (fr) * 2003-06-19 2007-09-05 Daiichi Seiyaku Co Procede d'introduction selective de composants amino
ES2515092T3 (es) 2003-12-11 2014-10-29 Sunovion Pharmaceuticals Inc. Combinación de un sedante y un modulador neurotransmisor y métodos de mejorar la calidad del sueño y de tratar la depresión
US7572783B2 (en) 2004-08-13 2009-08-11 Amgen Inc. Substituted benzofused heterocycles
KR100869388B1 (ko) 2004-10-12 2008-11-21 에프. 호프만-라 로슈 아게 인지 장애를 치료하기 위한이미다조[1,5-ａ]트라이아졸로[1,5-ｄ]벤조다이아제핀유도체
CN101084220B (zh) * 2004-10-20 2010-12-15 弗·哈夫曼-拉罗切有限公司 卤素取代的苯并二氮杂*衍生物
JP4783375B2 (ja) * 2004-10-20 2011-09-28 エフ．ホフマン−ラ ロシュ アーゲー イミダゾベンゾジゼピン誘導体
WO2006063708A1 (fr) 2004-12-14 2006-06-22 F.Hoffmann-La Roche Ag Imidazo-benzodiazepines tetracycliques en tant que modulateurs des recepteurs gaba
US8510055B2 (en) 2005-08-03 2013-08-13 The Johns Hopkins University Methods for characterizing and treating cognitive impairment in aging and disease
WO2007019312A2 (fr) * 2005-08-03 2007-02-15 The Johns Hopkins University Methodes permettant de caracteriser et de traiter un trouble cognitif du au vieillissement ou une maladie
AU2006301377B2 (en) * 2005-10-11 2012-03-08 F. Hoffmann-La Roche Ag Imidazo benzodiazepine derivatives
WO2007053596A1 (fr) 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
US9156836B2 (en) * 2008-05-16 2015-10-13 Synta Pharmaceuticals Corp. Tricyclic triazole compounds that modulate HSP90 activity
WO2010057795A1 (fr) 2008-11-18 2010-05-27 F. Hoffmann-La Roche Ag Alkylcyclohexyléthers de dihydrotétrazabenzoazulènes
BRPI0922303B1 (pt) * 2008-11-28 2019-11-12 Hoffmann La Roche arilciclo-hexiléteres de di-hidrotetra-azabenzoazulenos, seu processo de preparação, composição farmacêutica que os compreende e uso
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
JP5916746B2 (ja) 2010-11-15 2016-05-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのピリダジン誘導体、組成物、および方法
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CA2885148A1 (fr) * 2012-09-21 2014-03-27 Uwm Research Foundation, Inc. Nouveaux agonistes gabaa et leurs procedes d'utilisation pour lutter contre l'hyperexcitabilite et l'inflammation bronchiques au cours de l'asthme
CN106068256B (zh) * 2013-12-20 2020-10-23 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂*衍生物、组合物和方法
JP6987384B2 (ja) * 2015-06-19 2021-12-22 エージンバイオ， インコーポレイテッド ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
US10059718B2 (en) * 2016-01-04 2018-08-28 Tabomedex Biosciences, LLC Fused quadracyclic compounds, compositions and uses thereof
US10973479B2 (en) 2016-05-16 2021-04-13 Canon Medical Systems Corporation X-ray diagnosis apparatus, X-ray diagnosis apparatus controlling method, and X-ray diagnosis system
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물
JP7514534B2 (ja) * 2018-06-19 2024-07-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法
KR102151969B1 (ko) * 2019-12-11 2020-09-04 주식회사 지투비 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창
CN112979658B (zh) * 2021-02-22 2022-05-31 南湖实验室 一种氟马西尼的制备方法
WO2024039886A1 (fr) 2022-08-19 2024-02-22 Agenebio, Inc. Dérivés de benzoazépine, compositions et méthodes de traitement de déficience cognitive

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK174086D0 (da) 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
TW201311B (fr) 1991-06-17 1993-03-01 Hoffmann La Roche

