SG47877A1 - Use of tetrahydrocarbazone derivatives as 5HT receptor agonists - Google Patents

Use of tetrahydrocarbazone derivatives as 5HT receptor agonists

Info

Publication number
SG47877A1
SG47877A1 SG1996004938A SG1996004938A SG47877A1 SG 47877 A1 SG47877 A1 SG 47877A1 SG 1996004938 A SG1996004938 A SG 1996004938A SG 1996004938 A SG1996004938 A SG 1996004938A SG 47877 A1 SG47877 A1 SG 47877A1
Authority
SG
Singapore
Prior art keywords
tetrahydrocarbazone
derivatives
receptor agonists
agonists
receptor
Prior art date
Application number
SG1996004938A
Other languages
English (en)
Inventor
Alberto Julio Kaulmann
Francis David King
Laramie Mary Gaster
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG47877(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SG47877A1 publication Critical patent/SG47877A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG1996004938A 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT receptor agonists SG47877A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments

Publications (1)

Publication Number Publication Date
SG47877A1 true SG47877A1 (en) 1998-04-17

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996004938A SG47877A1 (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT receptor agonists

Country Status (34)

Country Link
US (2) US5464864A (cs)
EP (1) EP0591280B1 (cs)
JP (1) JP3261502B2 (cs)
KR (1) KR100251571B1 (cs)
CN (1) CN1034072C (cs)
AP (1) AP344A (cs)
AT (1) ATE170746T1 (cs)
BR (2) BR9206237A (cs)
CA (1) CA2113726C (cs)
CZ (3) CZ150596A3 (cs)
DE (2) DE69226953T2 (cs)
DK (1) DK0591280T3 (cs)
FI (1) FI103967B1 (cs)
GB (1) GB9113802D0 (cs)
HU (1) HU218907B (cs)
IE (1) IE922062A1 (cs)
IL (4) IL102322A (cs)
LU (1) LU90939I2 (cs)
MA (1) MA22563A1 (cs)
MX (1) MX9203444A (cs)
NL (1) NL300103I2 (cs)
NO (2) NO304774B1 (cs)
NZ (1) NZ243288A (cs)
PL (3) PL169392B1 (cs)
PT (1) PT100620B (cs)
RU (1) RU2137474C1 (cs)
SA (1) SA92130141B1 (cs)
SG (1) SG47877A1 (cs)
SI (1) SI9200125B (cs)
SK (3) SK280907B6 (cs)
TW (1) TW214544B (cs)
UA (1) UA41254C2 (cs)
WO (1) WO1993000086A1 (cs)
ZA (1) ZA924658B (cs)