Also Published As

Publication number Publication date
CN1474820A (zh) 2004-02-11
NO324706B1 (no) 2007-12-03
UY27026A1 (es) 2002-06-20
GC0000375A (en) 2007-03-31
WO2002040487A3 (fr) 2002-09-26
DE60103776T2 (de) 2005-07-14
PA8532401A1 (es) 2002-08-26
EP1337535A2 (fr) 2003-08-27
ZA200303435B (en) 2004-08-05
IL155813A0 (en) 2003-12-23
DK1337535T3 (da) 2004-10-25
YU35603A (sh) 2006-05-25
CA2427576A1 (fr) 2002-05-23
CN1191255C (zh) 2005-03-02
BG107817A (bg) 2004-07-30
NO20032208L (no) 2003-05-15
SK7232003A3 (en) 2004-03-02
CA2427576C (fr) 2007-11-06
NZ525413A (en) 2005-02-25
TR200402073T4 (tr) 2004-10-21
JP2004517070A (ja) 2004-06-10
PL362925A1 (en) 2004-11-02
MY141675A (en) 2010-06-15
PE20020583A1 (es) 2002-07-06
CZ20031597A3 (cs) 2003-11-12
RU2278865C2 (ru) 2006-06-27
HUP0303281A3 (en) 2005-05-30
ATE268776T1 (de) 2004-06-15
HRP20030360A2 (en) 2005-04-30
BR0115393A (pt) 2004-07-06
JP4088151B2 (ja) 2008-05-21
NO20032208D0 (no) 2003-05-15
WO2002040487A2 (fr) 2002-05-23
ECSP034607A (es) 2003-06-25
CZ295256B6 (cs) 2005-06-15
HK1062442A1 (en) 2004-11-05
US6743789B2 (en) 2004-06-01
DE60103776D1 (de) 2004-07-15
AR031345A1 (es) 2003-09-17
AU1700702A (en) 2002-05-27
JO2359B1 (en) 2006-12-12
TWI239333B (en) 2005-09-11
US20020103371A1 (en) 2002-08-01
KR20030045192A (ko) 2003-06-09
HUP0303281A2 (hu) 2004-01-28
GT200100230A (es) 2002-07-04
MXPA03004251A (es) 2003-09-22
ES2220831T3 (es) 2004-12-16
RU2003116895A (ru) 2005-02-20
EP1337535B1 (fr) 2004-06-09
KR100504300B1 (ko) 2005-07-28
MA26962A1 (fr) 2004-12-20
AU2002217007B2 (en) 2006-11-30
PT1337535E (pt) 2004-09-30

Similar Documents

Publication Publication Date Title
AU1700702A (en) Benzodiazepine derivatives as gaba a receptor modulators
GB0027773D0 (en) Gaba B receptors
HK1066544A1 (en) ImidazoÄ1,5-AÜpyrimido Ä5,4-DÜ benzazepine derivatives as gaba a receptor modulators
AU2001255024A1 (en) A distributor unit
IL150912A0 (en) Adenosine receptor modulators
GB0302292D0 (en) A means for applying images to other images
AU3238102A (en) Estrogen receptor modulators
IL155035A0 (en) Benzodiazepine derivatives
AU3468599A (en) Gaba b receptor
GB0000474D0 (en) Receptor
AU1252102A (en) Receptor
EP1064992A4 (fr) Dispositif de distribution pour multi-réacteurs
GB0029637D0 (en) A scooter
GB2368855B (en) A tiling system
AU2001283880A1 (en) Polyamides
IL153180A0 (en) Polyamides
PL344820A1 (en) Distributor
GB0009269D0 (en) Receptor
GB0031096D0 (en) Receptor
GB0014761D0 (en) Receptor
GB2348592B (en) Riding aid
CA89634S (en) Seat for a bicycle
GB0016335D0 (en) A means for applying images to other images
GB0021422D0 (en) A means for applying images to other images
AU3611599A (en) Gaba a receptor epsilon2 subunit