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US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
EP0749962B1 (en) * 1995-06-23 2000-11-02 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
MXPA04002826A (es) * 2001-09-28 2004-07-02 Hoffmann La Roche Formas pseudopolimorficas de carvedilol.
NZ537772A (en) 2002-06-21 2007-05-31 Suven Life Sciences Ltd Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
BR0312176A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario
NZ540842A (en) 2002-11-28 2008-05-30 Suven Life Sciences Ltd N-arylsulfonyl-3-aminoalkoxyindoles
DK1581492T3 (da) 2002-11-28 2008-11-10 Suven Life Sciences Ltd N-arylsulfonyl-3-substituerede indoler med serotoninreceptoraffinitet, fremgangsmåde til fremstilling heraf og en farmaceutisk sammensætning indeholdende disse
BRPI0316895C1 (pt) 2002-12-18 2021-05-25 Suven Life Sciences Ltd composto, processo para a preparação do composto, composição farmacêutica e uso do composto
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
SI2051962T1 (sl) * 2006-08-07 2012-02-29 Actelion Pharmaceuticals Ltd Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-ocetne kisline
SI2124556T1 (sl) 2006-10-09 2015-01-30 Charleston Laboratories, Inc. Farmacevtske sestave
MX2009008582A (es) 2007-02-11 2009-10-30 Map Pharmaceuticals Inc Metodo para la administracion terapeutica de dihidroergotamina para permitir un rapido alivio de la migraña mientras se minimiza el perfil de efectos secundarios.
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
CA3066426A1 (en) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
US9204906B2 (en) 2009-10-22 2015-12-08 Nuvasive, Inc. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
US9399053B2 (en) 2011-07-22 2016-07-26 The University Of Chicago Treatments for migraine and related disorders
HK1216250A1 (zh) 2012-12-21 2016-10-28 Map Pharmaceuticals, Inc. 8'-羟基-二氢麦角胺化合物及组合物
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
WO2025038666A2 (en) * 2023-08-13 2025-02-20 GATC Health Corp Compounds and methods for treating addiction
CN119499195A (zh) * 2024-11-26 2025-02-25 青岛国信制药有限公司 一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
TW214544B (cs) 1993-10-11
JP3261502B2 (ja) 2002-03-04
PT100620A (pt) 1993-09-30
FI935842A0 (fi) 1993-12-23
SI9200125A (en) 1992-12-31
NL300103I2 (nl) 2003-02-03
CZ282061B6 (cs) 1997-05-14
UA41254C2 (uk) 2001-09-17
AU652842B2 (en) 1994-09-08
HUT68961A (en) 1995-08-28
SK280905B6 (sk) 2000-09-12
CA2113726A1 (en) 1993-01-07
MA22563A1 (fr) 1992-12-31
BR9206237A (pt) 1995-04-11
NO304774B1 (no) 1999-02-15
DK0591280T3 (da) 1999-02-15
ZA924658B (en) 1993-12-24
IL102322A0 (en) 1993-01-14
CZ282327B6 (cs) 1997-06-11
HK1014669A1 (en) 1999-09-30
IE922062A1 (en) 1992-12-30
FI103967B (fi) 1999-10-29
RU2137474C1 (ru) 1999-09-20
BR1100460A (pt) 2000-07-18
FI103967B1 (fi) 1999-10-29
JPH06508827A (ja) 1994-10-06
SK131993A3 (en) 1994-06-08
MX9203444A (es) 1993-12-01
NO2005011I2 (no) 2008-02-11
NO934800D0 (no) 1993-12-23
HU218907B (hu) 2000-12-28
US5464864A (en) 1995-11-07
US5637611A (en) 1997-06-10
SI9200125B (en) 2001-12-31
DE69226953T2 (de) 1999-05-12
PL169392B1 (pl) 1996-07-31
KR100251571B1 (ko) 2000-07-01
GB9113802D0 (en) 1991-08-14
ATE170746T1 (de) 1998-09-15
NL300103I1 (nl) 2002-12-02
CZ150596A3 (en) 1997-05-14
WO1993000086A1 (en) 1993-01-07
CZ150696A3 (en) 1997-06-11
IL117105A (en) 1998-01-04
IL117104A (en) 1997-09-30
IL117105A0 (en) 1996-06-18
SK280906B6 (sk) 2000-09-12
NO934800L (no) 1993-12-23
PL171034B1 (en) 1997-02-28
FI935842A7 (fi) 1993-12-23
CN1034072C (zh) 1997-02-19
IL117104A0 (en) 1996-06-18
NZ243288A (en) 1994-09-27
PL169410B1 (pl) 1996-07-31
DE69226953D1 (de) 1998-10-15
PT100620B (pt) 1999-01-29
IL102322A (en) 1997-09-30
SA92130141B1 (ar) 2005-12-18
DE10299042I2 (de) 2005-02-03
NO2005011I1 (no) 2005-05-18
AP9200403A0 (en) 1992-07-31
CZ282083B6 (cs) 1997-05-14
CN1069726A (zh) 1993-03-10
CA2113726C (en) 2008-02-19
EP0591280B1 (en) 1998-09-09
CZ286193A3 (en) 1994-07-13
LU90939I2 (fr) 2002-09-24
AU1977592A (en) 1993-01-25
EP0591280A1 (en) 1994-04-13
DE10299042I1 (de) 2003-02-20
SK280907B6 (sk) 2000-09-12
AP344A (en) 1994-07-05

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